New promising targets to control neuropathic pain
No abstract available (Source: Pain)
Source: Pain - August 21, 2019 Category: Anesthesiology Tags: Commentary Source Type: research

Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients: Erratum.
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Erratum Source Type: research

Reply to Tapia et al.
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Spinal cord stimulation for failed back surgery: all that glitters is not gold
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to Dildine and Atlas
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

The need for diversity in research on facial expressions of pain
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Parallels between lumbosacral radiculopathy and complex regional pain syndrome: α: 1: -adrenoceptor upregulation, reduced dermal nerve fibre density, and hemisensory disturbances in postsurgical sciatica
Residual lower-limb pain after low back surgery (postsurgical sciatica) and complex regional pain syndrome (CRPS) involving a lower limb are separate conditions but may share some mechanisms (eg, tissue inflammation, neuroimmune disturbances, and central neuroplasticity). As adrenergically evoked pain contributes, in part, to CRPS, whether an adrenergic mechanism also contributes to postsurgical sciatica was investigated in this study. Immunohistochemistry was used to identify α1-adrenoceptors (α1-AR) on nerve fibres and other targets in the affected and contralateral skin of 25 patients with postsurgical sciat...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Endogenous pain modulation in children with functional abdominal pain disorders
Functional abdominal pain disorders (FAPDs) are common among young individuals. To date, relatively little is known regarding the function of the endogenous analgesic mechanisms in this vulnerable group. Therefore, this case–control study aimed to compare conditioned pain modulation (CPM), pressure algometry, and psychosocial variables in 39 young children (aged 6-12 years) with FAPD and 36 age- and sex-matched pain-free controls. Pressure algometry was used to assess pressure pain thresholds (PPTs) at both symptomatic (umbilicus) as remote (trapezius and tibia) test sites. Conditioned pain modulation was recorded as...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Interleukin 6 decreases nociceptor expression of the potassium channel KV1.4 in a rat model of hand–arm vibration syndrome
Chronic muscle pain is a prominent symptom of the hand–arm vibration syndrome (HAVS), an occupational disease induced by exposure to vibrating power tools, but the underlying mechanism remains unknown. We evaluated the hypothesis that vibration induces an interleukin 6 (IL-6)-mediated downregulation of the potassium voltage-gated channel subfamily A member 4 (KV1.4) in nociceptors leading to muscle pain. Adult male rats were submitted to a protocol of mechanical vibration of the right hind limb. Twenty-four hours after vibration, muscle hyperalgesia was observed, concomitant to increased levels of IL-6 in the gastroc...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

The role of narrative in the development of children's pain memories: influences of father– and mother–child reminiscing on children's recall of pain
