Filtered By:
Condition: Brain Tumor
This page shows you your search results in order of relevance. This is page number 13.
Order by Relevance | Date
Total 810 results found since Jan 2013.
Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway.
In conclusion, eupatilin had an inhibitory effect on proliferation, invasion and migration, and promoted apoptosis of glioma cells through suppression of the Notch‑1 signaling pathway. Therefore, eupatilin may have potential as an effective agent for the treatment of glioma.
PMID: 26676446 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - December 20, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway.
In conclusion, SEPT7 is involved in glioma cell migration with the assistance of cofilin phospho‑mediated cytoskeleton locomotion.
PMID: 26846171 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 9, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Construction and analysis of the regulatory network disturbed by the silenced Sp1 transcription factor in HeLa cells
Conclusion: While Sp1 was silenced by siRNA, the regulatory network in HeLa cells changed a lot. Genes related to cell cycle and apoptosis in the cell nucleus were dysregulated and the p53 signaling pathway was disturbed.
Source: Journal of Cancer Research and Therapeutics - February 15, 2016 Category: Cancer & Oncology Authors: Fengyan LiLijun YuLi LiMeiyan Wei Source Type: research
Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression.
Abstract
PH domain leucine-rich repeats protein phosphatase 1(PHLPP1) belongs to a novel family of Ser/Thr protein phosphatases: PHLPP serves as tumor suppressor in several cancers. However, little knowledge about the expression of PHLPP1 in human glioma tumor tissue and its role in inflammation response in glioma cells was known. Glioma samples were obtained from a total of 37 patients including 16 males and 21 females with surgical removal of the brain tumor. PHLPP1 protein and inflammatory cytokines were measured by Western blot analysis and immunohistochemistry while mRNA was determined by RT-PCR. The levels o...
Source: International Immunopharmacology - March 10, 2016 Category: Allergy & Immunology Authors: Teng DC, Sun J, An YQ, Hu ZH, Liu P, Ma YC, Han B, Shi Y Tags: Int Immunopharmacol Source Type: research
β-catenin knockdown inhibits the proliferation of human glioma cells in vitro and in vivo.
Authors: Wang Z, Chen Q
Abstract
β-catenin is a crucial oncogene that is capable of regulating cancer progression. The aim of the present study was to clarify whether β-catenin was associated with the proliferation and progress of glioma. In order to knockdown the expression of β-catenin in human U251 glioma cells, three pairs of small interfering (si)RNA were designed and synthesized and the most effective siRNA was selected and used for silencing the endogenous β-catenin, which was detected by western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Proliferation was s...
Source: Experimental and Therapeutic Medicine - March 23, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research
Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells
Conclusion: In addition to the DNA damage it does, its inhibitory effect on IKCa channels accompanied by membrane depolarization could be an important mechanism underlying TMZ-induced antineoplastic actions.Cell Physiol Biochem 2016;38:1727-1742
Source: Cellular Physiology and Biochemistry - May 9, 2016 Category: Cytology Source Type: research
JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production
In this study, we used glioma cell lines and H2O2 to investigate the role of JNK in glioma cell parthanatos induced by oxidative stress. We found that exposure to H2O2 not only induced intracellular accumulation of ROS but also resulted in glioma cell death in a concentration- and incubation time-dependent manner, which was accompanied with cytoplasmic formation of PAR polymer, expressional upregulation of PARP-1, mitochondrial depolarization, and AIF translocation to nucleus. Pharmacological inhibition of PARP-1 with 3AB or genetic knockdown of its level with siRNA rescued glioma cell death, as well as suppressed cytoplas...
Source: Molecular Neurobiology - May 15, 2016 Category: Neurology Source Type: research
Frequent Nek1 overexpression in human gliomas.
Abstract
Never in mitosis A (NIMA)-related kinase 1 (Nek1) regulates cell cycle progression to mitosis. Its expression and potential functions in human gliomas have not been studied. Here, our immunohistochemistry (IHC) assay and Western blot assay results showed that Nek1 expression was significantly upregulated in fresh and paraffin-embedded human glioma tissues. Its level in normal brain tissues was low. Nek1 overexpression in human gliomas was correlated with the proliferation marker (Ki-67), tumor grade, Karnofsky performance scale (KPS) and more importantly, patients' poor survival. Further studies showed th...
