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Total 107 results found since Jan 2013.

Research Articles A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
Tau inclusions are a shared feature of many neurodegenerative diseases, among them frontotemporal dementia caused by tau mutations. Treatment approaches for these conditions include targeting posttranslational modifications of tau proteins, maintaining a steady-state amount of tau, and preventing its tendency to aggregate. We discovered a new regulatory pathway for tau degradation that operates through the farnesylated protein, Rhes, a GTPase in the Ras family. Here, we show that treatment with the farnesyltransferase inhibitor lonafarnib reduced Rhes and decreased brain atrophy, tau inclusions, tau sumoylation, and tau ub...
Source: Science Translational Medicine - March 26, 2019 Category: Biomedical Science Authors: Hernandez, I., Luna, G., Rauch, J. N., Reis, S. A., Giroux, M., Karch, C. M., Boctor, D., Sibih, Y. E., Storm, N. J., Diaz, A., Kaushik, S., Zekanowski, C., Kang, A. A., Hinman, C. R., Cerovac, V., Guzman, E., Zhou, H., Haggarty, S. J., Goate, A. M., Fish Tags: Research Articles Source Type: research

Carbosilane dendrimers with phosphonium terminal groups are low toxic non-viral transfection vectors for siRNA cell delivery
Publication date: Available online 13 March 2019Source: International Journal of PharmaceuticsAuthor(s): Regina Herma, Dominika Wrobel, Michaela Liegertová, Monika Müllerová, Tomáš Strašák, Marek Maly, Alena Semerádtová, Marcel Štofik, Dietmar Appelhans, Jan MalyAbstractNon-viral gene delivery vectors studied in the gene therapy applications are often designed with the cationic nitrogen containing groups necessary for binding and cell release of nucleic acids. Disadvantage is a relatively high toxicity which restricts the in vivo use of such nanoparticles. Here we show, that the 3rd generation carbosilane dendrim...
Source: International Journal of Pharmaceutics - March 13, 2019 Category: Drugs & Pharmacology Source Type: research

PMA-triggered PKCε activity enhances Nrf2-mediated antiviral response on fish rhabdovirus infection
Publication date: April 2019Source: Fish & Shellfish Immunology, Volume 87Author(s): Yun-Fei Dang, Tian-Xiu Qiu, Da-Wei Song, Lei LiuAbstractViral infection is often accompanied with alteration of intracellular redox state, especially an imbalance between reactive oxygen species (ROS) production and antioxidant cellular defenses. The previous studies showed that an antioxidant cellular defense system, the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), played an important role against spring viraemia of carp virus (SVCV) infection in fish. To further reveal the mediated mechanism that Nrf2 active s...
Source: Fish and Shellfish Immunology - February 26, 2019 Category: Biology Source Type: research

Molecular cloning and preliminary functional analysis of six RING-between-ring (RBR) genes in grass carp (Ctenopharyngodon idellus)
Publication date: April 2019Source: Fish & Shellfish Immunology, Volume 87Author(s): Lifei Luo, Denghui Zhu, Rong Huang, Lv Xiong, Rumana Mehjabin, Libo He, Lanjie Liao, Yongming Li, Zuoyan Zhu, Yaping WangAbstractUbiquitination is a post-translational modification of proteins that is widely present in eukaryotic cells. There is increasing evidence that ubiquitinated proteins play crucial roles in the immune response process. In mammals, RING-between-RING (RBR) proteins play a key role in regulating immune signaling as the important E3 ubiquitin ligases during ubiquitination. However, the function of RBR in fish is still u...
Source: Fish and Shellfish Immunology - January 9, 2019 Category: Biology Source Type: research

Molecular cloning and functional characterization of a short peptidoglycan recognition protein from triangle-shell pearl mussel (Hyriopsis cumingii)
In this study, we cloned and functionally analyzed a short PGRP (HcPGRP2) from the triangle-shell pearl mussel Hyriopsis cumingii. The full-length cDNA sequence of HcPGRP2 gene was 1185 bp containing an open reading frame of 882 bp encoding a 293 amino acid protein. HcPGRP2 was predicted to have two SH3b domains and a conserved C-terminal PGRP domain. Quantitative real-time RT-PCR showed that HcPGRP2 was expressed in all examined tissues and its expression was induced most significantly by Staphylococcus aureus and Vibrio parahaemolyticus in the hepatopancreas and gills. RNA interference by siRNA results revealed that HcPG...
Source: Fish and Shellfish Immunology - December 7, 2018 Category: Biology Source Type: research

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19
Conclusion: CAFs promote the stemness and chemoresistance of CRC by transferring exosomal H19. H19 activated the β-catenin pathway via acting as a competing endogenous RNA sponge for miR-141, while miR-141 inhibited the stemness of CRC cells. Our findings indicate that H19 expressed by CAFs of the colorectal tumor stroma contributes to tumor development and chemoresistance.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jing Ren, Liang Ding, Dongya Zhang, Guoping Shi, Qianyun Xu, Sunan Shen, Yaping Wang, Tingting Wang, Yayi Hou Tags: Research Paper Source Type: research

Naa15 knockdown enhances c2c12 myoblast fusion and induces defects in zebrafish myotome morphogenesis
Publication date: Available online 29 November 2018Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Olivier Monestier, Aurélie Landemaine, Jérôme Bugeon, Pierre-Yves Rescan, Jean-Charles GabillardAbstractThe understanding of muscle tissue formation and regeneration is essential for the development of therapeutic approaches to treat muscle diseases or loss of muscle mass and strength during ageing or cancer. One of the critical steps in muscle formation is the fusion of muscle cells to form or regenerate muscle fibres.To identify new genes controlling myoblast fusion, w...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - November 29, 2018 Category: Molecular Biology Source Type: research

