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Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response —The final results of the D-first study
(Source: Leukemia Research)
Source: Leukemia Research - January 19, 2018 Category: Hematology Authors: Yuho Najima, Chikashi Yoshida, Noriyoshi Iriyama, Shin Fujisawa, Hisashi Wakita, Shigeru Chiba, Shinichiro Okamoto, Kimihiro Kawakami, Naoki Takezako, Takashi Kumagai, Kazuma Ohyashiki, Jun Taguchi, Shingo Yano, Tadahiko Igarashi, Yasuji Kouzai, Satoshi M Tags: Research paper Source Type: research

Prognostic analysis according to the 2017 ELN risk  stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study
(Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Yasuhiko Harada, Yasunobu Nagata, Rika Kihara, Yuichi Ishikawa, Norio Asou, Shigeki Ohtake, Shuichi Miyawaki, Toru Sakura, Yukiyasu Ozawa, Noriko Usui, Heiwa Kanamori, Yoshikazu Ito, Kiyotoshi Imai, Youko Suehiro, Shinichi Kobayashi, Kunio Kitamura, Emiko Tags: Research paper Source Type: research

Targeting the IL-17/IL-6 axis can alter growth of Chronic Lymphocytic Leukemia in vivo/in vitro
(Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Fang Zhu, Lindsay McCaw, David E. Spaner, Reginald M. Gorczynski Tags: Research paper Source Type: research

New synergistic combinations of differentiation-inducing agents in the treatment of acute promyelocytic leukemia cells
(Source: Leukemia Research)
Source: Leukemia Research - January 15, 2018 Category: Hematology Authors: Amir Amanzadeh, Vahid Molla-kazemiha, Saeed Samani, Mahdi Habibi-Anbouhi, Kayhan Azadmanesh, Mohsen Abolhassani, Mohammad Ali Shokrgozar Tags: Research paper Source Type: research

Expression of autophagy related genes in chronic lymphocytic leukemia is associated with disease course
Chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world, accounts for ∼40% of all adult leukemia. Though the pathogenesis of CLL is not entirely clear, accumulation of monoclonal CD5+/CD19+/CD23+ B lymphocytes is indicated mainly resulted from failure to undergo apoptosis rather than excessive proliferation [1]. There are a considerable number of patients with CLL w ho do not need treatment until treatment indications are present, while a proportion of patients have aggressive disease progression, which fully reflects the high degree of prognosis heterogeneity of CLL. (Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Yi-Lin Kong, Ying Huang, Jia-Zhu Wu, Xin Cao, Jin-Hua Liang, Yi Xia, Wei Wu, Lei Cao, Hua-Yuan Zhu, Li Wang, Lei Fan, Jian-Yong Li, Wei Xu Tags: Research paper Source Type: research

Pegaspargase-related high-grade hepatotoxicity in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not predict recurrent hepatotoxicity with subsequent doses
(Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Patrick W. Burke, Ibrahim Aldoss, Matthew A. Lunning, Sean M. Devlin, Martin S. Tallman, Vinod Pullarkat, Ann M. Mohrbacher, Dan Douer Tags: Research paper Source Type: research

NM23 downregulation and lysophosphatidic acid receptor EDG2/lpa1 upregulation during myeloid differentiation of human leukemia cells
A common mechanism for inhibition of leukemia cell myeloid differentiation and breast cancer cell motility involving NM23 and EDG2. (Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Junko Okabe-Kado, Yuki Hagiwara-Watanabe, Nozomi Niitsu, Takashi Kasukabe, Yasuhiko Kaneko Tags: Research paper Source Type: research

Therapeutic effects of tyrosine kinase inhibitors and subtypes of BCR-ABL1 transcripts in Japanese chronic myeloid leukemia patients with three-way chromosomal translocations
(Source: Leukemia Research)
Source: Leukemia Research - January 3, 2018 Category: Hematology Authors: Koiti Inokuchi, Kazutaka Nakayama, Tetsuzo Tauchi, Tomoiku Takaku, Norio Yokose, Hiroki Yamaguchi, Takashi Kumagai, Norio Komatsu, Kazuma Ohyashiki Tags: Research paper Source Type: research

