Filtered By:
Condition: Brain Tumor

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 810 results found since Jan 2013.

High epiregulin expression in human U87 glioma cells relies on IRE1¿ and promotes autocrine growth through EGF receptor
Conclusion: EREG may contribute to glioma progression under the control of IRE1alpha, as exemplified here by the autocrine proliferation loop mediated in U87 cells by the growth factor through ErbB1.
Source: BMC Cancer - December 13, 2013 Category: Cancer & Oncology Authors: Gregor AufArnaud JabouilleMaylis DeluginSylvaine GuéritRaphael PineauSophie NorthNatalia PlatonovaMarlène MaitreAlexandre FavereauxPeter VajkoczyMasaharu SenoAndreas BikfalviDmitri MinchenkoOleksandr MinchenkoMichel Moenner Source Type: research

PHF20L1 Antagonizes DNMT1 Degradation DNA and Chromosomes
Inheritance of DNA cytosine methylation pattern during successive cell division is mediated by maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1). Lysine 142 of DNMT1 is methylated by the SET domain containing lysine methyltransferase 7 (SET7), leading to its degradation by proteasome. Here we show that PHD finger protein 20-like 1 (PHF20L1) regulates DNMT1 turnover in mammalian cells. Malignant brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner. PHF20L1 knockdown by siRNA resulted in decreased amounts of...
Source: Journal of Biological Chemistry - March 20, 2014 Category: Chemistry Authors: Esteve, P.–O., Terragni, J., Deepti, K., Chin, H. G., Dai, N., Espeȷo, A., Correa, I. R., Bedford, M. T., Pradhan, S. Tags: Cell Biology Source Type: research

Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway.
This study investigated the effect of cordycepin on a rat glioma cell line. Cordycepin caused apoptosis in C6 glioma cells in a time- and concentration-dependent manner, but did not affect the survival of primary cultured rat astrocytes. Cordycepin increased the total protein levels of p53 and phosphorylated p53 in the C6 cells. Levels of cleaved caspase-7 and poly (ADP-ribose) polymerase (PARP), but not cleaved caspase-3, were also increased after cordycepin treatment. Specific inhibitors for p53 and caspases abrogated cordycepin-induced caspase-7 and PARP cleavage, and prevented cordycepin-induced apoptosis. Moreover, si...
Source: Chemico-Biological Interactions - April 2, 2014 Category: Molecular Biology Authors: Chen Y, Yang SH, Hueng DY, Syu JP, Liao CC, Wu YJ Tags: Chem Biol Interact Source Type: research

P53 induction accompanying G2/M arrest upon knockdown of tumor suppressor HIC1 in U87MG glioma cells.
In this study, we investigated the role of HIC1 in cell cycle and proliferation of glioma cell line U87MG which has wild type p53, in both serum-containing and serum-deprived medium. Microscopic analysis and MTT assay showed reduced cell number and rate of proliferation upon HIC1 knock down compared to control siRNA (p = 0.025) and untreated cells (p = 0.03) in serum-containing medium and serum-free medium (p = 0.014 vs control siRNA; p = 0.018 vs untreated cells). Cell cycle analysis revealed an arrest at G2/M phase of cell cycle with no demonstrable increase in apoptosis with both medium. An increased expression ...
Source: Molecular and Cellular Biochemistry - July 4, 2014 Category: Biochemistry Authors: Kumar S Tags: Mol Cell Biochem Source Type: research

Rcor2 underexpression in senescent mice: a target for inflammaging?
Conclusions: Data presented here show interplay between Rcor2 downregulation and increased inflammation and suggest that Rcor2 may be a key regulator of inflammaging.
Source: Journal of Neuroinflammation - July 23, 2014 Category: Neurology Authors: María Alvarez-LópezPatricia Molina-MartínezMarco Castro-FreireMarta Cosín-TomásRosa CristòfolMarcelina PárrizasRosa EscorihuelaMerce PallàsCoral SanfeliuPerla Kaliman Source Type: research

Mig-2 attenuates cisplatin-induced apoptosis of human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways.
Conclusion:Mig-2 significantly attenuates the antitumor action of cisplatin against human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways. The F3 subdomain of mig-2 is necessary and sufficient for this effect. PMID: 25152024 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - August 25, 2014 Category: Drugs & Pharmacology Authors: Ou YW, Zhao ZT, Wu CY, Xu BN, Song YM, Zhan QM Tags: Acta Pharmacol Sin Source Type: research

PAX8 expression is associated with SHH/WNT subtypes, desmoplastic histology and patient survival in human medulloblastomas
ConclusionIn summary, high PAX8 expression is linked to better prognosis in medulloblastomas potentially by suppressing both proliferative and migratory properties of MB cells. The distinct spatio‐temporal expression pattern of PAX8 during brain development might contribute to the understanding of distinct MB subtype histogenesis.
Source: Neuropathology and Applied Neurobiology - October 1, 2014 Category: Neurology Authors: Patrick N. Harter, Peter Baumgarten, Jenny Zinke, Karl Schilling, Stefan Baader, Ann‐Kathrin Hartmetz, Jens Schittenhelm, Rudi Beschorner, Stefan Liebner, Dorothea Schulte, Karl‐Heinz Plate, Paul Gutwein, Andrey Korshunov, Stefan M. Pfister, David T. Tags: Original Article Source Type: research

