Regional brain signal variability: a novel indicator of pain sensitivity and coping
Abstract: Variability in blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI) signals reflects the moment-by-moment fluctuations in resting-state fMRI (rs-fMRI) activity within specific areas of the brain. Regional BOLD signal variability was recently proposed to serve an important functional role in the efficacy of neural systems because of its relationship to behavioural performance in aging and cognition studies. We previously showed that individuals who better cope with pain have greater fluctuations in interregional functional connectivity, but it is not known whether regional brain s...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Genetic variants associated with thermal pain sensitivity in a paediatric population
Abstract: Pain sensitivity is an inherited factor that varies strongly between individuals. We investigated whether genetic polymorphisms in the candidate genes COMT, OPRM1, OPRD1, TAOK3, TRPA1, TRPV1, and SCN9A are contributing to experimental pain variability between children. Our study included 136 children and adolescents (8-18 years). Cold and heat pain thresholds were determined with a Thermal Sensory Analyzer. Women and young children were significantly more sensitive to pain (P G G-allele carriers (AG and GG) rated the hot stimulus as significantly less painful than did OPRM1 118A>G AA genotyped individuals (2[1...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption
In this study, the influence of OCT1 genetic polymorphisms on pharmacokinetics and analgesic efficacy of tramadol in patients recovering from surgery was analyzed in addition to the CYP2D6 genotype. Postoperative patients who received tramadol through patient-controlled analgesia were enrolled. Genotypes resulting in 0, 1, or 2 active OCT1 alleles were determined as well as CYP2D6 genotypes. The primary endpoint was the 24-hour postoperative tramadol consumption in patients with 0 vs at least 1 active OCT1 allele. Secondary endpoint was the OCT1-dependent plasma concentration (areas under the concentration–time curve...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain
Abstract: Although several genetic factors have been associated with postsurgical morphine requirements, those involving the innate immune system and cytokines have not been well investigated. The aim of this study was to investigate the contribution of genetic variability in innate immune signalling pathways to variability in morphine dosage after elective caesarean section under spinal anaesthesia in 133 Indian, 230 Malay, and 598 Han Chinese women previously studied. Twenty single nucleotide polymorphisms in 14 genes involved in glial activation (TLR2, TLR4, MYD88, MD2), inflammatory signalling (IL2, IL6, IL10, IL1B, IL...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Disproportionate longer-term opioid use among U.S. adults with mood disorders
Abstract: Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of pain conditions before and after controlling for patient characteristics and clinical disability. We analyzed 33,450 adults with likely acute or potentially chronic pain conditions who were not using opioids at baseline. Among respondents with likely acute pain conditions, those with mood disorders in...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Opioid prescribing for patients with cancer in the last year of life: a longitudinal population cohort study
Abstract: We linked UK cancer registry data with the corresponding electronic primary care medical records of 6080 patients who died of cancer over a 7-year period in a large United Kingdom city. We extracted all prescriptions for analgesics issued to each patient in the linked cohort during the 12 months before death and analysed the extent and duration of strong opioid treatment with clinical and patient characteristics. Strong opioids were prescribed for 48% of patients in the last year of life. Median interval between first prescription of a strong opioid and death was 9 weeks (interquartile range 3-23). Strong opioid ...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Mindfulness-based stress reduction and cognitive behavioral therapy for chronic low back pain: similar effects on mindfulness, catastrophizing, self-efficacy, and acceptance in a randomized controlled trial
Abstract: Cognitive behavioral therapy (CBT) is believed to improve chronic pain problems by decreasing patient catastrophizing and increasing patient self-efficacy for managing pain. Mindfulness-based stress reduction (MBSR) is believed to benefit patients with chronic pain by increasing mindfulness and pain acceptance. However, little is known about how these therapeutic mechanism variables relate to each other or whether they are differentially impacted by MBSR vs CBT. In a randomized controlled trial comparing MBSR, CBT, and usual care (UC) for adults aged 20 to 70 years with chronic low back pain (N = 342), we examine...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Topical Review Source Type: research

