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Condition: Pain

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Total 374 results found since Jan 2013.

Upregulation of lncRNA-NONRATT021203.2 in the dorsal root ganglion contributes to cancer-induced pain via CXCL9 in rats.
In this study, we found that lncRNA-NONRATT021203.2 was increased in the CIP rats and that lncRNA-NONRATT021203.2-siRNA could relieve hyperalgesia in these rats. For elucidation of the underlying mechanism, we showed that lncRNA-NONRATT021203.2 could target C-X-C motif chemokine ligand 9 (CXCL9), which was increased in the CIP rats, and that CXCL9-siRNA could relieve hyperalgesia. At the same time, silencing lncRNA-NONRATT021203.2 expression decreased the mRNA and protein levels of CXCL9. Immunofluorescence analysis showed that CXCL9 was mainly expressed in the CGRP-positive and IB4-positive DRG neurons. Further research s...
Source: Biochemical and Biophysical Research communications - February 11, 2020 Category: Biochemistry Authors: Sun RM, Wei J, Wang SS, Xu GY, Jiang GQ Tags: Biochem Biophys Res Commun Source Type: research

Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats
We examined whether spinal high mobility group box 1 (HMGB1) is involved in morphine tolerance and its underlying mechanisms by using a model of repeated intrathecal (i.t.) injections of morphine. The results showed that chronic i.t. morphine exposure led to increased expression of HMGB1, Toll-like receptor 4 (TLR4), and receptor for advanced glycation end products (RAGE) and their mRNAs in the dorsal horn. Morphine challenge also promoted HMGB1 expression and release in cultured spinal neurons, but these effects were inhibited by TAK-242, naloxone (antagonists of TLR4), and TLR4 siRNA. Intrathecal coadministration of morp...
Source: Neurotherapeutics - December 25, 2019 Category: Neurology Source Type: research

MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.
Abstract Previous studies have demonstrated that myeloid zinc finger 1 (MZF1) in the dorsal root ganglion (DRG) participates in neuropathic pain induced by chronic-constriction injury (CCI) via regulation of voltage-gated K+ channels (Kv). Emerging evidence indicates that transient receptor potential vanilloid 1 (TRPV1) is involved in the development and maintenance of neuropathic pain. Although it is known that the transcription of TRPV1 is regulated by Kruppel-like zinc-finger transcription factor 7 (Klf7)-and that the structure of TRPV1 is similar to that of Kv-few studies have systematically investigated the r...
Source: Neural Plasticity - October 6, 2019 Category: Neurology Authors: Xing F, Gu H, Niu Q, Fan X, Wang Z, Yuan J, Li Z, Xu JT, Zhang W Tags: Neural Plast Source Type: research

Analgesic effect of resveratrol on colitis-induced visceral pain via inhibition of TRAF6/NF- κB signaling pathway in the spinal cord.
In conclusion, our results suggest that RSV exerts the effects of antinociception on colitis-induced visceral hyperalgesia through inhibition of spinal TRAF6/NF-κB signaling pathway and the production of inflammatory mediators in the spinal cord, suggesting a new application of RSV for the treatment of visceral pain. PMID: 31536729 [PubMed - as supplied by publisher]
Source: Brain Research - September 15, 2019 Category: Neurology Authors: Lu Y, Xu HM, Han Y, Zhang YL Tags: Brain Res Source Type: research

New approaches to tumour therapy with siRNA-decorated and chitosan-modified PLGA nanoparticles.
Conclusions: The formulation we developed is a potential carrier system for both treatment of cancer and prevention of pain, especially for metastatic cancers. PMID: 31491363 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - September 8, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Receptor for Activated C Kinase 1 Mediates the Chronic Constriction Injury-induced Neuropathic Pain in the Rats’ Peripheral and Central Nervous System
In this study, the biological effects and mechanisms of RACK1 contributes to the pathogenesis of chronic constriction injury (CCI)-induced neuropathic pain were investigated. By western blot and staining, we found that RACK1 protein changed in dorsal root ganglion (DRG) neurons and spinal cord (SC) neurons except glial cells after CCI. Especially, RACK1 was co-located with IB4-, CGRP-positive neurons, suggesting it was related to integrate nociceptive information from the primary afferents in DRG. The successful establishment of CCI models also directly led to mechanical allodynia and heat hyperalgesia, which could be rev...
Source: Neuroscience Letters - September 4, 2019 Category: Neuroscience Source Type: research

Chikungunya virus requires cellular chloride channels for efficient genome replication
In this study, we investigated the role of host-cell chloride (Cl-) channels on CHIKV replication.We demonstrate that specific pharmacological Cl- channel inhibitors significantly inhibit CHIKV replication in a dose-dependent manner, suggesting that Cl-channels are pro-viral factors in human cells. Further analysis of the effect of the inhibitors on CHIKV attachment, entry, viral protein expression and replicon replication demonstrated that Cl- channels are specifically required for efficient CHIKV genome replication. This was conserved in mosquito cells, where CHIKV replication and genome copy number was significantly red...
Source: PLoS Neglected Tropical Diseases - September 3, 2019 Category: Tropical Medicine Authors: Marietta M üller Source Type: research

