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Functional interaction of Junctophilin 2 with small conductance Ca2+ ‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes
ConclusionsThe present data provide evidence that the functional interaction between JP2 and SK2 channels is present in the native mouse heart tissue. Junctophilin 2, as junctional membrane complex (JMC)protein, is an important regulator of the cardiac SK channels.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - October 21, 2017 Category: Physiology Authors: Hong K. Fan, Tian X. Luo, Wei D. Zhao, Yong H. Mu, Yang Yang, Wen J. Guo, Hui Y. Tu, Qian Zhang Tags: Regular Paper Source Type: research
Aberrant Splicing Induced by Dysregulated Rbfox2 Produces Enhanced Function of CaV1.2 Calcium Channel and Vascular Myogenic Tone in HypertensionNovelty and Significance Vascular Myogenic Tone
Calcium influx from activated voltage-gated calcium channel CaV1.2 in vascular smooth muscle cells is indispensable for maintaining myogenic tone and blood pressure. The function of CaV1.2 channel can be optimized by alternative splicing, one of post-transcriptional modification mechanisms. The splicing factor Rbfox2 is known to regulate the CaV1.2 pre-mRNA alternative splicing events during neuronal development. However, Rbfox2’s roles in modulating the key function of vascular CaV1.2 channel and in the pathogenesis of hypertension remain elusive. Here, we report that the proportion of CaV1.2 channels with alternative e...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Yingying Zhou, Jia Fan, Huayuan Zhu, Li Ji, Wenyong Fan, Isha Kapoor, Yue Wang, Yuan Wang, Guoqing Zhu, Juejin Wang Tags: Ion Channels/Membrane Transport, Vascular Biology, Hypertension Original Articles Source Type: research
Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.
Abstract
A deficient pancreatic β-cell mass increases the risk of type 2 diabetes mellitus. Here, we investigated the effects of testosterone on the development of pancreatic β-cell mass in male rats. The β-cell mass of male rats castrated at 6 weeks of age was reduced to ~30% of that of control rats at 16 weeks of age, and castration caused glucose intolerance. Loss of β-cell mass occurred due to decreases in islet density/pancreas and β-cell cluster size. Castration was negatively associated with the number of Ki67-positive β-cells and positively associated with the number of TUNEL-positive β-cells. These...
Source: Am J Physiol Endocri... - November 14, 2017 Category: Endocrinology Authors: Harada N, Yoda Y, Yotsumoto Y, Masuda T, Takahashi Y, Katsuki T, Kai K, Shiraki N, Inui H, Yamaji R Tags: Am J Physiol Endocrinol Metab Source Type: research
CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells.
Authors: Jiang Z, Jiang J, Zhao B, Yang H, Wang Y, Guo S, Deng Y, Lu D, Ma T, Wang H, Wang J
Abstract
Osteosarcoma (OS) is the most common primary malignancy of the bone affecting children and adolescents. Copine 1 (CPNE1) is a highly conserved calcium-dependent phospholipid-binding protein and may function in regulating signal transduction and membrane trafficking. In the present study, we investigated CPNE1 expression in osteosarcoma tissues and cells, and studied the effects of small interfering RNA (siRNA)-targeting CPNE1 on proliferation, metastasis and chemosensitivity of the osteosarcoma cells. The results ...
Source: Oncology Reports - December 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Functional interaction of Junctophilin 2 with small ‐ conductance Ca2+‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes
ConclusionThe present data provide evidence that the functional interaction between JP2 and SK2 channels is present in the native mouse heart tissue. Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels.
Source: Acta Physiologica - December 7, 2017 Category: Physiology Authors: H. K. Fan, T. X. Luo, W. D. Zhao, Y. H. Mu, Y. Yang, W. J. Guo, H. Y. Tu, Q. Zhang Tags: ORIGINAL ARTICLE Source Type: research
Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity Metabolism
In conclusion, the relatively low endogenous Spl expression level in insulin-secreting cells contributes to their extraordinary vulnerability to proinflammatory cytokine toxicity and may therefore represent a promising target for β-cell protection in type 1 diabetes mellitus.
Source: Journal of Biological Chemistry - December 8, 2017 Category: Chemistry Authors: Claudine Hahn, Karolina Tyka, Julie D. Saba, Sigurd Lenzen, Ewa Gurgul-Convey Tags: Molecular Bases of Disease Source Type: research
Heme oxygnease-1 induction by methylene blue protects RAW264.7 cells from hydrogen peroxide-induced injury.
Abstract
Althoughmethylene blue (MB) has showed strong antioxidant effect, its effect related with heme oxygenase-1(HO-1) is still unclear. Thus, we investigated the effects of MB on HO-1 protein content and enzyme activity, and its protective effect against hydrogen peroxide (H2O2)- induced oxidative damage in RAW264.7 macrophage. The cellviability and the release of lactate dehydrogenase of RAW264.7 were determined. The mitochondrial functions were valuated through these indexes: content of adenosine triphosphate, superoxide dismutase, concentration of reactive oxygen species and mitochondrial membrane potential...