Updating the definition of pain
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Topical Review Source Type: research

Reliability of conditioned pain modulation: a systematic review
Abstract: A systematic literature review was undertaken to determine if conditioned pain modulation (CPM) is reliable. Longitudinal, English language observational studies of the repeatability of a CPM test paradigm in adult humans were included. Two independent reviewers assessed the risk of bias in 6 domains; study participation; study attrition; prognostic factor measurement; outcome measurement; confounding and analysis using the Quality in Prognosis Studies (QUIPS) critical assessment tool. Intraclass correlation coefficients (ICCs) less than 0.4 were considered to be poor; 0.4 and 0.59 to be fair; 0.6 and 0.75 good a...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

Young children's ability to report on past, future, and hypothetical pain states: a cognitive-developmental perspective
Abstract: Children are at times asked by clinicians or researchers to rate their pain associated with their past, future, or hypothetical experiences. However, little consideration is typically given to the cognitive-developmental requirements of such pain reports. Consequently, these pain assessment tasks may exceed the abilities of some children, potentially resulting in biased or random responses. This could lead to the over- or under-treatment of children's pain. This review provides an overview of factors, and specifically the cognitive-developmental prerequisites, that may affect a child's ability to report on nonpre...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

Promoting experimental rigor in the conduct of conditioned pain modulation studies: the importance of reliability
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Why does depression promote long-term opioid use?
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Mechanisms, mechanisms, mechanisms: it really does all boil down to mechanisms
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Curcumin reduces pain in DOMS
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Harnessing positive placebo effect and minimize negative nocebo effect: the art of a healing profession
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Chronic physical illness in early life and risk of chronic widespread and regional pain at age 68: evidence from the 1946 British birth cohort
This study aimed to examine the associations between serious illness in earlier life and risk of pain in old age using data from a large nationally representative British birth cohort, the Medical Research Council (MRC) National Survey of Health and Development (NSHD). Serious illness was defined as any experience of illness before age 25 requiring hospital admission of ≥28 days. Pain was self-reported at age 68, with chronic widespread pain (CWP) defined according to American College of Rheumatology criteria. Multinomial logistic regression was used to test associations of serious illness in early life with CWP, chroni...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Impaired conditioned pain modulation in youth with functional abdominal pain
This study assessed CPM to evoked thermal pain in 140 youth (ages 10-17), 63 of whom had FAP and 77 of whom were healthy controls. Multilevel models demonstrated weaker CPM effects in youth with FAP than in healthy youth, as evident in slower within-person decreases in pain ratings during the conditioning phase. Weaker CPM effects were associated with greater somatic symptom severity and functional disability. Pain responses in youth with FAP were heterogeneous, with 43% of youth showing an unexpected increase in pain ratings during the conditioning phase, suggesting sensitization rather than CPM-related pain inhibition. T...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Effects of topical combinations of clonidine and pentoxifylline on capsaicin-induced allodynia and postcapsaicin tourniquet-induced pain in healthy volunteers: a double-blind, randomized, controlled study
Abstract: This double-blind randomized controlled study was designed to evaluate the analgesic effects of topical treatments with clonidine (CLON) and pentoxifylline (PTX) tested alone or as low- and high-dose combinations in a human experimental model of pain. Of 69 healthy subjects aged 18 to 60 years, 23 each were randomly allocated to low-dose (0.04% + 2%) and high-dose (0.1% + 5%) CLON + PTX groups. Both of these groups also received their corresponding placebos in one of 2 treatment periods separated by at least 48 hours. Twenty-three additional subjects received either CLON (0.1%) or PTX (5%) as single drug treatmen...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study
Abstract: Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model of inflammatory pain (unilateral, 1 mg/mL in 100 µL) was evaluated in 11 studies across 8 centres. Following a standard protocol, data from participating centres were collected centrally and analysed with a restricted maximum likelihood-based mixed model for repeated measures. The total popula...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

