Hypoalgesic placebo effects can occur with transparent disclosures
No abstract available (Source: Pain)
Source: Pain - November 21, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Problematic use of prescribed opioids for chronic noncancer pain—no scarcity of data outside the United States
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury
Abstract AbstractMore than half of individuals experiencing major thermal burn injury (MThBI) receive an autologous skin graft (autograft), in which skin is removed from a healthy “donor” site and transplanted to the burn site. Persistent pain and itch at the graft site are major causes of suffering and disability in MThBI survivors. African Americans have a higher risk of MThBI, and in other clinical settings African Americans experience a greater burden of pain and itch relative to European Americans. However, to our knowledge, ethnic differences in skin graft site pain and itch outcomes after MThBI have not ...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Bleeding out the quality-adjusted life years: evaluating the burden of primary dysmenorrhea using time trade-off and willingness-to-pay methods
Abstract AbstractPrimary dysmenorrhea (PD), or painful menstruation in the absence of identified uterine pathology, affects 5 to 9 in every 10 reproductive-aged women. Despite its high prevalence, just a few studies with very small patient numbers have focused on health-related quality of life impairment in PD. We aimed to assess health-related quality of life values for a severe and a mild hypothetical PD health state using 10-year time trade-off and willingness-to-pay methods. In 2015, a nationwide convenience sample of women, aged between 18 and 40 years, was recruited using an Internet-based cross-sectional survey in H...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component
Abstract AbstractNeuropathic pain is an integral component of several chronic pain conditions and poses a major health problem worldwide. Despite emerging understanding of mechanisms behind neuropathic pain, the available treatment options are still limited in efficacy or associated with side effects, therefore making it necessary to find viable alternatives. In a genetic screen, we recently identified SerpinA3N, a serine protease inhibitor secreted in response to nerve damage by the dorsal root ganglion neurons and we showed that SerpinA3N acts against induction of neuropathic pain by inhibiting the T-cell- and neutrophil...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

