Interactive process of facial communication of pain
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

Sham opioids relieve multidimensional aspects of chronic back pain
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

Postsurgical pain in children: unraveling the interplay between child and parent psychosocial factors
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Commentaries Source Type: research

John J. Bonica: born 100 years ago
No abstract available (Source: Pain)
Source: Pain - September 30, 2017 Category: Anesthesiology Tags: Editorial Source Type: research

Thanks to reviewers for 2017
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Thanks to reviewers Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Statin-related musculoskeletal pain in Parkinson's disease
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Adding ketamine to an opioid in a patient-controlled analgesia device: is it really relevant in the pediatric population?
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Brain imaging of pain sensitization in patients with knee osteoarthritis
Abstract: A relevant aspect in osteoarthritic pain is neural sensitization. This phenomenon involves augmented responsiveness to painful stimulation and may entail a clinically worse prognosis. We used functional magnetic resonance imaging (fMRI) to study pain sensitization in patients with knee osteoarthritis. Sixty patients were recruited and pain sensitization was clinically defined on the basis of regional spreading of pain (spreading sensitization) and increased pain response to repeated stimulation (temporal summation). Functional magnetic resonance imaging testing involved assessing brain responses to both pressure ...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain and learning in primary school: a population-based study
The objective of this study was to quantify the association of pain and academic achievement while taking into account the presence of co-occurring emotional symptoms. A population-based stratified random sample of 1239 students aged 8 to 9 years from primary schools in Melbourne, Australia, was recruited for the Childhood to Adolescence Transition Study. Children indicated sites of pain that had lasted for a day or longer in the past month using a pain manikin. Depressive- and anxiety-related symptoms were assessed using child-reported items. National assessment results for reading and numeracy were used to measure academ...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Cebranopadol, a novel first-in-class analgesic drug candidate: first experience in patients with chronic low back pain in a randomized clinical trial
Abstract: Chronic low back pain (LBP) is a common condition, usually with the involvement of nociceptive and neuropathic pain components, high economic burden and impact on quality of life. Cebranopadol is a potent, first-in-class drug candidate with a novel mechanistic approach, combining nociceptin/orphanin FQ peptide and opioid peptide receptor agonism. We conducted the first phase II, randomized, double-blind, placebo- and active-controlled trial, evaluating the analgesic efficacy, safety, and tolerability of cebranopadol in patients with moderate-to-severe chronic LBP with and without neuropathic pain component. Patie...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Safety and efficacy of neublastin in painful lumbosacral radiculopathy: a randomized, double-blinded, placebo-controlled phase 2 trial using Bayesian adaptive design (the SPRINT trial)
In conclusion, while this study showed some evidence of pain relief with neublastin, particularly at the lowest dose, there was no clear dose–response relationship for pain reduction or the most common adverse event of pruritus. (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Spinal microglia are required for long-term maintenance of neuropathic pain
Abstract: While spinal microglia play a role in early stages of neuropathic pain etiology, whether they are useful targets to reverse chronic pain at late stages remains unknown. Here, we show that microglia activation in the spinal cord persists for>3 months following nerve injury in rodents, beyond involvement of proinflammatory cytokine and chemokine signalling. In this chronic phase, selective depletion of spinal microglia in male rats with the targeted immunotoxin Mac1-saporin and blockade of brain-derived neurotrophic factor–TrkB signalling with intrathecal TrkB Fc chimera, but not cytokine inhibition, almos...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Nonhistaminergic and mechanical itch sensitization in atopic dermatitis
