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Nutrition: Iron

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Total 255 results found since Jan 2013.

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells
CONCLUSION: Taken together, our findings indicate that temozolomide may suppress cell growth partly by inducing ferroptosis by targeting DMT1 expression in glioblastoma cells.PMID:34427071 | PMC:PMC8382730 | DOI:10.3349/ymj.2021.62.9.843
Source: Yonsei Medical Journal - August 24, 2021 Category: Universities & Medical Training Authors: Qingxin Song Shanxin Peng Zhiqing Sun Xueyuan Heng Xiaosong Zhu Source Type: research

Ferritin: A Multifunctional Nanoplatform for Biological Detection, Imaging Diagnosis, and Drug Delivery
We reported that human HFn could selectively deliver a large amount of cargo into tumors in vivo via transferrin receptor 1 (TfR1)-mediated tumor-cell-specific targeting followed by rapid internalization. By the use of the intrinsic tumor-targeting property and unique nanocage structure of human HFn, a broad variety of cargo-loaded HFn formulations have been developed for biological analysis, imaging diagnosis, and medicine development. In view of the intrinsic tumor-targeting property, unique nanocage structure, lack of immunogenicity, and definite in vivo behavior, human HFn holds promise to promote therapeutic drugs, di...
Source: Cell Research - August 20, 2021 Category: Cytology Authors: Ningning Song Jianlin Zhang Jiao Zhai Juanji Hong Chang Yuan Minmin Liang Source Type: research

Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium
In conclusion, hepcidin likely binds Fe2+, but not Cd2+. Because Fe2+ and Cd2+ compete for functional binding sites in proteins, hepcidin affects their free metal ion pools and differentially impacts downstream processes and cell fate.PMID:34181029 | DOI:10.1007/s00204-021-03106-z
Source: Archives of Toxicology - June 28, 2021 Category: Toxicology Authors: Stephanie Probst Johannes Fels Bettina Scharner Natascha A Wolff Eleni Roussa Rachel P L van Swelm Wing-Kee Lee Frank Th évenod Source Type: research

Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells
AbstractTargeting the elimination of activated hepatic stellate cells (HSCs) and blocking excessive deposition of extracellular matrix are recognized as an effective strategy for the treatment of hepatic fibrosis. As a newly discovered programmed cell death mode, the regulatory mechanism of ferroptosis in the clearance of activated HSCs has not been fully elucidated. In the present study, we reported that the induction of ferroptosis in activated HSCs was required for dihydroartemisinin (DHA) to alleviate hepatic fibrosis. Treatment with DHA could improve the damage of hepatic fibrosis in vivo and inhibit the activation of...
Source: BioFactors - June 16, 2021 Category: Biochemistry Authors: Zili Zhang, Xian Wang, Zilong Wang, Zhiyue Zhang, Yashi Cao, Zonghui Wei, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng Tags: Research Communication Source Type: research

Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway
In this study, mouse hippocampal HT-22 cells were treated with ferric ammonium citrate (FAC) alone or together with IRN, and we found IRN reduced the FAC-induced cell damage. Then, cells were treated with IRN following treatment with FAC after transfection with miR-122-5p inhibitor, and the results showed IRN reduced the FAC-induced decrease of miR-122-5p levels and relieved the ferroptosis by detecting ferroptotic marker proteins, iron ion concentration and oxidative stress level; after transfection with miR-122-5p inhibitor, the protective effects of IRN against FAC-induced ferroptosis in these cells were weakened. TP53 ...
Source: Neurochemical Research - May 4, 2021 Category: Neuroscience Authors: Haikang Zhao Xiaoqiang Li Lei Yang Liang Zhang Xiaobing Jiang Wenwen Gao Peng Chen Yingying Cheng Fenglu Wang Jianrong Liu Source Type: research

MRI-Visible Nanovehicle for Efficient siRNA Delivery
Methods Mol Biol. 2021;2282:195-208. doi: 10.1007/978-1-0716-1298-9_13.ABSTRACTVisualizing siRNA delivery through medical imaging methods has drawn much attentions in recent gene therapy studies. Among them, iron oxide-based magnetic resonance imaging (MRI) is regarded as one of the most promising imaging modalities for its high spatial resolution as well as deep penetration and real-time properties. In this chapter, a detailed protocol of an amphiphilic superparamagnetic iron oxide (SPIO) nanovehicle-based siRNA delivery is described, mainly focusing on SPIO/siRNA complexes formation and characterization, in vitro and in ...
Source: Mol Biol Cell - April 30, 2021 Category: Molecular Biology Authors: Rongrong Jin Wencheng Zhu Gan Lin Gang Liu Hua Ai Source Type: research

Lysosomal escaped protein nanocarriers for nuclear-targeted siRNA delivery
Anal Bioanal Chem. 2021 Mar 26. doi: 10.1007/s00216-021-03297-5. Online ahead of print.ABSTRACTIn the process of drug carrier design, lysosome degradation in cells is often neglected, which makes a considerable number of drugs not play a role. Here, we have constructed a tumor treatment platform (Apn/siRNA/NLS/HA/Apt) with unique lysosomal escape function and excellent cancer treatment effect. Apoferritin (Apn) has attracted more and more attention because of its high uniformity, modifiability, and controllability. Meanwhile, its endogenous nature can avoid the risk of immune response being eliminated. We used aptamer modi...
Source: Anal Sci - March 26, 2021 Category: Chemistry Authors: Xiuping Cao Xinxin Shang Yingshu Guo Xiaofei Zheng Wenxin Li Di Wu Li Sun Shanliang Mu Chuanen Guo Source Type: research