Thanks to reviewers for 2016
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Thanks to reviewers Source Type: research

The epidemiology of chronic pain: Erratum.
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Errata Source Type: research

“Symptom vs sensory profiling” - taking one step after the other: Erratum.
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Errata Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

We agree with the need for a new term but disagree with the proposed terms
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

A tale of 2 ADFs—with 2 different abuse-deterrent formulations
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Withdrawal-associated injury site pain (WISP): a descriptive case series of an opioid cessation phenomenon
Abstract: Withdrawal pain can be a barrier to opioid cessation. Yet, little is known about old injury site pain in this context. We conducted an exploratory mixed-methods descriptive case series using a web-based survey and in-person interviews with adults recruited from pain and addiction treatment and research settings. We included individuals who self-reported a past significant injury that was healed and pain-free before the initiation of opioids, which then became temporarily painful upon opioid cessation—a phenomenon we have named withdrawal-associated injury site pain (WISP). Screening identified WISP in 47 pe...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Clinical Note Source Type: research

Benefit and harm of adding ketamine to an opioid in a patient-controlled analgesia device for the control of postoperative pain: systematic review and meta-analyses of randomized controlled trials with trial sequential analyses
Abstract: Ketamine is often added to opioids in patient-controlled analgesia devices. We tested whether in surgical patients, ketamine added to an opioid patient–controlled analgesia decreased pain intensity by ≥25%, cumulative opioid consumption by ≥30%, the risk of postoperative nausea and vomiting by ≥30%, the risk of respiratory adverse effects by ≥50%, and increased the risk of hallucination not more than 2-fold. In addition, we searched for evidence of dose-responsiveness. Nineteen randomized trials (1349 adults, 104 children) testing different ketamine regimens added to various opioids were identif...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Peripheral neuropathic changes in pachyonychia congenita
Abstract: We compared patterns of intraepidermal nerve fibers and mechanoreceptors from affected and unaffected plantar skin from patients with pachyonychia congenita (PC) and control subjects. Plantar biopsies from 10 genetically confirmed patients with PC (with a mutation in KRT6A) were performed at the ball of the foot (affected skin) and the arch (unaffected) and were compared to biopsies from corresponding locations in 10 control subjects. Tissue was processed to visualize intraepidermal nerve fibers (IENF) (PGP9.5), subsets of IENF (CGRP, substance P, tyrosine hydroxylase), myelinated nerve fiber (neurofilament H, NF...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain quality descriptors in community-dwelling older adults with nonmalignant pain
This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Study, 560 participants aged ≥70 years reported chronic pain in the baseline assessment, which included a home interview and clinic exam. Pain quality was assessed using a modified version of the McGill Pain Questionnaire (MPQ) consisting of 20 descriptors from which 3 categories were derived: cognitive/affecti...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Musculoskeletal complaints while growing up from age 11 to age 14: the PIAMA birth cohort study
This study showed that MSC is already common at an early age and that already at age 14 the factor with the strongest association is an earlier episode of MSCs. Sleeping problems and tiredness may also play a role in the early development of MSCs, either as determinant or as a consequence. (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

The indirect costs of back problems (dorsopathies) in Australians aged 45 to 64 years from 2015 to 2030: results from a microsimulation model, Health&WealthMOD2030
This study projected the indirect costs of back problems through lost productive life years (PLYs) from the individual's perspective (lost disposable income), the governmental perspective (reduced taxation revenue, greater welfare spending), and the societal perspective (lost gross domestic product, GDP) from 2015 to 2030, using Health&WealthMOD2030—Australia's first microsimulation model on the long-term impacts of ill-health. Quantile regression analysis was used to examine differences in median weekly income, welfare payments, and taxes of people unable to work due to back problems with working full-time witho...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

