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Cancer: Acute Leukemia

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Total 260 results found since Jan 2013.

Kinesin family member  2A acts as a potential prognostic marker and treatment target via interaction with PI3K/AKT and RhoA/ROCK pathways in acute myeloid leukemia
Oncol Rep. 2022 Jan;47(1):18. doi: 10.3892/or.2021.8229. Epub 2021 Nov 18.ABSTRACTKIF2A has been shown to be involved in the regulation of AML pathology, however, the mechanistic role of KIF2A in AML has not been fully identified. The present study aimed to identify the underlying mechanism of KIF2A regulation of AML cell function and chemosensitivity. A total of 58 patients with AML and 30 healthy subjects were enrolled for clinical analysis. AML cells (KG‑1 and Kasumi‑1) were transfected with KIF2A or control small interfering (si)RNA. PI3K/AKT pathway activator (740 Y‑P) and RhoA overexpression plasmid were added ...
Source: Oncology Reports - November 18, 2021 Category: Cancer & Oncology Authors: Xinglin Liang Ruixiang Xia Source Type: research

LINC00265/miR-4500 Axis Accelerates Acute Lymphoblastic Leukemia Progression by Enhancing STAT3 Signals
CONCLUSION: Mechanistically, LncRNA LINC00265 can competitively interact with miR-4500 and thereby up-regulates STAT3 signaling and enhances the malignancy of tumors.PMID:34737643 | PMC:PMC8560060 | DOI:10.2147/CMAR.S274590
Source: Cell Research - November 5, 2021 Category: Cytology Authors: Donglu Zhao Qi Xing Hang Song Yan Zhao Guiying Guo Source Type: research

Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma
AbstractSAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia. Cytarabine is an essential component in the Nordic mantle cell lymphoma protocols (MCL2 and MCL3) for induction and high-dose chemotherapy treatment before autologous stem cell transplantation for younger patients with mantle cell lymphoma (MCL). We here investigated the expression of SAMHD1 in a population-based cohort of MCL (N = 150). SAMHD1 was highly variably expre...
Source: Virchows Archiv - November 4, 2021 Category: Pathology Source Type: research

ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration
Acta Biochim Biophys Sin (Shanghai). 2021 Sep 11:gmab117. doi: 10.1093/abbs/gmab117. Online ahead of print.ABSTRACTThe fusion gene of ABL1 is closely related to tumor proliferation, invasion, and migration. It has been reported recently that ABL1 itself is required for T-cell acute lymphoblastic leukemia (T-ALL) cell migration induced by CXCL12. Further experiments revealed that ABL1 inhibitor Nilotinib inhibited leukemia cell migration induced by CXCL12, indicating the possible application of Nilotinib in T-ALL leukemia treatment. However, the interacting proteins of ABL1 and the specific mechanisms of their involvement i...
Source: Acta Biochimica et Biophysica Sinica - September 11, 2021 Category: Biochemistry Authors: Jixian Luo Huiguang Zheng Sen Wang Dingyun Li Wenli Ma Lan Wang M James C Crabbe Source Type: research

HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8
Biol Chem. 2020 Dec 17;402(4):461-468. doi: 10.1515/hsz-2020-0196. Print 2021 Mar 26.ABSTRACTThe chemoresistance is one of the major challenges for acute myeloid leukemia (AML) treatment. We found that the expression of histone deacetylase 8 (HDAC8) was increased in daunorubicin (DNR) resistant AML cells, while targeted inhibition of HDAC8 by its specific siRNA or inhibitor can restore sensitivity of DNR treatment . Further, targeted inhibition of HDAC8 can suppress expression of interleukin 6 (IL-6) and IL-8. While recombinant IL-6 (rIL-6) and rIL-8 can reverse si-HDAC8-resored DNR sensitivity of AML cells. Mechanistical ...
Source: Biological Chemistry - May 3, 2021 Category: Chemistry Authors: Jieying Wu Ling Zhang Yashu Feng Bijay Khadka Zhigang Fang Jiajun Liu Source Type: research

