Filtered By:
Condition: Brain Tumor

This page shows you your search results in order of relevance. This is page number 18.

Order by Relevance | Date

Total 810 results found since Jan 2013.

LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1
In this study, HOTAIR expression was found to be positively regulated by TRPM7, significantly upregulated in glioma tissues, and is a poor prognosis factor for glioma patients. Moreover, reduced HOTAIR expression impeded the proliferation and invasion of glioma cells. Mechanistically, HOTAIR directly interacted with miR-301a-3p, and downregulation of miR-301a-3p efficiently reversed FOSL1 suppression induced by siRNA HOTAIR, which implied that HOTAIR positively regulated FOSL1 level through sponging miR-301a-3p and played an oncogenic role in glioma progression. In contrast to HOTAIR's role, miR-301a-3p alone served as a t...
Source: Cellular Signalling - March 16, 2022 Category: Cytology Authors: Shanchun Guo Pendelton King Emily Liang Alyssa A Guo Mingli Liu Source Type: research

The role of A-kinase interacting protein 1 in regulating progression and stemness as well as indicating the prognosis in glioblastoma
CONCLUSIONS: AKIP1 regulates the malignant behaviors and stemness of GBM via regulating multiple carcinogenetic pathways.PMID:35691247 | DOI:10.1016/j.tranon.2022.101463
Source: Translational Oncology - June 12, 2022 Category: Cancer & Oncology Authors: Jingxia Tang Shirong Peng Haifeng Yan Ming Ni Xiaodan Hou Peizhi Ma Yuanlong Li Source Type: research

Intelligent Nanoparticles With pH-Sensitive Co-Delivery of Temozolomide and siEGFR to Ameliorate Glioma Therapy
In this study, pH-sensitive and GBM-targeting nanovesicle (Tf-PEG-PAE(SS)) was fabricated. The chemotherapy drug (TMZ) and EGFR inhibitor (EGFR-siRNA) were co-encapsulated in the nanocarrier, and their anticancer outcomes were investigated in detail. In vitro experiments have shown that the nanocarrier transports TMZ and EGFR-siRNA efficiently into U87 cells, causing a vigorous apoptotic response by silencing the proliferative EGFR gene and increasing the drug concentration of TMZ simultaneously. An experimental study in mice bearing orthotropic glioma revealed that the accumulated nanocarriers in the tumor site could inhi...
Source: Frontiers in Genetics - July 12, 2022 Category: Genetics & Stem Cells Source Type: research

TfR Aptamer Enhanced Blood ‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma
Biomimetic nanocomplex (TMPsM) nanopartcles with dual blood-brain barrier (BBB)  targeting capability are prepared for simultaneous accurate diagnosis and effective treatment of glioma through single intracellular transglutaminase 2-triggered self-assembly aggregation-induced emission imaging and RNAi therapy. The dual BBB targeting biomimetic outer shells endow it with enhanc ed BBB penetration, prolonged blood circulation, and ensure the delivery of inner cores into brain tumor sites for theranostic agents release. AbstractEngineering a versatile nanocomplex integrating effective penetration of the blood-brain barrier (...
Source: Small - October 6, 2022 Category: Nanotechnology Authors: Juan Su, Zhipeng Yao, Zixuan Chen, Sisi Zhou, Zhi Wang, Hongping Xia, Songqin Liu, Yafeng Wu Tags: Research Article Source Type: research

Cancers, Vol. 15, Pages 834: Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
Johannes F. Fahrmann The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is frequently activated in various cancer types. Aberrant activation of NRF2 in cancer is attributed to gain-of-function mutations in the NRF2-encoding gene NFE2L2 or a loss of function of its suppressor, Kelch-like ECH-associated protein 1 (KEAP1). NRF2 activation exerts pro-tumoral effects in part by altering cancer cell metabolism. Previously, we reported a novel mechanism of NRF2 tumoral immune suppression through the selective upregulation of the tryptophan-metabolizing enzyme kynureninase (KYNU) in lung adenocarcinoma. In the cu...
Source: Cancers - January 29, 2023 Category: Cancer & Oncology Authors: Ricardo A. Le ón-Letelier Ali H. Abdel Sater Yihui Chen Soyoung Park Ranran Wu Ehsan Irajizad Jennifer B. Dennison Hiroyuki Katayama Jody V. Vykoukal Samir Hanash Edwin J. Ostrin Johannes F. Fahrmann Tags: Article Source Type: research

The prognostic value of DAAM2 in lower grade glioma, liver cancer, and breast cancer
ConclusionDAAM2 had a specific value in foretelling the prognosis of LGG, LIHC, and BRCA. High expression level of DAAM2 has longer survival rates in LGG and LIHC. The knockdown of DAAM2 retards the proliferation, invasion, and migration of BRCA cells. This study provides a novel sight of DAAM2 into the exploration of a potential biomarker in pan-cancer.
Source: Clinical and Translational Oncology - February 15, 2023 Category: Cancer & Oncology Source Type: research

Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
In this study, we found that inhibition of T-type Ca(2+) channels in GBM cells significantly reduced their survival and resistance to therapy. Moreover, either T-type selective antagonists, such as mibefradil, or siRNA-mediated knockdown of the T-type channel alpha subunits not only reduced cell viability and clonogenic potential, but also induced apoptosis. In response to channel blockade or ablation, we observed reduced phosphorylation of Akt and Rictor, suggesting inhibition of the mTORC2/Akt pathway. This was followed by reduction in phosphorylation of anti-apoptotic Bad and caspases activation. The apoptotic response ...
Source: Biochemical Pharmacology - December 31, 2012 Category: Drugs & Pharmacology Authors: Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J Tags: Biochem Pharmacol Source Type: research

FoxM1 and Stress Response Cell Biology
In this study we found that FoxM1 was up-regulated by heat shock factor 1 (HSF1) under heat shock stress condition in multiple cell lines. Knockdown of HSF1 with HSF1 siRNA or inhibition of HSF1 with a HSF1 inhibitor abrogated heat shock-induced expression of FoxM1. Genetic deletion of HSF1 in mouse embryo fibroblast cells also abolished heat shock stress-induced FoxM1 expression. Moreover, we showed that HSF1 directly bound to FoxM1 promoter and increased FoxM1 promoter activity. Furthermore, we demonstrated that FoxM1 was required for the G2-M phase progression through regulating Cdc2, Cdc20, and Cdc25B under a mild heat...
Source: Journal of Biological Chemistry - January 18, 2013 Category: Chemistry Authors: Dai, B., Gong, A., Jing, Z., Aldape, K. D., Kang, S.-H., Sawaya, R., Huang, S. Tags: Gene Regulation Source Type: research

Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde.
In this study, we examined the effects of transmethylation on tumorigenic responses and its regulatory mechanism using an upregulation strategy of adenosylhomocysteine (SAH) acting as a negative feedback inhibitor. Treatment with adenosine dialdehyde (AdOx), an inhibitor of transmethylation-suppressive adenosylhomocysteine (SAH) hydrolase (SAHH), enhanced the level of SAH and effectively blocked the proliferation, migration, and invasion of cancer cells; the treatment also induced the differentiation of C6 glioma cells and suppressed the neovascular genesis of eggs in a dose-dependent manner. Through immunoblotting analysi...
Source: Biochemical Pharmacology - January 24, 2013 Category: Drugs & Pharmacology Authors: Kim JH, Lee YG, Yoo S, Oh J, Jeong D, Song WK, Yoo BC, Rhee MH, Park J, Cha SH, Hong S, Cho JY Tags: Biochem Pharmacol Source Type: research

Suppression of Chloride Channel 3 Expression Facilitates Sensitivity of Human Glioma U251 Cells to Cisplatin Through Concomitant Inhibition of Akt and Autophagy
In this study, we investigated the role of chloride channel‐3 (ClC‐3) in cisplatin resistance. Autophagy was demonstrated by accumulation of LC3‐II, beclin 1 and Atg12‐Atg5. The ultrastructure changes were observed under electron microscope. Chemical staining with acridine orange or MDC was used to detect acidic vesicular organelles. Quantification of apoptosis was detected by PI and Annexin V staining. The mechanisms involved in the Akt pathway and autophagy were studied by western blot analysis. Our results showed that Akt phosphorylation and autophagy were induced by cisplatin in human glioma U251 cells. Specifi...
Source: The Anatomical Record Part B: The New Anatomist - February 13, 2013 Category: Anatomy Authors: Jing Su, Ye Xu, Lei Zhou, Hui‐Mei Yu, Jin‐Song Kang, Ning Liu, Cheng‐Shi Quan, Lian‐Kun Sun Tags: Full Length Article Source Type: research

Suppression of Chloride Channel 3 Expression Facilitates Sensitivity of Human Glioma U251 Cells to Cisplatin Through Concomitant Inhibition of Akt and Autophagy.
In this study, we investigated the role of chloride channel-3 (ClC-3) in cisplatin resistance. Autophagy was demonstrated by accumulation of LC3-II, beclin 1 and Atg12-Atg5. The ultrastructure changes were observed under electron microscope. Chemical staining with acridine orange or MDC was used to detect acidic vesicular organelles. Quantification of apoptosis was detected by PI and Annexin V staining. The mechanisms involved in the Akt pathway and autophagy were studied by western blot analysis. Our results showed that Akt phosphorylation and autophagy were induced by cisplatin in human glioma U251 cells. Specific inhibi...
Source: Anatomical Record - February 13, 2013 Category: Anatomy Authors: Su J, Xu Y, Zhou L, Yu HM, Kang JS, Liu N, Quan CS, Sun LK Tags: Anat Rec (Hoboken) Source Type: research

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma
Conclusions: In summary, we demonstrated that EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas.
Source: Molecular Cancer - April 25, 2013 Category: Cancer & Oncology Authors: Yasufumi KatanasakaYasuo KoderaYuka KitamuraTatsuya MorimotoTomohide TamuraFumiaki Koizumi Source Type: research