Reply to Sharma et al.
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Correspondence Source Type: research

Efficacy of spinal cord stimulation: uncertain at best
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Correspondence Source Type: research

Response to Moisset et al.
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Correspondence Source Type: research

Pregabalin: a better neuropathic pain treatment in rodents than in humans
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Correspondence Source Type: research

Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization
Next-generation transcriptomics in combination with imaging-based approaches have emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal subpopulations. The mouse DRG has been well characterized by many independently conducted studies with convergent findings, but few studies have directly compared expression of population markers between mouse and human. This is important because of our increasing reliance on the mouse as a preclinical model for translational studies. Although calcitonin gene-related peptide (CGRP) and P2X purinergic ion channel type 3 receptor (P2X3R) have been used to ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

The transition from acute to chronic pain: dynamic epigenetic reprogramming of the mouse prefrontal cortex up to 1 year after nerve injury
Chronic pain is associated with persistent structural and functional changes throughout the neuroaxis, including in the prefrontal cortex (PFC). The PFC is important in the integration of sensory, cognitive, and emotional information and in conditioned pain modulation. We previously reported widespread epigenetic reprogramming in the PFC many months after nerve injury in rodents. Epigenetic modifications, including DNA methylation, can drive changes in gene expression without modifying DNA sequences. To date, little is known about epigenetic dysregulation at the onset of acute pain or how it progresses as pain transitions ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Small-fibre pathology has no impact on somatosensory system function in patients with fibromyalgia
We aimed to investigate whether small-fibre pathology, a common skin biopsy finding in patients with fibromyalgia, implies clinically important abnormalities of somatosensory system function and verify whether it is associated with voltage-gated sodium channel variants. In 57 consecutively enrolled patients with fibromyalgia, we used skin biopsy to distinguish patients with and without small-fibre pathology. In all patients, we assessed somatosensory system function using quantitative sensory testing (QST) and laser-evoked potentials and investigated voltage-gated sodium channel genotyping. We then compared these variables...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens
Diseases and disorders such as Parkinson disease, schizophrenia, and chronic pain are characterized by altered mesolimbic dopaminergic neurotransmission. Dopamine release in the nucleus accumbens influences behavior through both tonic and phasic signaling. Tonic dopamine levels are hypothesized to inversely regulate phasic signals through dopamine D2 receptor feedback inhibition. We tested this hypothesis directly in the context of ongoing pain. Tonic and phasic dopamine signals were measured using fast-scan controlled-adsorption voltammetry and fast-scan cyclic voltammetry, respectively, in the nucleus accumbens shell of ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Nicotinamide riboside relieves paclitaxel-induced peripheral neuropathy and enhances suppression of tumor growth in tumor-bearing rats
This study examined whether NR also blunts the loss of intraepidermal nerve fibers induced by paclitaxel, which is associated with peripheral neuropathy. The work was conducted in female rats with N-methyl-nitrosourea (MNU)-induced tumors of the mammary gland to increase its translational relevance, and to assess the interaction of NR with paclitaxel and NR's effect on tumor growth. Once daily oral administration of 200 mg/kg NR p.o. beginning with the first of 3 i.v. injections of 6.6 mg/kg paclitaxel to tumor-bearing rats significantly decreased paclitaxel-induced hypersensitivity to tactile and cool stimuli, as well as ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Daily intermittent fasting in mice enhances morphine-induced antinociception while mitigating reward, tolerance, and constipation
The opioid epidemic has plagued the United States with high levels of abuse and poor quality of life for chronic pain patients requiring continuous use of opioids. New drug discovery efforts have been implemented to mitigate this epidemic; however, new medications are still limited by low efficacy and/or high side effect and abuse potential. Intermittent fasting (IF) has recently been shown to improve a variety of pathological states, including stroke and neuroinflammation. Numerous animal and human studies have shown the benefits of IF in these disease states, but not in pain and opioid treatment. We thus subjected male a...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability
We examined the role of interleukin-10 (IL-10) in resolution of neuropathic pain induced by cisplatin. In search of an underlying mechanism, we studied the effect of cisplatin and IL-10 on spontaneous activity (SA) in dorsal root ganglia neurons. Cisplatin (2 mg/kg daily for 3 days) induced mechanical hypersensitivity that resolved within 3 weeks. In both sexes, resolution of mechanical hypersensitivity was delayed in Il10−/− mice, in WT mice treated intrathecally with neutralizing anti-IL-10 antibody, and in mice with cell-targeted deletion of IL-10R1 on advillin-positive sensory neurons. Electrophysiologicall...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain
