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Nutrition: Iron
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Total 255 results found since Jan 2013.
Involvement of REV-ERBalpha dysregulation and ferroptosis in aristolochic acid I-induced renal injury
In conclusion, we identify REV-ERBα as a regulator of AAI-induced renal injury via promoting ferroptosis. Targeting REV-ERBα may represent a promising approach for management of AAI nephropathy.PMID:34673015 | DOI:10.1016/j.bcp.2021.114807
Source: Pharmacological Reviews - October 21, 2021 Category: Drugs & Pharmacology Authors: Yi Wang Zhigang Wang Zhengping Wu Menglin Chen Dong Dong Pei Yu Danyi Lu Baojian Wu Source Type: research
Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes
Biomed Pharmacother. 2021 Nov;143:112223. doi: 10.1016/j.biopha.2021.112223. Epub 2021 Sep 25.ABSTRACTFerroptosis is a recently recognized process of cell death characterized by accumulation of iron-dependent lipid peroxides. Herein, we demonstrate that peroxisome proliferator-activated receptor δ (PPARδ) inhibits ferroptosis of mouse embryonic fibroblasts (MEFs) derived from cysteine/glutamate transporter (xCT)-knockout mice. Activation of PPARδ by the specific ligand GW501516 led to a dose-dependent decrease in ferroptotic cell death triggered by xCT deficiency, along with decreased levels of intracellular iron accumu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Jung Seok Hwang Eunsu Kim Hyuk Gyoon Lee Won Jin Lee Jun Pil Won Jinwoo Hur Junichi Fujii Han Geuk Seo Source Type: research
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells
CONCLUSION: Taken together, our findings indicate that temozolomide may suppress cell growth partly by inducing ferroptosis by targeting DMT1 expression in glioblastoma cells.PMID:34427071 | PMC:PMC8382730 | DOI:10.3349/ymj.2021.62.9.843
Source: Yonsei Medical Journal - August 24, 2021 Category: Universities & Medical Training Authors: Qingxin Song Shanxin Peng Zhiqing Sun Xueyuan Heng Xiaosong Zhu Source Type: research