Source: Biochemical Pharmacology - January 5, 2018 Category: Drugs & Pharmacology Authors: Zhang XT, Sun XQ, Wu C, Chen JL, Yuan JJ, Pang QF, Wang ZP Tags: Biochem Pharmacol Source Type: research
Calcium ‐sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 18, 2018 Category: Cytology Authors: Amanda D'Espessailles, Yuly A Mora, Cecilia Fuentes, Mariana Cifuentes Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Interfering RNA against PKC- α Inhibits TNF-α-induced IP3R1 Expression and Improves Glomerular Filtration Rate in Rats with Fulminant Hepatic Failure.
CONCLUSION: RNAi targeting PKC-α inhibited TNF-α-induced IP3R1 overexpression, and in turn improved compromised GFR in the development of acute kidney injury during FHF in rats.
PMID: 29357415 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - January 10, 2018 Category: Physiology Authors: Wang DL, Dai WY, Wang W, Wen Y, Zhou Y, Zhao YT, Wu J, Liu P Tags: Am J Physiol Renal Physiol Source Type: research
A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.
This article is protected by copyright. All rights reserved.
PMID: 29368348 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - January 25, 2018 Category: Physiology Authors: Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M Tags: J Physiol Source Type: research
Factor XII and uPAR upregulate neutrophil functions to influence wound healing
Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-deficient mice (F12–/–) had fewer neutrophils recruited than WT mice. We discovered that neutrophils produced a pool of FXII that is functionally distinct from hepatic-derived FXII and contributes to neutrophil trafficking at sites of inflammation. FXII signals in neutrophils through urokinase plasminogen activator receptor–mediated (uPAR-mediated) Akt2 phosphorylation at S474...
Source: Journal of Clinical Investigation - January 30, 2018 Category: Biomedical Science Authors: Evi X. Stavrou, Chao Fang, Kara L. Bane, Andy T. Long, Clément Naudin, Erdem Kucukal, Agharnan Gandhi, Adina Brett-Morris, Michele M. Mumaw, Sudeh Izadmehr, Alona Merkulova, Cindy C. Reynolds, Omar Alhalabi, Lalitha Nayak, Wen-Mei Yu, Cheng-Kui Qu, Howar Source Type: research
Attenuation of PERK enhances glucose-stimulated insulin secretion in islets
In conclusion, partial PERK inhibition induced BiP expression in islets, increased glucose-stimulated calcium transit and islet insulin contents and enhanced GSIS, suggesting that low-dose PERK inhibitors could potentially be used to treat insulin deficiency.
Source: Journal of Endocrinology - January 30, 2018 Category: Endocrinology Authors: Kim, M. J., Min, S. H., Shin, S. Y., Kim, M. N., Lee, H., Jang, J. Y., Kim, S.-W., Park, K. S., Jung, H. S. Tags: Research Source Type: research
Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin.
Abstract
The mammalian skin has a photosensitive system comprised by several opsins, including rhodopsin (OPN2) and melanopsin (OPN4). Recently, our group showed that UVA (4.4 kJ/m2) leads to immediate pigment darkening (IPD) in murine normal and malignant melanocytes. We show the role of OPN2 and OPN4 as UVA sensors: UVA-induced IPD was fully abolished when OPN4 was pharmacologically inhibited by AA9253 or when OPN2 and OPN4 were knocked down by siRNA in both cell lines. Our data, however, demonstrate that phospholipase C/protein kinase C pathway, a classical OPN4 pathway, is not involved in UVA-induced IPD in ...
Source: European Journal of Cell Biology - January 26, 2018 Category: Cytology Authors: de Assis LVM, Moraes MN, Magalhães-Marques KK, Castrucci AM Tags: Eur J Cell Biol Source Type: research
Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel.
CONCLUSION: Our results suggest that azelnidipine has potent antiatherosclerotic properties by inhibition of macrophage activation through Cav1.2.
PMID: 29398679 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - February 7, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
High-fat-diet induces airway hyperresponsiveness partly through activating CD38 signaling pathway.
This study aimed to detect the effect of CD38 signaling pathway on the AHR of overweight/obese mice. The HFD-fed mice exhibited a significantly higher baseline airway resistance (Rn), and the increasing rates of Rn responded to increasing doses of methacholine compared with the LFD-fed mice. High-fat-diet increased CD38 expressions both in lung tissues and primary cultured ASMCs. Besides, preincubation with TNF-α led to a higher expression of CD38 protein and increased intracellular calcium in ASMC of the HFD-fed mice. Furthermore, CD38 gene knockdown through transfection of CD38 siRNA decreased the concentration of intra...
Source: International Immunopharmacology - February 1, 2018 Category: Allergy & Immunology Authors: Chong L, Zhang W, Yu G, Zhang H, Zhu L, Li H, Shao Y, Li C Tags: Int Immunopharmacol Source Type: research
