L-Tetrahydropalmatine Induces Apoptosis in EU-4 Leukemia cells by Down-Regulating X-linked inhibitor of apoptosis protein and increases the sensitivity towards Doxorubicin.

CONCLUSION: Findings of the study confirm that L-THP resulted in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP caused activation of caspase and resulted in apoptosis, L-THP may be a novel molecule for inducing apoptosis specifically in p53 null leukemia EU-4 cells. PMID: 28721806 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28721806?dopt=Abstract

Source: Current Molecular Medicine - July 18, 2017 Category: Molecular Biology Authors: Li S, Chen D, Pei R, Lu Y, Zhang P, Ma J, Liu X, Du X, Sha K, Chen L, Cao J, Zhuang X, Wu J, Li L, Fan Z, Ye P, Tang S, Zhang B, Shi X, Li K Tags: Curr Mol Med Source Type: research