Quantitative assessment of jak2 v617f and calr mutations in philadelphia negative myeloproliferative neoplasms
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Ambrus G ángó, Réka Mózes, Zsófia Boha, Béla Kajtár, Botond Timár, Péter Attila Király, Richárd Kiss, Viktória Fésüs, Noémi Nagy, Judit Demeter, Gábor Körösmezey, Zita Borbényi, Imelda Marton, Anita Szőke, Tamás Masszi, Péter Farkas, Tags: Research paper Source Type: research

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Rena Kamijo, Hidehiro Itonaga, Rika Kihara, Yasunobu Nagata, Tomoko Hata, Norio Asou, Shigeki Ohtake, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Tomoki Naoe, Hitoshi Kiyoi, Yasushi Miyazaki Tags: Research paper Source Type: research

Perforin gene variation influences survival in childhood acute lymphoblastic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Aleksandra Jaworowska, Agata Pastorczak, Joanna Trelinska, Kamila Wypyszczak, Maciej Borowiec, Wojciech Fendler, Lukasz Sedek, Tomasz Szczepanski, Rafal Ploski, Wojciech M łynarski Tags: Research paper Source Type: research

Acute and Sub-acute Neurological toxicity in children treated for acute lymphoblastic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Natalia C. Millan, Anal ía Pastrana, Myriam R. Guitter, Pedro A. Zubizarreta, María S. Monges, María S. Felice Source Type: research

Disease characteristics and clinical outcomes in patients aged less than 40 with chronic lymphocytic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Bartlomiej M. Getta, Sean Devlin, Jae H. Park, Martin S. Tallman, Ellin Berman Tags: Research paper Source Type: research

Genotypic and Clinical Heterogeneity Within NCCN Favorable-risk Acute Myeloid Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Stephen A. Strickland, Aaron C. Shaver, Michael Byrne, Robert D. Daber, P. Brent Ferrell, David R. Head, Sanjay R. Mohan, Claudio A. Mosse, Tamara K. Moyo, Thomas P. Stricker, Cindy Vnencak-Jones, Michael R. Savona, Adam C. Seegmiller Tags: Research paper Source Type: research

The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Huihui Zhao, Huayuan Zhu, Jiayu Huang, Yu Zhu, Ming Hong, Han Zhu, Jingjing Zhang, Shan Li, Lijia Yang, Yun Lian, Shuai Wang, Jianping Mao, Yaoyu Chen, Jianyong Li, Sixuan Qian Tags: Research paper Source Type: research

Comparative study of porcine anti-human lymphocyte immunoglobulin and rabbit anti-human thymocyte immunoglobulin as a first-line treatment of acquired severe aplastic anemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Miao Chen, Chao Liu, Xinhui Qiao, Daobin Zhou, Junling Zhuang, Bing Han Tags: Research paper Source Type: research

Leukemia cells impair normal hematopoiesis and induce functionally loss of hematopoietic stem cells through immune cells and inflammation
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Ping Cui, Yuhua Zhang, Maoxiang Cui, Zhihong Li, Guang Ma, Rufeng Wang, Ning Wang, Shujuan Huang, Jie Gao Tags: Research paper Source Type: research

Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - January 2, 2018 Category: Hematology Authors: Shu-mei Wang, Wei-xin Zeng, Wan-shui Wu, Lu-lu Sun, Dan Yan Tags: Research paper Source Type: research

Editorial Board
(Source: Leukemia Research)
Source: Leukemia Research - January 1, 2018 Category: Hematology Source Type: research

3q26/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: An early event associated with a poor prognosis
(Source: Leukemia Research)
Source: Leukemia Research - December 22, 2017 Category: Hematology Authors: Zhihong Hu, Shimin Hu, Changsheng Ji, Zhenya Tang, Beenu Thakral, Sanam Loghavi, L.Jeffrey Medeiros, Wei Wang Tags: Research paper Source Type: research