This study examined the role of parent–child reminiscing about a recent painful surgery in young children's pain memory development. Participants included 112 children (Mage = 5.3 years; 60% boys) who underwent a tonsillectomy and one of their parents (34% fathers). Pain was assessed in hospital and during the recovery phase at home. Two weeks after surgery, parents and children attended a laboratory visit to participate in a structured narrative elicitation task wherein they reminisced about the surgery. Four weeks after surgery, children completed an established pain memory interview using the same previously admin...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain-related functional interference in patients with chronic neuropathic postsurgical pain: an analysis of registry data
Although chronic postsurgical pain (CPSP) is a major health care problem, pain-related functional interference has rarely been investigated. Using the PAIN OUT registry, we evaluated patients' pain-related outcomes on the first postoperative day, and their pain-related interference with daily living (Brief Pain Inventory) and neuropathic symptoms (DN4: douleur neuropathique en 4 questions) at 6 months after surgery. Endpoints were pain interference total scores (PITS) and their association with pain and DN4 scores. Furthermore, possible risk factors associated with impaired function at M6 were analyzed by ordinal regressio...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study
Data from preclinical research have been suggested to suffer from a lack of inherent reproducibility across laboratories. The goal of our study was to replicate findings from a previous report that demonstrated positive effects of Meteorin, a novel neurotrophic factor, in a rat model of neuropathic pain induced by chronic constriction injury (CCI). Notably, 5 to 6 intermittent subcutaneous (s.c.) injections of Meteorin had been reported to produce reversal of mechanical allodynia/thermal hyperalgesia after injury, wherein maximum efficacy of Meteorin was reached slowly and outlasted the elimination of the compound from the...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Somatosensory predictors of response to pregabalin in painful chemotherapy-induced peripheral neuropathy: a randomized, placebo-controlled, crossover study
Painful chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and treatment-resistant sequela of many chemotherapeutic medications. Ligands of α2δ subunits of voltage-gated Ca2+ channels, such as pregabalin, have shown efficacy in reducing mechanical sensitivity in animal models of neuropathic pain. In addition, some data suggest that pregabalin may be more efficacious in relieving neuropathic pain in subjects with increased sensitivity to pinprick. We hypothesized that greater mechanical sensitivity, as quantified by decreased mechanical pain threshold at the feet, would be predictive of a greate...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia
In this study, we expanded on previous findings related to the 3 SNPs in the opioid receptor mu subunit (OPRM1 rs1799971), catechol-O-methyltransferase (COMT rs4680), and fatty acid amide hydrolase (FAAH rs324420) genes associated with placebo hypoalgesia and tested the effect of a 3-way interaction on placebo hypoalgesia. Using 2 well-established placebo procedures (verbal suggestion and learning paradigm), we induced significant placebo hypoalgesic effects in 160 healthy participants. We found that individuals with OPRM1 AA combined with FAAH Pro/Pro and those carrying COMT met/met together with FAAH Pro/Pro showed signi...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

