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The Impact of Oral Arsenic and All-Trans-Retinoic Acid on Coagulopathy in Acute Promyelocytic Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 15, 2017 Category: Hematology Authors: Hong-Hu Zhu, Zhi-Ping Guo, Jin-Song Jia, Qian Jiang, Hao Jiang, Xiao-Jun Huang Tags: Research paper Source Type: research

Iron chelation therapy in lower IPSS risk myelodysplastic syndromes; which subtypes benefit?
(Source: Leukemia Research)
Source: Leukemia Research - November 11, 2017 Category: Hematology Authors: Shannon A. Wong, Heather A. Leitch Tags: Research paper Source Type: research

Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Tamara B. Garcia, Susan P. Fosmire, Christopher C. Porter Tags: Research paper Source Type: research

A Phase 1/2 Study of Rigosertib in Patients with Myelodysplastic Syndromes (MDS) and MDS Progressed to Acute Myeloid Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Shyamala C. Navada, Steven M. Fruchtman, Rosalie Odchimar-Reissig, Erin P. Demakos, Michael E. Petrone, Patrick S. Zbyszewski, James F. Holland, Lewis R. Silverman Tags: Research paper Source Type: research

Chk1 inhibitors overcome imatinib resistance in chronic myeloid leukemia cells
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Hu Lei, Jin Jin, Meng Liu, Xiangyun Li, Hao Luo, Li Yang, Hanzhang Xu, Yingli Wu Tags: Research paper Source Type: research

Ex-vivo Sensitivity Profiling to Guide Clinical Decision Making in Acute Myeloid Leukemia: A Pilot Study
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Ronan T. Swords, Diana Azzam, Hassan Al-Ali, Ines Lohse, Claude-Henry Volmar, Justin M. Watts, Aymee Perez, Ana Rodriguez, Fernando Vargas, Roy Elias, Francisco Vega, Arthur Zelent, Shaun P. Brothers, Taher Abbasi, Jonathan Trent, Shaukat Rangwala, Yehuda Tags: Research paper Source Type: research

Altered EZH2 Splicing and Expression is Associated with Impaired Histone H3 Lysine 27 Tri-Methylation in Myelodysplastic Syndrome
(Source: Leukemia Research)
Source: Leukemia Research - November 4, 2017 Category: Hematology Authors: Mizuho Shirahata-Adachi, Chisako Iriyama, Akihiro Tomita, Yasuhiro Suzuki, Kazuyuki Shimada, Hitoshi Kiyoi Tags: Research paper Source Type: research

Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma
(Source: Leukemia Research)
Source: Leukemia Research - November 2, 2017 Category: Hematology Authors: Pingyi Liu, Lingling Chen Tags: Research paper Source Type: research

Frondoside A Potentiates the Effects of Conventional Therapeutic Agents in Acute Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 2, 2017 Category: Hematology Authors: F.H. Sajwani, P. Collin, T.E. Adrian Tags: Research paper Source Type: research

Editorial board and publication information
(Source: Leukemia Research)
Source: Leukemia Research - November 1, 2017 Category: Hematology Source Type: research

Predictors for Requiring Re-induction Chemotherapy in Acute Myeloid Leukemia Patients with Residual Disease on Day 14 Bone Marrow Assessment
(Source: Leukemia Research)
Source: Leukemia Research - November 1, 2017 Category: Hematology Authors: Victoria R. Nachar, Anthony J. Perissinotti, Gianni B. Scappaticci, Dale L. Bixby, Bernard L. Marini Tags: Research paper Source Type: research

Dicer1 gene and mirna dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - October 30, 2017 Category: Hematology Authors: Hakan Ozdogan, Bala Gur Dedeoglu, Yasemin Oztemur Islakoglu, Alp Aydos, Sevil Kose, Arzu Atalay, Zeynep Arzu Yegin, Ferit Avcu, Duygu Uckan Cetinkaya, Osman Ilhan Tags: Research paper Source Type: research

JAK2V617F Detection and Allele Burden Measurement in Saliva vs. Peripheral Blood in Patients with Myelofibrosis
(Source: Leukemia Research)
Source: Leukemia Research - October 30, 2017 Category: Hematology Authors: Paolo Strati, Christopher B Benton, Taghi Manshouri, Ying Zhang, Joseph E. Bove, Gabriela Sanchez-Petitto, Srdan Verstovsek Tags: Research paper Source Type: research

