Quantitative sensory test correlates with neuropathy, not with pain
No abstract available (Source: Pain)
Source: Pain - February 23, 2018 Category: Anesthesiology Tags: Commentary Source Type: research

Dangerously numb: opioids, benzodiazepines, chronic pain, and posttraumatic stress disorder
No abstract available (Source: Pain)
Source: Pain - February 23, 2018 Category: Anesthesiology Tags: Commentary Source Type: research

Publishing the best basic and applied pain science: open science and PAIN
No abstract available (Source: Pain)
Source: Pain - February 23, 2018 Category: Anesthesiology Tags: Editorial Source Type: research

Surgical interventions for the treatment of painful neuroma: a comparative meta-analysis
A consensus on the optimal treatment of painful neuromas does not exist. Our objective was to identify available data and to examine the role of surgical technique on outcomes following surgical management of painful neuromas. In accordance with the PRISMA guidelines, we performed a comprehensive literature search to identify studies measuring the efficacy of the surgical treatment of painful neuromas in the extremities (excluding Morton's neuroma and compression neuropathies). Surgical treatments were categorized as excision-only, excision and transposition, excision and cap, excision and repair, or neurolysis and coverag...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Potentiation of cortical excitatory transmission in chronic pain
No abstract available (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: PAIN Pictured Source Type: research

Corrigendum to postoperative pain treatment after total hip arthroplasty: a systematic review by Karlsen et al. PAIN 2015;1568–30
No abstract available (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Correspondence Source Type: research