Abstract: Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Nonhistaminergic itch pathways are suggested to dominate in AD itch, contributing to an “itch-scratch-itch cycle” that prolongs and worsens itch, pain, and skin lesions. We hypothesized that nonhistaminergic neuronal sensitization contributes to itch in AD. Hence, we compared sensitivity with thermal, mechanical, and chemical pruritic stimuli in patients with AD and controls. The study comprised 25 patients with AD with chronic itch and 25 healthy controls. Questionnaires on itch characteristics were administered, and sensory test...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels
Abstract: Pathophysiological mechanisms underlying pain associated with cancer are poorly understood. microRNAs (miRNAs) are a class of noncoding RNAs with emerging functional importance in chronic pain. In a genome-wide screen for miRNAs regulated in dorsal root ganglia (DRG) neurons in a mouse model of bone metastatic pain, we identified miR-34c-5p as a functionally important pronociceptive miRNA. Despite these functional insights and therapeutic potential for miR-34c-5p, its molecular mechanism of action in peripheral sensory neurons remains unknown. Here, we report the identification and validation of key target transc...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity
Abstract: Peripheral tissue inflammation or injury causes glutamate release from nociceptive axons, keratinocytes, and Schwann cells, resulting in thermal hypersensitivity. However, the detailed molecular mechanisms underlying glutamate-induced thermal hypersensitivity are unknown. The aim of this study was to clarify the involvement of peripheral transient receptor potential (TRP) TRP vanilloid 1 (TRPV1), TRP ankyrin 1 (TRPA1), and protein kinase C epsilon (PKCε) in glutamate-induced pain hypersensitivity. The amount of glutamate in the facial tissue was significantly increased 3 days after facial Complete Freund'...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Pain sensation in human osteoarthritic knee joints is strongly enhanced by diabetes mellitus
Abstract: The major burden of knee joint osteoarthritis (OA) is pain. Since in elder patients diabetes mellitus is an important comorbidity of OA, we explored whether the presence of diabetes mellitus has a significant influence on pain intensity at the end stage of knee OA, and we aimed to identify factors possibly related to changes of pain intensity in diabetic patients. In 23 diabetic and 47 nondiabetic patients with OA undergoing total knee arthroplasty, we assessed the pain intensity before the operation using the “Knee Injury and Osteoarthritis Outcome Score”. Furthermore, synovial tissue, synovial fluid...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation
Abstract: Metastatic bone pain is the single most common form of cancer pain and persists as a result of peripheral and central inflammatory, as well as neuropathic mechanisms. Here, we provide the first characterization of sphingolipid metabolism alterations in the spinal cord occurring during cancer-induced bone pain (CIBP). Following femoral arthrotomy and syngenic tumor implantation in mice, ceramides decreased with corresponding increases in sphingosine and the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P). Intriguingly, de novo sphingolipid biosynthesis was increased as shown by the elevations of d...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Dose–response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation
Abstract: Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as “mustard oil”) has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose–response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, and 90%) and vehicle (paraffin) were applied for 5 minutes to 3 × 3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were a...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis
Abstract: Chronic pain and hyperalgesia, as well as pain resulting from episodes of vaso-occlusion, are characteristic features of sickle cell disease (SCD) and are difficult to treat. Since there is growing evidence that increasing local levels of endocannabinoids can decrease hyperalgesia, we examined the effects of URB597, a fatty acid amide hydrolase (FAAH) inhibitor, which blocks the hydrolysis of the endogenous cannabinoid anandamide, on hyperalgesia and sensitization of cutaneous nociceptors in a humanized mouse model of SCD. Using homozygous HbSS-BERK sickle mice, we determined the effects of URB597 on mechanical h...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms
We examined response frequency to mechanical stimulation of the paw, muscle withdrawal thresholds, and expression of phosphorylation of the NR1 subunit of the N-methyl-D-aspartate receptor (p-NR1) and serotonin transporter (SERT) in the RVM. Mice that had performed 5 days of voluntary wheel running prior to the induction of the model were compared with sedentary mice. Sedentary mice showed significant increases in mechanical paw withdrawal frequency and a reduction in muscle withdrawal threshold; wheel running prevented the increase in paw withdrawal frequency. Naloxone-treated and MOR−/− mice had increases in ...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

