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Cancer: Acute Leukemia
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Total 260 results found since Jan 2013.
SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia
Conclusion: We suggest that specific types of leukaemia may present an opportunity for the development of SRPK1-targeted therapies to be used in combination with established chemotherapeutic drugs.PMID:36895328 | PMC:PMC9988938 | DOI:10.3389/bjbs.2023.11041
Source: British Journal of Biomedical Science - March 10, 2023 Category: Laboratory Medicine Authors: Chigeru Wodi Tareg Belali Ruth Morse Sean Porazinski Michael Ladomery Source Type: research
Cancers, Vol. 15, Pages 834: Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
Johannes F. Fahrmann
The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is frequently activated in various cancer types. Aberrant activation of NRF2 in cancer is attributed to gain-of-function mutations in the NRF2-encoding gene NFE2L2 or a loss of function of its suppressor, Kelch-like ECH-associated protein 1 (KEAP1). NRF2 activation exerts pro-tumoral effects in part by altering cancer cell metabolism. Previously, we reported a novel mechanism of NRF2 tumoral immune suppression through the selective upregulation of the tryptophan-metabolizing enzyme kynureninase (KYNU) in lung adenocarcinoma. In the cu...
Source: Cancers - January 29, 2023 Category: Cancer & Oncology Authors: Ricardo A. Le ón-Letelier Ali H. Abdel Sater Yihui Chen Soyoung Park Ranran Wu Ehsan Irajizad Jennifer B. Dennison Hiroyuki Katayama Jody V. Vykoukal Samir Hanash Edwin J. Ostrin Johannes F. Fahrmann Tags: Article Source Type: research
High expression of LOC541471, GDAP1, SOD1, and STK25 is associated with poor overall survival of patients with acute myeloid leukemia
ConclusionsHigh expression of LOC541471, GDAP1, SOD1, and STK25 may be biomarkers for risk stratification of AML patients, which may provide novel insight into evaluating prognosis, monitoring progression, and designing combinational targeted therapies.
Source: Cancer Medicine - January 28, 2023 Category: Cancer & Oncology Authors: Xibao Yu,
Cunte Chen,
Yanyun Hu,
Kehan Li,
Yikai Zhang,
Zheng Chen,
Dingrui Nie,
Rili Gao,
Youxue Huang,
Mengjun Zhong,
Caixia Wang,
Shunqing Wang,
Yixin Zeng,
Yangqiu Li,
Chengwu Zeng Tags: RESEARCH ARTICLE Source Type: research
Cancers, Vol. 14, Pages 4262: Novel UHRF1-MYC Axis in Acute Lymphoblastic Leukemia
na Konopleva
Samir Hanash
Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc...
Source: Cancers - August 31, 2022 Category: Cancer & Oncology Authors: Soyoung Park Ali H. Abdel Sater Johannes F. Fahrmann Ehsan Irajizad Yining Cai Hiroyuki Katayama Jody Vykoukal Makoto Kobayashi Jennifer B. Dennison Guillermo Garcia-Manero Charles G. Mullighan Zhaohui Gu Marina Konopleva Samir Hanash Tags: Article Source Type: research
Dual Targeting of Anti-Apoptotic Proteins Enhances Chemosensitivity of the Acute Myeloid Leukemia Cells
CONCLUSIONS: Our investigation suggests that suppression of Mcl-1 and survivin by siRNA can effectually inhibit cell growth and overcome chemoresistance of AML cells. Therefore siRNAs may be an important adjuvant in chemotherapy for AML patients.PMID:35901361 | DOI:10.31557/APJCP.2022.23.7.2523
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2022 Category: Cancer & Oncology Authors: Behzad Baradaran Roya Nazmabadi Zohreh Ariyan Ebrahim Sakhinia Hadi Karami Source Type: research
