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Total 255 results found since Jan 2013.

The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC)
We examined a possible role for CD228 in the regulation of osteogenesis and adipogenesis of hBM-MSC. Surprisingly, siRNA-mediated CD228 knockdown increased the expression of the transcription factor DLX5 and enhanced osteogenesis of hBM-MSC evidenced by an increased expression of the runt-related transcription factor 2 (RUNX2), osterix (Osx), and osteocalcin (OC), as well as higher alkaline phosphatase (ALP) activity and extracellular calcium deposition. Interestingly, hBM-MSC transfected with CD228 siRNA also showed an increase in intracellular lipid level during adipogenesis, indicated by oil red O staining of differenti...
Source: International Journal of Medical Sciences - March 22, 2021 Category: Biomedical Science Authors: Maria Dubon Sooho Lee Ji-Hong Park Jae-Yong Lee Dongchul Kang Source Type: research

Dexmedetomidine reverses MTX-induced neurotoxicity and inflammation in hippocampal HT22 cell lines via NCOA4-mediated ferritinophagy
Aging (Albany NY). 2021 Feb 25;13. doi: 10.18632/aging.202626. Online ahead of print.ABSTRACTThe incidence of chemotherapy-induced cognitive impairment (CICI) has attracted massive attention. Some studies have demonstrated the neuroprotective effects of dexmedetomidine (DEX). Here, alterations in nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy were investigated as the possible causes of DEX's neuroprotection of HT22 cells against methotrexate (MTX)-induced neurotoxicity. We used various concentrations of DEX and NCOA4-siRNA to treat MTX-induced neurotoxicity and inflammation in HT22 cells. The biomarkers of ...
Source: Aging - February 26, 2021 Category: Biomedical Science Authors: Jingli Chen Juan Wang Chenxi Li Huang Ding Jishi Ye Zhongyuan Xia Source Type: research

The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes.
In conclusion, ellagic acid is an effective skin-whitening agent and might be used as a topical applicant. PMID: 33545118 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Authors: Yang HL, Lin CP, Vudhya Gowrisankar Y, Huang PJ, Chang WL, Shrestha S, Hseu YC Tags: Biochem Pharmacol Source Type: research

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
This study was mainly conducted in primary human endometrial stromal cells. Therefore, the function of FPNin vivo need to be further investigated.WIDER IMPLICATIONS OF THE FINDINGSOur findings reveal that erastin may serve as a potential therapeutic treatment for endometriosis.STUDY FUNDING/COMPETING INTEREST(S)This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors declare no conflict of interest.
Source: Human Reproduction - December 30, 2020 Category: Reproduction Medicine Source Type: research

Inhibition of HIF-1 α/EP4 axis by hyaluronate-trimethyl chitosan-SPION nanoparticles markedly suppresses the growth and development of cancer cells.
In this study, we used hyaluronate (HA), and trimethyl chitosan (TMC) recoated superparamagnetic iron oxide nanoparticles (SPIONs) loaded with HIF-1α-silencing siRNA and the EP4 antagonist (E7046) to treat cancer cells and assessed the effect of combination therapy on cancer progression. The results showed that optimum physicochemical characteristics of NPs (size 126.9 nm, zeta potential 27 mV, PDI < 0.2) and linkage of HA with CD44 molecules overexpressed on cancer cells could deliver siRNAs to cancer cells and significantly suppress the HIF-1α in them. Combination therapy of cancer cells by using HIF-1α siR...
Source: International Journal of Biological Macromolecules - November 20, 2020 Category: Biochemistry Authors: Karpisheh V, Afjedi JF, Afjadi MN, Haeri MS, Sough TSA, Asl SH, Edalati M, Atyabi F, Masjedi A, Hajizadeh F, Izadi S, Tekie FSM, Hajiramezanali M, Sojoodi M, Jadidi-Niaragh F Tags: Int J Biol Macromol Source Type: research

miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
CONCLUSIONS: Our results support the existence of a link between the liver cell mitochondria and miR-34a/SIRT1 signaling. Potential endogenous modulators of NAFLD pathogenesis may ultimately provide new tools for therapeutic intervention. PMID: 33098868 [PubMed - as supplied by publisher]
Source: Archives of Biochemistry and Biophysics - October 21, 2020 Category: Biochemistry Authors: Wang L, Sun M, Cao Y, Ma L, Shen Y, Velikanova AA, Li X, Sun C, Zhao Y Tags: Arch Biochem Biophys Source Type: research

Targeted nanomedicine with anti-EGFR scFv for siRNA delivery into triple negative breast cancer cells.
Abstract A targeted nanomedicine with humanized anti-EGFR scFv (NM-scFv) was developed for siRNA delivery into triple negative breast cancer (TNBC) cells. NM-scFv consisted of i) targeted nanovector (NV-scFv): nano-cargo with targeting properties; ii) siRNA: pharmacological agent and iii) cationic polymers (chitosan, poly-L-arginine): for siRNA complexation and endosomal escape. NV-scFv was based on superparamagnetic nanoparticle (SPION) labeled with DylightTM680, a PEG layer and a humanized anti-EGFR scFv. The PEG density was optimized from 236±3 to 873±4 PEGs/NV-scFv and the number of targeting ligands per NV-...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 12, 2020 Category: Drugs & Pharmacology Authors: Vinh Nguyen P, Hervé-Aubert K, David S, Lautram N, Passirani C, Chourpa I, Aubrey N, Allard-Vannier E Tags: Eur J Pharm Biopharm Source Type: research

ASAP Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.0c12042
Source: ACS Applied Materials and Interfaces - September 17, 2020 Category: Materials Science Authors: Yulin Zhang, Xiao Fu, Junsheng Jia, Tobias Wikerholmen, Kaiyan Xi, Yang Kong, Junpeng Wang, Haijun Chen, Yuan Ma, Zhiwei Li, Chuanwei Wang, Qichao Qi, Frits Thorsen, Jian Wang, Jiwei Cui, Xingang Li, and Shilei Ni Source Type: research

Identification and functional characterization of natural resistance-associated macrophage protein 2 from sea cucumber Apostichopus japonicus.
In this study, a unique echinoderm Nramp2 was identified from sea cucumber Apostichopus japonicus (designated as AjNramp2). The cDNA sequence of AjNramp2 was 2360 bp, with a putative open reading frame of 1713 bp, encoding a typical Nramp domain containing protein with 570 amino acid residues. Structural analysis revealed that AjNramp2 consisted of highly conserved helix regions similar with the human Nramp2. Spatial expression analysis revealed that AjNramp2 was ubiquitously expressed in all examined tissues, with the highest level found in the intestine. Immunohistochemistry assay showed that AjNramp2 was mainly located ...
Source: Developmental and Comparative Immunology - August 21, 2020 Category: Allergy & Immunology Authors: Huang B, Lv Z, Li Y, Li C Tags: Dev Comp Immunol Source Type: research