The relationship of sociodemographic and psychological variables with chronic pain variables in a low-income population
This study analyzes key factors associated with chronic pain within an understudied and underserved population. The sample is characterized by a triple disparity with respect to income, education/literacy, and racial barriers that substantially increase the vulnerability to the negative consequences of chronic pain. The study examined the pretreatment data of 290 participants enrolled in the Learning About My Pain trial, a randomized controlled comparative effectiveness trial of psychosocial interventions (B.E.T., Principal Investigator, Patient-Centered Outcomes Research Institute Contract No. 941; clinicaltrials.gov iden...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Sequential analysis of child pain behavior and maternal responses: an observational study
Abstract: This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomfort with mothers present. Video recordings of their interactions were edited into 30-second segments and coded by 2 raters for presence of child pain behavior, maternal solicitousness, and nontask conversation. Kappa reliabilities ranged from 0.83 to 0.95. Maternal CAT was positively associated with ...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury
Abstract: Increasing evidence indicates that both microglia and satellite glial cell (SGC) activation play causal roles in neuropathic pain development after peripheral nerve injury; however, the activation mechanisms and their contribution to neuropathic pain remain elusive. To address this issue, we generated Ikkβ conditional knockout mice (Cnp-Cre+/−/Ikkβf/f; cIkkβ−/−) in which IKK/NF-κB-dependent proinflammatory SGC activation was abrogated. In these mice, nerve injury–induced spinal cord microglia activation and pain hypersensitivity were significantly attenuated compared t...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Chronic discrimination and bodily pain in a multiethnic cohort of midlife women in the Study of Women's Health Across the Nation
Abstract: A growing literature links discrimination to key markers of biobehavioral health. While racial or ethnic differences in pain are seen in experimental and clinical studies, the authors were interested in how chronic discrimination contributes to pain within multiple racial or ethnic groups over time. Participants were 3056 African American, Caucasian, Chinese, Hispanic, and Japanese women from the Study of Women's Health Across the Nation. The Everyday Discrimination Scale was assessed from baseline through 13 follow-up examinations. The bodily pain subscale of the MOS 36-Item Short-Form Health Survey (SF-36) was ...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat
Abstract: Vincristine (VNC) is commonly used to treat pediatric cancers, including the most prevalent childhood malignancy, acute lymphoblastic leukemia. Although clinical evidence suggests that VNC causes peripheral neuropathy in children, the degree to which pediatric chemotherapeutic regimens influence pain sensitivity throughout life remains unclear, in part because of the lack of an established animal model of chemotherapy-induced neuropathic pain during early life. Therefore, this study investigated the effects of VNC exposure between postnatal days (P) 11 and 21 on mechanical and thermal pain sensitivity in the deve...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Translational pain assessment: could natural animal models be the missing link?
Abstract: Failure of analgesic drugs in clinical development is common. Along with the current “reproducibility crisis” in pain research, this has led some to question the use of animal models. Experimental models tend to comprise genetically homogeneous groups of young, male rodents in restricted and unvarying environments, and pain-producing assays that may not closely mimic the natural condition of interest. In addition, typical experimental outcome measures using thresholds or latencies for withdrawal may not adequately reflect clinical pain phenomena pertinent to human patients. It has been suggested that ...
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