The relationship between regional pain with or without neuropathic symptoms and chronic widespread pain
This study was performed to test whether the risk of developing chronic widespread pain (CWP) in those with regional pain was augmented in those with symptoms of neuropathic pain (NP). Persons free of CWP completed the Douleur Neuropathique 4 (scores ≥3 indicating NP); demographics; Hospital Anxiety and Depression scale; Pittsburgh Sleep Quality Index; and pain medications. Participants were classified as having no pain, regional pain with no symptoms of NP ( JOURNAL/jpain/04.02/00006396-201908000-00014/math_14MM1/v/2019-07-21T190841Z/r/image-tiff ), or regional pain with symptoms of NP (NP). At the 12-month follow-up...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner
Postoperative pain management continues to be suboptimal because of the lack of effective nonopioid therapies and absence of understanding of sex-driven differences. Here, we asked how the NLRP3 inflammasome contributes to postoperative pain. Inflammasomes are mediators of the innate immune system that are responsible for activation and secretion of IL-1β upon stimulation by specific molecular signals. Peripheral IL-1β is known to contribute to the mechanical sensitization induced by surgical incision. However, it is not known which inflammasome mediates the IL-1β release after surgical incision. Among the 9...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Progesterone relates to enhanced incisional acute pain and pinprick hyperalgesia in the luteal phase of female volunteers
The role of sex hormones on postsurgical pain perception is basically unclear. Here, we studied the role of endogenous gonadal hormones for pain and hyperalgesia in human volunteers after experimental incision. A 4-mm incision was made in the volar forearm of 15 female volunteers both in the follicular and the luteal phase (random block design). Somatosensory profiles were assessed at baseline and 1 to 72 hours after incision by quantitative sensory testing, compared between both cycle phases, and related to individual plasma levels of gonadal hormones. Sensory testing at baseline revealed significantly lower pain threshol...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen
Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, postsurgical pain continues to be a frequent and undermanaged condition. Here, we investigate the analgesic potential of pharmacological NaV1.7 inhibition in a mouse model of acute postsurgical pain, based on incision of the plantar skin and underlying muscle of the hind paw. We demonstrate that local and systemic treatment with the selective NaV1.7 inhibitor μ-theraphotoxin-Pn3a is effectively antiallodynic in this model and completely reverses mechanical hypersensitivity in the absence of motor adverse ...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain
Peripheral inflammation produces a long-lasting latent sensitization of spinal nociceptive neurons, that is, masked by tonic inhibitory controls. We explored mechanisms of latent sensitization with an established four-step approach: (1) induction of inflammation; (2) allow pain hypersensitivity to resolve; (3) interrogate latent sensitization with a channel blocker, mutant mouse, or receptor antagonist; and (4) disrupt compensatory inhibition with a receptor antagonist so as to reinstate pain hypersensitivity. We found that the neuropeptide Y Y1 receptor antagonist BIBO3304 reinstated pain hypersensitivity, indicative of a...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response
This study demonstrates the utility of advanced, high-precision genetic mapping populations in resolving specific molecular mechanisms of variation in pain sensitivity. (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Remembering the pain of surgery 1 year later: a longitudinal examination of anxiety in children's pain memory development
Children who develop greater negatively-biased recall of pain (ie, recalled pain is higher than the initial pain report) following surgery are at risk for developing chronic pain; therefore, identifying risk factors for the development of biased pain memories is important. Higher anxiety has been implicated in the development of greater negatively-biased recall of pain; however, studies have not examined anxiety at multiple time points before and after a surgery and its relationship to children's postsurgical pain memories after 1 year. This prospective study examined a cohort of 237 children and adolescents undergoing maj...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Cortisol affects pain sensitivity and pain-related emotional learning in experimental visceral but not somatic pain: a randomized controlled study in healthy men and women
Despite growing interest in the role of stress mediators in pain chronicity, the effects of the stress hormone cortisol on acute pain remain incompletely understood. In a randomized, double-blind, placebo-controlled study with N = 100 healthy volunteers, we tested the effects of oral hydrocortisone (20 mg) in 2 widely used pain models for the visceral and somatic modality. Salivary cortisol was increased in the hydrocortisone group (time × group: P (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Efficacy of a transdiagnostic emotion–focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial
This study addresses the efficacy of a transdiagnostic emotion–focused exposure treatment (“hybrid”) for chronic pain patients with comorbid emotional problems. Adults (n = 115) with chronic musculoskeletal pain and functional and emotional problems were included in a 2-centre, parallel randomized controlled, open-label trial comparing this treatment to an active control condition receiving a guided Internet-delivered pain management treatment based on CBT principles (iCBT). The hybrid treatment (n = 58, 10-16 sessions) integrates exposure in vivo for chronic pain based on the fear-avoidance model with an...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Pharmacological interventions for chronic pain in children: an overview of systematic reviews
We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) or chronic cancer-related pain (CCRP). We searched the Cochrane Database of Systematic Reviews, Medline, EMBASE, and DARE for systematic reviews from inception to March 2018. We conducted reference and citation searches of included reviews. We included children (0-18 years of age) with CNCP or CCRP. We extract...
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Habituation to pain: a motivational-ethological perspective
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Topical Review Source Type: research