In this study, we identified candidate genes in cancer cell lines that encode for secreted or cell surface proteins that may drive nociception. To undertake this work, we used an acute cancer pain mouse model, transcriptomic analysis of publicly available human tumor-derived cell line data, and a literature review. Cancer cell line supernatants were assigned a phenotype based on evoked nociceptive behavior in an acute cancer pain mouse model. We compared gene expression data from nociceptive and nonnociceptive cell lines. Our analyses revealed differentially expressed genes and pathways; many of the identified genes were n...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain can be conditioned to voluntary movements through associative learning: an experimental study in healthy participants
Abstract: Experimental data suggest that associative learning can influence defensive avoidance behavior and pain perception in humans. However, whether voluntary movements can become conditioned stimuli (CSs) and influence pain responses is yet to be evaluated. Forty healthy volunteers participated in this study. Electrocutaneous stimuli applied to the shoulder at pain threshold level (UStest) and at pain tolerance level (US) were determined before a movement-conditioning paradigm. First, reaching movements to visual cues shown on one side of a computer screen were associated with the US (CS+ movements) on 80% of trials...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Estimands and missing data in clinical trials of chronic pain treatments: advances in design and analysis
In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%. Major reasons for early withdrawal in these studies include perceived lack of efficacy and adverse events. Commonly used strategies for accommodating missing data include last observation carried forward, baseline observation carried forward, and more principled methods such as mixed-model repeated-measures and multiple imputation. All these methods require strong and untestable assumptions concerning the conditional distribution of outcomes after dropout, given the observed data. We review recent dev...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Patterns of prescription opioid utilization among adolescents and adults with comorbid chronic pain and mental health diagnosis
Our goal was to examine the association between mental health disorders (MHD) and subsequent risk of opioid use among commercially insured youth and adults (aged 14-64 years) with comorbid chronic noncancer pain (CNCP) conditions. We conducted a retrospective cohort study using IQVIA Health Plan Claims database from January 1, 2006, to December 31, 2015. Chronic noncancer pain was defined as any diagnosis of back, head, neck, arthritis, or chronic pain (index date). Mental health disorders were assessed in the 12 months before the index pain diagnosis. Based on days supply (none, acute, and chronic) and average daily dose ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Effects of hypnosis, cognitive therapy, hypnotic cognitive therapy, and pain education in adults with chronic pain: a randomized clinical trial
This study evaluated the relative efficacy of 4 treatment sessions each of 4 nonpharmacological treatments: (1) hypnotic cognitive therapy (using hypnosis to alter the meaning of pain); (2) standard cognitive therapy; (3) hypnosis focused on pain reduction, and (4) pain education. One hundred seventy-three individuals with chronic pain were randomly assigned to receive 4 sessions of 1 of the 4 treatments. Primary (pain intensity) and secondary outcome measures were administered by assessors unaware of treatment allocation at pretreatment, posttreatment, and 3-, 6-, and 12-month follow-up. Treatment effects were evaluated u...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers–Danlos syndrome
Classical Ehlers–Danlos syndrome (cEDS) is a connective tissue disorder caused by heterozygous mutations in one of the type V collagen-encoding genes, COL5A1 or COL5A2. cEDS is characterized by generalized joint hypermobility and instability, hyperextensible, fragile skin, and delayed wound healing. Chronic pain is a major problem in cEDS patients, but the underlying mechanisms are largely unknown, and studies in animal models are lacking. Therefore, we assessed pain-related behaviors in haploinsufficient Col5a1+/− mice, which clinically mimic human cEDS. Compared to wild-type (WT) littermates, 15 to 20-week-ol...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Attentional biases in pediatric chronic pain: an eye-tracking study assessing the nature of the bias and its relation to attentional control
This study used eye-gaze tracking to examine attentional biases to pain-related stimuli in a clinical sample of youth with chronic pain and pain-free controls. The moderating role of attentional control was also examined. Youth with chronic pain (n = 102) and pain-free controls (n = 53) viewed images of children depicting varying levels of pain expressiveness paired with neutral faces while their eye gaze was recorded. Attentional control was assessed using both a questionnaire and a behavioural task. Both groups were more likely to first fixate on high pain faces but showed no such orienting bias for moderate or low pain ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

The Graphical Index of Pain: a new web-based method for high-throughput screening of pain
In conclusion, GRIP allows for high-resolution assessment and presentation of pain location and distribution with minimal use of time. (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Out of office hours: scalable, on-demand, digital support for patients tapering prescription opioids
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Perspectives Source Type: research

Low back pain: it is time to embrace complexity
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Perspectives Source Type: research