A population-based study of quantitative sensory testing in adolescents with and without chronic pain
Abstract: Quantitative sensory testing (QST) has been used to characterize pain sensitivity in individuals with and without pain conditions. Research remains limited in pediatric populations, hindering the ability to expand the utility of QST toward its potential application in clinical settings and clinical predictive value. The aims of this study were to examine pain sensitivity using QST in adolescents with chronic pain compared to adolescents without chronic pain and identify predictors of pain sensitivity. A population-based study conducted from 2010 to 2011 provided data on 941 adolescents, 197 were classified as hav...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice
This study aimed to investigate the functional involvement of Ca2+/calmodulin-dependent protein kinase II (CaMKIIα) in the persistent and refractory pain associated with SCD. We found that nonevoked ongoing pain as well as evoked hypersensitivity to mechanical and thermal stimuli were present in Berkeley sickle cell transgenic mice (BERK mice), but not nonsickle control littermates. Prominent activation of CaMKIIα was observed in the dorsal root ganglia and spinal cord dorsal horn region of BERK mice. Intrathecal administration of KN93, a selective inhibitor of CaMKII, significantly attenuated mechanical allody...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Survey of herbal cannabis (marijuana) use in rheumatology clinic attenders with a rheumatologist confirmed diagnosis
Abstract: Cannabinoids may hold potential for the management of rheumatic pain. Arthritis, often self-reported, is commonly cited as the reason for the use of medicinal herbal cannabis (marijuana). We have examined the prevalence of marijuana use among 1000 consecutive rheumatology patients with a rheumatologist-confirmed diagnosis and compared in an exploratory manner the clinical characteristics of medicinal users and nonusers. Current marijuana use, medicinal or recreational, was reported by 38 patients (3.8%; 95% CI: 2.8-5.2). Ever use of marijuana for medical purposes was reported by 4.3% (95% CI: 3.2-5.7), with 28 (2...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case–control study
We present the first evidence of regional white matter (axonal) abnormalities in men and women with UCPPS, compared with positive (irritable bowel syndrome, IBS) and healthy controls. Epidemiological and neuroimaging data were collected from participants with UCPPS (n = 52), IBS (n = 39), and healthy sex- and age-matched controls (n = 61). White matter microstructure, measured as fractional anisotropy (FA), was examined by diffusion tensor imaging. Group differences in regional FA positively correlated with pain severity, including segments of the right corticospinal tract and right anterior thalamic radiation. Increased c...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine
In conclusion, CGRP did not induce PS, whereas PACAP38 induced PS in 48% of patients. However, CGRP and PACAP38 did not induce more PS in patients who developed an attack compared with those who did not develop an attack. (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Open-label placebo treatment in chronic low back pain: a randomized controlled trial
Abstract: This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland–Morris Disability Questionnaire. In an exploratory follow-up, participants on TAU received placebo pills for 3 additional weeks. We...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Subthalamic deep brain stimulation modulates conscious perception of sensory function in Parkinson's disease
Abstract: Subthalamic deep brain stimulation (STN-DBS) is used to treat refractory motor complications in Parkinson disease (PD), but its effects on nonmotor symptoms remain uncertain. Up to 80% of patients with PD may have pain relief after STN-DBS, but it is unknown whether its analgesic properties are related to potential effects on sensory thresholds or secondary to motor improvement. We have previously reported significant and long-lasting pain relief after DBS, which did not correlate with motor symptomatic control. Here we present secondary data exploring the effects of DBS on sensory thresholds in a controlled way ...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