Abnormal CD25 expression on hematopoietic cells in myelodysplastic syndromes
(Source: Leukemia Research)
Source: Leukemia Research - December 15, 2017 Category: Hematology Authors: Pei Liu, Huijuan Jiang, Mengting Che, Rong Fu, Huaquan Wang, Lijuan Li, Wei Zhang, Jinglian Tao, Shan Gao, Zonghong Shao Tags: Research paper Source Type: research

Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric AML
(Source: Leukemia Research)
Source: Leukemia Research - December 8, 2017 Category: Hematology Authors: Di Zhan, Yingchi Zhang, Peifang Xiao, Xinchang Zheng, Min Ruan, Jingliao Zhang, Aili Chen, Yao Zou, Yumei Chen, Gang Huang, Shaoyan Hu, Qian-fei Wang, Xiaofan Zhu Tags: Letter to the Editor Source Type: research

Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - December 5, 2017 Category: Hematology Authors: A.H. Cull, D. Mahendru, B. Snetsinger, D. Good, K. Tyryshkin, A. Chesney, Z. Ghorab, M. Reis, R. Buckstein, R.A. Wells, M.J. Rauh Tags: Research paper Source Type: research

Myelodysplastic syndromes without peripheral monocytosis but with evidence of marrow monocytosis share clinical and molecular characteristics with CMML
(Source: Leukemia Research)
Source: Leukemia Research - December 1, 2017 Category: Hematology Authors: E. Schuler, F. Frank, B. Hildebrandt, B. Betz, C. Strupp, M. Rudelius, C. Aul, T. Schroeder, N. Gattermann, R. Haas, U. Germing Tags: Research paper Source Type: research

Prognostic importance of Aurora Kinases and mitotic spindle genes transcript levels in Myelodysplastic Syndrome
(Source: Leukemia Research)
Source: Leukemia Research - November 27, 2017 Category: Hematology Authors: Daniela de Paula Borges, Ant ônio Wesley Araújo dos Santos, Carlos Roberto Koscky Paier, Howard Lopes Ribeiro, Marília Braga Costa, Izabelle Rocha Farias, Roberta Taiane Germano de Oliveira, Ivo Gabriel da Frota França, Gabrielle Melo Cavalcante, Síl Tags: Research paper Source Type: research

Editorial board and publication information
(Source: Leukemia Research)
Source: Leukemia Research - November 23, 2017 Category: Hematology Source Type: research

Extracellular Vesicles in Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 22, 2017 Category: Hematology Authors: Alejandro Pando, John L. Reagan, Peter Quesenberry, Loren D. Fast Tags: Invited review Source Type: research

Therapeutic drug monitoring of ponatinib using a simple high-performance liquid chromatography method in Japanese patients
(Source: Leukemia Research)
Source: Leukemia Research - November 22, 2017 Category: Hematology Authors: Maiko Abumiya, Masatomo Miura, Naoto Takahashi Tags: Research paper Source Type: research

The Impact of Oral Arsenic and All-Trans-Retinoic Acid on Coagulopathy in Acute Promyelocytic Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 15, 2017 Category: Hematology Authors: Hong-Hu Zhu, Zhi-Ping Guo, Jin-Song Jia, Qian Jiang, Hao Jiang, Xiao-Jun Huang Tags: Research paper Source Type: research

Iron chelation therapy in lower IPSS risk myelodysplastic syndromes; which subtypes benefit?
(Source: Leukemia Research)
Source: Leukemia Research - November 11, 2017 Category: Hematology Authors: Shannon A. Wong, Heather A. Leitch Tags: Research paper Source Type: research

Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Tamara B. Garcia, Susan P. Fosmire, Christopher C. Porter Tags: Research paper Source Type: research

