Disruption of working memory and contralateral delay activity by nociceptive stimuli is modulated by task demands
Top–down processes allow the selection and prioritization of information by limiting attentional capture by distractors, and these mechanisms depend on task demands such as working memory (WM) load. However, bottom–up processes give salient stimuli a stronger neuronal representation and provoke attentional capture. The aim of this study was to examine the effect of salient nociceptive stimuli on WM while manipulating task demands. Twenty-one healthy participants performed a change detection task during which they had to determine whether 2 successive visual arrays were different or the same. Task demands were modulated...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine
In conclusion, patients with CM who were not responsive to preventive treatment were associated with augmented resting-state occipital alpha activity. Moreover, changes in migraine attack frequency were associated with baseline occipital alpha power. However, the prognostic feature of visual alpha oscillation seems to be inherent because it is not altered by flunarizine treatment. These findings may be useful for developing personalised migraine treatment plans. (Source: Pain)
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Observing treatment outcomes in other patients can elicit augmented placebo effects on pain treatment: a double-blinded randomized clinical trial with patients with chronic low back pain
Clinical research on social observational learning (SoL) as an underlying mechanism for inducing expectancy and eliciting analgesic placebo effects is lacking. This double-blinded randomized controlled clinical trial investigated the influence of SoL on medication-augmenting placebo effects in 44 patients with chronic low back pain. Our hypothesis was that observing positive drug effects on pain and mobility in another patient could increase pain reduction and functional capacity. To test this, we compared the effects of observing positive treatment outcomes in a sham patient (the social learning group [SoLG]) vs hearing t...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
A multicenter, randomized, double-blind, placebo-controlled, comparative study to evaluate the efficacy and safety of newly developed diclofenac patches in patients with cancer pain
This phase III multicenter randomized double-blind placebo-controlled comparative study evaluated the efficacy and safety of diclofenac sodium patches for the treatment of cancer pain. The study consisted of a 2-week to 4-week open-label dose-titration phase and a 4-week double-blind phase. In the double-blind phase, patients who were expected to continue treatment of cancer pain with nonopioid analgesics alone were randomized to the diclofenac sodium patch or placebo group. Once-daily diclofenac sodium patches were started at 150 mg/day (2 patches) and could be increased up to 225 mg/day (3 patches). The primary efficacy ...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Exploring sex differences in alpha brain activity as a potential neuromarker associated with neuropathic pain
Alpha oscillatory activity (8-13 Hz) is the dominant rhythm in the awake brain and is known to play an important role in pain states. Previous studies have identified alpha band slowing and increased power in the dynamic pain connectome (DPC) of people with chronic neuropathic pain. However, a link between alpha-band abnormalities and sex differences in brain organization in healthy individuals and those with chronic pain is not known. Here, we used resting-state magnetoencephalography to test the hypothesis that peak alpha frequency (PAF) abnormalities are general features across chronic central and peripheral conditions ...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Brain structure, psychosocial, and physical health in acute and chronic back pain: a UK Biobank study
We examined, cross-sectionally, 11,106 individuals from the UK Biobank who (1) were pain-free (n = 5616), (2) had acute back pain (n = 1746), (3) had chronic localised back pain (CBP; n = 1872), or (4) had chronic back pain and additional chronic pain sites (CWP; n = 1872). We found differences in structural brain measures in the chronic pain groups alone. Both CBP and CWP groups had lower primary somatosensory cortex {CBP mean difference (MD) (95% confidence interval [CI]): −250 (−393, −107) mm3, P (Source: Pain)
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Pain persistence and the pain modulatory system: an evolutionary mismatch perspective
No abstract available (Source: Pain)
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Perspective Source Type: research
Nerve pathology and neuropathic pain after whiplash injury: a systematic review and meta-analysis
There is no clear understanding of the mechanisms causing persistent pain in patients with whiplash-associated disorder (WAD). The aim of this systematic review was to assess the evidence for nerve pathology and neuropathic pain in patients with WAD. EMBASE, PubMed, CINAHL (EBSCO), and MEDLINE were searched from inception to September 1, 2020. Study quality and risk of bias were assessed using the Newcastle–Ottawa Quality Assessment Scales. Fifty-four studies reporting on 390,644 patients and 918 controls were included. Clinical questionnaires suggested symptoms of predominant neuropathic characteristic in 34% of patient...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Can perioperative psychological interventions decrease the risk of postsurgical pain and disability? A systematic review and meta-analysis of randomized controlled trials
Many patients experience pain after surgery. Psychological factors such as emotion and cognition are shown to be associated with the development of acute and chronic postsurgical pain (CPSP). Therefore, the question arises whether targeting these psychological factors can reduce negative postsurgical outcomes. The aim of the current review was to investigate the efficacy of perioperative psychological interventions in reducing (sub)acute postsurgical pain and CPSP and disability in adults. Randomized controlled trials were identified through 4 databases (Web of Science, PsychINFO, PubMed, and Cumulative Index to Nursing an...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Potential role of blood biomarkers in patients with fibromyalgia: a systematic review with meta-analysis
Fibromyalgia (FM) is a complex chronic pain condition. Its symptoms are nonspecific, and to date, no objective test exists to confirm FM diagnosis. Potential objective measures include the circulating levels of blood biomarkers. This systematic review and meta-analysis aim to review studies assessing blood biomarkers' levels in patients with FM compared with healthy controls. We systematically searched the PubMed, MEDLINE, EMBASE, and PsycINFO databases. Fifty-four studies reporting the levels of biomarkers in blood in patients with FM were included. Data were extracted, and the methodological quality was assessed independ...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: a systematic review and meta-analysis
The aim of this review or meta-analysis is to synthesize the prevalence of post-coronavirus disease (COVID) pain symptoms of musculoskeletal origin in hospitalized or nonhospitalized patients recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well as medRxiv and bioRxiv preprint servers were searched up to May 1, 2021. Studies or preprints reporting data on post-COVID pain symptoms such as myalgias, arthralgias, or chest pain after SARS-CoV-2 infection and collected by personal, telephonic, or electronical interview were i...
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
The yin and yang of pragmatic clinical trials of behavioral interventions for chronic pain: balancing design features to maximize impact
No abstract available (Source: Pain)
Source: Pain - June 24, 2022 Category: Anesthesiology Tags: Topical Review Source Type: research
Reply to Karlsen et al. Consensus on a core outcome set: a panel decision
No abstract available (Source: Pain)
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Opioid consumption as a core outcome domain in postoperative pain management
No abstract available (Source: Pain)
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Chronic nociplastic and neuropathic pain: how do they differentiate?
No abstract available (Source: Pain)
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
