Impact of variability in baseline pain on the placebo response in randomized, placebo-controlled, crossover trials in peripheral neuropathic pain
In conclusion, in this retrospective data analysis, there was no impact of baseline pain variability on the placebo response in controlled clinical trials with a crossover design in patients with peripheral neuropathic pain. (Source: Pain)
Source: Pain - February 14, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Within-day rhythms of pain and cognitive function in people with and without fibromyalgia: synchronous or syncopated?
Cognitive dysfunction is a common fibromyalgia (FM) symptom and can impact on the daily lives of those affected. We investigated whether within-day pain intensity ratings were associated with contemporaneous objective and subjective measures of cognitive function and whether within-day increases in pain intensity preceded increases in cognitive dysfunction or vice versa. Inclusion of a non-FM group allowed us to examine whether effects were specific to FM. Fifty people with FM and 50 non-FM controls provided 7 days of data. Cognitive tests (processing speed and working memory) and ecological momentary assessments (pain int...
Source: Pain - February 14, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Postinjury stimulation triggers a transition to nociplastic pain in mice
Acute injury–induced pain can transition to chronic nociplastic pain, which predominantly affects women. To facilitate studies on the underlying mechanisms of nociplastic pain, we developed a mouse model in which postinjury thermal stimulation (intermittent 40°C water immersion for 10 minutes at 2 hours postcapsaicin) prolongs capsaicin (ie, experimental injury)-induced transient mechanical hypersensitivity outside of the injury area. Although capsaicin injection alone induced mechanical and thermal hypersensitivity that resolved in ∼7 days (slower recovery in females), the postinjury stimulation prolonged capsaicin-i...
Source: Pain - February 14, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin
In conclusion, we show for the first time in humans that LPA can cause pain as well as itch dependent on the mode of application and activates afferent human C fibers. Itch may arise from focal activation of few nerve fibers with distinct spatial contrast to unexcited surrounding afferents and a specific combination of activated fiber subclasses might contribute. (Source: Pain)
Source: Pain - February 14, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Enhanced mindfulness-based stress reduction in episodic migraine—effects on sleep quality, anxiety, stress, and depression: a secondary analysis of a randomized clinical trial
Patients with migraine suffer from high morbidity related to the repeated headache attacks, characteristic of the disorder, poor sleep, and a high prevalence of comorbid psychosocial disorders. Current pharmacological therapies do not address these aspects of migraine, but nonpharmacological treatments such as mindfulness-based stress reduction (MBSR) have been shown to improve both pain and psychological well-being. In this secondary analysis, we examined the change over time in sleep quality and psychosocial outcomes from the magnetic resonance imaging outcomes for mindfulness meditation clinical trial and assessed how t...
Source: Pain - February 14, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