A Phase 1/2 Study of Rigosertib in Patients with Myelodysplastic Syndromes (MDS) and MDS Progressed to Acute Myeloid Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Shyamala C. Navada, Steven M. Fruchtman, Rosalie Odchimar-Reissig, Erin P. Demakos, Michael E. Petrone, Patrick S. Zbyszewski, James F. Holland, Lewis R. Silverman Tags: Research paper Source Type: research

Chk1 inhibitors overcome imatinib resistance in chronic myeloid leukemia cells
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Hu Lei, Jin Jin, Meng Liu, Xiangyun Li, Hao Luo, Li Yang, Hanzhang Xu, Yingli Wu Tags: Research paper Source Type: research

Ex-vivo Sensitivity Profiling to Guide Clinical Decision Making in Acute Myeloid Leukemia: A Pilot Study
(Source: Leukemia Research)
Source: Leukemia Research - November 10, 2017 Category: Hematology Authors: Ronan T. Swords, Diana Azzam, Hassan Al-Ali, Ines Lohse, Claude-Henry Volmar, Justin M. Watts, Aymee Perez, Ana Rodriguez, Fernando Vargas, Roy Elias, Francisco Vega, Arthur Zelent, Shaun P. Brothers, Taher Abbasi, Jonathan Trent, Shaukat Rangwala, Yehuda Tags: Research paper Source Type: research

Altered EZH2 Splicing and Expression is Associated with Impaired Histone H3 Lysine 27 Tri-Methylation in Myelodysplastic Syndrome
(Source: Leukemia Research)
Source: Leukemia Research - November 4, 2017 Category: Hematology Authors: Mizuho Shirahata-Adachi, Chisako Iriyama, Akihiro Tomita, Yasuhiro Suzuki, Kazuyuki Shimada, Hitoshi Kiyoi Tags: Research paper Source Type: research

Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma
(Source: Leukemia Research)
Source: Leukemia Research - November 2, 2017 Category: Hematology Authors: Pingyi Liu, Lingling Chen Tags: Research paper Source Type: research

Frondoside A Potentiates the Effects of Conventional Therapeutic Agents in Acute Leukemia
(Source: Leukemia Research)
Source: Leukemia Research - November 2, 2017 Category: Hematology Authors: F.H. Sajwani, P. Collin, T.E. Adrian Tags: Research paper Source Type: research

Editorial board and publication information
(Source: Leukemia Research)
Source: Leukemia Research - November 1, 2017 Category: Hematology Source Type: research

Predictors for Requiring Re-induction Chemotherapy in Acute Myeloid Leukemia Patients with Residual Disease on Day 14 Bone Marrow Assessment
(Source: Leukemia Research)
Source: Leukemia Research - November 1, 2017 Category: Hematology Authors: Victoria R. Nachar, Anthony J. Perissinotti, Gianni B. Scappaticci, Dale L. Bixby, Bernard L. Marini Tags: Research paper Source Type: research

Dicer1 gene and mirna dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia
(Source: Leukemia Research)
Source: Leukemia Research - October 30, 2017 Category: Hematology Authors: Hakan Ozdogan, Bala Gur Dedeoglu, Yasemin Oztemur Islakoglu, Alp Aydos, Sevil Kose, Arzu Atalay, Zeynep Arzu Yegin, Ferit Avcu, Duygu Uckan Cetinkaya, Osman Ilhan Tags: Research paper Source Type: research

JAK2V617F Detection and Allele Burden Measurement in Saliva vs. Peripheral Blood in Patients with Myelofibrosis
(Source: Leukemia Research)
Source: Leukemia Research - October 30, 2017 Category: Hematology Authors: Paolo Strati, Christopher B Benton, Taghi Manshouri, Ying Zhang, Joseph E. Bove, Gabriela Sanchez-Petitto, Srdan Verstovsek Tags: Research paper Source Type: research

