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Cancer: Acute Leukemia

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Total 260 results found since Jan 2013.

High expression of lnc-CRNDE presents as a biomarker for acute myeloid leukemia and promotes the malignant progression in acute myeloid leukemia cell line U937.
CONCLUSIONS: LncRNA-CRNDE is highly expressed in the bone marrow tissues of AML patients, and the expression level is negatively correlated with the total survival of those clinical patients. Meanwhile, the expression is higher in FAB type M4 and M5 than that in M1, M2 and M3. LncRNA-CRNDE promotes the proliferation and cell cycle of U937 cells, and inhibits cell apoptosis, which is expected to become a molecular marker for predicting and treating AML. PMID: 29461608 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome
Conclusions: To our knowledge, this report is the first to demonstrate that lncRNAKcnq1ot1 downregulation is responsible for QT interval prolongation induced by ATO at least partially by repressingKcnq1 expression. lncRNAKcnq1ot1 has important pathophysiological functions in the heart and could become a novel antiarrhythmic target.Cell Physiol Biochem 2018;45:192 –202
Source: Cellular Physiology and Biochemistry - January 16, 2018 Category: Cytology Source Type: research

Enhancement of chemosensitivity by simultaneously silencing of Mcl-1 and Survivin genes using small interfering RNA in human myelomonocytic leukaemia.
Authors: Jafarlou M, Shanehbandi D, Dehghan P, Mansoori B, Othman F, Baradaran B Abstract Acute myeloid leukaemia (AML) is a genetically heterogeneous, severe and rapidly progressing disease triggered by blocking granulocyte or monocyte differentiation and maturation. Overexpression of myeloid cell leukaemia-1 (Mcl-1) and Survivin is associated with drug resistance, tumour progression and inhibition of apoptotic mechanisms in leukaemia and several cancers. In the present study, we examined the combined effect of etoposide and dual siRNA-mediated silencing of Mcl-1 and Survivin on U-937 AML cells. The AML cells were...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 10, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Acute myotube protein synthesis regulation by IL-6-related cytokines
IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the involvement of the ...
Source: AJP: Cell Physiology - November 1, 2017 Category: Cytology Authors: Gao, S., Durstine, J. L., Koh, H.-J., Carver, W. E., Frizzell, N., Carson, J. A. Tags: RESEARCH ARTICLE Source Type: research

Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation.
CONCLUSIONS: HHEX is expressed in multiple types of AML, with the highest levels seen in t(8;21) AML. HHEX was essential for Kasumi-1 cell proliferation and may represent a potential therapeutic target enabling against AML. PMID: 29263042 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - November 1, 2017 Category: Laboratory Medicine Authors: Zhang S, Ma L, Chen Y, Xu H, Chen S, Wu W Tags: Ann Clin Lab Sci Source Type: research

Acute myotube protein synthesis regulation by IL-6-related cytokines.
Abstract IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the i...
Source: Am J Physiol Cell Ph... - November 1, 2017 Category: Cytology Authors: Gao S, Durstine JL, Koh HJ, Carver WE, Frizzell N, Carson JA Tags: Am J Physiol Cell Physiol Source Type: research

Decreased expression of the augmenter of liver regeneration results in growth inhibition and increased chemosensitivity of acute T lymphoblastic leukemia cells.
In conclusion, the results of this study demonstrated that targeted inhibition of the ALR expression in Jurkat cells triggered cell growth inhibition and sensitized cells to VCR via promoting apoptosis and regulating the cell cycle. PMID: 29048676 [PubMed - as supplied by publisher]
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Physcion blocks cell cycle and induces apoptosis in human B cell precursor acute lymphoblastic leukemia cells by downregulating HOXA5.
This study is aimed to investigate the anti-leukemia activity of physcion in ALL. Our results have showed that physcion could significantly suppress cell growth, induce apoptosis and blocked cell cycle progression in vitro. Mechanistically, we found that physcion downregulated the expression of HOXA5, which is responsible for the anti-leukemia activity of physcion. To verify this finding, siRNA targeting HOXA5 and overexpressing plasmid were used to repress HOXA5 expression and introduce ectopic overexpression of HOXA5 in ALL cell lines, respectively. Our results showed that overexpression of HOXA5 significantly abrogated ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 10, 2017 Category: Drugs & Pharmacology Authors: Gao F, Liu W, Guo Q, Bai Y, Yang H, Chen H Tags: Biomed Pharmacother Source Type: research

Suppression of miR-708 inhibits the Wnt/ β-catenin signaling pathway by activating DKK3 in adult B-all.
Suppression of miR-708 inhibits the Wnt/β-catenin signaling pathway by activating DKK3 in adult B-all. Oncotarget. 2017 Jul 18;: Authors: Zhang Y, Li H, Cao R, Sun L, Wang Y, Fan S, Zhao Y, Kong D, Cui L, Lin L, Wang K, Li Y, Zhou J Abstract Inactivation of Dickkopf-3 (DKK3) is closely associated with a poor prognosis in various solid tumor and hematologic malignancies. Promoter hypermethylation is one potential cause of DKK3 inactivation. However, whether other mechanisms lead to DKK3 inactivation and the subsequent effects of these inactivations on cell proliferation and the Wnt signaling pathway in...
Source: Oncotarget - August 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

