Filtered By:
Condition: Pain
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 374 results found since Jan 2013.
P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling
CONCLUSION: These findings suggest that targeting the microglial P2X7R activated NLRP3/IL-1beta signaling pathway could serve as a potential strategy for BCP treatment.PMID:36375190
Source: Pain Physician - November 14, 2022 Category: Anesthesiology Authors: Ping Wu Xiaoqi Wu Guohua Zhou Yin Wang Xiaojun Liu Run Lv YanSong Liu Qingping Wen Source Type: research
14-3-3 γ mediates the long-term inhibition of peripheral kappa opioid receptor antinociceptive signaling by norbinaltorphimine
Neuropharmacology. 2022 Sep 17:109251. doi: 10.1016/j.neuropharm.2022.109251. Online ahead of print.ABSTRACTLong-term inhibition of kappa opioid receptor (KOR) signaling in peripheral pain-sensing neurons is a potential obstacle for development of peripherally-restricted KOR agonists that produce analgesia. Such a long-term inhibitory mechanism is invoked from activation of c-Jun N-terminal kinase (JNK) that follows a single injection of the KOR antagonist norbinaltorphimine (norBNI). This effect requires protein synthesis of an unknown mediator in peripheral pain-sensing neurons. Using 2D difference gel electrophoresis wi...
Source: Neuropharmacology - September 20, 2022 Category: Drugs & Pharmacology Authors: Michael J Wedemeyer Elaine M Jennings Hudson R Smith Teresa S Chavera Raehannah J Jamshidi Kelly A Berg William P Clarke Source Type: research
Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study
In conclusion, our study demonstrates that GAB2 is a potential therapeutic target for OA.PMID:36007472 | DOI:10.1016/j.bbrc.2022.08.006
Source: Biochemical and Biophysical Research communications - August 25, 2022 Category: Biochemistry Authors: Haokun Mo Siying Yang An-Min Chen Source Type: research
CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats
CONCLUSION: CAV-1 mediates the functional coupling of microglia, astrocytes, and neurons, and thus EPAC-1/CAV-1 plays an important role in CPSP exacerbation.PMID:35958678 | PMC:PMC9357801 | DOI:10.1155/2022/8566840
Source: Pain Research and Management - August 12, 2022 Category: Anesthesiology Authors: Qian Hua Shiren Shen Yibin Qin Su Cao Source Type: research
Case Report: Lack of Response to Givosiran in a Case of ALAD Porphyria
Discussion: No adverse effects of givosiran on the liver were observed in this patient with cirrhosis during 6 months of treatment with givosiran. The patient has continued to have recurrent attacks, with transient decreases in ALA levels only as related to treatment of his attacks with hemin. Our experience limited to one patient with ADP suggests that givosiran may not be effective in this type of acute porphyria. Since ADP may have an erythropoietic component, treatment with hydroxyurea, which was beneficial in one previous case, is planned.
Source: Frontiers in Genetics - August 4, 2022 Category: Genetics & Stem Cells Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
