Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model.

CONCLUSIONS: CD146 is a potential therapeutic target, and folic acid-conjugated NPs delivering siRNA may facilitate gene therapy in malignant gliomas.
PMID: 32707539 [PubMed - as supplied by publisher]

Source: Journal of Neurosurgery - July 23, 2020 Category: Neurosurgery Authors: Fukui N, Yawata T, Nakajo T, Kawanishi Y, Higashi Y, Yamashita T, Aratake T, Honke K, Ueba T Tags: J Neurosurg Source Type: research