A data science approach to candidate gene selection of pain regarded as a process of learning and neural plasticity
Abstract: The increasing availability of “big data” enables novel research approaches to chronic pain while also requiring novel techniques for data mining and knowledge discovery. We used machine learning to combine the knowledge about n = 535 genes identified empirically as relevant to pain with the knowledge about the functions of thousands of genes. Starting from an accepted description of chronic pain as displaying systemic features described by the terms “learning” and “neuronal plasticity,” a functional genomics analysis proposed that among the functions of the 535 “pain gen...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Characterizing the pain score trajectories of hospitalized adult medical and surgical patients: a retrospective cohort study
We describe a 1-year, retrospective, observational study to characterize pain trajectories of hospitalized adults during the first 48 hours after admission at an urban academic medical center. Using a subgroup of patients who presented with significant pain (pain score>4; n = 7762 encounters), we characterized pain trajectories and measured area under the curve, slope of the trajectory for the first 2 hours after admission, and pain intensity at plateau. We used mixed-effects regression to assess the association between pain score and sociodemographics (age, race, and gender), pain medication orders (opioids, nonopioids...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain
Abstract: Rewards influence responses to acute painful stimuli, but the relationship of chronic pain to hedonic or motivational aspects of reward is not well understood. We independently evaluated hedonic qualities of sweet or bitter tastants and motivation to seek food reward in rats with experimental neuropathic pain induced by L5/6 spinal nerve ligation. Hedonic response was measured by implantation of intraoral catheters to allow passive delivery of liquid solutions, and “liking/disliking” responses were scored according to a facial reactivity scale. Spinal nerve ligation rats did not differ from controls i...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Dural stimulation in rats causes brain-derived neurotrophic factor–dependent priming to subthreshold stimuli including a migraine trigger
Abstract: Migraine is one of the most common and most disabling disorders. Between attacks, migraine patients are otherwise normal but are sensitized to nonnoxious events known as triggers. The purpose of these studies was to investigate whether a headache-like event causes sensitization, or priming, to subsequent subthreshold events. Interleukin-6 (IL-6) was applied to the rat cranial dura mater which produced cutaneous facial and hind paw allodynia that lasted 24 hours. At 72 hours, IL-6–treated rats developed allodynia in response to dural stimulation with either a pH 6.8 or pH 7.0 solution and to a systemic nitri...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain
Abstract: Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumor proliferation, further compromising patient quality of life. Angiotensin-(1-7) (Ang-(1-7)) binds and activates the Mas receptor (MasR). Angiotensin-(1-7)/MasR activation modulates inflammatory signaling after acute tissue insult, yet no studies have investigated whether Ang-(1-7)/MasR play a role i...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Parabrachial complex links pain transmission to descending pain modulation
Abstract: The rostral ventromedial medulla (RVM) has a well-documented role in pain modulation and exerts antinociceptive and pronociceptive influences mediated by 2 distinct classes of neurons, OFF-cells and ON-cells. OFF-cells are defined by a sudden pause in firing in response to nociceptive inputs, whereas ON-cells are characterized by a “burst” of activity. Although these reflex-related changes in ON- and OFF-cell firing are critical to their pain-modulating function, the pathways mediating these responses have not been identified. The present experiments were designed to test the hypothesis that nocicepti...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
In conclusion, these data indicate that PEA in the ACC can reduce inflammatory pain-related behaviour, possibly via AEA-induced activation of CB1 receptors and associated modulation of neuronal activity in the basolateral amygdala. (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

The Vulvar Pain Assessment Questionnaire inventory
Abstract: Millions suffer from chronic vulvar pain (ie, vulvodynia). Vulvodynia represents the intersection of 2 difficult subjects for health care professionals to tackle: sexuality and chronic pain. Those with chronic vulvar pain are often uncomfortable seeking help, and many who do so fail to receive proper diagnoses. The current research developed a multidimensional assessment questionnaire, the Vulvar Pain Assessment Questionnaire (VPAQ) inventory, to assist in the assessment and diagnosis of those with vulvar pain. A large pool of items was created to capture pain characteristics, emotional/cognitive functioning, phy...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Discriminative ability of reflex receptive fields to distinguish patients with acute and chronic low back pain
Abstract: Low back pain has a life time prevalence of 70% to 85%. Approximately 10% to 20% of all patients experience recurrent episodes or develop chronic low back pain. Sociodemographic, clinical, and psychological characteristics explain the transition from acute to chronic low back pain only to a limited extent. Altered central pain processing may be a contributing mechanism. The measurement of reflex receptive fields (RRF) is a novel method to assess altered central pain processing. The RRF area denotes the area of the foot sole from which spinal nociceptive reflexes can be elicited. It was shown to be enlarged in pat...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Breakthrough cancer pain: twenty-five years of study
Abstract: Breakthrough cancer pain (BTcP) is an episode of severe pain that “breaks through” a period of persistent pain at least partly controlled by a stable opioid regimen. Although mentioned in the literature decades ago, it has been only 25 years since the first effort to define and measure it. Controversy about the definition of BTcP continues despite an international effort to achieve consensus. Nevertheless, common approaches to measurement of BTcP have led to a robust literature, including many surveys that have described prevalence, characteristics, and association with adverse outcomes. Measurement a...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Pain Classics Source Type: research