The role of spatial frequency information in the decoding of facial expressions of pain: a novel hybrid task
In this study, we investigated whether perpetual preference differences exist for low-SF and high-SF pain information. A novel hybrid expression paradigm was used in which 2 different expressions, one containing low-SF information and the other high-SF information, were combined in a facial hybrid. Participants are instructed to identify the core expression contained within the hybrid, allowing for the measurement of SF information preference. Three experiments were conducted (46 participants in each) that varied the expressions within the hybrid faces: respectively pain-neutral, pain-fear, and pain-happiness. In order to ...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development
Abstract AbstractSignificant age- and experience-dependent remodelling of spinal and supraspinal neural networks occur, resulting in altered pain responses in early life. In adults, endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which modify pain responses, but the role they play in acute responses to pain and postnatal neurodevelopment is unknown. Here, we have studied the changing role of the ECs in the brainstem nuclei essential for the control of nociception from birth to adulthood in both rats and humans. Using in vivo electrophysiology, we show that substantial functional changes occur...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors
Abstract AbstractNeurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations or a homozygous deletion of the Nf1 gene, is characterized by tumorigenesis, cognitive dysfunction, seizures, migraine, and pain. Omic studies on human NF1 tissues identified an increase in the expression of collapsin response mediator protein 2 (CRMP2), a cytosolic protein reported to regulate the trafficking and activity of presynaptic N-type voltage-gated calcium (Cav2.2) channels. Because neurofibromin, the protein product of the Nf1 gene, binds to and inhibits CRMP2, the neurofibromin–CRMP2 signaling cascade will...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis
Abstract AbstractPsoriasis is often accompanied by itch, but the mechanisms behind this symptom remain elusive. Dynamic changes in epidermal innervation have been observed under chronic itch conditions. Therefore, we investigated whether epidermal innervation is altered in the imiquimod-induced psoriasis mouse model, whether blockade of neurotrophic growth factor signaling can reduce these changes, and whether this system can impact psoriatic itch. Over the 7-day time course of imiquimod treatment, the density of epidermal nonpeptidergic nerves significantly increased, whereas the density of peptidergic nerves significantl...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Psychological interventions that target sleep reduce pain catastrophizing in knee osteoarthritis
This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait through the pain catastrophizing scale and measured as a daytime and nocturnal state through daily diaries. Secondary analyses were conducted on data collected as part of a randomized controlled trial assessing the effectiveness of cognitive behavioral therapy for insomnia in patients with KOA at 5 different time points: pretreatment, midtreatment and posttreatment and at 3- and 6-month follow-up. One hundred patients diagnosed with KOA and insomnia were randomized to rec...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Nervous system delivery of antilysophosphatidic acid antibody by nasal application attenuates mechanical allodynia after traumatic brain injury in rats
Abstract AbstractLysophosphatidic acid (LPA) is a bioactive lipid that impacts neurological outcomes after neurotrauma by inhibiting neuroregeneration, promoting inflammation, and contributing to behavioral deficits. Blocking LPA signaling with a novel anti-LPA monoclonal antibody (mAb) is neuroprotective after traumatic brain injury (TBI) if given to injured animals whose blood–brain barrier (BBB) has been compromised. It is hypothesized that the anti-LPA mAb could improve chronic pain initiated by TBI. However, poor brain penetration after systemic application of the antibody makes access to the central nervous sys...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C
Abstract AbstractOral Bulleyaconitine A (BLA) is effective for treating neuropathic pain in human patients, but the underlying mechanism is poorly understood. Here, we tested whether BLA blocked voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) neurons. Compelling evidence shows that voltage-gated sodium channels are upregulated in uninjured DRG neurons but downregulated in injured ones following peripheral nerve injury. We found that BLA preferably inhibited Na+ currents in uninjured DRG neurons in neuropathic rats. Compared to sham rats, IC50 values for resting and inactivated Na+ currents were 113 and ...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372
Abstract AbstractThe purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate–gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (372TPKH375), which is absent in the splice variant P2X2bR. We therefore investigated the effects of Cdk5 and its neuronal activator, p35, on P2X2aR function. We found an interaction between P2X2aR and Cdk5/p35 by co-immunofluorescence and co-immunoprecipitation in HEK293 cells. We also found that threonine phosphorylation was significantly increased in HEK293 cel...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Day-to-day experience in resolution of pain after surgery
Abstract AbstractWe know little about the individual pain experience of patients recovering from surgery in the first weeks after hospital discharge. Here, we examine individual differences in the day-to-day experience after 2 major surgeries: lower limb total major joint arthroplasty (TJA) and cesarean delivery (CD). Fifty-five TJA patients and 157 CD patients were recruited to complete questionnaires and record their daily pain experiences after surgery. After hospital discharge, patients recorded their pain intensity once daily for 60 days (CD) or twice daily for 2 weeks, once daily for 2 weeks, weekly for 8 weeks, and ...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Reactive oxygen species affect spinal cell type-specific synaptic plasticity in a model of neuropathic pain
This study examined the roles of 2 biologically important ROS––superoxide [·O2] and hydroxyl radicals [·OH]––in neuropathic mechanical hyperalgesia and cell type-specific spinal synaptic plasticity. The [·O2] donor induced stronger mechanical hyperalgesia than the [·OH] donor in naive mice. The [·O2] scavenger showed greater antihyperalgesic effect than [·OH] scavengers in the spinal nerve ligation (SNL) mouse model of neuropathic pain. In addition, the [·O2] donor induced both STTn-LTP and GABAn-LTD, but the [·OH] donor induced only GABAn-LTD....
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Autonomic responses to tonic pain are more closely related to stimulus intensity than to pain intensity
Abstract AbstractPain serves the protection of the body by translating noxious stimulus information into a subjective percept and protective responses. Such protective responses rely on autonomic responses that allocate energy resources to protective functions. However, the precise relationship between objective stimulus intensity, subjective pain intensity, autonomic responses, and brain activity is not fully clear yet. Here, we addressed this question by continuously recording pain ratings, skin conductance, heart rate, and electroencephalography during tonic noxious heat stimulation of the hand in 39 healthy human subje...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Peripheral oxytocin receptors inhibit the nociceptive input signal to spinal dorsal horn wide-dynamic-range neurons
This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Indeed, local peripheral OT blocked the first sensorial activity of Aδ and C fibers recorded in the spinal cord neurons. Furthermore, using the formalin behavioral nociceptive test, we demonstrated that only ipsilateral OTR activation inhibits pain behavior. Our data are reinforced by the fact that the OTR protein is expressed in the sciatic nerve. Consistent with this, immunofluorescence of primary afferent fibers suggest that OTRs could be located in nociceptive-specific terminals of the skin....
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics
Abstract AbstractThe advent of optogenetic tools has allowed unprecedented insights into the organization of neuronal networks. Although recently developed technologies have enabled implementation of optogenetics for studies of brain function in freely moving, untethered animals, wireless powering and device durability pose challenges in studies of spinal cord circuits where dynamic, multidimensional motions against hard and soft surrounding tissues can lead to device degradation. We demonstrate here a fully implantable optoelectronic device powered by near-field wireless communication technology, with a thin and flexible ...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Defining chronic pain in epidemiological studies: a systematic review and meta-analysis
The objective was to document the operational definitions applied in epidemiological studies of chronic pain and to examine whether pain definitions and other methodological factors are systematically related to prevalence estimates. MEDLINE, EMBASE, and PsychINFO were searched for original research reports with study samples of at least 1000 individuals, excluding studies of less than 5 out of 15 selected body regions and studies solely concerned with specific pain conditions. Meta-analyses and meta-regressions were applied with random effects models; covariates were geography, sampling year, survey method, sampling frame...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