Role of ZHX2 in regulating dorsal root ganglion μ-opioid receptor expression in mice with peripheral nerve injuryinduced pain hypersensitivity.
CONCLUSIONS: ZHX2 knockdown in the DRG reverses CCI-induced down-regulation of μ opioid receptor to alleviate periphery nerve injury-induced pain hypersensitivity in mice. PMID: 31511211 [PubMed - in process]
Source: Journal of Southern Medical University - August 29, 2019 Category: Universities & Medical Training Authors: Sheng H, Mo K Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity
This study investigated the existence of the inflammasome in dorsal root ganglion (DRG) and the functional significance in the development of inflammatory pain hypersensitivity. Tissue inflammation was induced in male C57BL/6 mice with complete Freund's adjuvant (CFA) or ceramide injection into the hind paw. Behavioral testing was performed to investigate inflammation-induced pain hypersensitivity. Ipsilateral L5 DRGs were obtained for analysis. Expression of nucleotide oligomerization domain-like receptors (NLRs) was analyzed with real-time PCR. Cleaved interleukin (IL)-1β and NLRP2 expression was investigated with immun...
Source: Pain - August 21, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

i-Fect Delivers circRNA and miRNA
Blocks Bone Cancer PainAltered expression of circular RNA (circRNA) is recognized as a contributor to malignant pain where microRNA (miRNA) exerts an essential effect. Researchers used ouri-FectTMTransfection Kit to knock them down. Zhongqi Zhang, Xiaoxia Zhang, Yanjing Zhang, Jiyuan Li, Zumin Xing. Yiwen Zhang.Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model. Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model. Journal of Molecular Neuroscience. pp 1 –10Intrathecal Administration of miRNA and circRN...
Source: Neuromics - August 4, 2019 Category: Neuroscience Tags: Bone Cancer Pain circRNA iFect miRNA Transfection Transfection Reagents Source Type: news

Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats.
Abstract Neuropathic pain is evoked by aberrant sensory processing in the peripheral or central nervous system, which is characterized by persistent pain, tactile allodynia, or hyperalgesia. Neuroinflammation is associated with the initiation and maintenance of persistent pain in both the peripheral and central nervous systems. Hydrogen sulfide plays important regulatory roles in different physiological and pathological conditions. Therefore, we investigated the effect of hydrogen sulfide on allodynia, hyperalgesia and cytokine release in rats with neuropathic pain and the related regulatory mechanism. Neuropathic...
Source: International Immunopharmacology - July 16, 2019 Category: Allergy & Immunology Authors: Chen H, Xie K, Chen Y, Wang Y, Wang Y, Lian N, Zhang K, Yu Y Tags: Int Immunopharmacol Source Type: research

AAV-mediated siRNA against TRPV1 reduces nociception in a rat model of bone cancer pain.
Conclusions: Knockdown of TRPV1 effectively ameliorated mechanical allodynia and thermal hyperalgesia induced by TCI. Our data demonstrated that modulate the expression of TRPV1 in the spinal cord could be a potential therapeutic approach for bone cancer pain. PMID: 31296147 [PubMed - as supplied by publisher]
Source: Neurological Research - July 13, 2019 Category: Neurology Tags: Neurol Res Source Type: research

EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis.
CONCLUSION: Altogether, EPHA3 could potentially promote the autophagy and apoptosis of macrophages in endometriosis via inhibition of the mTOR signaling pathway, highlighting the potential of EPHA3 as the target to treat endometriosis. PMID: 31262977 [PubMed - as supplied by publisher]
Source: Bioscience Reports - June 30, 2019 Category: Biomedical Science Authors: Xu H, Gao Y, Shu Y, Wang Y, Shi Q Tags: Biosci Rep Source Type: research

Correction to: lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia
In the original version of this article “lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia”, which we have published in Mol Neurobiol (2017) 54:511–523.
Source: Molecular Neurobiology - June 25, 2019 Category: Neurology Source Type: research

Dihydroartemisinin derivative DC32 inhibits inflammatory response in osteoarthritic synovium through regulating Nrf2/NF- κB pathway.
In conclusion, DC32 inhibited the inflammatory response in osteoarthritic synovium through regulating Nrf2/NF-κB pathway and attenuated OA. In this way, DC32 may be a potential agent in the treatment of OA. PMID: 31228817 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - June 18, 2019 Category: Allergy & Immunology Authors: Li YN, Fan ML, Liu HQ, Ma B, Dai WL, Yu BY, Liu JH Tags: Int Immunopharmacol Source Type: research