Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia

CONCLUSIONS: Overall, the current findings demonstrate that EVI-1 overexpression converges on the regulation of miR-124 promoter methylation and activation of the RAS/ERK pathway in AML carcinogenesis, and suggest EVI-1 and/or miR-124 as therapeutic targets for this dismal disease.PMID:35835333 | DOI:10.1016/j.cellsig.2022.110402

Source: Cellular Signalling - July 14, 2022 Category: Cytology Authors: Wenjing Lang Xiaofeng Han Jiayi Cai Fangyuan Chen Lan Xu Hua Zhong Jihua Zhong Source Type: research