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Nutrition: Calcium

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Total 675 results found since Jan 2013.

Developmental changes in the expression and function of TRPC6 channels related the F-actin organization during differentiation in podocytes.
Abstract The transient receptor potential canonical (TRPC) 6 channel is an important ion channel located in podocytes, which plays an essential role in regulating calcium homeostasis of the cell signaling. Podocytes are specialized, terminally differentiated cells surrounding glomerular capillaries, and are the subject of keen interest because of their key roles in kidney development and disease. Here we wonder whether TRPC6 channels undergo developmental changes in the expression and function during the podocyte differentiation, and whether they contribute to the maturation of podocytes. Using morphological, immu...
Source: Cell Calcium - September 3, 2015 Category: Cytology Authors: Liu Z, Yang J, Zhang X, Xu P, Zhang T, Yang Z Tags: Cell Calcium Source Type: research

TRPC3-mediated Ca(2+) entry contributes to mouse airway smooth muscle cell proliferation induced by lipopolysaccharide.
Abstract Airway remodeling is a histopathological hallmark of chronic respiratory diseases that includes airway smooth muscle cell (ASMC) proliferation. Canonical transient receptor potential channel-3 (TRPC3)-encoded nonselective cation channels (NSCCs) are important native constitutively active channels that play significant roles in physiological and pathological conditions in ASMCs. Lipopolysaccharides (LPSs), known as lipoglycans and endotoxin, have been proven to be inducers of airway remodeling, though the mechanisms remain unclear. We hypothesized that TRPC3 is important in LPS-induced airway remodeling by...
Source: Cell Calcium - June 22, 2016 Category: Cytology Authors: Chen XX, Zhang JH, Pan BH, Ren HL, Feng XL, Wang JL, Xiao JH Tags: Cell Calcium Source Type: research

Progesterone analogue protects stressed photoreceptors via bFGF ‐mediated calcium influx
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - September 30, 2016 Category: Neuroscience Authors: Alice C. Wyse ‐Jackson, Sarah L. Roche, Ana M. Ruiz‐Lopez, Jennifer N. Moloney, Ashleigh M. Byrne, Thomas G. Cotter Tags: Research Report Source Type: research

Investigation of morin-induced insulin secretion in cultured pancreatic cells.
This article is protected by copyright. All rights reserved. PMID: 28699234 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - July 12, 2017 Category: Drugs & Pharmacology Authors: Lin MH, Hsu CC, Lin J, Cheng JT, Wu MC Tags: Clin Exp Pharmacol Physiol Source Type: research

Calreticulin regulates TGF- β1-induced epithelial mesenchymal transition through modulating Smad signaling and calcium signaling.
In this study, we demonstrated in vitro that TGF-β1-induced EMT elevated the expression of CRT in A549 lung cancer cells. Subsequently, we confirmed that overexpression CRT had no capacity to induce A549 cells EMT alone, but successfully enhanced TGF-β1-induced-EMT. Furthermore, knockdown of CRT in A549 cells significantly suppressed changes of EMT marks expression induced by TGF-β1. On treatment with TGF-β1, overexpression of CRT could enhance the phosphorylation of both Smad2 and Smad3. Consistently, the knockdown of CRT by siRNA-CRT could inhibit Smad signaling pathway activated by TGF-β1. These results indicated t...
Source: The International Journal of Biochemistry and Cell Biology - August 1, 2017 Category: Biochemistry Authors: Wu Y, Xu X, Ma L, Yi Q, Sun W, Tang L Tags: Int J Biochem Cell Biol Source Type: research

Induction of retinal ‐dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer
ConclusionsThe distinct time‐phases of Ca2+ influx in MCs induced by UVA or UVB contribute to the consecutive stimulation of melanosome transfer, thereby providing a potent photoprotection against harmful UV radiation.
Source: Cell Proliferation - August 23, 2017 Category: Cytology Authors: Qing ‐Mei Hu, Wen‐Juan Yi, Meng‐Yun Su, Shan Jiang, Shi‐Zheng Xu, Tie‐Chi Lei Tags: ORIGINAL ARTICLE Source Type: research

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

Estrogen and cigarette sidestream smoke particulate matter exhibit ER{alpha}-dependent tumor-promoting effects in lung adenocarcinoma cells
This study demonstrates that estrogen has ERα-dependent tumor-promoting activity. CSSP acts like estrogen and shows a potential to enhance estrogen-induced ERα action.
Source: AJP: Lung Cellular and Molecular Physiology - September 1, 2017 Category: Respiratory Medicine Authors: Kuo, L.-C., Cheng, L.-C., Lee, C.-H., Lin, C.-J., Chen, P.-Y., Li, L.-A. Tags: RESEARCH ARTICLE Source Type: research

Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats.
Abstract Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 4, 2017 Category: Drugs & Pharmacology Authors: Wang LY, Cheng KC, Li Y, Niu CS, Cheng JT, Niu HS Tags: Biomed Pharmacother Source Type: research

KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma
Conclusions: Our observations suggested KCa3.1 might be a promising novel therapeutic target in intrahepatic cholangiocarcinoma.
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Penghong Song, Yehui Du, Wenfeng Song, Hao Chen, Zefeng Xuan, Long Zhao, Jun Chen, Jian Chen, Danjing Guo, Cheng Jin, Yongchao Zhao, Biguang Tuo, Shusen Zheng Tags: Research Paper Source Type: research

Inhibition of the mitochondrial calcium uniporter inhibits A β-induced apoptosis by reducing reactive oxygen species-mediated endoplasmic reticulum stress in cultured microglia.
In this study, we found increased mitochondrial Ca(2+) concentration in Aβ-treated primary microglia and BV-2 cells; also, the MCU inhibitor Ru360 significantly attenuated Aβ-induced microglial apoptosis, whereas the MCU activator spermine augmented it. In addition, Ru360 significantly attenuated Aβ-induced mitochondrial reactive oxygen species (ROS) production, as well as endoplasmic reticulum (ER) stress characterized by glucose-regulated protein 78 (GRP78) and C/-EBP homologous protein (CHOP) expression. Spermine, however, exerted the opposite effects on mitochondrial ROS production and ER stress. We also found that ...
Source: Brain Research - September 19, 2017 Category: Neurology Authors: Xie N, Wu C, Wang C, Cheng X, Zhang L, Zhang H, Lian Y Tags: Brain Res Source Type: research

Mfn2-Mediated Preservation of Mitochondrial Function Contributes to the Protective Effects of BHAPI in Response to Ischemia
This study investigated the protective effects of N ′-(1-(2-((4-(4,4,5,5-tetramethyl-1,2,3-dioxoborolan-2-yl)benzyl)oxy)phenyl)ethylidene (BHAPI) on an in vitro ischemia model mimicked by oxygen and glucose deprivation (OGD) in neuronal HT22 cells. The results showed that BHAPI significantly increased cell viability and decreased lactate dehydrogen ase (LDH) release after OGD. BHAPI treatment also reduced apoptosis, as measured by flow cytometry, and suppressed caspase-3 activation. These protective effects were accompanied by preserved mitochondrial membrane potential (MMP), reduced mitochondrial swelling, promoted mito...
Source: Journal of Molecular Neuroscience - September 26, 2017 Category: Neuroscience Source Type: research

Distal-less homeobox 5 is a master regulator of the osteogenesis of human mesenchymal stem cells.
Abstract Mesenchymal stem cells (MSCs) differentiate into multiple lineages and are a promising source of cells for clinical use. Previously, we found that the gene distal‑less homeobox 5 (DLX5) is specifically expressed in MSCs with osteogenic potential. Understanding the mechanism of osteogenesis is necessary for successful bone regeneration using MSCs. The aim of this study was to examine the function of the DLX5 gene in MSCs during osteogenesis (bone development). We analyzed the possible association between DLX5 expression and osteogenesis-, chondrogenesis- and adipogenesis-related gene expression in diff...
Source: International Journal of Molecular Medicine - September 19, 2017 Category: Molecular Biology Authors: Heo JS, Lee SG, Kim HO Tags: Int J Mol Med Source Type: research

Cationic liposomes suppress intracellular calcium ion concentration increase via inhibition of PI3 kinase pathway in mast cells
Publication date: December 2017 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1859, Issue 12 Author(s): Yoshikazu Inoh, Aki Haneda, Satoshi Tadokoro, Satoru Yokawa, Tadahide Furuno Cationic liposomes are commonly used as vectors to effectively introduce foreign genes (antisense DNA, plasmid DNA, siRNA, etc.) into target cells. Cationic liposomes are also known to affect cellular immunocompetences such as the mast cell function in allergic reactions. In particular, we previously showed that the cationic liposomes bound to the mast cell surface suppress the degranulation induced by cross-linking of high ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - October 3, 2017 Category: Biochemistry Source Type: research

Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.
Authors: Mahbouli S, Der Vartanian A, Ortega S, Rougé S, Vasson MP, Rossary A Abstract NADPH oxidase (NOX) complexes (a family of seven isoforms) drive cellular ROS production in patho-logical processes such as cancer. NOX-driven ROS production is involved in cell mechanisms from signalling to oxidative stress. Leptin, an adipokine overexpressed in obese patients, has been investigated in studies on breast carcinogenesis, but its effects on oxidative stress remain largely unexplored, especially in breast cancer. The study used three human mammary epithelial cell models presenting different neoplastic status (healt...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research