Systematic review with meta-analysis of childhood and adolescent risk and prognostic factors for musculoskeletal pain
Abstract: A variety of factors may be involved in the development and course of musculoskeletal (MSK) pain. We undertook a systematic review with meta-analysis to synthesize and evaluate the quality of evidence about childhood and adolescent factors associated with onset and persistence of MSK pain, and its related disability. Studies were identified from searches of electronic databases (PubMed, EMBASE, PsycINFO, CINAHL, and Web of Science), references of included studies, and the Pediatric Pain mail list. Two independent reviewers assessed study inclusion, completed data extraction, and evaluated the quality of evidence ...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model
Abstract: Offspring of parents with chronic pain are at increased risk for pain and adverse mental and physical health outcomes (Higgins et al, 2015). Although the association between chronic pain in parents and offspring has been established, few studies have addressed why or how this relation occurs. Identifying mechanisms for the transmission of risk that leads to the development of chronic pain in offspring is important for developing preventive interventions targeted to decrease risk for chronic pain and related outcomes (eg, disability and internalizing symptoms). This review presents a conceptual model for the inter...
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

Compassion and chronic pain
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Topical Review Source Type: research

The time course of acute pain in hospitalized patients: exciting progress in data and methods
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Breakthrough pain: just pain?
No abstract available (Source: Pain)
Source: Pain - November 22, 2016 Category: Anesthesiology Tags: Commentary Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

“Symptom vs sensory profiling”—taking one step after the other
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Additional considerations for increasing placebo response
No abstract available (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

