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Cancer: Acute Leukemia

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Total 260 results found since Jan 2013.

Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα
Abstract Oroxylin A (OA) is a flavonoid derived from a Chinese herb that has previously been reported to inhibit the proliferation of several cancer cell lines. It is found that OA significantly inhibited the growth of myeloid leukemia cell lines and as xenografts in immunodeficient mice and primary blasts from acute myelogenous leukemia (AML) patients. Furthermore, OA‐induced cell cycle arrest and differentiation were observed in OA‐treated AML cell lines. OA‐induced increase of CD11b/CD14 expression was reversed by GW9662, a specific PPARγ inhibitor, or transient transfection with PPARγ siRNA. Docking study showe...
Source: International Journal of Cancer - August 13, 2013 Category: Cancer & Oncology Authors: Hui Hui, Yan Chen, Hao Yang, Kai Zhao, Qian Wang, Li Zhao, Xiaotang Wang, Zhiyu Li, Na Lu, Qinglong Guo Tags: Cancer Therapy Source Type: research

The wilms tumor suppressor WT1 enhances CD95L expression and promotes activation‐induced‐cell‐death in leukemic T cells
In this study, we investigated WT‐1 expression in ten T‐ALL cell lines established from leukemia/lymphoma patients. We show that consistent with the finding in primary T‐ALL cells, most of the leukemic T‐cell lines tested do not over‐express WT1 proteins. We found that leukemic T‐cells over‐expressing WT1 protein produce higher levels of CD95L and show elevated CD95L‐mediated activation‐induced cell death compared to cells lacking or expressing low levels of WT1. Ectopic expression of WT1 in the WT1‐non‐expressing leukemic T‐cell line increases CD95L expression and elevates activation‐induced apop...
Source: International Journal of Cancer - July 7, 2013 Category: Cancer & Oncology Authors: Konstantina Bourkoula, Christoph Englert, Marco Giaisi, Rebecca Köhler, Peter H. Krammer, Min Li‐Weber Tags: Cancer Cell Biology Source Type: research

Transcription factor AP-2α regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression.
Abstract Transcription factor AP-2α mediates transcription of a number of genes implicated in mammalian development, cell proliferation and carcinogenesis. In the current study, we identified Hoxa7, Hoxa9 and Hox cofactor Meis1 as AP-2α target genes, which are involved in myeloid leukemogenesis. Luciferase reporter assays revealed that overexpression of AP-2α activated transcription activities of Hoxa7, Hoxa9 and Meis1, whereas siRNA of AP-2α inhibited their transcription activities. We found that AP-2 binding sites in regulatory regions of three genes activated their transcription by mutant analysis and AP-2...
Source: The International Journal of Biochemistry and Cell Biology - May 6, 2013 Category: Biochemistry Authors: Ding X, Yang Z, Zhou F, Wang F, Li X, Chen C, Li X, Hu X, Xiang S, Zhang J Tags: Int J Biochem Cell Biol Source Type: research

Endogenous stromal cell-derived factor-1 (CXCL12) supports autonomous growth of acute myeloid leukemia cells
Abstract: We investigated the role of endogenous stromal cell-derived factor-1 (SDF-1; CXCL12) in the survival and proliferation of acute myeloid leukemia (AML) cells in vitro. CD34+ cells from the peripheral blood of five patients with AML, as well as five AML cell lines, produced and secreted SDF-1. Knock-down of endogenous SDF-1 expression using siRNA technology downregulated the constitutive phosphorylation of SDF-1-related signaling molecules and significantly inhibited spontaneous proliferation of the AML cell lines during a 3-day incubation in serum-free conditions. These results indicate that endogenous SDF-1 expre...
Source: Leukemia Research - March 7, 2013 Category: Hematology Authors: Ha-Yon Kim, Yoon-Suk Oh, Ik-Chan Song, Seong-Woo Kim, Hyo-Jin Lee, Hwan-Jung Yun, Samyong Kim, Deog-Yeon Jo Tags: Laboratory Studies Source Type: research

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
Conclusions: Notch1 signalling is required for hypoxia/HIF-1alpha-induced proliferation, invasion and chemoresistance in T-ALL. Pharmacological inhibitors of HIF-1alpha or Notch1 signalling may be attractive interventions for T-ALL treatment.
Source: Journal of Hematology and Oncology - January 5, 2013 Category: Hematology Authors: Jie ZouPeng LiFei LuNa LiuJianjian DaiJingjing YeXun QuXiulian SunDaoxin MaJino ParkChunyan Ji Source Type: research