Yoga for treating low back pain: a systematic review and meta-analysis
Yoga is frequently used for back pain relief. However, the evidence was judged to be of only low to moderate certainty. To assess the efficacy and safety of yoga in patients with low back pain, a meta-analysis was performed. Therefore, MEDLINE/PubMed, Scopus, and the Cochrane Library were searched to May 26, 2020. Only randomized controlled trials comparing Yoga with passive control (usual care or wait list), or an active comparator, for patients with low back pain and that assessed pain intensity or pain-related disability as a primary outcome were considered to be eligible. Two reviewers independently extracted data on s...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Brain predictors of multisite pain onset in children
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Commentary Source Type: research
Pharmacologic therapies for neuropathic pain: an assessment of reporting biases in randomized controlled trials
Several different reporting biases cited in scientific literature have raised concerns about the overestimation of effects and the subsequent potential impact on the practice of evidence-based medicine and human health. Up to 7% to 8% of the population experiences neuropathic pain (NP), and established treatment guidelines are based predominantly on published clinical trial results. Therefore, we examined published randomized controlled trials (RCTs) of first-line drugs for NP and assessed the relative proportions with statistically significant (ie, positive) and nonsignificant (ie, negative) results and their rates of cit...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Oxidative stress is associated with characteristic features of the dysfunctional chronic pain phenotype
This study tested whether the multidimensional pain and psychosocial features that characterize the dysfunctional CP phenotype are associated broadly with elevated oxidative stress (OS). Measures of pain intensity, bodily extent of pain, catastrophizing cognitions, depression, anxiety, sleep disturbance, pain interference, and function were completed by 84 patients with chronic osteoarthritis before undergoing total knee arthroplasty. Blood samples were obtained at the initiation of surgery before incision or tourniquet placement. Plasma levels of F2-isoprostanes and isofurans, the most highly specific measures of in vivo ...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
White matter changes in the trigeminal spinal tract in chronic migraineurs: an ex vivo study combining ultra–high-field diffusion tensor imaging and polarized light imaging microscopy
This study provides histological evidence that structural alterations occur in the sp5 in patients with CM as compared with healthy controls. Myelin density, as assessed by retardance values, showed to be higher, and a corresponding increase in fractional anisotropy values was observed. In addition, accompanying decreases in mean diffusivity, axial diffusivity, and radial diffusivity values were observed. This study shows that the sp5 undergoes neuroplastic changes, a feature which substantiates evidence for the hyperactivity of the Sp5 in patients with migraine. More insights are needed to observe whether these changes on...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Dissecting neuropathic from poststroke pain: the white matter within
In this study, we address these issues comparing stroke location in a CPSP group of 35 patients with 2 control groups: 27 patients with CNNP and 27 patients with stroke without pain. Brain MRI images were analyzed by 2 complementary approaches: an exploratory analysis using voxel-wise lesion symptom mapping, to detect significant voxels damaged in CPSP across the whole brain, and a hypothesis-driven, region of interest–based analysis, to replicate previously reported sites involved in CPSP. Odds ratio maps were also calculated to demonstrate the risk for CPSP in each damaged voxel. Our exploratory analysis showed that, b...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9
Human NaV1.9 (hNaV1.9), encoded by SCN11A, is preferentially expressed in nociceptors, and its mutations have been linked to pain disorders. NaV1.9 could be a promising drug target for pain relief. However, the modulation of NaV1.9 activity has remained elusive. Here, we identified a new candidate NaV1.9-interacting partner, protein arginine methyltransferase 7 (PRMT7). Whole-cell voltage-clamp recordings showed that coelectroporation of human SCN11A and PRMT7 in dorsal root ganglion (DRG) neurons of Scn11a−/− mice increased the hNaV1.9 current density. By contrast, a PRMT7 inhibitor (DS-437) reduced mNaV1.9 currents i...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Racial disparities in observers' attention to and estimations of others' pain
Research has demonstrated racial disparities in pain care such that Black patients often receive poorer pain care than White patients. Little is known about mechanisms accounting for the emergence of such disparities. The present study had 2 aims. First, we examined whether White observers' attentional processing of pain (using a visual search task [VST] indexing attentional engagement to and attentional disengagement from pain) and estimation of pain experience differed between White vs Black faces. Second, we examined whether these differences were moderated by (1) racially biased beliefs about pain experience and (2) th...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Does pain modality play a role in the interruptive function of acute visceral compared with somatic pain?