The cystine/glutamate antiporter system xc− drives breast tumor cell glutamate release and cancer-induced bone pain
Abstract: Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal etiology and lead to early cancer detection. Cancer-induced bone pain (CIBP) is inadequately managed with current standard-of-care analgesics and dramatically diminishes patient quality of life. While CIBP etiology is multifaceted, elevated levels of glutamate, an excitatory neurotransmitter, in the bon...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour
In this study, we show that nociceptive signalling after peripheral formalin injection increased p-H3S10 expression in the ipsilateral dorsal horn. This increase was maximal 30 minutes after formalin injection and occurred mainly within p-ERK-positive neurons. Spinal p-H3S10-enhanced expression was also observed in neurokinin 1 receptor (NK1R), c-Fos, and Zif268 positive neurons and was inhibited by ablation of serotonergic descending controls. The mitogen and stress-activated protein kinase 1 (MSK1) is downstream of ERK and can induce p-H3S10. We found that, after formalin injection, most phospho-MSK1 (p-MSK1)-positive ce...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation
In this study, we showed that CB1 receptors are expressed in both excitatory and inhibitory interneurons in substantia gelatinosa (SG). Patch-clamp recording of the evoked excitatory postsynaptic currents (eEPSCs) in mice after spinal nerve ligation (SNL) showed that electrical stimulation of Aβ-fibers (Aβ-ES) using clinical SCS-like parameters (50 Hz, 0.2 millisecond, 10 μA) induced prolonged depression of eEPSCs to C-fiber inputs in SG neurons. Pretreatment with CB1 receptor antagonist AM251 (2 μM) reduced the inhibition of C-eEPSCs by Aβ-ES in both excitatory and inhibitory SG neurons. We further de...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus
In this study, we conduct the first genome-wide association study to identify genetic factors associated with dysmenorrhea pain severity. A cohort of females of European descent (n = 11,891) aged 18 to 45 years rated their average dysmenorrhea pain severity. We used a linear regression model adjusting for age and body mass index, identifying one genome-wide significant (P (Source: Pain)
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice
Abstract: Cold exposure and a variety of types of mild stress increase pain in patients with painful disorders such as fibromyalgia syndrome. Acutely, stress induces thermogenesis by increasing sympathetic activation of beta-3 (β3) adrenergic receptors in brown adipose tissue. Chronic stress leads to the hypertrophy of brown adipose, a phenomenon termed adaptive thermogenesis. Based on the innervation of skeletal muscle by collaterals of nerves projecting to brown adipose, we theorized an association between brown adipose tissue activity and musculoskeletal hyperalgesia and tested this hypothesis in mice. Exposure to ...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Is alcohol consumption related to likelihood of reporting chronic widespread pain in people with stable consumption? Results from UK biobank
Abstract: Studies have suggested that alcohol consumption is strongly related to reduced reporting of chronic widespread pain (CWP) and level of disability in people with CWP or fibromyalgia. Direction of causality has not been established, that is whether the association is due to people's health influencing their alcohol consumption or vice versa. UK Biobank recruited over 500,000 people aged 40 to 69 years, registered at medical practices nationwide. Participants provided detailed information on health and lifestyle factors including pain and alcohol consumption. Total units consumed per week were calculated for current...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Reporting of cross-over clinical trials of analgesic treatments for chronic pain: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review and recommendations
Abstract: Cross-over trials are typically more efficient than parallel group trials in that the sample size required to yield a desired power is substantially smaller. It is important, however, to consider some issues specific to cross-over trials when designing and reporting them, and when evaluating the published results of such trials. This systematic review evaluated the quality of reporting and its evolution over time in articles of cross-over clinical trials of pharmacologic treatments for chronic pain published between 1993 and 2013. Seventy-six (61%) articles reported a within-subject primary analysis, or if no pri...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Mouse model of imiquimod-induced psoriatic itch
Abstract: Itch is a major indicator of psoriasis, but the underlying mechanisms behind this symptom are largely unknown. To investigate the neuronal mechanisms of psoriatic itch, we tested whether mice subjected to the imiquimod-induced psoriasis model exhibit itch-associated behaviors. Mice received daily topical applications of imiquimod to the rostral back skin for 7 days. Imiquimod-treated mice exhibited a significant increase in spontaneous scratching behavior directed to the treated area as well as touch-evoked scratching (alloknesis). To characterize this model, we measured the mRNA expression levels of pruritogens ...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Serum vitamin C and spinal pain: a nationwide study
This study used nationwide cross-sectional data from the U.S. National Health and Nutrition Examination Survey (NHANES) 2003–2004. Data were available for 4742 individuals aged ≥20 years. Suboptimal serum vitamin C concentrations were associated with the prevalence of neck pain (adjusted odds ratio [aOR]: 1.5; 95% confidence interval [CI]: 1.2-2.0), low back pain (aOR: 1.3; 95% CI: 1.0-1.6), and low back pain with pain below knee (aOR: 1.3; 95% CI: 1.0-1.9) in the past 3 months, self-reported diagnosis of arthritis/rheumatism (aOR: 1.4; 95% CI: 1.2-1.7), and related functional limitations' score (adjusted differen...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Efficacy and tolerability of buccal buprenorphine in opioid-experienced patients with moderate to severe chronic low back pain: results of a phase 3, enriched enrollment, randomized withdrawal study
Abstract: A buccal film of buprenorphine (BBUP) was evaluated for safety and efficacy in a multicenter, double-blind, placebo-controlled, enriched-enrollment, randomized-withdrawal study in opioid-experienced patients (30 to ≤160 mg/d morphine sulfate equivalent) with moderate to severe chronic low back pain taking around-the-clock opioid analgesics. Patients' opioid doses were tapered to ≤30 mg morphine sulfate equivalent before open-label titration with BBUP (range, 150-900 μg every 12 hours). Patients who responded (received adequate analgesia that was generally well tolerated for 14 days) were randomized to re...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia
Abstract: Crotalphine is a structural analogue to a novel analgesic peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus. Although crotalphine's analgesic effect is well established, its direct mechanism of action remains unresolved. The aim of the present study was to investigate the effect of crotalphine on ion channels in peripheral pain pathways. We found that picomolar concentrations of crotalphine selectively activate heterologously expressed and native TRPA1 ion channels. TRPA1 activation by crotalphine required intact N-terminal cysteine residues and ...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research

Increased cutaneous miR-let-7d expression correlates with small nerve fiber pathology in patients with fibromyalgia syndrome
Abstract: Fibromyalgia syndrome (FMS) is a chronic widespread pain condition probably comprising subgroups with different underlying pathomechanisms. There is increasing evidence for small nerve fiber impairment in subgroups of patients with FMS. MicroRNAs (miRNAs) regulate molecular factors determining nerve de- and re-generation. We investigated whether systemic and cutaneous miRNA expression in patients with FMS is related to small nerve fiber pathology. We confirmed previous findings of disturbed small fiber function and reduced intraepidermal nerve fiber density in subgroups of patients with FMS. We found 51 aberrantl...
Source: Pain - October 25, 2016 Category: Anesthesiology Tags: Research Paper Source Type: research