Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

Conclusions: Notch1 signalling is required for hypoxia/HIF-1alpha-induced proliferation, invasion and chemoresistance in T-ALL. Pharmacological inhibitors of HIF-1alpha or Notch1 signalling may be attractive interventions for T-ALL treatment.

http://www.jhoonline.org/content/6/1/3

Source: Journal of Hematology and Oncology - January 5, 2013 Category: Hematology Authors: Jie ZouPeng LiFei LuNa LiuJianjian DaiJingjing YeXun QuXiulian SunDaoxin MaJino ParkChunyan Ji Source Type: research