Naa15 knockdown enhances c2c12 myoblast fusion and induces defects in zebrafish myotome morphogenesis.
Abstract The understanding of muscle tissue formation and regeneration is essential for the development of therapeutic approaches to treat muscle diseases or loss of muscle mass and strength during ageing or cancer. One of the critical steps in muscle formation is the fusion of muscle cells to form or regenerate muscle fibres. To identify new genes controlling myoblast fusion, we performed a siRNA screen in c2c12 myoblasts. The genes identified during this screen were then studied in vivo by knockdown in zebrafish using morpholino. We found that N-alpha-acetyltransferase 15 (Naa15) knockdown enhanced c2c12 myoblas...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - November 29, 2018 Category: Biochemistry Authors: Monestier O, Landemaine A, Bugeon J, Rescan PY, Gabillard JC Tags: Comp Biochem Physiol B Biochem Mol Biol Source Type: research

ROS-induced HSP70 promotes cytoplasmic translocation of high-mobility group box 1b and stimulates antiviral autophagy in grass carp kidney cells Cell Biology
In this study, we found that both grass carp reovirus (GCRV) infection and hydrogen peroxide (H2O2) treatment induced the accumulation of reactive oxygen species (ROS) in C. idella kidney cells and stimulate autophagy. Suppressing ROS accumulation with N-acetyl-l-cysteine significantly inhibited GCRV-induced autophagy activation and enhanced GCRV replication. Although ROS-induced autophagy, in turn, restricted GCRV replication, further investigation revealed that the multifunctional cellular protein high-mobility group box 1b (HMGB1b) serves as a heat shock protein 70 (HSP70)–dependent, pro-autophagic protein in grass ca...
Source: Journal of Biological Chemistry - November 9, 2018 Category: Chemistry Authors: Youliang Rao, Quanyuan Wan, Hang Su, Xun Xiao, Zhiwei Liao, Jianfei Ji, Chunrong Yang, Li Lin, Jianguo Su Tags: Immunology Source Type: research

GSE114773 small RNA profiling of breast cancer cell lines knockdowns
Contributors : L Fish ; S Zhang ; H GoodarziSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe performed small RNA sequencing in breast cancer cells treated with siRNA for Control, DCGR8, DROSHA, TARBP2, DICER
Source: GEO: Gene Expression Omnibus - November 7, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

Molecular characterization of p38 MAPK from blunt snout bream (Megalobrama amblycephala) and its expression after ammonia stress, and lipopolysaccharide and bacterial challenge
Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Chun-Nuan Zhang, Samad Rahimnejad, Kang-Le Lu, Wen-Hao Zhou, Ji-Liang ZhangAbstractp38 mitogen-activated protein kinase (MAPK) is an important protein which plays a key role in regulating the innate immunity, so exploring its molecular characterization is helpful in understanding the resistance against microbial infections in cultured fish. Here, a full-length cDNA of p38 MAPK was cloned from liver of blunt snout bream (Megalobrama amblycephala) which covered 2419 bp with an open reading frame of 1086 bp encoding 361 amino acids. p38 MAP...
Source: Fish and Shellfish Immunology - November 4, 2018 Category: Biology Source Type: research

In-vitro inhibition of spring viremia of carp virus replication by RNA interference targeting the RNA-dependent RNA polymerase gene.
Abstract Spring viremia of carp, a fatal viral disease, is caused by the spring viremia of carp virus (SVCV) and can result in up to 70% mortalities in common carps and significant economic losses in several other cyprinid aquaculture. The present study aimed to investigate the possible control of SVCV replication in Epithelioma papulosum cyprini (EPC) cells using the RNA interference technology targeting the RNA-dependent RNA polymerase (L) gene of the SVCV that is essential for its replication. Three stealth small interfering RNA (siRNA) sequences were designed to target three different regions on the SVCV-L gen...
Source: Journal of Virological Methods - October 15, 2018 Category: Virology Authors: Marzouk Fouad A, Soliman H, Abdallah ESH, Ibrahim S, El-Matbouli M, Elkamel AA Tags: J Virol Methods Source Type: research

MiR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting host GS
This study provided information for understanding the molecular mechanism of SHVV pathogenicity and a potential antiviral strategy against SHVV infection.
Source: Fish and Shellfish Immunology - October 9, 2018 Category: Biology Source Type: research

Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella)
Publication date: Available online 2 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Pengfei Chu, Libo He, Denghui Zhu, Liangming Chen, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu, Yaping WangAbstractInterleukin-1 receptor-associated kinase (IRAK) family members play important roles in myeloid differentiation primary response 88 (MyD88)-dependent toll-like receptor (TLR) signaling, the crucial innate immune pathway in vertebrates. In the present study, the IRAK family gene IRAK-M (also called IRAK3) from grass carp (Ctenopharyngodon idella) was cloned and characterised. IRAK-M was mainly enriched in the sple...
Source: Fish and Shellfish Immunology - October 5, 2018 Category: Biology Source Type: research

The downregulation of hsa_circ_0012919, sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+T cells of SLE
Conclusion:Hsa_circ_0012919 could be regarded as a biomarker for SLE and hsa_circ_0012919 was the ceRNA for miR-125a-3p.
Source: Clinical Science - September 20, 2018 Category: Biomedical Science Authors: Zhang, C., Wang, X., Chen, Y., Wu, Z., Zhang, C., Shi, W. Tags: PublishAheadOfPrint Source Type: research