Persistent pain and cognitive decline in older adults: a systematic review and meta-analysis from longitudinal studies
Both persistent pain and cognitive decline prevalence increase with advancing age and are associated with functional decline. However, the association of pain and cognitive decline has not been evaluated yet by a systematic assessment of longitudinal studies. We aimed to assess the association of persistent pain as a risk factor for cognitive decline in community older adults, using data from longitudinal studies in a systematic review and meta-analysis. Publications were identified using a systematic search on PubMed, EMBASE, and Cochrane Library databases from inception to June 2019. Because heterogeneity across studies ...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

The social threats of COVID-19 for people with chronic pain
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Topical Review Source Type: research

The positive message in negative findings: brief psychosocial intervention can lead to lasting pain reduction using hypnosis, education, or cognitive approaches
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Commentary Source Type: research

Safe methods of imputation for clinical trials of interventions for chronic pain: promoting transparency and comparison
No abstract available (Source: Pain)
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Commentary Source Type: research

Assigning transcriptomic class in the trigeminal ganglion using multiplex in situ hybridization and machine learning
Single cell sequencing has provided unprecedented information about the transcriptomic diversity of somatosensory systems. Here, we describe a simple and versatile in situ hybridization (ISH)-based approach for mapping this information back to the tissue. We illustrate the power of this approach by demonstrating that ISH localization with just 8 probes is sufficient to distinguish all major classes of neurons in sections of the trigeminal ganglion. To further simplify the approach and make transcriptomic class assignment and cell segmentation automatic, we developed a machine learning approach for analyzing images from mul...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Impaired alcohol-induced dopamine release in the nucleus accumbens in an inflammatory pain model: behavioral implications in male rats
Recent studies have drawn the attention to the link between alcohol use disorder and the presence of pain. Indeed, the correct management of pain in patients with a previous history of alcohol use disorder has been reported to decrease the risk of relapse in alcohol drinking, suggesting that in this prone population, pain may increase the vulnerability to relapse. Previous data in male rats revealed that inflammatory pain desensitizes mu-opioid receptors in the ventral tegmental area and increases intake of high doses of heroin. Owing to the relevant role of mu-opioid receptors in alcohol effects, we hypothesize that pain ...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain
This study supports the safety and therapeutic potential of hemp-derived CBD for relieving arthritic pain and suggests follow-up investigations in humans are warranted. (Source: Pain)
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Acute visceral pain relief mediated by A3AR agonists in rats: involvement of N-type voltage-gated calcium channels
Pharmacological tools for chronic visceral pain management are still limited and inadequate. A3 adenosine receptor (A3AR) agonists are effective in different models of persistent pain. Recently, their activity has been related to the block of N-type voltage-gated Ca2+ channels (Cav2.2) in dorsal root ganglia (DRG) neurons. The present work aimed to evaluate the efficacy of A3AR agonists in reducing postinflammatory visceral hypersensitivity in both male and female rats. Colitis was induced by the intracolonic instillation of 2,4-dinitrobenzenesulfonic acid (DNBS; 30 mg in 0.25 mL 50% EtOH). Visceral hypersensitivity was as...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Brain gray matter abnormalities in osteoarthritis pain: a cross-sectional evaluation
The interaction between osteoarthritis (OA) pain and brain properties remains minimally understood, although anatomical and functional neuroimaging studies suggest that OA, similar to other chronic pain conditions, may impact as well as partly be determined by brain properties. Here, we studied brain gray matter (GM) properties in OA patients scheduled to undergo total joint replacement surgery. We tested the hypothesis that brain regional GM volume is distinct between hip OA (HOA) and knee OA (KOA) patients, relative to healthy controls and moreover, that these properties are related to OA pain. Voxel-based morphometry gr...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Imbalance of proresolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis
In this study, lipid mediator (LM) profiling of lumbar dorsal root ganglia (DRG), the site of sensory neuron cell bodies innervating the ankle joints, 5 days and 25 days after serum transfer demonstrated a shift in specialised proresolving LM profiles. Persistent nociception without joint swelling was associated with low concentrations of the specialised proresolving LM Maresin 1 (MaR1) and high macrophage numbers in DRG. MaR1 application to cultured DRG neurons inhibited both capsaicin-induced increase of intracellular calcium ions and release of calcitonin gene-related peptide in a dose-dependent manner. Furthermore, in ...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Differential expression of cerebrospinal fluid neuroinflammatory mediators depending on osteoarthritis pain phenotype
Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there are limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. In a prospective observational study, CSF inflammatory mediators were compared between patients with osteoarthritis (OA) who were undergoing total hip arthroplasty due to disabling pain symptoms (n = 52) and pain-free comparison controls (n = 30). In OA patients only, detailed clinical examination and quantitative sensory testing were completed. Cerebrospinal fluid samples were analyzed for 10 proin...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain
This study confirms that stimulation with tumor necrosis factor (TNF-α) results in expression of proinflammatory genes in mouse and human FLS (derived from osteoarthritis and rheumatoid arthritis patients), as well as increased secretion of cytokines from mouse TNF-α-stimulated FLS (TNF-FLS). Electrophysiological recordings from retrograde labelled knee neurons cocultured with TNF-FLS, or supernatant derived from TNF-FLS, revealed a depolarized resting membrane potential, increased spontaneous action potential firing, and enhanced TRPV1 function, all consistent with a role for FLS in mediating the sensitization...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin
High-threshold mechanosensitive and mechanoinsensitive (“silent”) nociceptors have similar electrical thresholds for transcutaneous sine wave stimulation at 4 Hz that selectively activates cutaneous C nociceptors in human skin. Their fundamentally different functions particularly in chronic pain warrant differential stimulation protocols. We used transcutaneously delivered slow depolarizing stimuli (half-sine, 500 ms duration, 0.01-1 mA) in humans to assess intensity–response relations for the induction of pain psychophysically and recorded activation of mechanosensitive and silent nociceptors in healthy ...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents
Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. These adverse effects hamper opioid use for treating chronic pain and contribute to dependence and abuse. S1P produces distinct effects through 5 G-protein-coupled receptors (S1PR1-5) and several intracellular targets. How S1P exerts its effects in response to morphine remains unknown. Here, we report that S1P contribute...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

