Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma

Conclusions:
In summary, we demonstrated that EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas.

Source: Molecular Cancer - April 25, 2013 Category: Cancer & Oncology Authors: Yasufumi KatanasakaYasuo KoderaYuka KitamuraTatsuya MorimotoTomohide TamuraFumiaki Koizumi Source Type: research