FOXM1c promotes oesophageal cancer metastasis by transcriptionally regulating IRF1 expression
ConclusionFOXM1c promotes the metastasis by transcriptionally targeting IRF1 and may serve as a potential prognostic predictor for oesophageal cancer. (Source: Cell Proliferation)
Source: Cell Proliferation - November 28, 2018 Category: Cytology Authors: Yuzhen Zhou,
Qi Wang,
Li Chu,
Weixing Dai,
Xiaozhou Zhang,
Jianfeng Chen,
Long Zhang,
Peipei Ding,
Xin Zhang,
Hongyu Gu,
Pingzhao Zhang,
Ling Li,
Wei Zhang,
Luying Li,
Xinyue Lv,
Danlei Zhou,
Guoxiang Cai,
Liang Chen,
Kuaile Zhao,
Weigu Tags: ORIGINAL ARTICLE Source Type: research
Matrix stiffness regulates arteriovenous differentiation of endothelial progenitor cells during vasculogenesis in nude mice
ConclusionsMatrix stiffness regulates the arteriovenous differentiation of EPCs during vasculogenesis in nude mice through the Ras/Mek pathway. (Source: Cell Proliferation)
Source: Cell Proliferation - November 28, 2018 Category: Cytology Authors: Changyue Xue,
Qian Huang,
Tao Zhang,
Dan Zhao,
Quanquan Ma,
Taoran Tian,
Xiaoxiao Cai Tags: ORIGINAL ARTICLE Source Type: research
CSE1L participates in regulating cell mitosis in human seminoma
ConclusionsOverall, these findings showed that CSE1L plays a pivotal role in maintaining cell proliferation and cell division in seminomas. (Source: Cell Proliferation)
Source: Cell Proliferation - November 28, 2018 Category: Cytology Authors: Chunyan Liu,
Jiajing Wei,
Kang Xu,
Xiaosong Sun,
Huiping Zhang,
Chengliang Xiong Tags: ORIGINAL ARTICLE Source Type: research
MiR ‐326/Sp1/KLF3: A novel regulatory axis in lung cancer progression
ConclusionsOur data demonstrate that miR ‐326/Sp1/KLF3 regulatory axis is involved in the development of lung cancer, which hints the potential target for the further therapeutic strategy against lung cancer. (Source: Cell Proliferation)
Source: Cell Proliferation - November 28, 2018 Category: Cytology Authors: Rong Wang,
Jiali Xu,
Jing Xu,
Wei Zhu,
Tianzhu Qiu,
Jun Li,
Meiling Zhang,
Qianqian Wang,
Tongpeng Xu,
Renhua Guo,
Kaihua Lu,
Yongmei Yin,
Yanhong Gu,
Lingjun Zhu,
Puwen Huang,
Ping Liu,
Lianke Liu,
Wei De,
Yongqian Shu Tags: ORIGINAL ARTICLE Source Type: research
High PD ‐L1 expression in the tumour cells did not correlate with poor prognosis of patients suffering for oral squamous cells carcinoma: A meta‐analysis of the literature
This study aimed to investigate, through a meta‐analysis, a potential correlati on between PD‐L1 expression and the prognostic outcomes in patients with oral squamous cell carcinoma.Materials and methodsThe studies were identified by searching PubMed, SCOPUS, Web of Science and were assessed by two of the authors. After the selection process, 11 articles met eligibility criteria and were included in the meta ‐analysis. Quality assessment of studies was performed according to the REMARK guidelines, and the risk of biases across studies was investigated through Q andI2 tests. Meta ‐analysis was performed to investiga...
Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Giuseppe Troiano,
Vito C. A. Caponio,
Khrystyna Zhurakivska,
Claudia Arena,
Giuseppe Pannone,
Marco Mascitti,
Andrea Santarelli,
Lorenzo Lo Muzio Tags: REVIEW ARTICLE Source Type: research
TGF ‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
ConclusionsFor the first time, these results revealed a vital role of TGF ‐β1 in cell‐cell communication in chondrocytes via gap junction formation. We describe the regulatory mechanism, the involvement of TGF‐β type I receptor and the nuclear translocation of Smad3/4. (Source: Cell Proliferation)
Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Qingxuan Wang,
Chenchen Zhou,
Xiaobing Li,
Linyi Cai,
Jing Zou,
Demao Zhang,
Jing Xie,
Wenli Lai Tags: ORIGINAL ARTICLE Source Type: research
AP2a enhanced the osteogenic differentiation of mesenchymal stem cells by inhibiting the formation of YAP/RUNX2 complex and BARX1 transcription
ConclusionsOur discoveries revealed that AP2a may regulate the osteogenic differentiation in an indirect way through competing with RUNX2 to relieve the RUNX2 activity which inhibited by YAP, and also in a direct way via targeting the BARX1 and directly repressed its transcription. Thus, our discoveries shed new light on the mechanism of direct differentiation of MSCs and provide candidate targets for improving the osteogenic differentiation and enhancing bone tissue regeneration. (Source: Cell Proliferation)
Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Xiao Lin,
Haoqing Yang,
Lijun Wang,
Wenzhi Li,
Shu Diao,
Juan Du,
Songlin Wang,
Rui Dong,
Jun Li,
Zhipeng Fan Tags: ORIGINAL ARTICLE Source Type: research
High PD ‐L1 expression in the tumour cells did not correlate with poor prognosis of patients suffering for oral squamous cells carcinoma: A meta‐analysis of the literature
This study aimed to investigate, through a meta‐analysis, a potential correlati on between PD‐L1 expression and the prognostic outcomes in patients with oral squamous cell carcinoma.Materials and methodsThe studies were identified by searching PubMed, SCOPUS, Web of Science and were assessed by two of the authors. After the selection process, 11 articles met eligibility criteria and were included in the meta ‐analysis. Quality assessment of studies was performed according to the REMARK guidelines, and the risk of biases across studies was investigated through Q andI2 tests. Meta ‐analysis was performed to investiga...
Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Giuseppe Troiano,
Vito C. A. Caponio,
Khrystyna Zhurakivska,
Claudia Arena,
Giuseppe Pannone,
Marco Mascitti,
Andrea Santarelli,
Lorenzo Lo Muzio Tags: REVIEW ARTICLE Source Type: research
TGF ‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
ConclusionsFor the first time, these results revealed a vital role of TGF ‐β1 in cell‐cell communication in chondrocytes via gap junction formation. We describe the regulatory mechanism, the involvement of TGF‐β type I receptor and the nuclear translocation of Smad3/4. (Source: Cell Proliferation)
Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Qingxuan Wang,
Chenchen Zhou,
Xiaobing Li,
Linyi Cai,
Jing Zou,
Demao Zhang,
Jing Xie,
Wenli Lai Tags: ORIGINAL ARTICLE Source Type: research
AP2a enhanced the osteogenic differentiation of mesenchymal stem cells by inhibiting the formation of YAP/RUNX2 complex and BARX1 transcription
ConclusionsOur discoveries revealed that AP2a may regulate the osteogenic differentiation in an indirect way through competing with RUNX2 to relieve the RUNX2 activity which inhibited by YAP, and also in a direct way via targeting the BARX1 and directly repressed its transcription. Thus, our discoveries shed new light on the mechanism of direct differentiation of MSCs and provide candidate targets for improving the osteogenic differentiation and enhancing bone tissue regeneration. (Source: Cell Proliferation)
Source: Cell Proliferation - November 15, 2018 Category: Cytology Authors: Xiao Lin,
Haoqing Yang,
Lijun Wang,
Wenzhi Li,
Shu Diao,
Juan Du,
Songlin Wang,
Rui Dong,
Jun Li,
Zhipeng Fan Tags: ORIGINAL ARTICLE Source Type: research
Melatonin protects mesenchymal stem cells from autophagy ‐mediated death under ischaemic ER‐stress conditions by increasing prion protein expression
ConclusionMelatonin protects against ER stress/autophagy ‐induced apoptotic cell death by augmenting PrPC expression. Thus, melatonin ‐treated MSCs could be a potential cell‐based therapeutic agent for ER stress–induced ischaemic diseases, and melatonin‐induced PrPC might be a key molecule in ameliorating ER stress and autophagy. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Jun Hee Lee,
Yeo Min Yoon,
Yong ‐Seok Han,
Seo Kyung Jung,
Sang Hun Lee Tags: ORIGINAL ARTICLE Source Type: research
Nuclear factor ‐kappa B‐dependent X‐box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation
ConclusionsUnfolded protein response reinforces the survival and proliferation of NPCs under TNF ‐α stimulation by activating the XBP1 pathway, and NF‐κB serves as a vital mediator in these events. The XBP1 signalling of UPR can be a novel therapeutic target in IDD. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Lu Chen,
Zhi ‐Yang Xie,
Lei Liu,
Lei Zhu,
Feng Wang,
Pan Fan,
Arjun Sinkemani,
Cong Zhang,
Xin Hong,
Xiao‐Tao Wu Tags: ORIGINAL ARTICLE Source Type: research
IL ‐33 guides osteogenesis and increases proliferation and pluripotency marker expression in dental stem cells
ConclusionsIL ‐33 treatment impairs osteogenesis of PDLSCs and DPSCs, while increases their clonogenicity, proliferation and pluripotency marker expression. After exposure to IL‐33, osteogenic capacity of cells stayed intact. NF‐κB and β‐catenin are implicated in the effects achieved by IL‐33 in PDLSC s and DPSCs. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Tamara Kukolj,
Drenka Trivanovi ć,
Slavko Mojsilović,
Ivana Okić Djordjević,
Hristina Obradović,
Jelena Krstić,
Aleksandra Jauković,
Diana Bugarski Tags: ORIGINAL ARTICLE Source Type: research
Prognostic values of long noncoding RNA PVT1 in various carcinomas: An updated systematic review and meta ‐analysis
In conclusion, PVT1 may be a potential biomarker of poor prognosis for patients with different cancer types. (Source: Cell Proliferation)
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Meizhu Xiao,
Ying Feng,
Chongdong Liu,
Zhenyu Zhang Tags: REVIEW ARTICLE Source Type: research
CASC2: An emerging tumour ‐suppressing long noncoding RNA in human cancers and melanoma
AbstractDeregulation of long noncoding RNAs (lncRNAs) has been implicated in tumourigenesis. Cancer Susceptibility Candidate 2 (CASC2) is a lncRNA downregulated in multiple cancer types, including endometrial, lung, gastric and colorectal cancers. CASC2 functions as a tumour ‐suppressive lncRNA though multiple mechanisms, such as sequestration of oncogenic microRNAs and repression of Wnt/β‐catenin signalling. Pertinent to clinical practice, the use of CASC2 as a prognostic marker has been demonstrated in sporadic studies. These findings suggested that CASC2 might p lay an important role in human cancers and melanoma. ...
Source: Cell Proliferation - November 14, 2018 Category: Cytology Authors: Xin Yu,
Heyi Zheng,
Gary Tse,
Lin Zhang,
William Ka Kei Wu Tags: REVIEW ARTICLE Source Type: research
