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Nutrition: Fish

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Total 107 results found since Jan 2013.

Characterization of chinese tongue sole (Cynoglossus semilaevis) 24-dehydrocholesterol reductase: Expression profile, epigenetic modification, and its knock-down effect
Gen Comp Endocrinol. 2021 Jul 26:113870. doi: 10.1016/j.ygcen.2021.113870. Online ahead of print.ABSTRACTThe sexual size dimorphism of the Chinese tongue sole (Cynoglossus semilaevis) has greatly obstructed its sustainable development; however, the underlying mechanism remains unclear. Based on C. semilaevis transcriptomic information, 24-dehydrocholesterol reductase (dhcr24) was identified in steroid biosynthesis, showing female-liver-biased expression. Dhcr24 has been reported to participate in various processes, such as cholesterol synthesis, oxidative stress response, neuroprotection, and cell survival. The present stu...
Source: General and Comparative Endocrinology - July 29, 2021 Category: Endocrinology Authors: Na Wang Zhihong Gong Jialin Wang Wenteng Xu Qian Yang Songlin Chen Source Type: research

FoxO3 Modulates LPS-Activated Hepatic Inflammation in Turbot (Scophthalmus maximus L.)
In mammals, forkhead box O3 (foxo3) plays important roles in liver immune system. The foxo3 can regulate cell cycle, DNA repair, hypoxia, apoptosis and so on. However, as such an important transcription factor, few studies on foxo3 in fish have been reported. The present study characterized the foxo3 in turbot (Scophthalmus maximus L.). Lipopolysaccharide (LPS) incubated in vitro (hepatocytes) and injected in vivo (turbot liver) were used to construct inflammatory models. The foxo3 was interfered and overexpressed to investigate its functions in liver inflammation. The open reading frame (ORF) of foxo3 was 1998 bp (base pa...
Source: Frontiers in Immunology - July 1, 2021 Category: Allergy & Immunology Source Type: research

TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage
Neurochem Res. 2021 May 10. doi: 10.1007/s11064-021-03318-w. Online ahead of print.ABSTRACTReportedly, TWIK-related spinal cord K+ (TRESK) deficiency in spinal cord neurons positively correlates with the mechanism underlying neuropathic pain (NP). However, the precise effects of TRESK on neurons of the spinal cord remain elusive. In the present study, we investigated the impact of TRESK silencing on spinal cord neurons to further elucidate the downstream mechanisms of TRESK. Herein, neurons of the dorsal spinal cord were cultured as a cell model for investigations. Apoptosis, oxidative stress, and DNA damage-related protei...
Source: Neurochemical Research - May 11, 2021 Category: Neuroscience Authors: Pei Liu Ye Cheng Huiling Xu Haicheng Huang Simin Tang Fuhu Song Jun Zhou Source Type: research

Genes, Vol. 12, Pages 297: Functions of Forkhead Box O on Glucose Metabolism in Abalone Haliotis discus hannai and Its Responses to High Levels of Dietary Lipid
In conclusion, abalone foxo can be regulated by dietary lipid and can regulate gluconeogenesis or glycolysis in response to changes of dietary lipid levels, in which glycogen metabolism plays an important role.
Source: Genes - February 20, 2021 Category: Genetics & Stem Cells Authors: Liu Wang Yanlin Guo Mingzhu Pan Xinxin Li Dong Huang Yue Liu Chenglong Wu Wenbing Zhang Kangsen Mai Tags: Article Source Type: research

Nothobranchius fish: an untapped resource for studying aging-related neurodegeneration.
Authors: Genade T Abstract New models in which aging-related neurodegeneration more closely resembling the combination of pathologies that develop in aging humans are needed. The fish Nothobranchius, which naturally develops such pathologies over the course of its short lifespan, is one such model. This review compares the lifespans and pathologies of different Nothobranchius strains to those of current vertebrate models of aging. Furthermore, existing data pertaining to neurodegeneration in these fish is discussed in the context of their reported neuropathologies, along with open questions related to mammalian chr...
Source: Current Aging Science - February 5, 2021 Category: Geriatrics Tags: Curr Aging Sci Source Type: research

R848 Is Involved in the Antibacterial Immune Response of Golden Pompano (Trachinotus ovatus) Through TLR7/8-MyD88-NF- κB-Signaling Pathway
In conclusion, these results indicate that R848 plays an essential role in the antibacterial immunity of golden pompano via the TLR7/8-Myd88-NF-κB- signaling pathway.
Source: Frontiers in Immunology - January 18, 2021 Category: Allergy & Immunology Source Type: research

LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Conclusions: Our findings reveal that MALAT1 may regulate EMT, proliferation, and migration of LECs as a ceRNA by "sponging" miR-204-5p and targeting Smad4, and serve as a promising therapeutic target in preventing PCO. PMID: 33327804 [PubMed - as supplied by publisher]
Source: Current Eye Research - December 17, 2020 Category: Opthalmology Authors: Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J Tags: Curr Eye Res Source Type: research

Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging
ConclusionsOur data indicate that circCSNK1G3 can induce HOXA10 expression and, thereby, promote the growth and metastasis of LUAD cells through hsa-miR-143-3p sponging. As such, our data highlight the targetability of the circCSNK1G3/miR-143-3p/HOXA10 signaling axis in patients with LUAD.Graphical abstract
Source: Cellular Oncology - October 29, 2020 Category: Cancer & Oncology Source Type: research

Characterization of Novel Aptamers Specifically Directed to Red-Spotted Grouper Nervous Necrosis Virus (RGNNV)-Infected Cells for Mediating Targeted siRNA Delivery
In this study, we generated three aptamers against red-spotted grouper nervous necrosis virus (RGNNV)-infected grouper brain (GB) cells using the Cell-SELEX (cell based-systematic evolution of ligands by exponential enrichment) technology. The selected aptamers formed stable stem-loop structures, and could specifically recognize RGNNV-infected GB cells, with calculated dissociation constants (Kd) of 27.96, 29.3, and 59.5 nM for aptamers GBN2, GBN10, and GBN34, respectively. They also recognized RGNNV-infected brain tissues. The three aptamers were non-toxic and showed antiviral activities both in vitro and in vivo. Fluores...
Source: Frontiers in Microbiology - April 29, 2020 Category: Microbiology Source Type: research

Effects of siRNA silencing on the susceptibility of the fish cell line CHSE-214 to Yersinia ruckeri
AbstractYersinia ruckeri is a facultative intracellular enterobacterium mostly known as the causative agent of enteric redmouth disease in salmonid fish. In the present study, we applied RNA inhibition to silence twenty pre-selected genes on the genome of a fish cell line (CHSE-214) followed by a gentamicin assay to quantify the effect of silencing on the cells ’ susceptibility to infection and found that silencing of 18 out of 20 genes significantly reduced the number ofY. ruckeri recovered. These findings improve our understanding of the infection process byY. ruckeri and of the interactions between this bacterial pathogen and host cells.
Source: Veterinary Research - March 19, 2020 Category: Veterinary Research Source Type: research

Long non-coding RNA PVT1 regulates the migration of hepatocellular carcinoma HepG2 cells via miR-3619-5p/MKL1 axis.
In this study, we investigated the relationship between PVT1 and MKL1 as a novel regulatory mechanism underlying HCC progression. We used HepG2 and Cos‑7 cell lines. Transfection experiments with miR-3619-5p mimics/inhibitor, PVT1, siRNA-PVT1, MKL1, or siRNA-MKL1 were performed. RNA and protein levels were analyzed by quantitative reverse transcription PCR and Western blot, respectively. Cell migration was assessed by Transwell assay. Luciferase assays, RNA-FISH, RNA immunoprecipitation, and chromatin immunoprecipitation assays were performed to confirm the interaction between PVT1, miR-3619-5p, and MKL1 in HCC cells. Ov...
Source: Bosnian Journal of Basic Medical Sciences - March 12, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Common carp pentraxin gene: Evidence for its role in ovarian differentiation and growth.
Abstract Pentraxins (PTX), is an evolutionarily conserved family, containing a PTX protein domain, having a role in acute immunological responses and fertility in higher vertebrates. However, information regarding the action of ptx on reproduction is extremely limited in fish. To study this, ptx cDNA was cloned for downstream analysis. Tissue distribution and ontogeny expression analysis indicated the prevalence of ptx in ovary. Varied phase-wise expression during carp ovarian cycle and elevated ptx expression after human chorionic gonadotropin induction, in vitro and in vivo, indicated probable regulation of gona...
Source: General and Comparative Endocrinology - January 21, 2020 Category: Endocrinology Authors: Raj Gupta Y, Senthilkumaran B Tags: Gen Comp Endocrinol Source Type: research

Molecular characterization of a RNA polymerase (RNAP) II (DNA directed) polypeptide H (POLR2H) in Pacific white shrimp (Litopenaeus vannamei) and its role in response to high-pH stress
Publication date: Available online 9 December 2019Source: Fish & Shellfish ImmunologyAuthor(s): Zhi-Zhan Luo, Hui-Ming Sun, Jing-Wen Guo, Peng Luo, Chao-Qun Hu, Wen Huang, Hu ShuAbstractRNA polymerase (RNAP) II (DNA-directed) (POLR2) genes are essential for cell viability under environmental stress and for the transfer of biological information from DNA to RNA. However, the function and characteristics of POLR2 genes in crustaceans are still unknown. In the present study, a POLR2H cDNA was isolated from Pacific white shrimp (Litopenaeus vannamei) and designated as Lv-POLR2H. The full-length Lv-POLR2H cDNA is 772 bp in leng...
Source: Fish and Shellfish Immunology - December 11, 2019 Category: Biology Source Type: research