Dual Targeting of Anti-Apoptotic Proteins Enhances Chemosensitivity of the Acute Myeloid Leukemia Cells

CONCLUSIONS: Our investigation suggests that suppression of Mcl-1 and survivin by siRNA can effectually inhibit cell growth and overcome chemoresistance of AML cells. Therefore siRNAs may be an important adjuvant in chemotherapy for AML patients.PMID:35901361 | DOI:10.31557/APJCP.2022.23.7.2523

Source: Asian Pacific Journal of Cancer Prevention - July 28, 2022 Category: Cancer & Oncology Authors: Behzad Baradaran Roya Nazmabadi Zohreh Ariyan Ebrahim Sakhinia Hadi Karami Source Type: research