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Cancer: Acute Leukemia
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Total 260 results found since Jan 2013.
Dual Targeting of Anti-Apoptotic Proteins Enhances Chemosensitivity of the Acute Myeloid Leukemia Cells
CONCLUSIONS: Our investigation suggests that suppression of Mcl-1 and survivin by siRNA can effectually inhibit cell growth and overcome chemoresistance of AML cells. Therefore siRNAs may be an important adjuvant in chemotherapy for AML patients.PMID:35901361 | DOI:10.31557/APJCP.2022.23.7.2523
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2022 Category: Cancer & Oncology Authors: Behzad Baradaran Roya Nazmabadi Zohreh Ariyan Ebrahim Sakhinia Hadi Karami Source Type: research
Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia
CONCLUSIONS: Overall, the current findings demonstrate that EVI-1 overexpression converges on the regulation of miR-124 promoter methylation and activation of the RAS/ERK pathway in AML carcinogenesis, and suggest EVI-1 and/or miR-124 as therapeutic targets for this dismal disease.PMID:35835333 | DOI:10.1016/j.cellsig.2022.110402
Source: Cellular Signalling - July 14, 2022 Category: Cytology Authors: Wenjing Lang Xiaofeng Han Jiayi Cai Fangyuan Chen Lan Xu Hua Zhong Jihua Zhong Source Type: research
