Interfering RNA against PKC- α Inhibits TNF-α-induced IP3R1 Expression and Improves Glomerular Filtration Rate in Rats with Fulminant Hepatic Failure.

CONCLUSION: RNAi targeting PKC-α inhibited TNF-α-induced IP3R1 overexpression, and in turn improved compromised GFR in the development of acute kidney injury during FHF in rats. PMID: 29357415 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29357415?dopt=Abstract

Source: American Journal of Physiology. Renal Physiology - January 10, 2018 Category: Physiology Authors: Wang DL, Dai WY, Wang W, Wen Y, Zhou Y, Zhao YT, Wu J, Liu P Tags: Am J Physiol Renal Physiol Source Type: research