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Total 107 results found since Jan 2013.
Identification and characterization of DEAD-box RNA helicase DDX3 in rainbow trout (Oncorhynchus mykiss) and its relationship with infectious hematopoietic necrosis virus infection
This study suggests that DDX3 has an important role in host defense against IHNV infection and these results may provide new insights into IHNV pathogenesis and antiviral drug research.PMID:35840014 | DOI:10.1016/j.dci.2022.104493
Source: Developmental and Comparative Immunology - July 15, 2022 Category: Allergy & Immunology Authors: Jing-Zhuang Zhao Li-Ming Xu Guang-Ming Ren Yi-Zhi Shao Tong-Yan Lu Source Type: research
GSE207658 Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Contributors : Georg Vogler ; Alexandre R ColasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identified. Postulating that impaired cardiomyocyte proliferation as a likely important contributing mechanism to HLHS pathogenesis, and we conducted a genome-wide siRNA screen to identify genes affecting proliferation of human iPSC-derived cardiomyocy...
Source: GEO: Gene Expression Omnibus - July 14, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Silenced LINC01134 Enhances Oxaliplatin Sensitivity by Facilitating Ferroptosis Through GPX4 in Hepatocarcinoma
ConclusionsWe identified LINC01134/Nrf2/GPX4 as a novel and critical axis to regulate HCC growth and progression. Targeting GPX4, knocking down LINC01134 or Nrf2 could be a potential therapeutic strategy for HCC.
Source: Frontiers in Oncology - July 8, 2022 Category: Cancer & Oncology Source Type: research
Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1
AbstractOxidative stress-induced autophagy dysfunction is involved in the pathogenesis of intervertebral disc degeneration (IVDD). MicroRNAs (miRNAs) not only have been regarded as important regulators of IVDD but also reported to be related to autophagy. This research was aimed to explore the role of miR-130b-3p in IVDD and its regulation on autophagy mechanism. The miR-130b-3p expression in the patient ’s degenerative nucleus pulposus (NP) samples and rat NP tissues was detected by qRT-PCR and FISH assay. The miR-130b-3p was knocked down or overexpressed in the human NP cells by lentivirus transfection. TBHP was used t...
Source: Apoptosis - April 18, 2022 Category: Molecular Biology Source Type: research
Identification and function of circular RNA hsa_circ_0071106: A novel biomarker for differentiation degree of esophageal squamous cell carcinoma
CONCLUSION: Hsa_circ_0071106 was a downregulated circRNA related to ESCC and promoted ESCC progression by regulating cell migration and invasion. These findings suggest that hsa_circ_0071106 could be a promising diagnostic biomarker and potential therapeutic target and might predict ESCC's histological differentiation degree.PMID:35390631 | DOI:10.1016/j.prp.2022.153875
Source: Cell Research - April 7, 2022 Category: Cytology Authors: Ying Tang Zhikui Gao Ran Liu Source Type: research
Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics
Adv Drug Deliv Rev. 2022 Mar 26;184:114236. doi: 10.1016/j.addr.2022.114236. Online ahead of print.ABSTRACTThe success of the messenger RNA-based COVID-19 vaccines of Moderna and Pfizer/BioNTech marks the beginning of a new chapter in modern medicine. However, the rapid rise of mRNA therapeutics has resulted in a regulatory framework that is somewhat lagging. The current guidelines either do not apply, do not mention RNA therapeutics, or do not have widely accepted definitions. This review describes the guidelines for preclinical biodistribution studies of mRNA/siRNA therapeutics and highlights the relevant differences for...
Source: Advanced Drug Delivery Reviews - March 30, 2022 Category: Drugs & Pharmacology Authors: P Vervaeke S E Borgos N N Sanders F Combes Source Type: research
Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling
In this study, we found that the transcription levels of key enzymes involved in glycolysis were regulated in varying degrees during SGIV infection based on the transcriptomic analysis. Quantitative PCR and western blot analysis also indicated that the expression of both glucose transporters (GLUT1 and GLUT2) and the enzymes of glucose metabolism (hexokinase 2, HK2 and pyruvate dehydrogenase complex, PDHX) were upregulated during SGIV infection in vivo or in vitro, suggesting that glycolysis might be involved in SGIV infection. Exogenous glucose supplementation promoted the expression of viral genes and infectious virion p...
Source: Frontiers in Microbiology - March 30, 2022 Category: Microbiology Source Type: research
Liver and muscle-specific effects of phoenixin-20 on the insulin-like growth factor system mRNAs in zebrafish
CONCLUSIONS: Collectively, this research shows that Pnx-20 is a tissue-specific regulator of the liver (suppressor) and muscle (stimulant) Igf signaling in both male and female zebrafish.PMID:35305530 | DOI:10.1016/j.ghir.2022.101456
Source: Cell Research - March 19, 2022 Category: Cytology Authors: Jithine Jayakumar Rajeswari Emilio J V élez Suraj Unniappan Source Type: research