A transcriptional toolbox for exploring peripheral neuroimmune interactions
Correct communication between immune cells and peripheral neurons is crucial for the protection of our bodies. Its breakdown is observed in many common, often painful conditions, including arthritis, neuropathies, and inflammatory bowel or bladder disease. Here, we have characterised the immune response in a mouse model of neuropathic pain using flow cytometry and cell-type-specific RNA sequencing (RNA-seq). We found few striking sex differences, but a very persistent inflammatory response, with increased numbers of monocytes and macrophages up to 3 1/2 months after the initial injury. This raises the question of whether t...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Neural correlates of conditioned pain responses in fibromyalgia subjects indicate preferential formation of new pain associations rather than extinction of irrelevant ones
Behavioral studies have demonstrated aberrant safety processing in fibromyalgia subjects (FMSs) and suggested that patients accumulate new potential pain-related threats more effectively than extinguishing no longer relevant ones. The aim of the current study was to investigate the neural correlates of conditioned pain responses and their relationship with emotional distress in FMS (n = 67) and healthy controls (HCs, n = 34). Using functional magnetic resonance imaging, we traced conditioned pain responses to an identical moderately painful pressure (P30) depending on whether it was following a green (P30green) or a red (P...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Tanezumab for chronic low back pain: a randomized, double-blind, placebo- and active-controlled, phase 3 study of efficacy and safety
In conclusion, tanezumab 10 mg significantly improved pain and function vs placebo in patients with difficult-to-treat chronic low back pain. Tanezumab was associated with a low rate of joint safety events, some requiring joint replacement. (Source: Pain)
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Premonitory symptoms in glyceryl trinitrate triggered migraine attacks: a case-control study
Spontaneous and pharmacologically provoked migraine attacks are frequently preceded by nonheadache symptoms called premonitory symptoms. Here, we systematically evaluated premonitory symptoms in migraine patients and healthy controls after glyceryl trinitrate (GTN) infusion. In women with migraine without aura (n = 34) and age-matched female controls (n = 24), we conducted systematically a semistructured interview assessing 21 possible premonitory symptoms every 15 minutes in the 5 hours after GTN infusion (0.5 µg/kg/min over 20 minutes). Migraine-like headaches occurred in 28/34 (82.4%) migraineurs (GTN responders)....
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids
This study assessed the efficacy of systemic administration of MMG22 at reducing pain behavior in the spared nerve injury (SNI) model of NP in mice, as well as its side-effect profile and abuse potential. MMG22 reduced mechanical hyperalgesia and spontaneous ongoing pain after SNI, with greater potency early (10 days) as compared to late (30 days) after injury. Systemic administration of MMG22 did not induce place preference in naive animals, suggesting absence of abuse liability when compared to traditional opioids. MMG22 also lacked the central locomotor, respiratory, and anxiolytic side effects of its monomeric pharmaco...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Associations between obstructive sleep apnea and prescribed opioids among veterans
Sleep disruption caused by obstructive sleep apnea (OSA) may be associated with hyperalgesia and may contribute to poor pain control and use of prescription opioids. However, the relationship between OSA and opioid prescription is not well described. We examine this association using cross-sectional data from a national cohort of veterans from recent wars enrolled from October 1, 2001 to October 7, 2014. The primary outcome was the relative risk ratio (RRR) of receiving opioid prescriptions for acute ( (Source: Pain)
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Fundamental sex differences in morphine withdrawal-induced neuronal plasticity
Withdrawal from systemic opioids can induce long-term potentiation (LTP) at spinal C-fibre synapses (“opioid-withdrawal-LTP”). This is considered to be a cellular mechanism underlying opioid withdrawal-induced hyperalgesia, which is a major symptom of the opioid withdrawal syndrome. Opioids can activate glial cells leading to the release of proinflammatory mediators. These may influence synaptic plasticity and could thus contribute to opioid-withdrawal-LTP. Here, we report a sexual dimorphism in the mechanisms of morphine-withdrawal-LTP in adult rats. We recorded C-fibre-evoked field potentials in the spinal co...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Virtual reality: physiological and behavioral mechanisms to increase individual pain tolerance limits
This study is novel in that, for the first time in VR research, appropriate controls for VR contexts, immersive characteristics (ie, control VR), and multifaceted objective and subjective outcomes were included in a within-subject study design conducted on healthy participants. Participants received heat thermal stimulations to determine how VR can increase individual heat-pain tolerance limits (primary outcome) measured in degrees Celsius and seconds while recording concurrent autonomic responses. We also assessed changes in pain unpleasantness, mood, situational anxiety, and level of enjoyment (secondary outcomes). The V...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription
Mixed lineage leukemia 1 (MLL1)-mediated histone H3 lysine 4 trimethylation (H3K4me3) of a subset of genes has been linked to the transcriptional activation critical for synaptic plasticity, but its potential contribution to neuropathic allodynia development remains poorly explored. Here, we show that MLL1, which is induced in dorsal horn neuron after spinal nerve ligation (SNL), is responsible for mechanical allodynia and increased H3K4me3 at metabotropic glutamate receptor subtype 5 (mGluR5) promoter. Moreover, SNL induced WD (Trp-Asp) repeat domain 5 subunit (WDR5) expression as well as the MLL1-WDR5 interaction accompa...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Patients' perspectives of pain in dialysis: systematic review and thematic synthesis of qualitative studies
Pain is a severe and common symptom in patients receiving dialysis but remains inadequately managed in clinical practice. Understanding patient experiences of pain can inform strategies to address this patient-important symptom. We aimed to describe patients' perspectives on causes, experiences, and impacts of dialysis-associated pain. MEDLINE, Embase, PsycINFO, and CINAHL were searched to August 2019 for all qualitative studies that described the perspectives of pain in adults aged 18 years or older receiving dialysis. Findings from the primary studies were analyzed using thematic synthesis. We included 60 studies across ...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Narrative Review Source Type: research

