TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages.

In conclusion, alterations of labile heme levels in macrophages following TLR4 stimulation play a crucial role in BACH1-mediated regulation of HO-1 expression. PMID: 31026585 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31026585?dopt=Abstract

Source: Free Radical Biology and Medicine - April 22, 2019 Category: Biology Authors: Sudan K, Vijayan V, Madyaningrana K, Gueler F, Igarashi K, Foresti R, Motterlini R, Immenschuh S Tags: Free Radic Biol Med Source Type: research