Tempo-spatial discrimination is lower for noxious stimuli than for innocuous stimuli
The exteroceptive sensory system is responsible for sensing external stimuli in relation to time and space. The aim of this study was to investigate the tempo-spatial properties of the exteroceptive system using painful laser heat and nonpainful mechanical touch stimulation. Thirteen healthy subjects were stimulated on the volar forearm using 2 paradigms: a continuous stimulation along a line on the skin and a 2-point stimulation. The line stimulations were delivered in both the distal and proximal direction with lengths of 25, 50, 75, and 100 mm. The 2-point stimulations were assessed by simultaneous stimuli at a point-to...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Interleukin 1β inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia/reperfusion-induced hypersensitivity
Issues of peripheral circulation have been increasingly suggested as an underlying cause of musculoskeletal pain in many conditions, including sickle cell anemia and peripheral vascular disease. We have previously shown in our model of transient ischemia and reperfusion (I/R) injury of the forelimb that individual group III and IV muscle afferents display altered chemosensitivity and mechanical thresholds 1 day after injury. Functional alterations corresponded to increased evoked and spontaneous pain-related behaviors and decreased muscle strength and voluntary activity—all actions that echo clinical symptoms of isch...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Communication about chronic pain and opioids in primary care: impact on patient and physician visit experience
This study video recorded 86 primary care visits involving 49 physicians and 86 patients taking long-term opioids for chronic musculoskeletal pain, systematically coded all pain-related utterances during these visits using a custom-designed coding system, and administered previsit and postvisit questionnaires. Multiple regression was used to identify communication behaviors and patient characteristics associated with patients' ratings of their visit experience, physicians' ratings of visit difficulty, or both. After adjusting for covariates, 2 communication variables—patient–physician disagreement and patient r...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Vigilance-related attention systems subserve the discrimination of relative intensity differences between painful stimuli
Humans require the ability to discriminate intensities of noxious stimuli to avoid future harm. This discrimination process seems to be biased by an individual's attention to pain and involves modulation of the relative intensity differences between stimuli (ie, Weber fraction). Here, we ask whether attention networks in the brain modulate the discrimination process and investigate the neural correlates reflecting the Weber fraction for pain intensity. In a delayed discrimination task, participants differentiated the intensity of 2 sequentially applied stimuli after a delay interval. Compared with nonpain discrimination, p...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Activity interruptions by pain impair activity resumption, but not more than activity interruptions by other stimuli: an experimental investigation
Interrupting ongoing activities whilst intending to resume them later is a natural response to pain. Whereas this response facilitates pain management, at the same time it may also disrupt task performance. Previous research has shown that activity interruptions by pain impair subsequent resumption of the activity, but not more than pain-irrelevant interruptions. Ongoing task complexity and pain threat value might influence interruption effects. In this experiment, we adjusted a paradigm from outside the field of pain to investigate how activity interruptions by pain affect task performance. Healthy participants (n = 69) w...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Variability in negative emotions among individuals with chronic low back pain: relationships with pain and function
Chronic pain is associated with elevated negative emotions, and resources needed to adaptively regulate these emotions can be depleted during prolonged pain. Studies of links between pain, function, and negative emotions in people with chronic pain, however, have focused almost exclusively on relationships among mean levels of these factors. Indexes that may reflect aspects of emotion regulation have typically not been analyzed. We propose that 1 index of emotion regulation is variability in emotion over time as opposed to average emotion over time. The sample was 105 people with chronic low back pain and 105 of their pain...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain
T lymphocytes play a pivotal role in endogenous regulation of inflammatory visceral pain. The analgesic activity of T lymphocytes is dependent on their production of opioids, a property acquired on antigen activation. Accordingly, we investigated whether an active recruitment of T lymphocytes within inflamed colon mucosa via a local vaccinal strategy may counteract inflammation-induced visceral pain in mice. Mice were immunized against ovalbumin (OVA). One month after immunization, colitis was induced by adding 3% (wt/vol) dextran sulfate sodium into drinking water containing either cognate antigen OVA or control antigen b...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Preschool children's coping responses and outcomes in the vaccination context: child and caregiver transactional and longitudinal relationships
This article, based on 2 companion studies, presents an in-depth analysis of preschoolers coping with vaccination pain. Study 1 used an autoregressive cross-lagged path model to investigate the dynamic and reciprocal relationships between young children's coping responses (how they cope with pain and distress) and coping outcomes (pain behaviors) at the preschool vaccination. Expanding on this analysis, study 2 then modeled preschool coping responses and outcomes using both caregiver and child variables from the child's 12-month vaccination (n = 548), preschool vaccination (n = 302), and a preschool psychological assessmen...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Association between pain and frailty among Chinese community-dwelling older adults: depression as a mediator and its interaction with pain
Pain and frailty are both prevalent and have severe health impacts among older adults. We conducted a cross-sectional observational study to examine the association between pain and frailty, and depression as a mediator and its interaction with pain on frailty among 1788 Chinese community-dwelling older adults. Physical frailty, pain intensity, and depressive symptoms were assessed using the Frailty Phenotype, the Faces Pain Scale-revised, and the 5-item Geriatric Depression Scale, respectively. We found that both pain (odds ratio [OR] = 1.61; 95% confidence interval [CI]: 1.32-1.97) and depressive symptoms (OR = 4.67; 95%...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Social learning pathways in the relation between parental chronic pain and daily pain severity and functional impairment in adolescents with functional abdominal pain
Having a parent with chronic pain (CP) may confer greater risk of persistence of CP from childhood into young adulthood. Social learning, such as parental modeling and reinforcement, represents one plausible mechanism for the transmission of risk of CP from parents to offspring. Based on a 7-day pain diary in 154 pediatric patients with functional abdominal CP, we tested a model in which parental CP predicted adolescents' daily average CP severity and functional impairment (distal outcomes) via parental modeling of pain behaviors and parental reinforcement of adolescent's pain behaviors (mediators) and adolescents' cogniti...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy
Phototoxicity-induced pain is a major clinical problem triggered by light acting on photosensitising drugs or endogenous porphyrins, notably protoporphyrin IX (PpIX), an intermediary in heme biosynthesis. Protoporphyrin IX accumulates in individuals with erythropoietic protoporphyria and is elevated during photodynamic therapy subsequent to application of 5-aminolevulinic acid (ALA). Pain occurs during irradiation of PpIX and responds poorly to conventional analgesics. Our objective was to develop a model of PpIX phototoxicity pain and investigate the potential of menthol as an analgesic. Application of ALA to the tails of...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