The impact of peripheral nerve blocks on perioperative outcome in hip and knee arthroplasty—a population-based study
Abstract: The role of anesthesia techniques on perioperative outcomes on a population level has recently gained widespread interest. Although mainly neuraxial vs general anesthesia has been addressed, population-level data on the impact of peripheral nerve blocks (PNBs) are still lacking. Therefore, we investigated the association between PNB use and outcomes using retrospective data on 1,062,152 recipients of hip and knee arthroplasties (total hip arthroplasty [THA]/total knee arthroplasty [TKA]) from the national Premier Perspective database (2006-2013). Multilevel multivariable logistic regression models measured associ...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Electroencephalographic signatures of pain and analgesia in rats
In this study, we hypothesized that pain increases EEG power and corticocortical coherence in different rat models of pain, whereas treatments with clinically effective analgesics reverse these changes. Our results show increased cortical power over S1 and prefrontal cortex (PFC) in awake, freely behaving rat models of acute, inflammatory and neuropathic pain. Coherence between PFC and S1 is increased at a late, but not early, time point during the development of neuropathic pain. Electroencephalography power is not affected by ibuprofen in the acute pain model. However, pregabalin and mexiletine reverse the changes in pow...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Expose or protect? A randomized controlled trial of exposure in vivo vs pain-contingent treatment as usual in patients with complex regional pain syndrome type 1
Abstract: Complex regional pain syndrome type I (CRPS-I) highly affects patients' ability to perform daily life activities. Pain-related fear might be a key target to reduce disability in chronic pain. Current treatments aiming at reducing pain show little improvements on pain and disability, whereas novel exposure-based treatments targeting pain-related fears have shown to be promising. We conducted a randomized controlled trial (N = 46) comparing exposure in vivo (EXP) with pain-contingent treatment as usual (TAU), for CRPS-I patients with at least moderate levels of pain-related fear. Primary outcome is self-reported di...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Electrical high-frequency stimulation of the human thoracolumbar fascia evokes long-term potentiation-like pain amplification
Abstract: Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia) on pain perception in the back in humans. In 16 healthy volunteers, the multifidus muscle and the overlying thoracolumbar fascia were stimulated with electrical high-frequency pulses (5 × 100 pulses at 100 Hz) through bipolar concentric needle electrodes placed at lumbar level (L3/L4). Electri...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

A standardized clinical evaluation of phenotypic diversity in diabetic polyneuropathy
Abstract: Diabetic polyneuropathy (DPN) is a major cause of neuropathic pain and a frequent target condition in analgesic treatment trials. Differences in the clinical symptoms and signs associated with DPN suggest distinct pathophysiological mechanisms underlying nerve damage and dysfunction that are likely to have therapeutic relevance. The aim of this study was to develop a tool for the bedside assessment of painful neuropathies such as DPN that captures the diversity of phenotypes. Sixty-one patients with type 2 diabetes and painful neuropathy, 19 patients with painless DPN, 25 patients with type 2 diabetes but no clin...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease
This study suggests that increased inhibition and decreased excitation in the spinal cord may be responsible for the reduced thermal sensitivity associated with AD-related pathology. (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Posttraumatic stress disorder symptoms in youth with vs without chronic pain
Abstract: Chronic pain and posttraumatic stress disorder (PTSD) symptoms have been found to co-occur in adults; however, research has not examined this co-occurrence in adolescence, when pediatric chronic pain often first emerges. The aims of this study were to compare the frequency and intensity of PTSD symptoms and stressful life events in cohorts of youth with (n = 95) and without (n = 100) chronic pain and their parents and to determine the association between PTSD symptoms, health-related quality of life, and pain symptoms within the chronic pain sample. All participants completed questionnaire measures through an onl...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Health-related quality of life and burden of disease in chronic pain measured with the 15D instrument
Abstract: Health-related quality of life (HRQoL) measurement aims to capture the complete, subjective health state of the patients and to comprehensively evaluate treatment outcomes. The aim of this study was to assess, using the 15D HRQoL instrument, HRQoL in a sample of 1528 chronic pain patients, referred to the multidisciplinary pain clinic of the Helsinki University Hospital during 2004 to 2012. The 15D results of the chronic pain patients were compared with those of a matched general population. To analyse the properties of the 15D, the results were compared with the preadmission questionnaire of the pain clinic, con...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

