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Cancer: Cancer in Adolescents

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Total 20 results found since Jan 2013.

ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling
Am J Cancer Res. 2023 Aug 15;13(8):3547-3558. eCollection 2023.ABSTRACTSarcomas constitute a heterogeneous group of mesenchymal cancers and are particularly common in children and adolescents, leading to significant lethality. Therefore, it is necessary to understand the underlying mechanisms by which genetic alterations promote sarcoma progression. Here, we demonstrate that loss-of-function of ATRX, a member of the SWI/SNF DNA-remodeling family, represses the interferon (IFN)-β response by inducing chromatin remodeling in sarcoma cells. We show that ATRX mutations are associated with worse prognosis and attenuate IFN-α/...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Xinrui Wang Zige Jin Shanshan Tang Xiyu Huang Shanshan Wang Xiaohe Ren Mafei Xu Source Type: research

Synergistic treatment of osteosarcoma with biomimetic nanoparticles transporting doxorubicin and siRNA
ConclusionDOX/siSUR-PLGA@MSCM NPs can show improved therapeutic effects in osteosarcoma patients due to the combination of a chemotherapeutic drug and gene therapy based on their good tumor targeting and biosafety.
Source: Frontiers in Oncology - January 23, 2023 Category: Cancer & Oncology Source Type: research

Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression
ConclusionOur results suggest that MDR1 is an attractive therapeutic target for chemoresistant OS. Tumor-specific virotherapy is thus a promising strategy for reversing chemoresistance in OS patients via suppression of MDR1 expression.
Source: Cancer Chemotherapy and Pharmacology - June 10, 2021 Category: Cancer & Oncology Source Type: research

Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter
CONCLUSION: knockdown of 91 H suppressed the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter in vitro and in vivo. Thus, 91 H may serve as a new target for the treatment of osteosarcoma.PMID:33499776 | PMC:PMC7844445 | DOI:10.1177/1533033821990006
Source: Technology in Cancer Research and Treatment - January 27, 2021 Category: Cancer & Oncology Authors: Suoli Cheng Jianping Zheng Xueqin Liu Jiandang Shi Fan Gong Xu Zhang Changhao Liu Cuiyun Liu Source Type: research

Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter.
CONCLUSION: knockdown of 91 H suppressed the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter in vitro and in vivo. Thus, 91 H may serve as a new target for the treatment of osteosarcoma. PMID: 33499776 [PubMed - in process]
Source: Technology in Cancer Research and Treatment - January 1, 2021 Category: Cancer & Oncology Authors: Cheng S, Zheng J, Liu X, Shi J, Gong F, Zhang X, Liu C, Liu C Tags: Technol Cancer Res Treat Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2
ConclusionOverall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment.
Source: Biomedicine and Pharmacotherapy - February 9, 2020 Category: Drugs & Pharmacology Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
CONCLUSION: Overall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment. PMID: 32044716 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 6, 2020 Category: Drugs & Pharmacology Authors: Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J Tags: Biomed Pharmacother Source Type: research

Furowanin A Exhibits Anti-proliferative and Pro-apoptotic Activities by Targeting Sphingosine Kinase 1 in Osteosarcoma.
This study is designed to evaluate the efficacy of Fur A against OS. The effect of Fur A on cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. Western blotting and quantitative real-time PCR (qRT-PCR) were performed to determine the protein and mRNA level of sphingosine kinase 1 (SphK1), respectively. To validate the role of SphK1 in the pro-apoptotic activity of Fur A, overexpressing SphK1 vector and siRNA targeting SphK1 were utilized to transfect OS cells. Moreover, a OS xenograft murine model was used to analyze the therapeutic efficacy of Fur A in vivo. Fur A treatment led to a dose-dependent decrease i...
Source: Anatomical Record - June 13, 2019 Category: Anatomy Authors: Wei K, Sun H, Chen X, Chen Q, Li Y, Wu H Tags: Anat Rec (Hoboken) Source Type: research