TLR4 deficiency abrogated widespread tactile allodynia, but not widespread thermal hyperalgesia and trigeminal neuropathic pain after partial infraorbital nerve transection
This study suggests that TLR4 may serve as a potential target for the management of widespread allodynia associated with orofacial pain. (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Dopaminergic tone does not influence pain levels during placebo interventions in patients with chronic neuropathic pain
Placebo effects have been reported in patients with chronic neuropathic pain. Expected pain levels and positive emotions are involved in the observed pain relief, but the underlying neurobiology is largely unknown. Patients with neuropathic pain are highly motivated for pain relief, and as motivational factors such as expectations of reward, as well as pain processing in itself, are related to the dopaminergic system, it can be speculated that dopamine release contributes to placebo effects in neuropathic pain. Nineteen patients with neuropathic pain after thoracic surgery were tested during a placebo intervention consisti...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Trajectories and predictors of the long-term course of low back pain: cohort study with 5-year follow-up
Low back pain (LBP) is a major health challenge globally. Research has identified common trajectories of pain over time. We aimed to investigate whether trajectories described in 1 primary care cohort can be confirmed in another, and to determine the prognostic value of factors collected 5 years prior to the identification of the trajectory. The study was conducted on 281 patients who had consulted primary care for LBP, at that point completed a baseline questionnaire, and then returned a questionnaire at 5-year follow-up plus at least 3 (of 6) subsequent monthly questionnaires. Baseline factors were measured using validat...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Attention bias modification training for adolescents with chronic pain: a randomized placebo-controlled trial
This study was registered on the NIHR Clinical Research Network Portfolio in August 2014 (UK Clinical Trials Gateway: CPMS 17251) and funded by a Research Training Fellowship awarded to Lauren Heathcote by Action Medical Research for Children. (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn
Multiple sclerosis (MS) is an autoimmune-inflammatory neurodegenerative disease that is often accompanied by a debilitating neuropathic pain. Disease-modifying agents slow down the progression of multiple sclerosis and prevent relapses, yet it remains unclear if they yield analgesia. We explored the analgesic potential of fingolimod (FTY720), an agonist and/or functional antagonist at the sphingosine-1-phosphate receptor 1 (S1PR1), because it reduces hyperalgesia in models of peripheral inflammatory and neuropathic pain. We used a myelin oligodendrocyte glycoprotein 35 to 55 (MOG35-55) mouse model of experimental autoimmun...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Potentiation of cortical excitatory transmission in chronic pain
No abstract available (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: PAIN Pictured Source Type: research

Surgical interventions for the treatment of painful neuroma: a comparative meta-analysis
A consensus on the optimal treatment of painful neuromas does not exist. Our objective was to identify available data and to examine the role of surgical technique on outcomes following surgical management of painful neuromas. In accordance with the PRISMA guidelines, we performed a comprehensive literature search to identify studies measuring the efficacy of the surgical treatment of painful neuromas in the extremities (excluding Morton's neuroma and compression neuropathies). Surgical treatments were categorized as excision-only, excision and transposition, excision and cap, excision and repair, or neurolysis and coverag...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research

Electroencephalography and magnetoencephalography in pain research—current state and future perspectives
No abstract available (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Topical Review Source Type: research