Cortisol increases visceral pain in women but not in men
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Commentaries Source Type: research

Reflections on hybrid transdiagnostic treatment, pain reduction, and emotion regulation
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Commentaries Source Type: research

Pain relief in children and adolescents
No abstract available (Source: Pain)
Source: Pain - July 25, 2019 Category: Anesthesiology Tags: Commentaries Source Type: research

Reply to Henningsen et al.
No abstract available (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Chronic primary pain: a pain-centered view of the world is too narrow
No abstract available (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to Bornstein et al.
No abstract available (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Vulvodynia: a neglected chronic pain diagnosis
No abstract available (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Correspondence Source Type: research

Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief
In this study, we conducted a longitudinal functional MRI study to test the hypothesis that the pain-relieving effect of ketamine is the result of reversal of abnormalities in regional low-frequency brain oscillations (LFOs) and abnormal cross-network functional connectivity (FC) of the dynamic pain connectome. We found that (1) ketamine decreased regional LFOs in the posterior cingulate cortex of the default mode network, (2) a machine-learning algorithm demonstrated that treatment-induced brain changes could be used to make generalizable inferences about pain relief, (3) treatment responders exhibited a significant decre...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

People in pain make poorer decisions
Chronic pain affects 1 in 5 people and has been shown to disrupt attention. Here, we investigated whether pain disrupts everyday decision making. In study 1, 1322 participants completed 2 tasks online: a shopping-decisions task and a measure of decision outcomes over the previous 10 years. Participants who were in pain during the study made more errors on the shopping task than those who were pain-free. Participants with a recurrent pain condition reported more negative outcomes from their past decisions than those without recurrent pain. In study 2, 44 healthy participants completed the shopping-decisions task with and wi...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Targeting the CaVα–CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy
Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. We targeted the high-affinity protein–protein interface of CaVβ's pocket within the CaVα subunit. Structure-based virtual screening of 50,000 small molecule library docked to the β subunit led to the identification of 2-(3,5-dimethylisoxa...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Cerebral cortical dimensions in headache sufferers aged 50 to 66 years: a population-based imaging study in the Nord-Trøndelag Health Study (HUNT-MRI)
Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in volume, thickness, or surface area in the anterior cingulate cortex, prefrontal cortex, and insula. In addition, exploratory analyses on volume, thickness, and surface area across the cerebral cortical mantle were performed. A total of 1006 participants (aged 50-66 years) from the general population were selected to an imaging study of the head at 1.5 T (HUNT-MRI). Two hundred eighty-three individuals suffere...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

The role of afferent input in postamputation pain: a randomized, double-blind, placebo-controlled crossover study
In this randomized, double-blind, placebo-controlled crossover study, we investigated whether a peripheral nerve block could temporarily eliminate phantom and stump pain after amputation. Amputees with constant postamputation pain were included and randomized to receive a nerve block with lidocaine 2% with adrenaline or saline in a crossover design. Spontaneous phantom and stump pain and evoked responses were assessed at baseline and at fixed time-points until 120 minutes after lidocaine or saline injection. The primary outcome was the difference in absolute change between worst pain intensity, either phantom or stump pain...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain
Diffuse noxious inhibitory controls (DNICs) is a pain-inhibits-pain phenomenon demonstrated in humans and animals. Diffuse noxious inhibitory control is diminished in many chronic pain states, including neuropathic pain. The efficiency of DNIC has been suggested to prospectively predict both the likelihood of pain chronification and treatment response. Little is known as to why DNIC is dysfunctional in neuropathic pain. Here, we evaluated DNIC in the rat L5/L6 spinal nerve ligation (SNL) model of chronic pain using both behavioral and electrophysiological outcomes. For behavior, nociceptive thresholds were determined using...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial
This study showed that LX-P has a comparable efficacy to LX-T, but with a better safety profile, being a therapeutic option for the treatment of posttraumatic injury pain. (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Somatotopically specific primary somatosensory connectivity to salience and default mode networks encodes clinical pain
Although several studies have found that chronic pain is characterized by increased cross-network connectivity between salience network, sensorimotor network, and default mode network (DMN), a large sample-size investigation allowing for a more reliable evaluation of somatotopic specificity and subgroup analyses with linkage to clinical pain intensity has been lacking. We enrolled healthy adults and a large cohort of patients (N = 181) suffering from chronic low back pain (cLBP). To specifically link brain connectivity with clinical pain intensity, patients were scanned at baseline and after performing physical maneuvers t...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Time for change: an experimental investigation of chronic pain patients' emotional and attitudinal responses to simulated opioid-tapering advice
Clinicians report reluctance to deliver opioid-tapering advice to patients with chronic pain, in part due to concerns that patients will be angry and dissatisfied. An experiment was conducted to examine chronic pain patients' emotional and attitudinal responses to simulated opioid-tapering advice. Patients scheduled for an initial assessment at a tertiary pain clinic and currently taking opioid medications for pain (N = 196) were randomly assigned to view video footage of a standardized patient receiving 1 of 3 forms of treatment advice: (1) stay on current medication (2) change to a different pain medication, or (3) taper...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

