A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain
This study suggests a possible mechanism of action of dextrose prolotherapy in noninflammatory muscle pain such as fibromyalgia and provides insights into treating other types of chronic pain. (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Positive affect and distraction enhance whereas negative affect impairs pain modulation in patients with recurrent low back pain and matched controls
Pathophysiological causes of low back pain (LBP) remain generally unclear, so focus has shifted to psychosocial features and central pain processing. Effects of attentional and affective manipulation on conditioned pain modulation and tonic pain perception were examined in 30 patients with recurrent LBP in 2 sessions, one with and one without clinical pain, and compared with healthy participants. Phasic cuff pressure on one leg, scored on a Numerical Rating Scale, was used for test stimuli, and contralateral tonic cuff pain rated on an electronic Visual Analogue Scale was the conditioning stimulus (CS). Test stimuli were a...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
To tolerate weather and to tolerate pain: two sides of the same coin? The Tromsø Study 7
This study used data from over 18,000 subjects aged 40 years or older from the general population, who participated in the Tromsø Study 7. They underwent a one-time assessment of cuff algometry pressure pain tolerance (PPT) and cold pain tolerance (CPT), tested with a cold pressor test. The results showed a clear seasonal variation in CPT. The rate of withdrawal in the cold pressor test was up to 75% higher in months in the warmer parts of the year compared with January 2016. There was no seasonal variation in PPT. The study not only found a nonrandom short-term variation in PPT but also indications of such a variation in...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence
Recent findings linked gastrointestinal disorders characterized by abdominal pain to gut microbiota composition. The present work aimed to evaluate the power of gut microbiota as a visceral pain modulator and, consequently, the relevance of its manipulation as a therapeutic option in reversing postinflammatory visceral pain persistence. Colitis was induced in mice by intrarectally injecting 2,4-dinitrobenzenesulfonic acid (DNBS). The effect of faecal microbiota transplantation from viscerally hypersensitive DNBS-treated and naive donors was evaluated in control rats after an antibiotic-mediated microbiota depletion. Faecal...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Effectiveness of training physical therapists in pain neuroscience education for patients with chronic spine pain: a cluster-randomized trial
Chronic spinal pain poses complex challenges for health care around the world and is in need of effective interventions. Pain neuroscience education (PNE) is a promising intervention hypothesized to improve pain and disability by changing individuals' beliefs, perceptions, and expectations about pain. Pain neuroscience education has shown promise in small, controlled trials when implemented in tightly controlled situations. Exploration of promising interventions through more pragmatic methodologies is a crucial but understudied step towards improving outcomes in routine clinical care. The purpose was to examine the impact ...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Trajectories of pregabalin use and their association with longitudinal changes in opioid and benzodiazepine use
Concomitant use of pregabalin with opioids and/or benzodiazepines is common, despite the increased risks. However, clinical trials suggest pregabalin can have an opioid-sparing effect when treating acute postoperative pain. We explored how opioid and benzodiazepine use changed over time in people initiating pregabalin, using dispensing claims data for a 10% sample of Australians (2013-19). Among 142,776 people initiating pregabalin (median age = 61 years, 57% female), we used group-based trajectory modelling to identify 6 pregabalin dose trajectories in the first year postinitiation. Two trajectories involved discontinuati...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse
CB2 cannabinoid receptors (CB2) are a promising therapeutic target that lacks unwanted side effects of CB1 activation. However, the cell types expressing CB2 that mediate these effects remain poorly understood. We used transgenic mice with CB2 promoter–driven expression of enhanced green fluorescent protein (EGFP) to study cell types that express CB2 and suppress neuropathic nociception in a mouse model of chemotherapy-induced peripheral neuropathy. Structurally distinct CB2 agonists (AM1710 and LY2828360) suppressed paclitaxel-induced mechanical and cold allodynia in CB2EGFP reporter mice with established neuropathy. An...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Conditioned pain modulation is more efficient in patients with painful diabetic polyneuropathy than those with nonpainful diabetic polyneuropathy
Endogenous pain modulation, as tested by the conditioned pain modulation (CPM) protocol, is typically less efficient in patients with chronic pain compared with healthy controls. We aimed to assess whether CPM is less efficient in patients with painful diabetic polyneuropathy (DPN) compared with those with nonpainful DPN. Characterization of the differences in central pain processing between these 2 groups might provide a central nervous system explanation to the presence or absence of pain in diabetic neuropathy in addition to the peripheral one. Two hundred seventy-one patients with DPN underwent CPM testing and clinical...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Clinical and neuroscience evidence supports the critical importance of patient expectations and agency in opioid tapering
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Perspective Source Type: research
To persist or not to persist? The dilemma of goal adjustment in chronic pain
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Topical Review Source Type: research
Behavioral outcomes of complete Freund adjuvant–induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis
Abstract:
Many analgesics inadequately address the psychiatric comorbidities of chronic and persistent pain, but there is no standard preclinical model of pain-altered behavior to support the development of new therapies. To explore this conflicting and inconclusive literature, we conducted a focused systematic review and meta-analysis on the effect of complete Freund adjuvant–induced (CFA) rodent hind paw inflammation on multiple classical indicators of exploratory behavior, stress coping, and naturalistic behavior. Our primary objective was to define CFA's effect on assays including, but not limited to, the elevate...
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Long-term opioid therapy unsettles us both coming and going
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Commentary Source Type: research
Advancing our understanding of neuropathic pain in diabetes mellitus using conditioned pain modulation: further considerations for age and testing site
No abstract available (Source: Pain)
Source: Pain - April 20, 2022 Category: Anesthesiology Tags: Commentary Source Type: research
Patient outcomes after opioid dose reduction among patients with chronic opioid therapy: erratum
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Erratum Source Type: research
Distinct synaptic mechanisms underlying the analgesic effects of γ-aminobutyric acid transporter subtypes 1 and 3 inhibitors in the spinal dorsal horn: erratum
No abstract available (Source: Pain)
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Erratum Source Type: research
