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Drug: Metformin
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Total 134 results found since Jan 2013.
Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway
CONCLUSION: Metformin protects against lipid formation in ALD by activating the LKB1/AMPK/ACC axis.PMID:35733070 | DOI:10.1007/s11033-022-07610-y
Source: Molecular Biology Reports - June 22, 2022 Category: Molecular Biology Authors: Fotian Xie Yuanming Zhong Dongmei Wang Kwok Fai So Jia Xiao Yi Lv Source Type: research
Metformin Regulates TET2 Expression to Inhibit Endometrial Carcinoma Proliferation: A New Mechanism
ConclusionsTET2 may play an important role in EC development and may be a prognostic marker. Moreover, TET2 may be involved in a novel mechanism by which metformin inhibits EC cell proliferation.
Source: Frontiers in Oncology - April 11, 2022 Category: Cancer & Oncology Source Type: research
Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and that this effect is independent of its hypoglycemic effect; however, the specific mechanism remains unclear. In this research, we explored the effect and specific mechanism of metformin in cerebral ischemia-reperfusion (I/R) injury by constructing a transient middle cerebral artery occlusion model in vivo and a glucose and oxygen deprivation/reoxygenation (OGD/R) model in vitro. The results of the in vivo experiments showed that acute treatment with...
Source: Frontiers in Pharmacology - April 1, 2022 Category: Drugs & Pharmacology Source Type: research
Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn
Neurochem Res. 2022 Mar 12. doi: 10.1007/s11064-022-03571-7. Online ahead of print.ABSTRACTChemotherapy-induced neuropathic pain is a major clinical problem with limited treatment options. Here, we show that metformin relieves bortezomib (BTZ)-evoked induction and maintenance of neuropathic pain by preventing the reduction in the expression of Beclin-1, an autophagy marker, in the spinal dorsal horn. Application of rapamycin or 3-methyladenine, autophagy inducer and inhibitor, respectively, affected the mechanical allodynia differently. Co-application of 3-methyladenine and metformin partially inhibited the effect of metfo...
Source: Neurochemical Research - March 12, 2022 Category: Neuroscience Authors: Meng Liu Yu-Ting Zhao You-You Lv Ting Xu Dai Li Yuan-Chang Xiong Wen-Jun Xin Su-Yan Lin Source Type: research
Metformin is a Novel Suppressor for Vimentin in Human Gastric Cancer Cell Line
In this study, AGS gastric cancer cells were treated with metformin and vimentin-specific siRNA (vim-siRNA) for 48 h. The impact of metformin and vim-siRNA on vimentin downregulation in AGS cells were analyzed by quantitative PCR and Western blot. Following treatment with metformin and vim-siRNA, cell motility, migration and invasion abilities of AGS cells were also analyzed. The results showed that inhibition of vimentin due to metformin was comparable with the vim-siRNA. Furthermore, wound-healing and invasion assays showed a significant decrease in migration and invasion of AGS cells following metformin and vim-siRNA tr...
Source: Cancer Control - February 18, 2022 Category: Cancer & Oncology Authors: Shiva Valaee Mehdi Shamsara Mohammad Mehdi Yaghoobi Source Type: research
Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
CONCLUSIONS: This study, for the first time, demonstrates that metformin can inhibit AVICs in vitro calcification by activating the PI3K/AKT signaling pathway; this suggests that metformin may provide a potential target for the treatment of CAVD. And the PI3K/AKT signaling pathway emerges as an important regulatory axis in the pathological mechanism of CAVD.PMID:34895136 | DOI:10.1186/s10020-021-00416-x
Source: Molecular Medicine - December 13, 2021 Category: Molecular Biology Authors: Qiao En Huang Zeping Wang Yuetang Wang Xu Wang Wei Source Type: research
Activated AMPK by metformin protects against fibroblast proliferation during pulmonary fibrosis by suppressing FOXM1
Pharmacol Res. 2021 Aug 24:105844. doi: 10.1016/j.phrs.2021.105844. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive and devastating lung disease of unknown etiology, excessive fibroblast proliferation serves as a key event to promote PF. Transcription factor forkhead box M1 (FOXM1) is not only a well-known proto-oncogene, but also an essential driver of cell proliferation. Recently, 5'-AMP-activated protein kinase (AMPK) is reported to reduce the incidence of PF. However, it remains elusive whether have an underlying relationship between AMPK and FOXM1 in fibroblast proliferation-mediated PF. Here, t...
Source: Cell Research - August 27, 2021 Category: Cytology Authors: Xuan Gu Yong-Yue Han Chong-Yang Yang Hui-Min Ji Yue-Jiao Lan Yu-Qian Bi Cheng Zheng Jiao Qu Ming-Han Cheng Jian Gao Source Type: research
Inhibition of AKT Enhances the Sensitivity of NSCLC Cells to Metformin
CONCLUSION: Inhibition of AKT can enhance the antitumor effect of metformin and would be a promising strategy to sensitize non-small-cell lung cancer to a combination of metformin with radiation or cisplatin.PMID:34230143 | DOI:10.21873/anticanres.15135
Source: Cell Research - July 7, 2021 Category: Cytology Authors: Se-Kyeong Jang Sung-Eun Hong DA-Hee Lee Ji Yea Kim Ji-Young Kim Jungil Hong In-Chul Park Hyeon-Ok Jin Source Type: research
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK α/TGF-β/Smad signalling in type 2 diabetic rats
This study aimed to evaluate the effect of SGLT2 inhibitor dapagliflozin (DAPA) on DCM especially for cardiac fibrosis and explore the underlying mechanism. In vivo, the model of type 2 diabetic rats was built with high-fat feeding and streptozotocin injection. Untreated diabetic rats showed cardiac dysfunction, increased myocardial fibrosis and EndMT, which was attenuated after treatment with DAPA and metformin. In vitro, HUVECs and primary cardiac fibroblasts were treated with DAPA and exposed to high glucose (HG). HG-induced EndMT in HUVECs and collagen secretion of fibroblasts were markedly inhibited by DAPA. Up-regula...
Source: J Cell Mol Med - June 25, 2021 Category: Molecular Biology Authors: Jingjing Tian Mingjun Zhang Mengying Suo Dian Liu Xuyang Wang Ming Liu Jinyu Pan Tao Jin Fengshuang An Source Type: research