The Pain Course: exploring predictors of clinical response to an Internet-delivered pain management program
Abstract: There is significant interest in the potential of Internet-delivered pain management programs for adults with chronic pain. Understanding the characteristics of people who do and do not benefit from Internet-delivered programs will help to guide their safe and effective use. Using a large sample from a previous randomised controlled trial of an established Internet-delivered pain management program, the Pain Course, this study (n = 463) examined whether several demographic, clinical, psychological, and treatment-related variables could be used to predict clinical response in levels of disability, depression, anxi...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity
Abstract: The relationship between glutamate and γ-aminobutyric acid (GABA) levels in the living human brain and pain sensitivity is unknown. Combined glutamine/glutamate (Glx), as well as GABA levels can be measured in vivo with single-voxel proton magnetic resonance spectroscopy. In this cross-sectional study, we aimed at determining whether Glx and/or GABA levels in pain-related brain regions are associated with individual differences in pain sensitivity. Experimental heat, cold, and mechanical pain thresholds were obtained from 39 healthy, drug-free individuals (25 men) according to the quantitative sensory testi...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers
In this study, we extend this finding in the complete Freund's adjuvant model of inflammatory pain and validate that the degree of conduction failure decreased and led to a greater amount of pain signals conveyed to the central nervous system. In complete Freund's adjuvant–injected animals, conduction failure occurred in a C-fiber-selective, activity-dependent manner and was associated with an increase in the rising slope of the C-fiber after-hyperpolarization potential. To target conduction failure in a therapeutic modality, we used ZD7288, an antagonist of hyperpolarization-activated, cyclic nucleotide–modula...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Using a graphical risk tool to examine willingness to take migraine prophylactic medications
Abstract: Many migraine sufferers use daily prophylactic therapy to reduce the frequency of their headache attacks. The Food and Drug Administration has approved several different medications for migraine prophylaxis, but it is not clear whether sufferers perceive these treatments to provide clinically significant benefits given their side effect profiles. Three hundred headache sufferers were recruited from the community and local headache clinics using print and television advertising. Participants reported experiencing problematic headache attacks with a median (IQR) frequency of 7.0 (4-13) headache days per month. Thes...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study
Abstract: Endogenous opioid system dysfunction potentially contributes to chronic pain in fibromyalgia (FM), but it is unknown if this dysfunction is related to established neurobiological markers of hyperalgesia. We previously reported that µ-opioid receptor (MOR) availability was reduced in patients with FM as compared with healthy controls in several pain-processing brain regions. In the present study, we compared pain-evoked functional magnetic resonance imaging with endogenous MOR binding and clinical pain ratings in female opioid-naive patients with FM (n = 18) using whole-brain analyses and regions of interest...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Does association of opioid use with pain and function differ by fibromyalgia or widespread pain status?
Abstract: Many consider chronic opioid therapy (COT) to be ineffective for fibromyalgia, but empirical evidence is limited. Among patients identified as initiating COT, we examined whether fibromyalgia was associated with different relationships of opioid use to pain and activity interference outcomes 12 months later. We obtained electronic data on diagnoses and opioid prescriptions. We obtained patient self-report data, including pain and activity interference measures, at baseline, 4 months, and 12 months. Among 1218 patients, 429 (35%) met our definition of fibromyalgia. Patients with and without fibromyalgia who had in...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Insular balance of glutamatergic and GABAergic signaling modulates pain processing
Abstract: Neuroimaging studies of patients with chronic pain have shown that neurotransmitter abnormalities, including increases in glutamate and decreases in GABA, could be responsible for the cortical hyperactivity and hyperalgesia/allodynia observed in some pain conditions. These finding are particularly evident in the insula, a brain region known to play a role in both the sensory–discriminative and the affective–motivational aspects of pain processing. However, clinical studies are not entirely able to determine the directionality of these findings, nor whether they are causal or epiphenomenon. Thus, a set...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