Source: Biochemical and Biophysical Research communications - May 28, 2016 Category: Biochemistry Authors: Zhu J, Cai Y, Liu P, Zhao W Tags: Biochem Biophys Res Commun Source Type: research
G9a inhibition induced PKM2 regulates autophagic responses.
Abstract
Epigenetic regulation by histone methyltransferase G9a is known to control autophagic responses. As the link between autophagy and metabolic homeostasis is widely accepted, we investigated whether G9a affects metabolic circuitries to affect autophagic response in glioma cells. Both pharmacological inhibition and siRNA mediated knockdown of G9a increased autophagy marker LC3B in glioma cells. G9a inhibitor BIX-01294 (BIX) induced Akt-dependent increase in HIF-1α expression and activity. Inhibition of Akt-HIF-1α axis reversed BIX-mediated (i) increase in LC3B expression and (ii) decrease in Yes-associated...
Source: The International Journal of Biochemistry and Cell Biology - July 10, 2016 Category: Biochemistry Authors: Ahmad F, Dixit D, Joshi SD, Sen E Tags: Int J Biochem Cell Biol Source Type: research
GFAP expression is regulated by Pax3 in brain glioma stem cells.
Authors: Su X, Liu X, Ni L, Shi W, Zhu H, Shi J, Chen J, Gu Z, Gao Y, Lan Q, Huang Q
Abstract
Glioblastomas are understood to evolve from brain glioma stem cells (BGSCs), and yet the biology underlying this model of tumorigenesis is largely unknown. Paired box 3 protein (Pax3) is a member of the paired box (Pax) family of transcription factors that is normally expressed during embryonic development, but has recently been implicated in tumorigenesis. The present study demonstrated that Pax3 is differentially expressed in U87MG human glioma cell, BGSC and normal 1800 human astrocyte lines. Herein, we identified tha...
Source: Oncology Reports - July 21, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma.
Authors: Xu Z, Gong J, Wang C, Wang Y, Song Y, Xu W, Liu Z, Liu Y
Abstract
Previous studies indicated that phosphoglycerate mutase 1 (PGAM1) is involved in many cancer types and promotes breast cancer progression. However, the role of PGAM1 in glioma remains unclear. The present study aimed to investigate the association of PGAM1 expression with glioma grade and the role of PGAM1 in proliferation, apoptosis, migration and invasion of glioma cells. The mRNA and protein expression of PGAM1 was analysed in glioma tissues and normal brain tissues. The expression of PGAM1 was examined further by immunohistochemical anal...
Source: Oncology Reports - September 1, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MiR-200c and miR-141 inhibit ZEB1 synergistically and suppress glioma cell growth and migration.
CONCLUSIONS: MiR-200c and miR-141 are significantly downregulated in glioma tissues and cell lines and can significantly induce ZEB1 mRNA degradation and suppress ZEB1 protein expression in the cells. ZEB1 is a functional downstream target of miR-200c and miR-141 in inhibiting glioma cell growth and migration.
PMID: 27608897 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 10, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
DDIS-06. Ku 70/80 IN GLIOMA - TARGETING WITH APTAMERS
CONCLUSIONS:Certain aptamers appear to readily bind to DNA repair proteins Ku70 and Ku80 and could be used for developing targeted therapy towards glioma. Western and knockdown analysis, confirm the specificity of binding and leads the way for in-vivo testing of aptamers.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Arora, M., Davis, C., Dawson, T., Alder, J., Lawrence, C., Shaw, L. Tags: DRUG DISCOVERY Source Type: research
(Pro)renin receptor is crucial for glioma development via the Wnt/ β-catenin signaling pathway.
CONCLUSIONS This is the first evidence that the PRR has an important role in development of glioma by aberrant activation of the Wnt/β-catenin signaling pathway. This receptor may be both a prognostic marker and a therapeutic target for glioma.
PMID: 28059652 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 5, 2017 Category: Neurosurgery Authors: Kouchi M, Shibayama Y, Ogawa D, Miyake K, Nishiyama A, Tamiya T Tags: J Neurosurg Source Type: research
A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma
ConclusionLncRNA UCA1 can promote the proliferation and cell cycle progression of glioma cells by upregulating cyclin D1 transcription. So UCA1 may serve as an independent prognostic indicator and a novel therapeutic target for glioma.
Source: Clinical and Translational Oncology - January 18, 2017 Category: Cancer & Oncology Source Type: research