The prevalence of neuropathic pain is high after treatment for breast cancer: a systematic review
Abstract AbstractPain is common, but often poorly managed after breast cancer treatment. Screening questionnaires and the Neuropathic Pain Special Interest Group (NeuPSIG) criteria are 2 clinical approaches used to determine whether pain has neuropathic components, which may enable better pain management. The aims of this review were (1) to synthesise data from the literature on neuropathic pain prevalence in women after breast cancer treatment; (2) to investigate whether the prevalence of neuropathic pain differed between studies using screening questionnaires and the NeuPSIG criteria. We searched for studies that adminis...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Observe to get pain relief: current evidence and potential mechanisms of socially learned pain modulation
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Topical Review Source Type: research

Beyond solicitousness: a comprehensive review on informal pain-related social support
Abstract AbstractAdults with chronic pain cite social support (SS) as an important resource. Research has mostly focused on general SS or pain-specific solicitousness, resulting in a limited understanding of the role of SS in pain experiences. Drawing on SS theoretical models, this review aimed to understand how pain-related SS has been conceptualized and measured and how its relationship with pain experiences has been investigated. Arksey and O'Malley scoping review framework guided the study. A database search (2000-2015) was conducted in PsycINFO, CINAHL, MEDLINE, and EMBASE using a combination of subject headings/keywo...
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

Pain-autonomic relationships: implications for experimental design and the search for an “objective marker” for pain
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

Oxytocin: pain relief in skin
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

A new optogenetic device for spinal cord control of pain
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

In memoriam: Professor Stephen J. Morley (1950–2017)
No abstract available (Source: Pain)
Source: Pain - October 26, 2017 Category: Anesthesiology Tags: Obituary Source Type: research