Clinical trial designs and models for analgesic medications for acute pain in neonates, infants, toddlers, children, and adolescents: ACTTION recommendations
Clinical trials to test the safety and efficacy of analgesics across all pediatric age cohorts are needed to avoid inappropriate extrapolation of adult data to children. However, the selection of acute pain models and trial design attributes to maximize assay sensitivity, by pediatric age cohort, remains problematic. Acute pain models used for drug treatment trials in adults are not directly applicable to the pediatric age cohorts–neonates, infants, toddlers, children, and adolescents. Developmental maturation of metabolic enzymes in infants and children must be taken into consideration when designing trials to test ...
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Comprehensive Review Source Type: research

Attention bias modification for children: what should we make of a null finding?
No abstract available (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Commentary Source Type: research

Cognitive dysfunction and pain: considerations for future research
No abstract available (Source: Pain)
Source: Pain - January 24, 2018 Category: Anesthesiology Tags: Commentary Source Type: research

Investigating generalizability of results from a randomized controlled trial of the management of chronic widespread pain: the MUSICIAN study Erratum.
No abstract available (Source: Pain)
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Erratum Source Type: research

Brain-derived neurotrophic factor–mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry
In this study, we investigated the output-specific regulatory roles of dopaminergic (DA) neurons within the ventral tegmental area (VTA) in depressive-like and nociceptive behaviors in mice subjected to unpredictable chronic mild stress (CMS), using the projection-specific electrophysiological recording, pharmacological manipulation, behavioral test, and molecular biology technologies. We demonstrated that CMS decreased the firing activity in VTA projecting to medial prefrontal cortex (VTA → mPFC), but not in VTA to nucleus accumbens (VTA → NAc), DA neurons. However, both VTA → mPFC and VTA → NAc DA neu...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia
Higher levels of fear have been shown to partly explain individual differences in placebo analgesic responding. The catechol-O-methyltransferase (COMT) rs4680 Val158Met polymorphism has been associated with both increased placebo analgesia and increased fear-related behavior, in what appears to be inconsistent findings in the literature. The aim of the study was therefore to investigate placebo analgesia and fear-related processes with regard to the COMT genotype, to sort out whether the Met-allele is associated with increased placebo analgesia or increased fear of pain (FOP). A 3 Group (Emla, placebo and natural history) ...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Differential effect of motor cortex stimulation on unit activities in the ventral posterior lateral thalamus in cats
Although motor cortex stimulation (MCS) is being increasingly used to treat chronic refractory neuropathic pain in humans, its mechanisms of action remain elusive. Studies in animals have suggested the involvement of subcortical structures, in particular, the thalamus. Most of these studies have been performed in rats, a species presenting significant differences in thalamic anatomy and function relative to primates, in particular, a very limited number of thalamic GABA interneurons. The aim of this study was to investigate the effects of MCS on single-unit activities of the thalamic ventral posterior lateral (VPL) nucleus...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