The Paediatric electronic Persistent Pain Outcomes Collaboration (PaedePPOC): establishment of a binational system for benchmarking children's persistent pain services
This study documents the establishment of PaedePPOC and presents baseline and initial outcome data. Binational consensus meetings determined the measures. Governance structures, collection protocols, information technology, site-specific logistics, and onsite training were achieved within 18 months. Children and parents complete baseline and progress questionnaires. Seven of 10 Australasian services provided data to PaedePPOC, with 1432 patients enrolled until June 2018. At baseline, patients were 12.4 ± (3.0) years, 68% female, 93% Australian-born, and 5% Aboriginal and/or Torres Strait Islander people. Most had mo...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer
Pain after surgery remains a major health problem, calling for optimized treatment regimens to maximize the efficacy of pharmacological interventions. In this randomized controlled trial, we tested in a routine surgical treatment setting whether postoperative pain can be reduced by a brief preoperative intervention, ie, positive verbal suggestions in combination with sham acupuncture, designed to optimize treatment expectations. We hypothesized that the expectancy intervention as add-on to patient-controlled intravenous analgesia with morphine reduces patient-reported postoperative pain and improves satisfaction with analg...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Incident injury is strongly associated with subsequent incident temporomandibular disorder: results from the OPPERA study
Cross-sectional studies confirm, as expected, a positive association between jaw injury and painful temporomandibular disorders (TMDs), but prospective evaluations are lacking. We prospectively assessed incident jaw injury, injury type, and development of TMD in adults aged 18 to 44 years. Data were collected from 3258 individuals from communities surrounding 4 US academic institutes between 2006 and 2008. At enrollment, participants reported no TMD history and no facial injuries in the previous 6 months. Quarterly, follow-up questionnaires assessed incident jaw injury, which was classified as intrinsic (attributed to yawn...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Modification of the Neuropathic Pain Symptom Inventory for use in eye pain (NPSI-Eye)
Chronic eye pain, which has previously been assumed to be due to ocular surface abnormalities (ie, “dry eye [DE] disease”), has recently garnered attention as a potential indicator of neuropathic ocular pain in some patients. The purpose of this study was to evaluate the psychometric properties of a modified version of the Neuropathic Pain Symptom Inventory in individuals with eye pain (NPSI-Eye). Enrolled participants (n = 397) completed the NPSI-Eye, general pain severity questionnaires, DE symptom report, and psychological health indices. Participants also underwent mechanical pain sensitivity testing of the...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Altered gray matter volume in sensorimotor and thalamic regions associated with pain in localized provoked vulvodynia: a voxel-based morphometry study
In this study, we tested the hypotheses that PVD compared with healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations in regions associated with sensorimotor, corticothalamic, and basal ganglia circuits. We also tested the replicability of previously reported gray matter increases in basal ganglia and hippocampal volumes in PVD vs HCs. In addition, disease specificity of GMV alterations were examined by comparing PVD with another chronic pain disorder. Finally, we examine whether GMV alterations are correlated with symptom measures. Structural magnetic resonance imaging was obtained in 119 premenopau...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

A deeper look at pain variability and its relationship with the placebo response: results from a randomized, double-blind, placebo-controlled clinical trial of naproxen in osteoarthritis of the knee
Previous studies have shown a robust correlation between variability of clinical pain scores and responsiveness to placebo (but not active drug) in pain studies, but explanations for these relationships are lacking. We investigated this further by assessing relationship between the Focused Analgesia Selection Test (FAST), a psychophysical method that quantifies pain reporting variability in response to experimental stimuli, variability of daily clinical pain scores as captured using diary, and response to treatment in the context of a randomized controlled crossover trial of naproxen vs placebo in knee osteoarthritis. Evok...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Preventive hypothermia as a neuroprotective strategy for paclitaxel-induced peripheral neuropathy
In conclusion, our findings indicate that early exposure to regional hypothermia alleviates paclitaxel-induced peripheral neuropathy. Therapeutic hypothermia may therefore represent an economical and nonpharmaceutical preventive strategy for CIPN in patients with localized solid tumors. (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

RNA-seq data in pain research–an illustrated guide
No abstract available (Source: Pain)
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: PAIN Pictured Source Type: research

Migraine understood as a sensory threshold disease
Migraine encompasses a broader spectrum of sensory symptoms than just headache. These “other” symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinally over time. Photophobia, for example, can be quantified by investigating the discomfort thresholds towards the luminance of light. The aim of this review is to look into how thresholds change in patients with migraine. We performed a PubMed search up to June 2018 targeting all peer-reviewed artic...
Source: Pain - June 26, 2019 Category: Anesthesiology Tags: Narrative Review Source Type: research