Towards repositioning of quinacrine for treatment of acute myeloid leukemia – Promising synergies and in vivo effects
Despite the recent advances in understanding the pathophysiology of acute myeloid leukemia (AML), the prognosis remains fatal for the majority of patients [1]. As of today, conventional AML treatment range from intensive chemotherapy, sometimes followed by hematopoietic stem cell transplantation, to hypomethylating agents or palliative treatment strategies. New treatment options and modalities are highly warranted. (Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Anna Eriksson, Efthymia Chantzi, M årten Fryknäs, Joachim Gullbo, Peter Nygren, Mats Gustafsson, Martin Höglund, Rolf Larsson Tags: Research paper Source Type: research

Therapeutic Options for Leukemic Transformation in Patients with Myeloproliferative Neoplasms
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Maliha Khan, Rabbia Siddiqi, Naseema Gangat Source Type: research

High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by wt1 gene expression in aml transplanted in cytologic complete remission.
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Anna Candoni, Federico De Marchi, Maria Elena Zannier, Davide Lazzarotto, Carla Fil ì, Maria Vittoria Dubbini, Nicholas Rabassi, Eleonora Toffoletti, Bonnie W. Lau, Renato Fanin Tags: Research paper Source Type: research

Clinical and biological significance of isolated Y chromosome loss in myelodysplastic syndromes and chronic myelomonocytic leukemia. A report from the Spanish MDS Group
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Meritxell Nomdedeu, Arturo Pereira, Xavier Calvo, Joan Colomer, Francesc Sole, Amparo Arias, Candida Gomez, Elisa Lu ño, Jose Cervera, Montserrat Arnan, Helena Pomares, Fernando Ramos, Itziar Oiartzabal, Blanca Espinet, Carme Pedro, Beatriz Arrizabalaga, Tags: Research paper Source Type: research

Towards repositioning of quinacrine for treatment of acute myeloid leukemia − promising synergies and in vivo effects
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Anna Eriksson, Efthymia Chantzi, M årten Fryknäs, Joachim Gullbo, Peter Nygren, Mats Gustafsson, Martin Höglund, Rolf Larsson Tags: Research paper Source Type: research

Impact of baseline cytogenetic findings and cytogenetic response on outcome of high-risk myelodysplastic syndromes and low blast count AML treated with Azacitidine
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Marie S ébert, Rami S Komrokji, Mikkael A. Sekeres, Thomas Prebet, Thomas Cluzeau, Valeria Santini, Emmanuel Gyan, Alessandro Sanna, Najla HAl Ali, Sean Hobson, Virginie Eclache, Alan List, Pierre Fenaux, Lionel Adès Tags: Research paper Source Type: research

Distinct EphB4-mediated mechanisms of apoptotic and resistance to dasatinib in human chronic myeloid leukemia and K562 cell lines
(Source: Leukemia Research)
Source: Leukemia Research - October 27, 2017 Category: Hematology Authors: Wei-Hong Zhao, Bin-Tao Huang, Jian-Yu Zhang, Qing-Chun Zeng Tags: Research paper Source Type: research

Nucleostemin silencing induces differentiation and potentiates all-trans-retinoic acid effects in human acute promyelocytic leukemia NB4 cells via autophagy
(Source: Leukemia Research)
Source: Leukemia Research - October 26, 2017 Category: Hematology Authors: Aila Fakhimahmadi, Farinaz Nazmi, Marveh Rahmati, Nazila Moghtaran Bonab, Mehrdad Hashemi, Mohammad Amin Moosavi Tags: Research paper Source Type: research

Differential T cell subsets and cytokine profile between steady-state and G-CSF-primed bone marrow and its association with graft-versus-host disease
(Source: Leukemia Research)
Source: Leukemia Research - October 26, 2017 Category: Hematology Authors: Eucario Le ón-Rodríguez, Monica M. Rivera-Franco, Diana Gómez-Martín, Jorge Romo-Tena, Guillermo Juárez-Vega, Javier Merayo-Chalico, Jorge Alcocer-Varela Tags: Research paper Source Type: research