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Drug: Metformin

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Total 134 results found since Jan 2013.

CXCR3 confers sorafenib resistance of HCC cells through regulating metabolic alteration and AMPK pathway.
Authors: Ren Y, Gu YK, Li Z, Xu GZ, Zhang YM, Dong MX, Wang Y, Zhou XB Abstract Currently, the acquired resistance of the hepatocellular carcinoma (HCC) first-line therapeutic agent-sorafenib (SOR) remains a major challenge for HCC management. Recent evidence suggested the association between CXCL/CXCRs chemokines and chemotherapy resistant in cancer cells. Hence, exploring the internal mechanism of CXCRs involved in SOR resistance will help to improve the efficacy of HCC. SOR-resistant HCC cells (Huh7-SOR) were established through escalating concentration of SOR. Glucose consumption, lactate production, intracellu...
Source: American Journal of Translational Research - April 11, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Metformin inhibits high glucose-induced smooth muscle cell proliferation and migration.
Abstract We investigated the protective effects and mechanism of action of metformin on high glucose-induced smooth muscle cell proliferation and migration. Vascular smooth muscle cells (VSMCs) were subjected to a series of concentrations (0-10 mM) of metformin. CCK-8, wound healing, and transwell assays were performed. Correlations between metformin concentration and high-mobility group box 1 (HMGB1) and miR-142-3p levels were assessed. In addition, miR-142-3p mimic and siRNA were used to investigate VSMC migration in the presence or absence of metformin. In the high-glucose condition, metformin decreased cell gr...
Source: Aging - March 23, 2020 Category: Biomedical Science Authors: Zhou DM, Ran F, Ni HZ, Sun LL, Xiao L, Li XQ, Li WD Tags: Aging (Albany NY) Source Type: research

Resveratrol attenuates diabetes-associated cell centrosome amplification via inhibiting the PKC α-p38 to c-myc/c-jun pathway.
In conclusion, our results suggest that PKCα-p38 to c-myc/c-jun is the signaling pathway of the diabetes-associated centrosome amplification, and resveratrol attenuates the centrosome amplification by inhibiting this signaling pathway. PMID: 31844893 [PubMed - as supplied by publisher]
Source: Acta Biochimica et Biophysica Sinica - December 15, 2019 Category: Biochemistry Authors: Wu Q, Chen X, He Q, Lang L, Xu P, Wang P, Lee SC Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
This study found that low concentrations of metformin did not affect cell proliferation but did inhibit adipogenic differentiation and promote osteogenic differentiation of PDLSCs. This positive effect was associated with activation of Akt signaling by metformin. Moreover, applying metformin as either a pretreatment or co-treatment could reduce the amount of reactive oxygen species, enhance antioxidant capacity, and rescue the cell viability and osteogenic differentiation that were negatively affected by H2O2-induced oxidative stress in PDLSCs. In addition, metformin was found to activate the Nrf2 signaling pathway in PDLS...
Source: Experimental Cell Research - November 8, 2019 Category: Cytology Authors: Jia L, Xiong Y, Zhang W, Ma X, Xu X Tags: Exp Cell Res Source Type: research

Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate –activated protein kinase pathway in nasal fibroblasts
ConclusionCSE has an inhibitory effect on cell migration and collagen gel contraction activity via the ROS/AMPK signaling pathway in nasal fibroblasts.
Source: International Forum of Allergy and Rhinology - November 5, 2019 Category: Allergy & Immunology Authors: Jae ‐Min Shin, Joo‐Hoo Park, Hyun‐Woo Yang, Heung‐Man Lee, Il‐Ho Park Tags: ORIGINAL ARTICLE Source Type: research

Metformin ‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition
ConclusionMetformin inhibited autophagy and enhanced osimertinib sensitivity via inducing AMPK activation in a time ‐dependent manner.
Source: The Clinical Respiratory Journal - October 6, 2019 Category: Respiratory Medicine Authors: Hengyi Chen, Caiyu Lin, Conghua Lu, Yubo Wang, Rui Han, Li Li, Shuai Hao, Yong He Tags: ORIGINAL ARTICLE Source Type: research