CBX2 is a functional target of miRNA let ‐7a and acts as a tumor promoter in osteosarcoma
Our study demonstrates that let ‐7a/CBX2 plays a crucial role in osteosarcoma progression. CBX2 could serve as a promising prognostic biomarker and potential therapeutic target for osteosarcoma patients. AbstractOsteosarcoma is the most common type of primary malignant tumor of skeletal with poor prognosis in children and adolescents. Accumulating evidence indicates that CBX2 is overexpressed in multiple human neoplasm and play a critical role in tumorigenesis and progression. However, its functional role and upstream regulation mechanism in osteosarcoma remain unknown. In the present study, tissue microarray (TMA) analy...
Source: Cancer Medicine - May 30, 2019 Category: Cancer & Oncology Authors: Qicai Han, Chao Li, Yuan Cao, Jie Bao, Kongfei Li, Ruipeng Song, Xiaolong Chen, Juan Li, Xuejian Wu Tags: ORIGINAL RESEARCH Source Type: research

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing
In conclusion, the method of NK cell transfection described in our present study is highly efficient, does not require expensive dedicated structures necessary for viral transduction and avoids possible risks associated with the use of viral vectors. Importantly, it may be applied to NK cells or NK-92 cell line, greatly improving their anti-tumor activity and providing a new NK cell-based platform for new protocols of adoptive immuno-therapy of cancer. Ethics Statement The Ethical Committee of IRCCS Bambino Gesù Pediatric Hospital approved the study (825/2014). Author Contributions TI designed and performed res...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells
This study is complemented by another report that found that hRSV infection induces significant expression of three miRNAs, namely hsa-miR-4448, hsa-miR-30a-5p, and hsa-miR-4634 in human DCs (104). Interestingly, this latter study also performed comparative analyses of miRNA profiles between DCs infected with hRSV and a related virus, namely the human metapneumovirus, and found that both viruses induced the expression of elevated levels of hsa-miR-4634. Elucidating the contribution of these miRNAs in DCs in response to hRSV remains to be determined. Dendritic Cell Phenotype and Migration Upon hRSV Infection in vivo Altho...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Carboxypeptidase E- ΔN promotes migration, invasion and epithelial-mesenchymal transition of human osteosarcoma cell lines through the Wnt/β-catenin pathway.
In this study, we investigated the effect of CPE-ΔN on cell migration, invasion and epithelial-mesenchymal transition (EMT) of OS cells, and illustrated the molecular mechanisms. We first constructed CPE-ΔN overexpressing human OS cell lines (143B and U2OS cells), and found that ectopic CPE-ΔN expression in OS cells enhanced cellular migratory and invasiveness abilities, and promoted EMT process. Further, overexpression of CPE-ΔN increased c-myc and nuclear β-catenin levels in OS cells, which suggested CPE-ΔN promoted the activation of Wnt/β-catenin pathway in OS cells. Treatment with β-catenin small interfering RN...
Source: Biochemistry and Cell Biology - December 3, 2018 Category: Biochemistry Authors: Fan S, Gao X, Chen P, Li X Tags: Biochem Cell Biol Source Type: research

The role of Chamaejasmine in cellular apoptosis and autophagy in MG-63 cells.
Conclusion：Our results show that chamaejasmine promotes apoptosis and autophagy by activating AMPK /mTOR signaling pathways with involvement of ROS in MG-63 cells. Chamaejasmine is a promising anti-cancer agent in OS treatment and further studies are needed to confirm its efficacy and safety in vivo or other cancer cells. PMID: 30463909 [PubMed - as supplied by publisher]
Source: Bioscience Reports - November 21, 2018 Category: Biomedical Science Authors: Yang D, Zhang H, Wu J, Ma R, Li Z, Wang K, Yang F Tags: Biosci Rep Source Type: research

Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF- κB signal pathway.
Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway. Toxicol Appl Pharmacol. 2018 May 27;: Authors: Ma B, Zhu J, Zhao A, Zhang J, Wang Y, Zhang H, Zhang L, Zhang Q Abstract Osteosarcoma (OS) is the most frequent and high mortality primary bone tumor in the adolescent. And it is well-known for poor prognosis due to high incidence of metastasis. Raddeanin A (RA), an active component of Anemone raddeana Regel, showed potential anti-cancer activities. However, the anti-tumor effect and molecular mechanism(s) of RA o...
Source: Toxicology and Applied Pharmacology - May 27, 2018 Category: Toxicology Authors: Ma B, Zhu J, Zhao A, Zhang J, Wang Y, Zhang H, Zhang L, Zhang Q Tags: Toxicol Appl Pharmacol Source Type: research

Mir-150 Up-Regulates Glut1 and Increases Glycolysis in Osteosarcoma Cells
Conclusion: These data suggest that miR-150 is involved in regulation of glycolysis in osteosarcoma cells by influencing Glut1 expression. PMID: 28547952 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - May 28, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research