Nothobranchius fish: an untapped resource for studying aging-related neurodegeneration.

Nothobranchius fish: an untapped resource for studying aging-related neurodegeneration. Curr Aging Sci. 2021 Feb 01;: Authors: Genade T Abstract New models in which aging-related neurodegeneration more closely resembling the combination of pathologies that develop in aging humans are needed. The fish Nothobranchius, which naturally develops such pathologies over the course of its short lifespan, is one such model. This review compares the lifespans and pathologies of different Nothobranchius strains to those of current vertebrate models of aging. Furthermore, existing data pertaining to neurodegeneration in these fish is discussed in the context of their reported neuropathologies, along with open questions related to mammalian chronopathologies. Specifically, the evidence for a Parkinson's disease-like pathology is discussed. Neurogenesis and age-related changes therein are discussed in the context of siRNA and neurodegeneration. We also discuss changes in the expression of neuropeptide Y in relation to the brain-gut axis and how these change with age. Agerelated behavioral changes are discussed, along with the assays used in their evaluation. Genetic discoveries are outlined and discussed with a view on DJ-1/NRF2 signaling in N. furzeri, and on insights gained from comparative genomics and siRNA studies. Finally, research focus areas are highlighted, and a case is made for the utility of these fish in the study of aging-related neu...
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research