The effect of pain on task switching: pain reduces accuracy and increases reaction times across multiple switching paradigms
We present 3 studies to test this hypothesis. In study 1, participants completed 2 versions of an alternating runs switching task under pain-free and thermal pain–induction conditions. Pain did not affect performance on either task. In studies 2 and 3, we examined 7 versions of the switching task using large general population samples, experiencing a variety of naturally occurring pain conditions, recruited and tested on the internet. On all tasks, participants with pain had longer reaction times on both switch and repeat trials compared with participants without pain, but pain did not increase switch costs. In studi...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Adolescent context of exposure to prescription opioids and substance use disorder symptoms at age 35: a national longitudinal study
The objective of this study was to examine the association of context of prescription opioid exposure (ie, medical or nonmedical) in adolescence with the subsequent risk of nonmedical use of prescription opioids (NMUPO) and substance use disorder (SUD) symptoms at age 35. Multiple cohorts of nationally representative probability samples of U.S. high school seniors (n = 4072) were surveyed through self-administered questionnaires and followed longitudinally from adolescence (modal age 18, graduating classes 1976-1996) to age 35 (1993-2013). Main outcome measures were past-year NMUPO and SUD symptoms. The medical and NMUPO d...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research—systematic review and meta-analysis
Abstract: Back schools are interventions that comprise exercise and education components. We aimed to systematically review the randomized controlled trial evidence on back schools for the treatment of chronic low back pain. By searching MEDLINE, Embase, and Cochrane Central as well as bibliographies, we identified 31 studies for inclusion in our systematic review and 5 of these for inclusion in meta-analyses. Meta-analyses for pain scores and functional outcomes revealed statistical superiority of back schools vs no intervention for some comparisons but not others. No meta-analysis was feasible for the comparison of back ...
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

The epidemiology of chronic pain
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: PAIN Pictured Source Type: research

Smell of pain: intersection of nociception and olfaction
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Topical Review Source Type: research

What the brain tells the spinal cord
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Topical Review Source Type: research

More than “just do it”—fear-based exposure for complex regional pain syndrome
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Taking adolescent prescription opioid use in context: risk stratification in early mid-life based on medical and nonmedical use
No abstract available (Source: Pain)
Source: Pain - September 27, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - August 24, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Changing pain-related knowledge may or may not reduce pain and improve function through changes in catastrophising
No abstract available (Source: Pain)
Source: Pain - August 24, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Persistent pain after breast cancer surgery
No abstract available (Source: Pain)
Source: Pain - August 24, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential
Abstract: Uncoupling the protein–protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action, abuse potential, and neurobehavioral toxicity of an improved mutant CRMP2 peptide. A homopolyarginine (R9)-conjugated CBD3-A6K (R9-CBD3-A6K) peptide inhibited the CaV2.2–CRMP2 interaction in a concentration-dependent fashion and diminished surface expression of CaV2.2 and depolarization-e...
Source: Pain - August 24, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Cognitive behavioral therapy for chronic pain is effective, but for whom?
This study was designed to examine differential response to treatment for patient subgroups to guide clinical decision-making for treatment. Based on existing literature, demographic (age, sex, race/ethnicity, and education) and clinical variables (disease severity, body mass index, patient treatment expectations, depression, and patient pain coping style) were specified a priori as potential moderators. Trial outcome variables (N = 15) included pain, fatigue, self-efficacy, quality of life, catastrophizing, and use of pain medication. Results yielded 5 significant moderators for outcomes at posttreatment: pain coping styl...
Source: Pain - August 24, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis
Abstract: Pain among individuals with knee osteoarthritis (OA) is associated with significant disability in older adults, and recent evidence demonstrates enhanced experimental pain sensitivity. Although previous research showed considerable heterogeneity in the OA clinical pain presentation, less is known regarding the variability in responses to experimental pain. The present study included individuals with knee OA (n = 292) who participated in the Understanding Pain and Limitations in Osteoarthritic Disease study and completed demographic and psychological questionnaires followed by a multimodal quantitative sensory tes...
Source: Pain - August 24, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research