Racial and ethnic differences in experimental pain sensitivity: systematic review and meta-analysis: Erratum.
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Erratum Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Neuroimaging of vagal nerve stimulation: are we missing a trick?
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Long noncoding RNA MRAK009713 is a novel regulator of neuropathic pain in rats
Abstract: Long noncoding RNAs have been implicated in neuropathy. Here, we identify and validate a long noncoding RNA, MRAK009713, as the primary regulator of neuropathic pain in chronic constriction injury (CCI) rats. MRAK009713 expression was markedly increased in CCI rats associated with enhanced pain behaviors, and small interfering RNA against MRAK009713 significantly reduced both mechanical and thermal hyperalgesia in the CCI rats. MRAK009713 is predicted to interact with the nociceptive P2X3 receptor by CatRAPID, a bioinformatics technology. Overexpression of MRAK009713 markedly increased expression of P2X3 in the d...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Cognitive load selectively influences the interruptive effect of pain on attention
Abstract: Pain is known to interrupt attentional performance. Such interference effects seem to occur preferentially for tasks that are complex and/or difficult. However, few studies have directly manipulated memory load in the context of pain interference to test this view. Therefore, this study examines the effect of experimental manipulations of both memory load and pain on 3 tasks previously found to be sensitive to pain interference. Three experiments were conducted. A different task was examined in each experiment, each comprising of a high- and low-cognitive load versions of the task. Experiment 1 comprised an atten...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Propranolol treatment prevents chronic central sensitization induced by repeated dural stimulation
We examined the effect of daily propranolol treatment (10 mg·kg−1 per os, 8 days) in a rat model of recurrent activation of dural nociceptors (repeated infusion of an inflammatory soup (IS) on the dura through a cannula every 2-3 days). Propranolol does not abort IS-induced acute cephalic mechanical allodynia but blocks the development of a chronic cutaneous hypersensitivity upon repeated IS injections. Furthermore, propranolol prevents (1) the elevated touch-evoked Fos expression within the trigeminocervical complex, (2) enhanced both spontaneous activity, and evoked responses of second-order trigeminovascula...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons
Abstract: Several studies implicated cyclic adenosine monophosphate (cAMP) as an important second messenger for regulating nociceptor sensitization, but downstream targets of this signaling pathway which contribute to neuronal plasticity are not well understood. We used a Cre/loxP-based strategy to disable the function of either HCN2 or PKA selectively in a subset of peripheral nociceptive neurons and analyzed the nociceptive responses in both transgenic lines. A near-complete lack of sensitization was observed in both mutant strains when peripheral inflammation was induced by an intradermal injection of 8br-cAMP. The lack...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Brain processing of the temporal dimension of acute pain in short-term memory
Abstract: The dynamics of noxious sensation shapes pain perception, yet the memory of the temporal dimension of pain remains almost completely unexplored. Here, brain activity during the memory of pain duration was contrasted with that associated with the memory of pain intensity using functional magnetic resonance imaging and a delayed reproduction task. Participants encoded, maintained during a short delay, and reproduced (1) the “duration” of pain (ie, onset-to-offset), (2) the “dynamics” of pain (ie, evolution of pain over time), or (3) the intensity of pain (ie, control with no explicit tempora...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Longitudinal change in parent and child functioning after internet-delivered cognitive-behavioral therapy for chronic pain
Abstract: Theoretical models of pediatric chronic pain propose longitudinal associations between children's pain experiences and parent and family factors. A large body of cross-sectional research supports these models, demonstrating that greater parent distress and maladaptive parenting behaviors are associated with greater child disability. Family-based cognitive-behavioral therapy interventions have been developed for youth with chronic pain which aim to improve child disability and reduce maladaptive parenting behaviors. However, little is known about temporal, longitudinal associations between parent and child functio...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study
Abstract: Chronic pain is often measured with a severity score that overlooks its spatial distribution across the body. This widespread pain is believed to be a marker of centralization, a central nervous system process that decouples pain perception from nociceptive input. Here, we investigated whether centralization is manifested at the level of the brain using data from 1079 participants in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network (MAPP) study. Participants with a clinical diagnosis of urological chronic pelvic pain syndrome (UCPPS) were compared to pain-free controls and patie...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Bidirectional association between fibromyalgia and gastroesophageal reflux disease: two population-based retrospective cohort analysis
Abstract: Fibromyalgia (FM) tends to coexist with gastroesophageal reflux disease (GERD). This retrospective cohort study was conducted to determine the bidirectional association between FM and GERD, using a nationwide database, the National Health Insurance of Taiwan. We established 2 study arms, including 35,117 patients with FM in arm 1 and 34,630 patients with GERD in arm 2, newly diagnosed between 2000 and 2010. For each study arm, we randomly selected 4-fold subjects with neither FM nor GERD from the same database, frequency matched by sex, age, and diagnosis date, as the respective control cohorts. Incidence of GERD...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Contextual influences on pain communication in couples with and without a partner with chronic pain
Abstract: This is an experimental study of pain communication in couples. Despite evidence that chronic pain in one partner impacts both members of the dyad, dyadic influences on pain communication have not been sufficiently examined and are typically studied based on retrospective reports. Our goal was to directly study contextual influences (ie, presence of chronic pain, gender, relationship quality, and pain catastrophizing) on self-reported and nonverbal (ie, facial expressions) pain responses. Couples with (n = 66) and without (n = 65) an individual with chronic pain (ICP) completed relationship and pain catastrophizi...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Disrupted offset analgesia distinguishes patients with chronic pain from healthy controls