High-risk prescribing and opioid overdose: prospects for prescription drug monitoring program–based proactive alerts
To develop a simple, valid model to identify patients at high risk of opioid overdose–related hospitalization and mortality, Oregon prescription drug monitoring program, Vital Records, and Hospital Discharge data were linked to estimate 2 logistic models; a first model that included a broad range of risk factors from the literature and a second simplified model. Receiver operating characteristic curves, sensitivity, and specificity of the models were analyzed. Variables retained in the final model were categories such as older than 35 years, number of prescribers, number of pharmacies, and prescriptions for long-acti...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain
There is an urgent need for better treatments for chronic pain, which affects more than 1 billion people worldwide. Antisense oligonucleotides (ASOs) have proven successful in treating children with spinal muscular atrophy, a severe infantile neurological disorder, and several ASOs are currently being tested in clinical trials for various neurological disorders. Here, we characterize the pharmacodynamic activity of ASOs in spinal cord and dorsal root ganglia (DRG), key tissues for pain signaling. We demonstrate that activity of ASOs lasts up to 2 months after a single intrathecal bolus dose. Interestingly, comparison of su...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669)
Musculoskeletal pain is a common cause of work absence, and early intervention is advocated to prevent the adverse health and economic consequences of longer-term absence. This cluster randomised controlled trial investigated the effect of introducing a vocational advice service into primary care to provide occupational support. Six general practices were randomised; patients were eligible if they were consulting their general practitioner with musculoskeletal pain and were employed and struggling at work or absent from work (Source: Pain)
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Chronic pain-related changes in cardiovascular regulation and impact on comorbid hypertension in a general population: the Tromsø study
Heart rate variability (HRV) and baroreflex sensitivity (BRS) are indexes reflecting the ability to maintain cardiovascular homeostasis amidst changing conditions. Evidence primarily from small studies suggests that both HRV and BRS may be reduced in individuals with chronic pain (CP), with potential implications for cardiovascular risk. We compared HRV and BRS between individuals with CP (broadly defined) and pain-free controls in a large unselected population sample. Participants were 1143 individuals reporting clinically meaningful CP and 5640 pain-free controls who completed a 106-second cold pressor test (CPT). Partic...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Brain oscillations reflecting pain-related behavior in freely moving rats
Recording oscillatory brain activity holds great promise in pain research. However, experimental results are variable and often difficult to reconcile. Some of these inconsistencies arise from the use of hypothesis-driven analysis approaches that (1) do not assess the consistency of the observed responses within and across individuals, and (2) do not fully exploit information sampled across the entire cortex. Here, we address these issues by recording the electrocorticogram directly from the brain surface of 12 freely moving rats. Using a hypothesis-free approach, we isolated brain oscillations induced by graded nociceptiv...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias
Pyrethroid insecticides are widely used for pest control in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging sensations, and paraesthesias. Despite the well-known effects of pyrethroids on sodium channels, actions on other channels that control sensory neuron excitability are less studied. Given the role of 2-pore domain potassium (K2P) channels in modulating sensory neuron excitability and firing, both in physiological and pathological conditio...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Guideline-recommended vs high-dose long-term opioid therapy for chronic noncancer pain is associated with better health outcomes: data from a representative sample of the German population
Recent evidence-based guidelines for long-term opioid therapy (LTOT) for chronic noncancer pain (CNCP) have defined daily morphine equivalent doses (MEQ/d) that require particular caution. The recommendation for a threshold MEQ/d is based on North American studies that have demonstrated negative health outcomes associated with high-dose LTOT for CNCP. We have conducted a retrospective cross-sectional study using an anonymized German health claims database, including 4,028,618 persons insured by 69 German statutory health insurances, representative of age and sex for the German population in 2014. Those receiving German gui...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors
Sleep disorders increase pain sensitivity and the risk of developing painful conditions; however, the underlying mechanisms are poorly understood. It has been suggested that nucleus accumbens (NAc) influences sleep-wake cycle by means of a balance between adenosine activity at A2A receptors and dopamine activity at D2 receptors. Because the NAc also plays an important role in pain modulation, we hypothesized that the NAc and its A2A and D2 receptors mediate the pronociceptive effect of rapid eye movement (REM) sleep deprivation (SD). We found that 24 hours of REM-SD induced an intense pronociceptive effect in Wistar rats, ...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Trajectories of musculoskeletal pain from adolescence to middle age: the role of early depressive symptoms, a 27-year follow-up of the Northern Swedish Cohort
Depression and musculoskeletal pain are associated, but long-term follow-up studies are rare. We aimed to examine the relationship of early depressive symptoms with developmental patterns of musculoskeletal pain from adolescence to middle age. Adolescents ending compulsory school (age 16) in Luleå, Northern Sweden, in 1981 (n = 1083) were studied and followed up in 1986, 1995, and 2008 (age 43) for musculoskeletal pain. Attrition was very low. Indicators for any and severe pain were based on pain in the neck-shoulders, low back, and the extremities. Latent class growth analyses were performed on 563 men and 503 women...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort
We studied children enrolled within 90 days of juvenile idiopathic arthritis diagnosis in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) prospective inception cohort to identify longitudinal trajectories of pain severity and features that may predict pain trajectory at diagnosis. A total of 1062 participants were followed a median of 24.3 months (interquartile range = 16.0-37.1 months). Latent trajectory analysis of pain severity, measured in a 100-mm visual analogue scale, identified 5 distinct trajectories: (1) mild-decreasing pain (56.2% of the cohort); (2) moderate-decreasing pain (28....
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