The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises
The current International Association for the Study of Pain (IASP) definition of pain as “An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” was recommended by the Subcommittee on Taxonomy and adopted by the IASP Council in 1979. This definition has become accepted widely by health care professionals and researchers in the pain field and adopted by several professional, governmental, and nongovernmental organizations, including the World Health Organization. In recent years, some in the field have reasoned that advances in our ...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Narrative Review Source Type: research

Noninvasive motor cortex stimulation effects on quantitative sensory testing in healthy and chronic pain subjects: a systematic review and meta-analysis
One of the potential mechanisms of motor cortex stimulation by noninvasive brain stimulation (NIBS) effects on pain is through the restoration of the defective endogenous inhibitory pain pathways. However, there are still limited data on quantitative sensory testing (QST), including conditioned pain modulation (CPM), supporting this mechanism. This systematic review and meta-analysis aimed to evaluate the effects of noninvasive motor cortex stimulation on pain perception as indexed by changes in QST outcomes. Database searches were conducted until July 2019 to include randomized controlled trials that performed sham-contro...
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

A practical guide to preclinical systematic review and meta-analysis
No abstract available (Source: Pain)
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Topical Review Source Type: research

Will biased ligands be the opioids of the future?
No abstract available (Source: Pain)
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Topical Review Source Type: research

Four decades later: what's new, what's not in our understanding of pain
No abstract available (Source: Pain)
Source: Pain - August 20, 2020 Category: Anesthesiology Tags: Commentary Source Type: research