L-Tetrahydropalmatine Induces Apoptosis in EU-4 Leukemia cells by Down-Regulating X-linked inhibitor of apoptosis protein and increases the sensitivity towards Doxorubicin.
CONCLUSION: Findings of the study confirm that L-THP resulted in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP caused activation of caspase and resulted in apoptosis, L-THP may be a novel molecule for inducing apoptosis specifically in p53 null leukemia EU-4 cells. PMID: 28721806 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - July 18, 2017 Category: Molecular Biology Authors: Li S, Chen D, Pei R, Lu Y, Zhang P, Ma J, Liu X, Du X, Sha K, Chen L, Cao J, Zhuang X, Wu J, Li L, Fan Z, Ye P, Tang S, Zhang B, Shi X, Li K Tags: Curr Mol Med Source Type: research

Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase.
In conclusion, -7 AMLs showed high sensitivity to L-Asp treatment due to low expression of ASNS. Thus, L-Asp may be considered for treatment of AML pediatric patients carrying -7, in order to improve the outcome of adverse-risk AMLs and t-MN patients. PMID: 28642445 [PubMed - as supplied by publisher]
Source: Oncotarget - June 25, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Silencing of LSD1 gene modulates histone methylation and acetylation and induces the apoptosis of JeKo-1 and MOLT-4 cells.
In this study, we evaluated LSD1, and histone H3 lysine 4 (H3K4)me1 and H3K4me2 expression in patients with MCL and silenced LSD1 in JeKo‑1 and MOLT‑4 cells, in order to define its role in JeKo‑1 and MOLT‑4 cell proliferation and apoptosis. We retrospectively analyzed the protein expression of LSD1, and mono- and dimethylated H3K4 (H3K4me1 and H3K4me2), and cyclin D1 and Ki67 in 30 cases of MCL by immunohistochemistry. The correlation of LSD1, H3K4me1 and H3K4me2 with Ki67 was determined by statistical analysis. LSD1 was silenced by small interfering RNA (siRNA). Cell apoptosis and cell proliferation were d...
Source: International Journal of Molecular Medicine - June 19, 2017 Category: Molecular Biology Authors: Zou ZK, Huang YQ, Zou Y, Zheng XK, Ma XD Tags: Int J Mol Med Source Type: research

Icariin induces apoptosis in acute promyelocytic leukemia by targeting PIM1.
CONCLUSIONS: Icariin potently inhibits the cell growth of APL in vitro through inducing caspase-dependent apoptosis. Hence, it can be considered as a promising candidate therapeutic agent for treating APL, although further studies including clinical trials are warranted. PMID: 29128809 [PubMed - as supplied by publisher]
Source: Pharmacological Reports - June 15, 2017 Category: Drugs & Pharmacology Authors: Zhang H, Li P, Li J, Song T, Wang L, Li E, Wang J, Wang L, Wei N, Wang Z Tags: Pharmacol Rep Source Type: research

LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen.
Authors: Liu W, Li T, Wang P, Liu W, Liu F, Mo X, Liu Z, Song Q, Lv P, Ruan G, Han W Abstract Leukocyte differentiation antigens (LDAs) play important roles in the immune system, by serving as surface markers and participating in multiple biological activities, such as recognizing pathogens, mediating membrane signals, interacting with other cells or systems, and regulating cell differentiation and activation. Data mining is a powerful tool used to identify novel LDAs from whole genome. LRRC25 (leucine rich repeat-containing 25) was predicted to have a role in the function of myeloid cells by a large-scale "omics" ...
Source: Protein and Cell - May 26, 2017 Category: Cytology Tags: Protein Cell Source Type: research

MicroRNA ‐9 plays a role in interleukin‐10‐mediated expression of E‐cadherin in acute myelogenous leukemia cells
We previously showed that the CD82/signal transducer and activator of transcription/interleukin‐10 (IL‐10) axis is activated in CD34+/CD38− AML cells that favor the bone marrow microenvironment. The present study explored the novel biological function of IL‐10 in regulation of expression of adhesion molecules in AML cells and found that exposing AML cells to IL‐10 induced expression of E‐cadherin, but not other adhesion molecules, including VLA4, CD29, and LFA1. Downregulation of E‐cadherin with an siRNA suppressed the adhesion of leukemia cells to bone marrow‐derived mesenchymal stem cells and enhanced the...
Source: Cancer Science - April 20, 2017 Category: Cancer & Oncology Authors: Chie Nishioka, Takayuki Ikezoe, Bin Pan, Kailin Xu, Akihito Yokoyama Tags: Original Article Source Type: research