The CALI-9: A brief measure for assessing activity limitations in children and adolescents with chronic pain
Pain-related functional limitations represent an important outcome domain to assess in children and adolescents with chronic pain. The aim of this study was to extend the empirical support of the 21-item Child Activity Limitations Interview (CALI-21), a well-validated measure of activity limitations, using a large, multisite sample and to develop a brief form of the measure with more interpretable scoring. A sample of 1616 youth and 1614 parents completed the CALI-21 at an initial appointment in 1 of 3 pain specialty clinics in the Midwest or Northwest United States, or as part of a research study after this initial visit....
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Chronic pain in families: a cross-sectional study of shared social, behavioural, and environmental influences
This study aimed to investigate the family-level contribution to an individual's chronic pain status. This was a cross-sectional study using the Generation Scotland: Scottish Family Health Study data set. This study focused on a nested cohort of dyads (only 2 relatives per family, n = 2714). Multi-level modelling was first performed to estimate the extent of variance in chronic pain at the family level. Then each member of the dyad was randomly assigned as either the exposure or outcome family member, and logistic regression was used to identify shared factors associated with the outcome of chronic pain status. Multi-level...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization
Chronic pain conditions are highly comorbid with insufficient sleep. While the mechanistic relationships between the 2 are not understood, chronic insufficient sleep may be 1 pathway through which central pain-modulatory circuits deteriorate, thereby contributing to chronic pain vulnerability over time. To test this hypothesis, an in-laboratory model of 3 weeks of restricted sleep with limited recovery (5 nights of 4-hour sleep per night followed by 2 nights of 8-hour sleep per night) was compared with 3 weeks of 8-hour sleep per night (control protocol). Seventeen healthy adults participated, with 14 completing both 3-wee...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Spouse criticism and hostility during marital interaction: effects on pain intensity and behaviors among individuals with chronic low back pain
Individuals with chronic pain may experience negative responses from spouse, family, and friends. Responses such as overt criticism and hostility may be associated with worsening pain and function for chronic pain sufferers. We used a laboratory procedure to evaluate whether variability in spouse criticism/hostility exhibited toward chronic low back pain (CLBP) patients during a conflictual discussion predicted variability in patient pain and function during a subsequent pain-induction task. Chronic low back pain patients (n = 71) and their spouses (n = 71) participated in a 10-minute discussion followed by the patient und...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects: a machine-learned analysis
This study provided a 246 × 10-sized data matrix (82 subjects assessed at baseline, following UV-B application, and following capsaicin application) with respect to 10 QST parameters, which we analyzed using machine-learning techniques. We observed statistically significant effects of the hypersensitization treatments in 9 different QST parameters. Supervised machine-learned analysis implemented as random forests followed by ABC analysis pointed to heat pain thresholds as the most relevantly affected QST parameter. However, decision tree analysis indicated that UV-B additionally modulated sensitivity to cold. Unsuper...
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research

Tired of pain? Toward a better understanding of fatigue in chronic pain
No abstract available (Source: Pain)
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Topical Review Source Type: research

Nucleus accumbens: a novel forebrain mechanism underlying the increase in pain sensitivity caused by rapid eye movement sleep deprivation
No abstract available (Source: Pain)
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Commentary Source Type: research

Sleep and pain are definitely coupled—but how tight is this coupling?
No abstract available (Source: Pain)
Source: Pain - January 1, 2018 Category: Anesthesiology Tags: Commentary Source Type: research