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Condition: Brain Tumor

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Total 810 results found since Jan 2013.

Roles of circ-CSPP1 on the proliferation and metastasis of glioma cancer.
CONCLUSIONS: Circ-CSPP1 promoted the proliferation, invasion, and migration of GC cells. PMID: 32495924 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

KDELR2 is an unfavorable prognostic biomarker and regulates CCND1 to promote tumor progression in glioma.
CONCLUSIONS: KDELR2 is highly expressed in human glioma tissues and cell lines, a higher expression of KDELR2 is associated with a poor prognosis of glioma patients. Moreover, KDELR2 regulated the cellular functions of U87 cells by targeting CCND1. The KDELR2/CCND1 axis may provide a new therapeutic target for the treatment of glioma and deepen our understanding of glioma mechanisms. PMID: 32534703 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - June 16, 2020 Category: Pathology Authors: Hui M, Nian J, Wang Z, Li X, Huang C Tags: Pathol Res Pract Source Type: research

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells.
CONCLUSIONS: Results of this investigation demonstrated that silencing of NAMPT mRNA with corresponding down-regulation of NAMPT protein and suppression of the glioma cell proliferation affected the expression of IRS1 gene as well as many other genes encoding the proliferation related proteins. It is possible that dysregulation of most of the studied genes in glioma cells after silencing of NAMPT is reflected by a complex of intergenic interactions and that NAMPT is an important factor for genome stability and regulatory mechanisms contributing to the control of glioma cell metabolism and proliferation. PMID: 32597148 ...
Source: Endocrine Regulations - July 2, 2020 Category: Endocrinology Tags: Endocr Regul Source Type: research

The guanine nucleotide exchange factor, LARG, and RhoC play a role in glioblastoma cell invasion and resistance.
Abstract Glioblastoma (GBM) is the most common primary malignant brain cancer in adults. A hallmark of GBM is aggressive invasion of tumor cells into the surrounding normal brain. The current standard of care therapy, as well as targeted therapies, have largely failed to specifically address this issue. Therefore, identifying key regulators of GBM cell migration and invasion is of particular interest. The leukemia-associated RhoGEF (LARG) has previously been implicated in cell invasion in other tumor types; however, the role of LARG in GBM pathobiology remains undefined. Here, we report that the expression level o...
Source: The American Journal of Pathology - July 17, 2020 Category: Pathology Authors: Ding Z, Dong Z, Yang Y, Fortin Ensign SP, Sabit H, Nakada M, Ruggieri R, Kloss JM, Symons M, Tran NL, Loftus JC Tags: Am J Pathol Source Type: research

Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model.
CONCLUSIONS: CD146 is a potential therapeutic target, and folic acid-conjugated NPs delivering siRNA may facilitate gene therapy in malignant gliomas. PMID: 32707539 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 23, 2020 Category: Neurosurgery Authors: Fukui N, Yawata T, Nakajo T, Kawanishi Y, Higashi Y, Yamashita T, Aratake T, Honke K, Ueba T Tags: J Neurosurg Source Type: research

MicroRNA ‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1.
In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA. PMID: 33537828 [PubMed - in process]
Source: Molecular Medicine - February 6, 2021 Category: Molecular Biology Authors: Li Q, Wu M, Fang G, Li K, Cui W, Li L, Li X, Wang J, Cang Y Tags: Mol Med Rep Source Type: research

Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.
Abstract Despite the advancements in primary brain tumour diagnoses and treatments, the mortality rate remains high, particularly in glioblastoma (GBM). Chemoresistance, predominantly in recurrent cases, results in decreased mean survival of patients with GBM. We aimed to determine the chemosensitisation and oncogenic characteristics of zinc finger protein 36-like 2 (ZFP36L2) in LN18 GBM cells via RNA interference (RNAi) delivery. We conducted a meta-analysis of microarray datasets and RNAi screening using pooled small interference RNA (siRNA) to identify the druggable genes responsive to GBM chemosensitivity. Tem...
Source: Molecular Biology Reports - February 15, 2021 Category: Molecular Biology Authors: Che Mat MF, Mohamad Hanif EA, Abdul Murad NA, Ibrahim K, Harun R, Jamal R Tags: Mol Biol Rep Source Type: research