Therapeutic Options for Leukemic Transformation in Patients with Myeloproliferative Neoplasms
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Maliha Khan, Rabbia Siddiqi, Naseema Gangat Source Type: research

High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by wt1 gene expression in aml transplanted in cytologic complete remission.
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Anna Candoni, Federico De Marchi, Maria Elena Zannier, Davide Lazzarotto, Carla Fil ì, Maria Vittoria Dubbini, Nicholas Rabassi, Eleonora Toffoletti, Bonnie W. Lau, Renato Fanin Tags: Research paper Source Type: research

Clinical and biological significance of isolated Y chromosome loss in myelodysplastic syndromes and chronic myelomonocytic leukemia. A report from the Spanish MDS Group
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Meritxell Nomdedeu, Arturo Pereira, Xavier Calvo, Joan Colomer, Francesc Sole, Amparo Arias, Candida Gomez, Elisa Lu ño, Jose Cervera, Montserrat Arnan, Helena Pomares, Fernando Ramos, Itziar Oiartzabal, Blanca Espinet, Carme Pedro, Beatriz Arrizabalaga, Tags: Research paper Source Type: research

Towards repositioning of quinacrine for treatment of acute myeloid leukemia − promising synergies and in vivo effects
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Anna Eriksson, Efthymia Chantzi, M årten Fryknäs, Joachim Gullbo, Peter Nygren, Mats Gustafsson, Martin Höglund, Rolf Larsson Tags: Research paper Source Type: research

Impact of baseline cytogenetic findings and cytogenetic response on outcome of high-risk myelodysplastic syndromes and low blast count AML treated with Azacitidine
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Marie S ébert, Rami S Komrokji, Mikkael A. Sekeres, Thomas Prebet, Thomas Cluzeau, Valeria Santini, Emmanuel Gyan, Alessandro Sanna, Najla HAl Ali, Sean Hobson, Virginie Eclache, Alan List, Pierre Fenaux, Lionel Adès Tags: Research paper Source Type: research

Distinct EphB4-mediated mechanisms of apoptotic and resistance to dasatinib in human chronic myeloid leukemia and K562 cell lines
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Wei-Hong Zhao, Bin-Tao Huang, Jian-Yu Zhang, Qing-Chun Zeng Tags: Research paper Source Type: research

Nucleostemin silencing induces differentiation and potentiates all-trans-retinoic acid effects in human acute promyelocytic leukemia NB4 cells via autophagy
(Source: Leukemia Research)
Source: Leukemia Research - October 26, 2017 Category: Hematology Authors: Aila Fakhimahmadi, Farinaz Nazmi, Marveh Rahmati, Nazila Moghtaran Bonab, Mehrdad Hashemi, Mohammad Amin Moosavi Tags: Research paper Source Type: research

Differential T cell subsets and cytokine profile between steady-state and G-CSF-primed bone marrow and its association with graft-versus-host disease
(Source: Leukemia Research)
Source: Leukemia Research - October 26, 2017 Category: Hematology Authors: Eucario Le ón-Rodríguez, Monica M. Rivera-Franco, Diana Gómez-Martín, Jorge Romo-Tena, Guillermo Juárez-Vega, Javier Merayo-Chalico, Jorge Alcocer-Varela Tags: Research paper Source Type: research

In vitro Studies on the role of recombinant human soluble thrombomodulin in the context of retinoic acid mediated APL differentiation Syndrome
(Source: Leukemia Research)
Source: Leukemia Research - October 18, 2017 Category: Hematology Authors: Shinsuke Kojima, Chie Nishioka, SungGi Chi, Akihito Yokoyama, Takayuki Ikezoe Tags: Research paper Source Type: research

CD41 immune staining of micromegakaryocytes improves the diagnosis of myelodysplastic syndrome and differentiation from pancytopenia
(Source: Leukemia Research)
Source: Leukemia Research - October 18, 2017 Category: Hematology Authors: Jinjin Huang, Zhiqiong Wang, Lifang Huang, Miao Zheng Tags: Research paper Source Type: research