TGF-β-induced hCG-β regulates redox homeostasis in glioma cells.
Abstract Transforming growth factor (TGF-β) is associated with the progression of glioblastoma multiforme (GBM)-the most malignant of brain tumors. Since there is a structural homology between TGF-β and human chorionic gonadotropin (hCG) and as both TGF-β and hCG-β are known regulators of oxidative stress and survival responses in a variety of tumors, the role of TGF-β in the regulation of hCG-β and its consequences on redox modulation of glioblastoma cells was investigated. A heightened hCG-β level was observed in GBM tumors. TGF-β treatment increased hCG-β expression in glioma cell lines, and this heigh...
Source: Molecular and Cellular Biochemistry - October 10, 2014 Category: Biochemistry Authors: Ahmad F, Ghosh S, Sinha S, Joshi SD, Mehta VS, Sen E Tags: Mol Cell Biochem Source Type: research

Rt-40 * the down-regulation of h-ferritin as an adjuvant therapy in human glioma
This study supports the potential of H-ferritin siRNA as an adjuvant therapy in glioma treatment.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Pang, M., Liu, X., Madhankumar, A. B., Slagle-Webb, B., Connor, J. Tags: RADIATION THERAPY (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Abstract LB-207: mTORC2/Akt signaling is modulated by noncanonical mitochondrial Notch1/PINK1 interaction in myc-amplified medulloblastoma tumorigenesis
Medulloblastoma is known to be the most malignant pediatric brain tumor. The armamentarium of targeted therapies to currently treat medulloblastoma and similar pediatric central nervous system malignancies is extremely limited, often necessitating the need to combat such tumors with modified regimens of therapeutic options designed originally to target adult neoplasms. Given such limited therapies, a budding focus on the role of mitochondrial dysregulation in the tumorigenesis of such pathologies merits consideration. Mitochondria are known to play fundamental roles in multiple processes conserved across eukaryotic species...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Feroze, A. H., Lee, K.-S., Gholamin, S., Wu, Z., Weissman, I., Lu, B., Mitra, S. S., Cheshier, S. Tags: Tumor Biology Source Type: research

Abstract 511: EGFR-initated NADPH oxidase activity regulates Fyn expression in glioblastoma multiforme
Glioblastoma multiforme (GBM) constitute the most aggressive and common form of primary brain tumors, conferring the worst clinical prognosis. Epidermal growth factor receptor (EGFR) amplification, mutation and re-arrangement are commonly observed genetic lesions in GBM. The most frequently occurring EGFR variant in GBM, EGFRvIII, is characterized by a truncated extracellular domain, leading to a receptor which is unable to bind ligand yet rendered constitutively active. In addition to increasing proliferation and survival signaling, EGFRvIII increases the production of reactive oxygen species (ROS); redox signaling in GBM...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Johnson, B., Chandra, J. Tags: Molecular and Cellular Biology Source Type: research

Abstract 5449A: PI3K and MEK inhibition in intracranial triple negative breast cancer: Efficacy of BKM120 and AZD6244 in preclinical mouse models
Conclusions: BKM120 and AZD6244 both improved survival in an IC TNBC SUM149 mouse model, with single agent AZD6244 being most efficacious. The siRNA screens indicate that combined treatment with BKM120 and AZD6244 should be synthetically lethal, suggesting that combination therapy may have underperformed due to toxicity. Ongoing in vitro and in vivo studies (including dosing schedules) will further characterize the effects of these drugs in intracranial TNBC. Citation Format: Amanda E.D. Van Swearingen, Marni B. Siegel, Ryan Bash, Brian Golitz, Charlene Santos, David Darr, Joel Parker, Gary L. Johnson, C. Ryan Miller, Care...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Swearingen, A. E. D. V., Siegel, M. B., Bash, R., Golitz, B., Santos, C., Darr, D., Parker, J., Johnson, G. L., Miller, C. R., Anders, C. K. Tags: Experimental and Molecular Therapeutics Source Type: research

Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells.
Authors: Parra E, Gutiérrez L, Ferreira J Abstract Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in recent years, little is known concerning the signaling pathways that control their expression in glioma cells. The aim of the present study was to assess the role of c-Jun-NH2-terminal kinases (JNKs) in the regulation of T98G glioblastoma cells treated with cisplatin in the presence or absence of siRNAs against JNK1 and JNK2. Addition of either s...
Source: Oncology Reports - November 16, 2014 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner.
In conclusion, HOTAIR promotes cell cycle progression in glioma as a result of the binding of its 5' domain to the PRC2 complex. PMID: 25428914 [PubMed - as supplied by publisher]
Source: Oncotarget - November 30, 2014 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells.
CONCLUSION: We demonstrate that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells. TRPM7 channel may represent a novel and promising target for therapeutic intervention of malignant glioma. PMID: 25438992 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 1, 2014 Category: Neuroscience Authors: Leng TD, Li MH, Shen JF, Liu ML, Li XB, Sun HW, Branigan D, Zeng Z, Si HF, Li J, Chen J, Xiong ZG Tags: CNS Neurosci Ther Source Type: research