A Novel Role for Brain and Acute Leukemia Cytoplasmic (BAALC) in Human Breast Cancer Metastasis
This study investigates BAALC expression in human breast cancers with the aim of determining if it plays a role in the pathogenesis of the disease. BAALC protein expression was examined by immunohistochemistry in breast cancer, and matched lymph node and normal breast tissue samples. The effect of gene expression on overall survival (OS), disease-free and distant metastasis free survival (DMFS) was assessed in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion we...
Source: Frontiers in Oncology - April 22, 2021 Category: Cancer & Oncology Source Type: research

ZEB2 knock-down induces apoptosis in human myeloid leukemia HL-60 cells.
CONCLUSION: Our study results suggest that ZEB2 suppression in myeloid leukemia cells through apoptosis induction could be a proper therapeutic method. PMID: 33475058 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - January 20, 2021 Category: Genetics & Stem Cells Authors: Fardi M, Mohammadi A, Baradaran B, Safaee S, Solali S Tags: Curr Gene Ther Source Type: research

Expression and role of fibroblast activation protein α in acute myeloid leukemia.
Authors: Mei S, Zhang Y, Yu L, Chen G, Zi F Abstract Currently, the prognosis of acute myeloid leukemia (AML) is poor. In the AML microenvironment, bone marrow (BM) mesenchymal stem cells (BMMSCs) serve an important role in protecting AML cells from chemotherapy‑induced apoptosis. The present study aimed to evaluate the expression of fibroblast activation protein α (FAPα) in BMMSCs and BM biopsy samples via flow cytometry, reverse transcription‑quantitative PCR and immunohistochemistry, as well as to identify the correlation between the expression of FAPα in BM with clinical parameters and survival of n...
Source: Oncology Reports - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells.
Authors: Kuang X, Xiong J, Lu T, Wang W, Zhang Z, Wang J Abstract Deubiquitylating enzyme ubiquitin-specific protease 1 (USP1) has been reported to be aberrantly overexpressed in cancers, and it plays a critical role in regulating various cellular processes, such as cell proliferation, apoptosis, and cell differentiation. However, the role of USP1 in B-cell acute lymphoblastic leukemia (B-ALL) remains largely undefined. USP1 expression in 30 newly diagnosed B-ALL patients was detected by real-time PCR and western blot. We found that USP1 was generally upregulated in the bone marrow cells derived from B-ALL patients...
Source: International Journal of Medical Sciences - January 6, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Cancers, Vol. 12, Pages 2766: Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia
Arnold Ganser Felicitas Thol Michael Heuser NUP98-NSD1-positive acute myeloid leukemia (AML) is a poor prognostic subgroup that is frequently diagnosed in pediatric cytogenetically normal AML. NUP98-NSD1-positive AML often carries additional mutations in genes including FLT3, NRAS, WT1, and MYC. The purpose of our study was to characterize the cooperative potential of the fusion and its associated Neuroblastoma rat sarcoma (NRAS) mutation. By constitutively expressing NUP98-NSD1 and NRASG12D in a syngeneic mouse model and using a patient-derived xenograft (PDX) model from a NUP98-NSD1-positive AML patient, we evalu...
Source: Cancers - September 25, 2020 Category: Cancer & Oncology Authors: Sagarajit Mohanty Nidhi Jyotsana Amit Sharma Arnold Kloos Razif Gabdoulline Basem Othman Courteney K. Lai Renate Schottmann Madhvi Mandhania Johannes Schmoellerl Florian Grebien Euan Ramsay Anitha Thomas Hans-Peter Vornlocher Arnold Ganser Felicitas Thol Tags: Article Source Type: research

GSE133112 BCL6 mediates Chemoresistance in Acute Myeloid Leukemia
Contributors : Kimihito Kawabata ; Cem Meydan ; Monica Guzman ; Ari MelnickSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBCL6 is a transcription repressor that plays a crucial role in germinal center formation and lymphomagenesis. However, its role in myeloid malignancies remains unclear. Here, we explored the role of BCL6 in acute myeloid leukemia (AML). Heterogeneous levels of BCL6 were found across AML cell lines and primary AML samples. Cells with higher levels of BCL6 were indeed sensitive to treatment with BCL6 inhibitors. Gene expression profiling of AML cells treated with BC...
Source: GEO: Gene Expression Omnibus - August 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research