Reply to Blatt
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Implications of hedonic effects of opioids in clinical practice
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Reply to Cohen
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Proposed clinical criteria for nociplastic pain in the musculoskeletal system are flawed
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Reply to Arandia and Di Paolo
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
On symptom perception, placebo effects, and the Bayesian brain
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Correspondence Source Type: research
Neurobiological antecedents of multisite pain in children
We examined structural and functional brain magnetic resonance imaging metrics in a subset of children from the first 2 assessments of the Adolescent Brain and Cognitive Development Study. Children (aged 9-10) who were pain free at baseline and then developed multisite pain 1 year later (n = 115) were matched to control children who were pain free at both timepoints (n = 230). We analyzed brain structure (cortical thickness and gray matter volume) and function (spontaneous neural activity and functional connectivity). Results were deemed significant at the cluster level P (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Associations of opioid prescription dose and discontinuation with risk of substance-related morbidity in long-term opioid therapy
This study used nationwide commercial insurance claims data and a within-individual design to examine associations of LtOT dose and discontinuation with substance-related morbidity. We identified 194,839 adolescents and adults who initiated opioid prescription in 2010 to 2018 and subsequently received LtOT. The cohort was followed for a median of 965 days (interquartile range, 525-1550), of which a median of 176 days (119-332) were covered by opioid prescription. During follow-up, there were 17,582 acute substance-related morbidity events, defined as claims for emergency visits, inpatient hospitalizations, and ambulance tr...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Heritability of musculoskeletal pain and pain sensitivity phenotypes: 2 generations of the Raine Study
This study provides support for the heritability of MSK pain and pain sensitivity to pressure, suggesting the need for further convergence of genetic and environmental factors in models for the development or maintenance of these pain disorders. (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Right anterior insula is associated with pain generalization in patients with fibromyalgia
This study investigated the neural structures and neuroanatomical networks associated with self-reported widespread pain in FM using magnetic resonance imaging. We collected clinical profiles and brain magnetic resonance imaging data of newly diagnosed patients with FM. A total of 138 patients with FM were divided into 3 subgroups based on the number of pain areas, with 3 to 8, 9 to 12, and 13 to 19 areas, respectively. Using voxel-based morphometry analysis, we first identified the neural structure that showed a trend of volumetric change across the 3 subgroups. We then used it as a candidate seed of interest with a seed-...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Prognostic factors, symptom evolution, and quality of life of posttraumatic trigeminal neuropathy
Neurosensory disturbances (NSDs) caused by injury to the trigeminal nerve can affect many aspects of daily life. However, factors affecting the persistence of NSDs in patients with posttraumatic trigeminal neuropathies (PTTNs) remain largely unknown. The identification of such risk factors will allow for the phenotyping of patients with PTTNs, which is crucial for improving treatment strategies. We therefore aimed to identify the prognostic factors of NSD persistence, pain intensity, and quality of life (QoL) in patients with PTTNs and to use these factors to create a prognostic prediction model. We first performed a bivar...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Intersectional identity approach to chronic pain disparities using latent class analysis
This study applied a relatively novel statistical approach (ie, Latent Class Analysis) to examine chronic pain disparities with an intersectional identity approach. Cross-sectional data were analyzed using pretreatment data from the Learning About My Pain trial, a randomized comparative effectiveness study of group-based psychosocial interventions (Patient-Centered Outcomes Research Institute Contract #941, Beverly Thorn, PI; clinicaltrials.gov identifier NCT01967342) for patients receiving care for chronic pain at low-income clinics in rural and suburban Alabama. Latent Class Analysis results suggested a 5-class model. To...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Diagnostic accuracy of the Pain (P), Enjoyment (E), and General activity (G) scale, a three-item questionnaire, for grading the impact of orofacial pain-related dysfunction
Purpose of this study was to examine the discriminative properties of the 3-item Pain (P), Enjoyment (E), and General activity (G) (PEG) questionnaire for grading impact of nondental orofacial pain. Two hundred eighty-six consecutive patients with orofacial pain of nondental origin filled out the PEG questionnaire and Graded Chronic Pain Scale (GCPS, version 2). Correlation between the PEG and GCPS scores, internal consistency of the PEG, and differences between groups were examined statistically (level of significance: P ≤ 0.05). The mean (±SD) age of the 213 patients (158 female) who were included in the analysis was ...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Netrin1 and reelin signaling are required for the migration of anterolateral system neurons in the embryonic spinal cord
Projection neurons of the spinal cord dorsal horn which transmit pain, itch, and temperature information to the brain comprise the anterolateral system (AS). A recent molecular and genetic study showed that many developing AS neurons express the transcription factor Phox2a and provided insights into the mechanisms of their ontogeny and wiring of nociceptive neuronal circuits. Here, we show that the loss of the axonal guidance and neuronal migration signal netrin1 results in impaired migration of mouse Phox2a+ AS neurons into the spinal lamina I. Furthermore, we show that in the absence of Dab1, an intracellular transducer ...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Barriers, facilitators, and resources to opioid deprescribing in primary care: experiences of general practitioners in Australia
Deprescribing is the systematic process of discontinuing drugs when harms outweigh the benefits. We conducted semistructured telephone interviews with 22 general practitioners (GPs) who had prescribed or deprescribed opioids in patients with chronic noncancer pain within the past 6 months to investigate the barriers and facilitators to deprescribing opioid analgesics in patients with chronic noncancer pain. We also explored GPs' perspectives on the available resources to assist them with opioid deprescribing. Interviews were audio-recorded, transcribed verbatim, and then coded using an iterative process until data saturati...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