Acute pain captures attentional resources and interferes with ongoing cognitive processes, including memory encoding. Despite broad clinical implications of this interruptive function of pain for the pathophysiology and treatment of chronic pain conditions, existing knowledge exclusively relies on studies using somatic pain models. Visceral pain is highly prevalent and seems to be more salient and threatening, suggesting that the interruptive function of pain may be higher in acute visceral compared with somatic pain. Implementing rectal distensions as a clinically relevant experimental model of visceral pain along with th...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Experimental evidence of a functional relationship within the brainstem trigeminocervical complex in humans
This study consists of 2 single-blinded, randomised protocols. Forty healthy participants were recruited in the propaedeutic protocol I. Electrical pain thresholds were measured on the V1 and the greater occipital nerve (GON) dermatome bilaterally as well as on the left forearm longitudinally before and after application of topical capsaicin. Protocol II was then online preregistered, and, additionally, the ipsilateral trigeminal dermatomes V2 and V3 were tested. Greater occipital nerve stimulation increased the EPT ipsilateral at V1 after 20 minutes (P = 0.006) compared with baseline, whereas trigeminal stimulation increa...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain
We examined amygdala rsFC in 46 youth with chronic pain and 29 healthy peers (age M = 15.8, SD = 2.9; 64 females) and its relationship with catastrophizing and threat-safety learning. We used a developmentally appropriate threat-safety learning paradigm and performed amygdala seed–based rsFC and whole-brain mediation analyses. Patients exhibited enhanced connectivity between the left amygdala and right supramarginal gyrus (SMG) (cluster-level P-FDR CS−; rp = 0.49, P = 0.001). Furthermore, in patients, elevated catastrophizing was associated with reduced left amygdala connectivity with SMG / parietal operculum, and incr...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Opioid-related risk perceptions in chronic pain: influence of patient gender and previous misuse behaviors
Little is known about the factors that influence providers' perceptions of patient risk for aberrant opioid use. Patient gender may interact with previous opioid misuse to influence these perceptions. We asked 131 physicians to view videos and vignettes for 8 virtual patients with chronic pain. Gender (male/female) and previous prescription opioid misuse (present/absent) varied across patients; the vignettes were otherwise balanced on demographic and clinical characteristics. For each patient, providers assessed 4 risk domains: opioid-related adverse events, opioid misuse or abuse, opioid addiction, and opioid diversion. R...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
A prospective long-term follow-up of dorsal root ganglion stimulation for the management of chronic intractable pain
In conclusion, DRG stimulation can provide effective pain relief and improved quality of life in patients suffering with neuropathic pain, although this study had a revision rate of 42% within the first 24 months, and 56% of IPGs that were replaced because of battery depletion had a shorter than expected battery life. (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Ketamine for refractory chronic pain: a 1-year follow-up study
This study focused on patients with 1 ketamine delivery procedure (n = 256). The primary endpoint was pain intensity (0-10 numerical pain rating scale) before and after ketamine every month for 1 year. Secondary outcomes aimed to identify pain trajectories by semiparametric mixture models and to collect adverse events. The following data were obtained for 256 patients: Pain intensity decreased significantly (6.8 ± 1.8, n = 240 at baseline vs 5.7 ± 1.8, n = 93 at 12 months; P (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
A ketogenic diet reduces mechanical allodynia and improves epidermal innervation in diabetic mice
Dietary interventions are promising approaches to treat pain associated with metabolic changes because they impact both metabolic and neural components contributing to painful neuropathy. Here, we tested whether consumption of a ketogenic diet could affect sensation, pain, and epidermal innervation loss in type 1 diabetic mice. C57Bl/6 mice were rendered diabetic using streptozotocin and administered a ketogenic diet at either 3 weeks (prevention) or 9 weeks (reversal) of uncontrolled diabetes. We quantified changes in metabolic biomarkers, sensory thresholds, and epidermal innervation to assess impact on neuropathy parame...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
