Reply to dos Santos Ferreira and Velly
No abstract available (Source: Pain)
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Cognitive decline over time in patients with chronic pain and headache: how can different outcomes be explained?
No abstract available (Source: Pain)
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Reply to Russo et al.
No abstract available (Source: Pain)
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Taxonomy and pain clinic patients
No abstract available (Source: Pain)
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Not being able to measure what is important, does not make things we can measure important
No abstract available (Source: Pain)
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Purinergic signaling between neurons and satellite glial cells of mouse dorsal root ganglia modulates neuronal excitability in vivo
Primary sensory neurons in dorsal root ganglia (DRG) are wrapped by satellite glial cells (SGCs), and neuron-SGC interaction may affect somatosensation, especially nociceptive transmission. P2-purinergic receptors (P2Rs) are key elements in the two-way interactions between DRG neurons and SGCs. However, because the cell types are in such close proximity, conventional approaches such as in vitro culture and electrophysiologic recordings are not adequate to investigate the physiologically relevant responses of these cells at a population level. Here, we performed in vivo calcium imaging to survey the activation of hundreds o...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours
Endometriosis is a chronic and debilitating condition, commonly characterised by chronic pelvic pain (CPP) and infertility. Chronic pelvic pain can be experienced across multiple pelvic organs, with comorbidities commonly effecting the bowel, bladder, and vagina. Despite research efforts into endometriosis pathophysiology, little is known about how endometriosis induces CPP, and as such, therapeutic interventions are lacking. The aim of this study was to characterise a syngeneic mouse model of endometriosis that mimics naturally occurring retrograde menstruation, thought to precede endometriosis development in patients, an...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
The cannabinoid agonist CB-13 produces peripherally mediated analgesia in mice but elicits tolerance and signs of central nervous system activity with repeated dosing
Activation of cannabinoid receptor type 1 (CB1) produces analgesia in a variety of preclinical models of pain; however, engagement of central CB1 receptors is accompanied by unwanted side effects, such as psychoactivity, tolerance, and dependence. Therefore, some efforts to develop novel analgesics have focused on targeting peripheral CB1 receptors to circumvent central CB1-related side effects. In the present study, we evaluated the effects of acute and repeated dosing with the peripherally selective CB1-preferring agonist CB-13 on nociception and central CB1-related phenotypes in a model of inflammatory pain in mice. We ...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Long-term neuropathic pain behaviors correlate with synaptic plasticity and limbic circuit alteration: a comparative observational study in mice
In this study, we used the spared nerve injury (SNI) model to characterize the development of sensory and aversive components of neuropathic pain and to determine their electrophysiological impact across prefrontal cortex and limbic regions. Moreover, we evaluated the regulation of several genes involved in immune response and inflammation triggered by SNI. We showed that SNI led to sensorial hypersensitivity (cold and mechanical stimuli) and depressive-like behavior lasting 12 months after nerve injury. Of interest, changes in nonemotional cognitive tasks (novel object recognition and Y maze) showed in 1-month SNI mice we...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Long-term prescription opioid users' risk for new-onset depression increases with frequency of use
Long-term opioid therapy (LTOT) is associated with increased risk for depression. It is not known if the frequency of opioid use during LTOT is associated with new-onset depression. We used Optum's de-identified Integrated Claims-Clinical dataset (2010-2018) to create a cohort of 5146 patients, 18 to 80 years of age, with an encounter or claims in the year before new LTOT. New LTOT was defined by>90-day opioid use after remaining opioid free for 6 months. Opioid use frequency during the first 90 days of LTOT was categorized into occasional use ( (Source: Pain)
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Serious opioid-related adverse outcomes associated with opioids prescribed by dentists
The objective of this study was to evaluate adverse outcomes and persistent opioid use (POU) after opioid prescriptions by dentists, based on whether opioids were overprescribed or within recommendations. A cross-sectional analysis of adults with a dental visit and corresponding opioid prescription (index) from 2011 to 2018 within a nationwide commercial claims database was conducted. Opioid overprescribing was defined as>120 morphine milligram equivalents per Centers for Disease Control and Prevention guidelines. Generalized estimating equation models were used to assess adverse outcomes (emergency department visits, hosp...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Impaired pain-related threat and safety learning in patients with chronic back pain
Pain-related learning mechanisms likely play a key role in the development and maintenance of chronic pain. Previous smaller-scale studies have suggested impaired pain-related learning in patients with chronic pain, but results are mixed, and chronic back pain (CBP) particularly has been poorly studied. In a differential conditioning paradigm with painful heat as unconditioned stimuli, we examined pain-related acquisition and extinction learning in 62 patients with CBP and 61 pain-free healthy male and female volunteers using valence and contingency ratings and skin conductance responses. Valence ratings indicate significa...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3–dependent sensitization
Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are associated with a risk of developing persistent pain. Increased osteoclast activity is often the hallmark of these bony pathologies and not only leads to bone remodeling but is also a source of pronociceptive factors that sensitize the bone-innervating nociceptors. Although historically bone loss in RA has been believed to be a consequence of inflammation, both bone erosion and pain can occur years before the symptom onset. Here, we have addressed the disconnection between inflammation, pain, and bone erosion by using a combination o...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Common bacterial metabolite indole directly activates nociceptive neuron through transient receptor potential ankyrin 1 channel
In this study, we investigated whether and how a common bacterial metabolite, indole, which is produced by normal microflora of the gastrointestinal tract and oral cavity, can directly activate nociceptive sensory neurons. We found that indole elicits calcium response and evokes inward currents in subsets of dorsal root ganglia (DRG) neurons. Intraplantar (i.pl.) injection of indole produced nocifensive behaviors in adult mice, which were enhanced in complete Freund’s adjuvant–induced chronic inflammatory condition. Indole increased calcitonin gene-related peptide release in DRG neurons, and i.pl. injection of indole i...
Source: Pain - July 30, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