Metformin sensitized NSCLC cells to Osimertinib via AMPK ‐dependent autophagy inhibition
ConclusionMetformin inhibited autophagy and enhanced osimertinib sensitivity via inducing AMPK activation in a time ‐dependent manner.
Source: The Clinical Respiratory Journal - September 27, 2019 Category: Respiratory Medicine Authors: Hengyi Chen, Caiyu Lin, Conghua Lu, Yubo Wang, Rui Han, Li Li, Shuai Hao, Yong He Tags: ORIGINAL ARTICLE Source Type: research

Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth.
CONCLUSIONS: MET+SIM treatment synergistically inhibits endometrial cancer cell viability. This may be mediated by apoptosis and mTOR pathway inhibition. Our results provide preclinical evidence that the combination of these well-tolerated drugs may warrant further clinical investigation for endometrial cancer treatment. PMID: 31178149 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - June 5, 2019 Category: Cancer & Oncology Authors: Kim JS, Turbov J, Rosales R, Thaete LG, Rodriguez GC Tags: Gynecol Oncol Source Type: research

RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial ‐protective effects of metformin under high glucose in HUVECs
AbstractImpaired angiogenesis in endothelial cells is a hallmark of diabetes vascular complications. Ras guanine ‐releasing protein 1 (RasGRP1) is a guanine nucleotide exchange factor for Ras, and its role in endothelial angiogenesis has not been investigated. Given the importance of Ras in vascular endothelial growth factor (VEGF)‐induced angiogenesis, we hypothesized that RasGRP1 may be a critical pathwa y downstream of VEGF and involved in endothelial angiogenesis. Furthermore, we investigate whether RasGRP1‐dependent VEGF signaling was downregulated under high glucose conditions mimicking diabetes and required fo...
Source: IUBMB Life - May 22, 2019 Category: Research Authors: Jing Xu, Miao Liu, Muqiao Yu, Jiayi Shen, Jiecan Zhou, Jinglei Hu, Yong Zhou, Wei Zhang Tags: Research Communication Source Type: research

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in  vitro and in vivo.
In conclusion, this study demonstrated that metformin alleviated the inflammatory response in the liver and the hepatocyte of the NASH model via STAT3-mediated autophagy induction. This mechanism provides a strategy for targeting the NASH inflammatory response. PMID: 30935688 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - March 28, 2019 Category: Biochemistry Authors: Li YL, Li XQ, Wang YD, Shen C, Zhao CY Tags: Biochem Biophys Res Commun Source Type: research

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1 α in NSCLC which can be overcome by OXPHOS inhibition.
CONCLUSION: These results describe a new cisplatin resistance mechanism in NSCLC based on a metabolic reprogramming that is therapeutically exploitable through PGC-1α downregulation or OXPHOS inhibitors. PMID: 30880247 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 13, 2019 Category: Biology Authors: Cruz-Bermúdez A, Laza-Briviesca R, Vicente-Blanco RJ, García-Grande A, Coronado MJ, Laine-Menéndez S, Palacios-Zambrano S, Moreno-Villa MR, Ruiz-Valdepeñas AM, Lendinez C, Romero A, Franco F, Calvo V, Alfaro C, Acosta PM, Salas C, Garcia JM, Provencio Tags: Free Radic Biol Med Source Type: research

Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A.
Abstract Metformin has been suggested to have cardiovascular protective effects. Previous researches showed that metformin activates Adenosine Monophosphate Activated Protein Kinase (AMPK) and Protein Phosphatase 2A (PP2A). This research aimed to elucidate whether and how metformin affects NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activity in oxidized low-density lipoprotein (ox-LDL) stimulated macrophages. Macrophages were treated with ox-LDL and metformin in a continuous manner, and NLRP3 inflammasome activation was evaluated by detecting IL-1β and caspase-1 p10 release by ELISA and western blot...
Source: European Journal of Pharmacology - March 5, 2019 Category: Drugs & Pharmacology Authors: Zhang L, Lu L, Zhong X, Yue Y, Hong Y, Li Y, Li Y Tags: Eur J Pharmacol Source Type: research