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Nutrition: Calcium
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Total 675 results found since Jan 2013.
Knockdown of sorcin increases HEI-OC1 cell damage induced by cisplatin in vitro
Arch Biochem Biophys. 2021 Mar 3:108752. doi: 10.1016/j.abb.2021.108752. Online ahead of print.ABSTRACTHearing loss caused by ototoxic drugs is a kind of acquired hearing loss. Cisplatin is one of the most commonly used drugs and its main action sites are hair cells (HCs). Sorcin is a drug-resistant calcium-binding protein belonging to the small penta-EF-hand protein family. Sorcin is highly expressed in many tissues, including bone, heart, brain, lung, and skin tissues. Single-cell RNA sequencing showed that sorcin was expressed in the outer HCs of mice, but its role remained unknown. We also found that sorcin was highly ...
Source: Archives of Biochemistry and Biophysics - March 6, 2021 Category: Biochemistry Authors: Dan Wang Suming Shi Yue-Lin Hsieh Jiali Wang Hui Wang Wuqing Wang Source Type: research
The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC)
We examined a possible role for CD228 in the regulation of osteogenesis and adipogenesis of hBM-MSC. Surprisingly, siRNA-mediated CD228 knockdown increased the expression of the transcription factor DLX5 and enhanced osteogenesis of hBM-MSC evidenced by an increased expression of the runt-related transcription factor 2 (RUNX2), osterix (Osx), and osteocalcin (OC), as well as higher alkaline phosphatase (ALP) activity and extracellular calcium deposition. Interestingly, hBM-MSC transfected with CD228 siRNA also showed an increase in intracellular lipid level during adipogenesis, indicated by oil red O staining of differenti...
Source: International Journal of Medical Sciences - March 22, 2021 Category: Biomedical Science Authors: Maria Dubon Sooho Lee Ji-Hong Park Jae-Yong Lee Dongchul Kang Source Type: research