Relationship between lenalidomide dose modification, duration of therapy, and long-term outcomes in patients with myelodysplastic syndromes
(Source: Leukemia Research)
Source: Leukemia Research - October 18, 2017 Category: Hematology Authors: Amy E. DeZern, Gary Binder, Quanhong Ni, Michael McGuire, B. Douglas Smith Tags: Research paper Source Type: research

Symptom burden profile in myelofibrosis patients with thrombocytopenia: lessons and unmet needs
(Source: Leukemia Research)
Source: Leukemia Research - October 13, 2017 Category: Hematology Authors: Allison H. Scotch, Heidi Kosiorek, Robyn Scherber, Amylou C. Dueck, Stefanie Slot, Sonja Zweegman, Peter A.W.te Boekhorst, Suzan Commandeur, Harry Schouten, Federico Sackmann, Ana Kerguelen Fuentes, Dolores Hern ández-Maraver, Heike L. Pahl, Martin Gries Tags: Research paper Source Type: research

Artesunate induces apoptosis via inhibition of STAT3 in THP-1 cells
(Source: Leukemia Research)
Source: Leukemia Research - October 6, 2017 Category: Hematology Authors: Mei Tan, Ying Rong, Qiong Su, Yan Chen Tags: Research paper Source Type: research

Unraveling the mechanisms behind iron overload and ineffective hematopoiesis in myelodysplastic syndromes
(Source: Leukemia Research)
Source: Leukemia Research - October 6, 2017 Category: Hematology Authors: Emanuele Angelucci, Paolo Cianciulli, Carlo Finelli, Cristina Mecucci, Maria Teresa Voso, Sante Tura Tags: Review Article Source Type: research

Welcome Address
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Hematology Specialist Association
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Congress Organization Committee
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Scientific Program
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Speaker Biographies
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Speaker Presentations
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Oral Presentations
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Poster Presentations
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Author index
(Source: Leukemia Research)
Source: Leukemia Research - October 1, 2017 Category: Hematology Source Type: research

Editorial board and publication information
(Source: Leukemia Research)
Source: Leukemia Research - September 30, 2017 Category: Hematology Source Type: research

Maintenance of cellular respiration indicates drug resistance in acute myeloid leukemia
(Source: Leukemia Research)
Source: Leukemia Research - September 28, 2017 Category: Hematology Authors: Katharina Henkenius, Brandon H Greene, Christina Barckhausen, Raimo Hartmann, Melanie M ärken, Tom Kaiser, Miriam Rehberger, Stephan K Metzelder, Wolfgang J Parak, Andreas Neubauer, Cornelia Brendel, Elisabeth Mack Tags: Research paper Source Type: research

Outcomes and Changes in Code Status of Patients with Acute Myeloid Leukemia Undergoing Induction Chemotherapy who were Transferred to the Intensive Care Unit
(Source: Leukemia Research)
Source: Leukemia Research - September 26, 2017 Category: Hematology Authors: Tamjeed Ahmed, Abby L. Koch, Scott Isom, Heidi D. Klepin, Jonathan M. Bishop, Leslie R. Ellis, Dmitriy Berenzon, Dianna Howard, Susan Lyerly, Bayard L. Powell, Timothy S. Pardee Tags: Research paper Source Type: research

Emerging Role of NUDT15 Polymorphisms in 6-Mercaptopurine Metabolism and Dose Related Toxicity in Acute Lymphoblastic Leukaemia
Despite more than 80% long term survival in ALL, morbidity due to drug related myelotoxicity remains high. Germline variants of thiopurine metabolizing enzymes (TPMT and ITPA) have been described which are associated with increased drug toxicity during maintenance phase, but their prevalence in different ethnic groups is variable to account for relatively high myelotoxicity incidence. NUDT15 variant (rs116855232) has been recently identified as a novel polymorphism related with thiopurine-induced leucopenia in inflammatory bowel disease and ALL. (Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: Minu Singh, Prateek Bhatia, Sanjeev Khera, Amita Trehan Tags: Review Article Source Type: research

Low Protein Z levels in Patients with Plasma Cell Neoplasms are inversely correlated with IL-6 levels
(Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: O. Gutwein, N. Rahimi-Levene, K. Herzog-Tzarfati, O. Garach-Jehoshua, A. Nagler, M. Izak, M. Koren-Michowitz Tags: Research paper Source Type: research

Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo
(Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: C éline Bouvy, Adeline Wannez, Julie Laloy, Christian Chatelain, Jean-Michel Dogné Tags: Research paper Source Type: research

Effect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells
(Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: Yiqun Huang, Yong Zou, Luhui Lin, Xudong Ma, Xiaohong Huang Tags: Research paper Source Type: research

Efficacy and safety of G-CSF, low-dose cytarabine and aclarubicin in combination with l-asparaginase, prednisone in the treatment of refractory or relapsed acute lymphoblastic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: Keshu Zhou, Yongping Song, Yanli Zhang, Xudong Wei, Yuewen Fu, Fengkuan Yu, Hu Zhou, Xinjian Liu, Jian Zhou, Baijun Fang Tags: Research paper Source Type: research

Early Reduction of serum TARC Levels may predict for success of ABVD as frontline treatment in patients with Hodgkin Lymphoma
Early reduction of TARC serum levels can predict success of treatment, being associated with achievement of interim PET-2 negative and favorable long-term outcome in HL patients receiving ABVD as front-line therapy. (Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: A. Guidetti, A. Mazzocchi, R. Miceli, E. Paterno ’, F. Taverna, F. Spina, F. Crippa, L. Farina, P. Corradini, A.M. Gianni, S. Viviani Tags: Research paper Source Type: research

Low-dose lenalidomide plus cytarabine in very elderly, unfit acute myeloid leukemia patients: final result of a phase ii study.
(Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: Giuseppe Visani, Felicetto Ferrara, Francesco Di Raimondo, Federica Loscocco, Fabio Fuligni, Stefania Paolini, Valentina Zammit, Eleonora Spina, Marco Rocchi, Axel Visani, Pier Paolo Piccaluga, Alessandro Isidori Tags: Research paper Source Type: research

Bortezomib in plasmablastic lymphoma: a glimpse of hope for a hard-to-treat disease
(Source: Leukemia Research)
Source: Leukemia Research - September 25, 2017 Category: Hematology Authors: Thomas A. Guerrero-Garcia, Renzo J. Mogollon, Jorge J. Castillo Tags: Invited review Source Type: research

ABO Identical and Washed Blood Transfusions as Candidate Strategies to Reduce Early Mortality in Acute Promyelocytic Leukemia
Despite dramatically improved long term outcomes seen with all-trans retinoic acid therapy, and now arsenic trioxide, in acute promyelocytic leukemia (APL), early mortality remains a substantial challenge. Recent data from a single center study and the Surveillance, Ep  idemiology and End Results (SEER) registry report 30day mortality rates of 26% (n=18 of 70) and 17% (n=238 of 1400), respectively. Early deaths are predominately due to hemorrhage. Patients with APL invariably have abnormal laboratory hemostasis tests. (Source: Leukemia Research)
Source: Leukemia Research - September 23, 2017 Category: Hematology Authors: Tanmay Sahai, Kelly Henrichs, Majed Refaai, Joanna M. Heal, Scott A. Kirkley, Amy E. Schmidt, Jason H. Mendler, Debra Masel, Jane Liesveld, Christopher Aquina, Neil Blumberg Tags: Meeting report Source Type: research

Genetic variations of bone marrow mesenchymal stromal cells derived from acute leukemia and myelodysplastic syndrome by targeted deep sequencing
(Source: Leukemia Research)
Source: Leukemia Research - September 20, 2017 Category: Hematology Authors: Kenko Azuma, Tomohiro Umezu, Satoshi Imanishi, Michiyo Asano, Seiichiro Yoshizawa, Seiichiro Katagiri, Kazuma Ohyashiki, Junko H. Ohyashiki Tags: Research paper Source Type: research

Randomized Phase II Trial of Cytosine Arabinoside with and without the CHK1 inhibitor MK-8776 in Relapsed and Refractory Acute Myeloid Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - September 19, 2017 Category: Hematology Authors: Jonathan A. Webster, Raoul Tibes, Larry Morris, Amanda L. Blackford, Mark Litzow, Mrinal Patnaik, Gary L. Rosner, Ivana Gojo, Robert Kinders, Lihua Wang, L. Austin Doyle, Catherine J. Huntoon, Larry M. Karnitz, Scott H. Kaufmann, Judith E. Karp, B. Dougla Tags: Research paper Source Type: research