A developmental perspective on the impact of chronic pain in late adolescence and early adulthood: implications for assessment and intervention
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Topical Review Source Type: research

New model of vincristine-induced neuropathic pain in children: a first step towards prediction and prevention
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Bridging the Gaps: Special Commentary Source Type: research

In memoriam: Gordon Waddell 1942 to 2017
No abstract available (Source: Pain)
Source: Pain - August 24, 2017 Category: Anesthesiology Tags: Obituary Source Type: research

Reply
No abstract available (Source: Pain)
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Pain versus analgesia: TAOK3 as a pharmacogene
No abstract available (Source: Pain)
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

A mouse model for pain and neuroplastic changes associated with pancreatic ductal adenocarcinoma
In this study, we describe an immunocompetent orthotopic mouse model of PDAC involving intrapancreatic growth of K8484 mouse PDAC cells, which reliably exhibits a large number of key characteristics of human PDAC, including its unique histopathology and neuroplastic changes. We observed that tumor-bearing mice demonstrated significant abdominal mechanical hypersensitivity to von Frey stimuli as well as on-going pain in the conditioned place preference paradigm. Moreover, a myriad of other behavioral tests revealed that indicators of overall well-being were significantly reduced in tumor-bearing mice as compared to sham mic...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Greater fear of visceral pain contributes to differences between visceral and somatic pain in healthy women
Abstract: This functional magnetic resonance imaging study addressed similarities and differences in behavioral and neural responses to experimental visceral compared with somatic pain stimuli and explored the contribution of fear of pain to differences between pain modalities. In N = 22 healthy women, we assessed blood oxygen level–dependent responses to rectal distensions and cutaneous heat stimuli matched for perceived pain intensity. Fear of pain and pain unpleasantness were assessed before and after scanning. Visceral pain was more fear evoking and more unpleasant, and trial-by-trial intensity ratings failed to ...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Repeated exposure to sucrose for procedural pain in mouse pups leads to long-term widespread brain alterations
Abstract: Oral sucrose is administered routinely to reduce pain of minor procedures in premature infants and is recommended as standard care in international guidelines. No human or animal studies on effects of early repeated sucrose exposure on long-term brain development have been done in the context of pain. We evaluated the effects of repeated neonatal sucrose treatment before an intervention on long-term brain structure in mouse pups. Neonatal C57Bl/6J mice (n = 109) were randomly assigned to one of 2 treatments (vehicle vs sucrose) and one of 3 interventions (handling, touch, or needle-prick). Mice received 10 interv...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Validation of EQ-5D and 15D in the assessment of health-related quality of life in chronic pain
Abstract: Chronic pain has a significant impact on quality of life. Measurement of health-related quality of life (HRQoL) is essential in the assessment of pain management outcomes, but different instruments have produced varying results. We assessed the validity of 2 HRQoL instruments, EuroQol 5 dimensions questionnaire (EQ-5D) and 15-dimensional health-related quality of life measure (15D), in patients with challenging chronic pain. Three hundred ninety-one chronic noncancer pain patients referred to tertiary pain clinics completed EQ-5D, 15D, and a broad set of questionnaires mapping socioeconomic factors, self-rated he...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

