Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin

In conclusion, we show for the first time in humans that LPA can cause pain as well as itch dependent on the mode of application and activates afferent human C fibers. Itch may arise from focal activation of few nerve fibers with distinct spatial contrast to unexcited surrounding afferents and a specific combination of activated fiber subclasses might contribute.
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research