Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo.

In conclusion, this study demonstrated that metformin alleviated the inflammatory response in the liver and the hepatocyte of the NASH model via STAT3-mediated autophagy induction. This mechanism provides a strategy for targeting the NASH inflammatory response. PMID: 30935688 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30935688?dopt=Abstract

Source: Biochemical and Biophysical Research communications - March 28, 2019 Category: Biochemistry Authors: Li YL, Li XQ, Wang YD, Shen C, Zhao CY Tags: Biochem Biophys Res Commun Source Type: research