Cancers, Vol. 13, Pages 944: Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma
wn Spencer J. Collis Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain tumours being diagnosed as high-grade malignancies known as glioblastomas. Despite de-bulking surgery combined with chemo-/radiotherapy regimens, the mean survival for these patients is only around 15 months, with less than 10% surviving over 5 years. This dismal prognosis highlights the urgent need to develop novel agents to improve the treatment of these tumours. To address this need, we carried out a human kinome siRNA screen to identify potential drug targets that augment the e...
Source: Cancers - February 24, 2021 Category: Cancer & Oncology Authors: Natasha Carmell Ola Rominiyi Katie N. Myers Connor McGarrity-Cottrell Aurelie Vanderlinden Nikita Lad Eva Perroux-David Sherif F. El-Khamisy Malee Fernando Katherine G. Finegan Stephen Brown Spencer J. Collis Tags: Article Source Type: research

MicroRNA ‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1
In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA.PMID:33537828 | DOI:10.3892/mmr.2021.11892
Source: Molecular Medicine Reports - February 4, 2021 Category: Molecular Biology Authors: Qing Li Mingjie Wu Guofang Fang Kuangwen Li Wengang Cui Liang Li Xia Li Junsheng Wang Yanhong Cang Source Type: research

Research Articles A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma
Glioblastoma (GBM) is one of the most difficult cancers to effectively treat, in part because of the lack of precision therapies and limited therapeutic access to intracranial tumor sites due to the presence of the blood-brain and blood-tumor barriers. We have developed a precision medicine approach for GBM treatment that involves the use of brain-penetrant RNA interference–based spherical nucleic acids (SNAs), which consist of gold nanoparticle cores covalently conjugated with radially oriented and densely packed small interfering RNA (siRNA) oligonucleotides. On the basis of previous preclinical evaluation, we cond...
Source: Science Translational Medicine - March 10, 2021 Category: Biomedical Science Authors: Kumthekar, P., Ko, C. H., Paunesku, T., Dixit, K., Sonabend, A. M., Bloch, O., Tate, M., Schwartz, M., Zuckerman, L., Lezon, R., Lukas, R. V., Jovanovic, B., McCortney, K., Colman, H., Chen, S., Lai, B., Antipova, O., Deng, J., Li, L., Tommasini-Ghelfi, S Tags: Research Articles Source Type: research

Intracellular Progesterone Receptor and cSrc Protein Working Together to Regulate the Activity of Proteins Involved in Migration and Invasion of Human Glioblastoma Cells
Glioblastomas are the most common and aggressive primary brain tumors in adults, and patients with glioblastoma have a median survival of 15 months. Some alternative therapies, such as Src family kinase inhibitors, have failed presumably because other signaling pathways compensate for their effects. In the last ten years, it has been proven that sex hormones such as progesterone (P4) can induce growth, migration, and invasion of glioblastoma cells through its intracellular progesterone receptor (PR), which is mostly known for its role as a transcription factor, but it can also induce non-genomic actions. These non-classic ...
Source: Frontiers in Endocrinology - March 26, 2021 Category: Endocrinology Source Type: research

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
AbstractGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell lines incubated with LY294002 and/or sorafenib were used in the experiments. Simult...
Source: Cell and Tissue Research - July 8, 2021 Category: Cytology Source Type: research

TRIM66 Overexpression Promotes Glioma Progression and Regulates Glucose Uptake Through cMyc/GLUT3 Signaling
CONCLUSION: TRIM66 was upregulated in human gliomas, where it promoted cell growth and chemoresistance. Our data also identified novel roles of TRIM66 in glioma progression. TRIM66 upregulates glucose uptake and mitochondrial function through the cMyc/GLUT3 signaling, which makes it a potential therapeutic target.PMID:34234562 | PMC:PMC8256720 | DOI:10.2147/CMAR.S293728
Source: Cell Research - July 8, 2021 Category: Cytology Authors: Yuequn Song Lifang Meng Jian Yu Zhi Cao Jizhou Sun Hongyu Zhao Source Type: research

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells
CONCLUSION: Taken together, our findings indicate that temozolomide may suppress cell growth partly by inducing ferroptosis by targeting DMT1 expression in glioblastoma cells.PMID:34427071 | DOI:10.3349/ymj.2021.62.9.843
Source: Yonsei Medical Journal - August 24, 2021 Category: Universities & Medical Training Authors: Qingxin Song Shanxin Peng Zhiqing Sun Xueyuan Heng Xiaosong Zhu Source Type: research