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Total 255 results found since Jan 2013.
Evaluation of liver specific ionizable lipid nanocarrierin the delivery of siRNA
Chem Phys Lipids. 2022 May 24:105207. doi: 10.1016/j.chemphyslip.2022.105207. Online ahead of print.ABSTRACTHepcidin, a key regulator of iron homeostasis, has been implicated in the pathogenesis of various iron-related diseases. Although small interfering RNA (siRNA) are potent to modulate the expression of hepcidin, their bioavailability remains a major issue. The β-galactopyranoside-conjugated liposomes (GAL-liposome) targeting liver synthesized hepcidin were prepared by thin lipid film hydration method to encapsulate siRNA and the conjugation of β-galactopyranoside to the lipid nanocarrier was achieved by covalent che...
Source: Chemistry and Physics of Lipids - May 27, 2022 Category: Lipidology Authors: Shilpa Rana Archana Bhatnagar Suman Singh Nirmal Prabhakar Source Type: research
Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis
CONCLUSION: This research suggested that H2S alleviated PM-induced emphysema and airway inflammation via restoring redox balance and inhibiting ferroptosis through regulating Nrf2-PPAR-ferritinophagy signaling pathway.PMID:35490984 | DOI:10.1016/j.freeradbiomed.2022.04.014
Source: Free Radical Biology and Medicine - May 1, 2022 Category: Biology Authors: Ying Wang Sha Liao Zihan Pan Simin Jiang Jing Fan Siwang Yu Lixiang Xue Jianling Yang Shaohua Ma Tong Liu Jing Zhang Yahong Chen Source Type: research
Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway
The molecular mechanism underlying the protective role of propofol against myocardial ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown that ferroptosis is an imperative pathological process in myocardial I/R injury. We hypothesized that propofol prevents myocardial I/R injury by inhibiting ferroptosis via the AKT/p53 signaling pathway. The ferroptosis-inducing agent erastin (E) and AKT inhibitor MK2206 (MK) were used to investigate the role of propofol in myocardial I/R injury. H9C2 cells treated without any reagents, erastin for 24 h, propofol for 1 h before adding erastin were as...
Source: Frontiers in Pharmacology - March 16, 2022 Category: Drugs & Pharmacology Source Type: research
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling
In conclusion, elabela antagonizes Ang II-mediated promotion of CMVECs ferroptosis, adverse myocardial remodeling, fibrosis and heart dysfunction through modulating the IL-6/STAT3/GPX4 signaling pathway. Targeting elabela-APJ axis serves as a novel strategy for hypertensive heart diseases.PMID:35122997 | DOI:10.1016/j.freeradbiomed.2022.01.020
Source: Free Radical Biology and Medicine - February 5, 2022 Category: Biology Authors: Zhenzhou Zhang Jianqiong Tang Jiawei Song Mengshi Xie Ying Liu Zhaojie Dong Xiaoyan Liu Xueting Li Miwen Zhang Yihang Chen Hongyu Shi Jiuchang Zhong Source Type: research
GAK and PRKCD kinases regulate basal mitophagy
Autophagy. 2022 Jan 9:1-3. doi: 10.1080/15548627.2021.2015154. Online ahead of print.ABSTRACTThe removal of mitochondria in a programmed or stress-induced manner is essential for maintaining cellular homeostasis. To date, much research has focused upon stress-induced mitophagy that is largely regulated by the E3 ligase PRKN, with limited insight into the mechanisms regulating basal "housekeeping" mitophagy levels in different model organisms. Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act a...
Source: Autophagy - January 10, 2022 Category: Cytology Authors: Michael J Munson Benan J Mathai Matthew Yoke Wui Ng Laura Trachsel-Moncho Laura R de la Ballina Anne Simonsen Source Type: research
Preparation and Preliminary Evaluation of Dual-functional Nanoparticles for MRI and siRNA Delivery
In conclusion, the visualized polycationic lipid siRNA delivery vehicle (LP-PEI1800-SPION) was successfully prepared in this experiment, which provides a research basis for further theranostics of liver cancer.
Source: Iranian Journal of Pharmaceutical Research - December 26, 2021 Category: Drugs & Pharmacology Source Type: research
siRNA@superparamagnetic iron oxide nanoparticles attenuate physiological toxicity of DEHP by suppressing autophagy pathway activities in Caenorhabditis elegans
Ecotoxicol Environ Saf. 2021 Dec 13;229:113083. doi: 10.1016/j.ecoenv.2021.113083. Online ahead of print.ABSTRACTBis(2-ethylhexyl)ortho-phthalate (DEHP) is a widely used plasticizer in polyvinyl chloride materials. Considering its widespread application, it has become a major environmental pollutant and can cause endocrine, reproductive system, and gastrointestinal disorders. Herein we aimed to elucidate the mechanisms via which DEHP causes cytotoxicity in Caenorhabditis elegans and assess whether siRNA@superparamagnetic iron oxide nanoparticles (SPIONs) can attenuate this effect. On exposing C. elegans to 10 μM DEHP, its...
Source: Ecotoxicology and Environmental Safety - December 16, 2021 Category: Environmental Health Authors: Yongyi Huang Xiling Du Te Liu Qiang Liu Source Type: research
Simultaneous blockade of TIGIT and HIF-1 α induces synergistic anti-tumor effect and decreases the growth and development of cancer cells
CONCLUSIONS: Present data suggest the combination treatment of TIGIT and HIF-1α as a novel treatment strategy against colorectal and breast cancer, but more researches are required to realize the complete role of TIGIT and HIF-1α inside the TME.PMID:34710844 | DOI:10.1016/j.intimp.2021.108288
Source: International Immunopharmacology - October 28, 2021 Category: Allergy & Immunology Authors: Mehrdad Fathi Simin Bahmanpour Asal Barshidi Hossein Rasouli Fariba Karoon Kiani Armin Mahmoud Salehi Khesht Sepideh Izadi Bentolhoda Rashidi Shiva Kermanpour Roya Mokhtarian Vahid Karpisheh Hadi Hassannia Hamed Mohammadi Ali Jalili Farhad Jadidi-Niaragh Source Type: research
Involvement of REV-ERB α dysregulation and ferroptosis in aristolochic acid I-induced renal injury
In conclusion, we identify REV-ERBα as a regulator of AAI-induced renal injury via promoting ferroptosis. Targeting REV-ERBα may represent a promising approach for management of AAI nephropathy.PMID:34673015 | DOI:10.1016/j.bcp.2021.114807
Source: Biochemical Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Authors: Yi Wang Zhigang Wang Zhengping Wu Menglin Chen Dong Dong Pei Yu Danyi Lu Baojian Wu Source Type: research