We examined whether OA depends on the increment duration before offset, and whether individual features of OA distinguish patients with chronic pain and healthy controls. We used a Peltier-type thermal stimulator and OA paradigms including 5-, 10-, or 15-s duration of 1°C-increment (T2) over 45°C. We first examined OA response, on the left volar forearm, at 3 different T2's in 40 healthy volunteers, and OA and constant stimulus responses in 12 patients with chronic pain and 12 matched healthy controls. We measured magnitude of OA ([INCREMENT]OA) and maximum visual analogue scale (VAS) latency (time to peak VAS) dur...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Nicotinic modulation of descending pain control circuitry
Abstract: Along with the well-known rewarding effects, activation of nicotinic acetylcholine receptors (nAChRs) can also relieve pain, and some nicotinic agonists have analgesic efficacy similar to opioids. A major target of analgesic drugs is the descending pain modulatory pathway, including the ventrolateral periaqueductal gray (vlPAG) and the rostral ventromedial medulla (RVM). Although activating nAChRs within this circuitry can be analgesic, little is known about the subunit composition and cellular effects of these receptors, particularly within the vlPAG. Using electrophysiology in brain slices from adult male rats,...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Visceral pain as a triggering factor for fibromyalgia symptoms in comorbid patients
Abstract: Fibromyalgia syndrome (FMS) is a central sensitization syndrome; however, peripheral pain sources potentially exacerbate its symptoms of chronic diffuse musculoskeletal pain and hyperalgesia. This prospective study evaluated visceral pain as a possible triggering factor for FMS pain and hyperalgesia in comorbid patients. Women with (1) FMS + irritable bowel syndrome (IBS); (2) FMS + primary dysmenorrhea (Dys); (3) FMS + Dys secondary to endometriosis (Endo); (4) FMS + colon diverticulosis (Div) were compared with FMS-only women, for fibromyalgia pain (number and intensity of episodes and analgesic consumption) ov...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Why and when social support predicts older adults' pain-related disability: a longitudinal study
Abstract: Pain-related social support has been shown to be directly associated with pain-related disability, depending on whether it promotes functional autonomy or dependence. However, previous studies mostly relied on cross-sectional methods, precluding conclusions on the temporal relationship between pain-related social support and disability. Also, research on the behavioral and psychological processes that account for such a relationship is scarce. Therefore, this study aimed at investigating the following longitudinally: (1) direct effects of social support for functional autonomy/dependence on pain-related disabilit...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Estrogens synthesized and acting within a spinal oligomer suppress spinal endomorphin 2 antinociception: ebb and flow over the rat reproductive cycle
Abstract: The magnitude of antinociception elicited by intrathecal endomorphin 2 (EM2), an endogenous mu-opioid receptor (MOR) ligand, varies across the rat estrous cycle. We now report that phasic changes in analgesic responsiveness to spinal EM2 result from plastic interactions within a novel membrane-bound oligomer containing estrogen receptors (mERs), aromatase (aka estrogen synthase), metabotropic glutamate receptor 1 (mGluR1), and MOR. During diestrus, spinal mERs, activated by locally synthesized estrogens, act with mGluR1 to suppress spinal EM2/MOR antinociception. The emergence of robust spinal EM2 antinociception...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Placebo effects of a sham opioid solution: a randomized controlled study in patients with chronic low back pain
This study tested the experimental placebo effect in a group of chronic pain patients. Forty-eight patients having chronic back pain participated in a randomized clinical trial that tested the efficacy of a sham opioid solution (NaCl) compared with an alleged neutral, completely inactive solution (NaCl). We shaped the placebo effect by 2 interventions: verbal instruction and conditioning. The patients were either told that the “solution reduces pain and improves physical capacity” or the “solution is neutral, a placebo.” Half of each group was additionally conditioned (coupling solution with reduced...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Child and parent pain catastrophizing and pain from presurgery to 6 weeks postsurgery: examination of cross-sectional and longitudinal actor-partner effects
This study examined dyadic relations between child and parent pain catastrophizing and child and parent ratings of child pain prior to (M = 4.01 days; “baseline”) and following surgery (M = 6.5 weeks; “acute follow-up”), as well changes in pain catastrophizing during this time in 167 youth (86% female; Mage = 14.55 years) undergoing spinal fusion surgery and 1 parent (89% mothers). Actor-partner interdependence models assessed cross-sectional and longitudinal intra- and interpersonal effects. Cross-sectionally, child pain catastrophizing was positively associated with child pain at baseline and acut...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Persistent postoperative pain after cardiac surgery: a systematic review with meta-analysis regarding incidence and pain intensity
Abstract: Persistent postoperative pain (PPP) has been described as a complication of cardiac surgery (CS). We aimed to study PPP after CS (PPPCS) by conducting a systematic review of the literature regarding its incidence, intensity, location, and the presence of neuropathic pain, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The review comprised 3 phases: a methodological assessment of 6 different databases identifying potential articles and screening for inclusion criteria by 2 independent reviewers; data extraction; and study quality assessment. Meta-analysis was used to estimate ...
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Most red flags for malignancy in low back pain guidelines lack empirical support: a systematic review
In conclusion, the origin and diagnostic accuracy of many red flags endorsed in guidelines are unclear. A “history of malignancy” and “strong clinical suspicion” are the only red flags with empirical evidence of acceptably high diagnostic accuracy. (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Multimodal pain therapy in chronic noncancer pain—gold standard or need for further clarification?
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Topical Review Source Type: research

Interactive process of facial communication of pain
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research