A longitudinal study of the influence of comorbidities and lifestyle factors on low back pain in older men
Abstract: Older adults are largely under-represented in low back pain (LBP) research. In light of the ageing population, it is crucial to understand the influence of comorbidities and lifestyle factors on the risk and prognosis of LBP in older adults. The aims of this study were to describe the course of LBP in older men; to investigate whether comorbidities/lifestyle factors can predict the course of LBP in older men; to assess if comorbidities/lifestyle factors increase the risk of developing LBP in older men. The study sample comprised 1685 older men living in suburban Sydney, Australia. Low back pain, sociodemographic ...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia
This study provides multiple lines of evidence supporting aberrant structural and functional patterns that are observed in patients with CTN, which may help us better understand the pathophysiology of CTN and facilitate the development of new therapies for this disease. (Source: Pain)
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Relationship between pubertal timing and chronic nonspecific pain in adolescent girls: the Young-HUNT3 study (2006-2008)
Abstract: The aim of this study was to examine a possible relationship between early puberty and chronic nonspecific pain in 13- to 18-year-old girls. All adolescents in Nord-Trøndelag County, Norway, were invited to participate in the Young-HUNT3 study (2006-2008). Of the invited girls, 81% answered the questionnaire and of these 3982 were 13 to 18 years of age. Menarche and perceived physical maturation were used as exposure measures. Early menarche was defined as (Source: Pain)
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Own and partner pain intensity in older couples: longitudinal effects on depressive symptoms
Abstract: Chronic pain has been linked to depression among individuals and their partners. Yet, little is known about long-term mutual influences between pain intensity and depressive symptoms within couples as they age. Using a nationally representative U.S. sample of wives and husbands aged 50 and older (mean = 64.53, SD = 7.86), this study explored the links between own and partner pain intensity and depressive symptoms across an 8-year period. A total of 963 heterosexual married couples drawn from the Health and Retirement Study completed interviews biennially from 2006 to 2014. Dyadic growth curve models examined mutu...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain
Abstract: Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice. Bladder biopsy specimens were obtained from patients with HIC. Specimens from the noncancerous portion of the bladder of patients with bladder cancer served as controls. The specimens were examined by immunohistochemistry and real-time polymerase chain reaction of TLR7. Loxor...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Learned expectations and uncertainty facilitate pain during classical conditioning
Abstract: Pain spontaneously activates adaptive and dynamic learning processes affecting the anticipation of, and the responses to, future pain. Computational models of associative learning effectively capture the production and ongoing changes in conditioned anticipatory responses (eg, skin conductance response), but the impact of this dynamic process on unconditional pain responses remains poorly understood. Here, we investigated the dynamic modulation of pain and the nociceptive flexion reflex by fear learning in healthy human adult participants undergoing a classical conditioning procedure involving an acquisition, rev...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Commensal bacterial modulation of the host immune response to ameliorate pain in a murine model of chronic prostatitis
Abstract: The human commensal microflora plays an essential role in modulating the immune response to control homeostasis. Staphylococcus epidermidis, a commensal bacterium most commonly associated with the skin exerts such effects locally, modulating local immune responses during inflammation and preventing superinfection by pathogens such as Staphylococcus aureus. Although the prostate is considered by many to be sterile, multiple investigations have shown that small numbers of gram-positive bacterial species such as S. epidermidis can be isolated from the expressed prostatic secretions of both healthy and diseased men. ...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Interacting influences of gender and chronic pain status on parasympathetically mediated heart rate variability in adolescents and young adults
Abstract: Considerable research links chronic pain to autonomic nervous system (ANS) dysfunction, specifically low heart rate variability (HRV) mediated by reduced parasympathetic activity. However, little is known about factors that influence ANS function in chronic pain. The ANS is the primary pathway for brain–gut communication, making it of particular interest in gastrointestinal disorders, such as irritable bowel syndrome, characterized by functional abdominal pain (FAP). We evaluated the relation of sex, pain severity, and psychological stress to ANS function in adolescents/young adults from a database of pedia...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons
Abstract: Painful neuropathy is the major dose-limiting side effect of paclitaxel chemotherapy. Mitochondrial dysfunction and adenosine triphosphate (ATP) deficit have previously been shown in peripheral nerves of paclitaxel-treated rats, but the effects of paclitaxel in the dorsal root ganglia (DRGs) have not been explored. The aim of this study was to determine the bioenergetic status of DRG neurons following paclitaxel exposure in vitro and in vivo. Utilising isolated DRG neurons, we measured respiratory function under basal conditions and at maximal capacity, glycolytic function, and Adenosine diphosphate (ADP)/ATP lev...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Effects of acute psychological stress on placebo and nocebo responses in a clinically relevant model of visceroception
Abstract: There is evidence to suggest a role of emotions in placebo and nocebo effects, but whether acute psychological stress changes the magnitude of placebo or nocebo responses has not been tested. In a clinically relevant model of visceroception, we assessed effects of acute psychological stress on changes in urgency and pain in response to positive or negative treatment suggestions. In 120 healthy volunteers, perceived urge-to-defecate and pain in response to individually calibrated rectal distensions were measured with visual analogue scales during a BASELINE. Participants then underwent the Trier Social Stress Test...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Nociceptor interleukin 10 receptor 1 is critical for muscle analgesia induced by repeated bouts of eccentric exercise in the rat
Abstract: Delayed-onset muscle soreness is typically observed after strenuous or unaccustomed eccentric exercise. Soon after recovery, blunted muscle soreness is observed on repeated eccentric exercise, a phenomenon known as repeated bout effect (RBE). Although regular physical activity decreases muscle hyperalgesia, likely because of increased production of the anti-inflammatory cytokine interleukin-10 (IL-10) in the skeletal muscle, whether IL-10 also contributes to the antinociceptive effect of RBE is unknown. Furthermore, whether IL-10 attenuates muscle hyperalgesia by acting on muscle nociceptors remains to be establi...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Epigenetics insights into chronic pain: DNA hypomethylation in fibromyalgia—a controlled pilot-study
Abstract: To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured by transcranial magnetic stimulation. DNA from the peripheral blood of patients with FM (n = 24) and HC (n = 24) were assessed using the Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) in patients with FM displaying a nonrandom distribution in regions of the genome. Sixty-nine percent of DMP in FM were hypomethyla...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients
In this study, we evaluated the impact of respiratory-gated auricular vagal afferent nerve stimulation (RAVANS), a novel neuromodulatory intervention based on an existing transcutaneous vagus nerve stimulation approach, in the modulation of brainstem activity and connectivity in migraine patients. We applied 3T–functional magnetic resonance imaging with improved in-plane spatial resolution (2.62 × 2.62 mm) in episodic migraine (interictal) and age- and sex-matched healthy controls to evaluate brain response to RAVANS (gated to either inhalation or exhalation) and sham stimulation. We further investigated RAVANS...
Source: Pain - July 26, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research