Canadian surveillance study of complex regional pain syndrome in children
This study describes the minimum incidence of pediatric complex regional pain syndrome (CRPS), clinical features, and treatments recommended by pediatricians and pain clinics in Canada. Participants in the Canadian Paediatric Surveillance Program reported new cases of CRPS aged 2 to 18 years monthly and completed a detailed case reporting questionnaire from September 2017 to August 2019. Descriptive analysis was completed, and the annual incidence of CRPS by sex and age groupings was estimated. A total of 198 cases were reported to the Canadian Paediatric Surveillance Program, and 168 (84.8%) met the case definition. The m...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Use of pharmacological and nonpharmacological treatments for chronic noncancer pain among people using opioids: a longitudinal cohort study
This study demonstrates that many Australians taking opioids long-term for CNCP also use nonopioid pharmacological and nonpharmacological treatments. The use of pharmacological treatments including nonsteroidal anti-inflammatory drugs, psychotropic medicines, and gabapentinoids, outside guidelines, warrants review. Furthermore, despite Australia's universal healthcare scheme subsidising some nonpharmacological treatments, overall use of these treatments was associated with having private health insurance, highlighting a need for more equitable service provision. (Source: Pain)
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: impact of preserved small nerve fiber function
Patients with chronic pain syndromes, such as those with painful peripheral neuropathy due to diabetes mellitus, have limited treatment options and suffer ongoing attrition of their quality of life. Safer and more effective treatment options are needed. One therapeutic approach encompasses phenotypic characterization of the neuropathic pain subtype, combined with the selection of agents that act on relevant mechanisms. ISC 17536 is a novel, orally available inhibitor of the widely expressed pain receptor, transient receptor potential ankyrin 1, which mediates nociceptive signaling in peripheral small nerve fibers. In this ...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Cortical mechanisms of visual hypersensitivity in women at risk for chronic pelvic pain
Increased sensory sensitivity across non-nociceptive modalities is a common symptom of chronic pain conditions and is associated with chronic pain development. Providing a better understanding of the brain–behavior relationships that underlie multimodal hypersensitivity (MMH) may clarify the role of MMH in the development of chronic pain. We studied sensory hypersensitivity in a cohort of women (n = 147) who had diary confirmation of menstrual status and were enriched with risk factors for chronic pelvic pain, such as dysmenorrhea and increased bladder sensitivity. We administered 2 experimental tasks to evaluate the cro...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Neural and behavioral correlates of human pain avoidance in participants with and without episodic migraine
The innate motivation to avoid pain can be disrupted when individuals experience uncontrollable stress, such as pain. This can lead to maladaptive behaviors, including passivity, and negative affect. Despite its importance, motivational aspects of pain avoidance are understudied in humans and their neural mechanisms vastly unknown. Rodent models suggest an important role of the periaqueductal gray, but it is unknown whether it subserves a similar role in humans. Furthermore, it is unclear whether pain avoidance is associated with individual differences in pain coping. Using functional magnetic resonance imaging, networks u...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Attentional interference by pain in a dishabituation procedure: an experimental investigation
In this study, we experimentally investigated this idea using the primary task paradigm in which participants had to identify the color of a circle (blue or yellow) as quickly as possible while ignoring painful or tactile distractors that are presented on some of the trials. In the first experiment, we were interested whether the attentional interference effect because of the presentation of the distractors and its habituation would differ between painful and tactile distractor stimuli. In the second experiment, we investigated dishabituation (ie, the phenomenon that the introduction of a different stimulus results in an i...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Measuring pain care quality in the Veterans Health Administration primary care setting
The lack of a reliable approach to assess quality of pain care hinders quality improvement initiatives. Rule-based natural language processing algorithms were used to extract pain care quality (PCQ) indicators from documents of Veterans Health Administration primary care providers for veterans diagnosed within the past year with musculoskeletal disorders with moderate-to-severe pain intensity across 2 time periods 2013 to 2014 (fiscal year [FY] 2013) and 2017 to 2018 (FY 2017). Patterns of documentation of PCQ indicators for 64,444 veterans and 124,408 unique visits (FY 2013) and 63,427 veterans and 146,507 visits (FY 2017...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Decrease in pain perception during acute SARS-CoV-2 infection: a case series
Many reports have described pain appearance or an increase of chronic pain concomitant to severe acute respiratory syndrome coronavirus 2 infection. Here, we describe the cases of 3 patients with chronic cancer pain, in which COVID-19 was associated with a dramatic reduction or disappearance of pain. Pain reappeared after recovery from COVID-19. Neurological imaging and pathological findings, when available, were inconclusive. To the best of our knowledge, this is the first case series reporting an acute reduction in pain perception in COVID-19. We believe further investigation is mandatory because it could shed new light ...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Clinical Note Source Type: research
Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations
This article was motivated by an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials consensus meeting and is based on the expert opinion of those who attended. In addition, a review of the benefit–risk assessment tools used in published chronic pain RCTs or highlighted by key professional organizations (ie, Cochrane, European Medicines Agency, Outcome Measures in Rheumatology, and U.S. Food and Drug Administration) was completed. Overall, the review found that benefit–risk metrics are not commonly used in RCTs of chronic pain despite the availability of published methods. A primary recommendatio...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Narrative Review Source Type: research
Measurement properties of grimace scales for pain assessment in nonhuman mammals: a systematic review
Facial expressions of pain have been identified in several animal species. The aim of this systematic review was to provide evidence on the measurement properties of grimace scales for pain assessment. The protocol was registered (SyRF#21-November-2019), and the study is reported according to the PRISMA guidelines. Studies reporting the development, validation, and the assessment of measurement properties of grimace scales were included. Data extraction and assessment were performed by 2 investigators, following the COnsensus-based Standards for the Selection of Health Measurement INstruments guidelines. Six categories of ...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Mechanisms of injustice: what we (do not) know about racialized disparities in pain
No abstract available (Source: Pain)
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Topical Review Source Type: research
Reply to Keyes and Rutherford
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Prevalence of addiction in chronic pain: reanalysis of Vowles et al., 2015
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Reply to Currie et al.
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Renaming burning mouth syndrome: implications and use for the Research Diagnostic Criteria for Burning Mouth Syndrome
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
