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A very unusual case of food allergy, between FPIES and IgE-mediated food allergy.
We describe an unusual case of FPIES to egg in a 21-months-old child, because of its clinical characteristics that reflect some aspects of IgE-mediated allergy and other of non IgE-mediated allergy. Although we believe that the most correct diagnosis for our case is FPIES, we think also that this is undoubtedly an atypical form. This is in fact, the first description of a patient who simultaneously has both clinical expressions of IgE-mediated FA that of FPIES. Our case highlights the need to review criteria for FPIES diagnosis. PMID: 28120606 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - January 27, 2017 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Spontaneous food allergy in Was ‐/‐ mice occurs independent of FcεRI‐mediated mast cell activation
ConclusionsWas‐/‐ mice provide a model of food allergy with the advantage of mimicking polysensitization and low food‐antigen IgE titers as observed in humans with clinical food allergy. This model will facilitate studies on aberrant immune responses during spontaneous disease development. Our results imply that therapeutic targeting of the IgE/FcεRI activation cascade will not affect sensitization to food.This article is protected by copyright. All rights reserved.
Source: Allergy - June 10, 2017 Category: Allergy & Immunology Authors: Willem S. Lexmond, Jeremy A. Goettel, Benjamin F. Sallis, Katelyn McCann, Edmond H. H. M. Rings, Erika Jensen ‐Jarolim, Samuel Nurko, Scott B. Snapper, Edda Fiebiger Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Meat allergy associated with α‐Gal – Closing diagnostic gaps by anti‐α‐Gal IgE immune profiling
ConclusionsDetection of individual sensitization patterns with different α‐Gal‐containing analytes provides the basis for an individual allergy diagnosis for α‐Gal sensitized patients. Higher amounts of α‐Gal in pork and beef innards compared to muscle meat as indicated by a higher staining intensity are a plausible explanation for the difference in allergic symptom severity.This article is protected by copyright. All rights reserved.
Source: Allergy - July 3, 2017 Category: Allergy & Immunology Authors: U. Jappe, S. Minge, B. Kreft, A. Ludwig, B. Przybilla, A. Walker, R. Varga, P. Seidel, T. Biedermann, W. Anem üller, A. Kromminga, F. Ruëff, H. Merk, N. Wagner, R. Treudler, M. Worm, I. Waldmann, J. Saloga, W. M. Becker, T. Goldmann, T. A. Platts‐Mill Tags: Original Article: Experimental Allergy and Immunology Source Type: research

The Efficacy of Oral Immunotherapy in Patients with Cow's Milk Allergy.
Abstract Cow's milk allergy is the most common type of food allergy that decrease the quality of life of patients and their families. The aim of this study was to evaluate the efficacy of oral immunotherapy in patients with cow's milk allergy. 14 patients above 3 years of age with a history of cow's milk allergy confirmed by positive double blind placebo controlled food challenge (DBPCFC) test, presence of serum IgE against cow's milk and positive SPT (skin prick test) were enrolled in this study. During the immunotherapy all patients received increasing amounts of cow's milk during three phases. The type and seve...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2017 Category: Allergy & Immunology Authors: Ebrahimi M, Gharagozlou M, Mohebbi A, Hafezi N, Azizi G, Movahedi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Eating out with a food allergy in the UK: Change in the eating out practices of consumers with food allergy following introduction of allergen information legislation
Conclusion & clinical relevanceFor many participants, the ‘ideal’ eating out experience was one in which a range of information resources were available, and where written allergen information was complemented by proactive and accommodating staff within an allergy‐aware environment. Whilst the onus is on legislators and food providers to ensure that adequate allergen information is provided, clinicians play an important role in encouraging patients with food allergy to pursue their legal right to make allergen enquiries in order to avoid accidental allergen ingestion when eating out.This article is protected by c...
Source: Clinical and Experimental Allergy - December 1, 2017 Category: Allergy & Immunology Authors: Fiona M. Begen, Julie Barnett, Ros Payne, Hazel M. Gowland, Audrey DunnGalvin, Jane S. Lucas Tags: Original Article ‐Clinical Allergy Source Type: research

Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis.
Authors: Pahus L, Gouitaa M, Sofalvi T, Alagha K, Gras D, Chanez P, Charpin D Abstract Summary: Different phenotypes of allergic rhinitis have been identified based on the seasonality of the allergen involved. Within pollinosis, importance has to be paid to the responsible pollen species. Guidelines for clinical management are mostly based on studies performed in patients with grass pollen allergy. Only few data is available on tree pollen allergy and more specifically on cypress pollen allergy. We focused on the clinical and biological features of cypress pollen allergy to determine whether it is associated with a...
Source: European Annals of Allergy and Clinical Immunology - January 21, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

School nurse perspectives on school policies for food allergy and anaphylaxis.
CONCLUSION: With one-third of school nurses reporting an allergic reaction in the past year, schools use many strategies to minimize allergen exposures and increase anaphylaxis preparedness. Most school nurses favor these policies and acknowledge barriers to implementation. PMID: 29508717 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - March 1, 2018 Category: Allergy & Immunology Authors: Kao LM, Wang J, Kagan O, Russell A, Mustafa SS, Houdek D, Smith B, Gupta R Tags: Ann Allergy Asthma Immunol Source Type: research

Oral allergy syndrome amongst young Mexicans: prevalence and associated factors.
Conclusions. Notably, the prevalence of OAS varies according to the geographic area. Personal histories of allergy to pollen or latex were the main factors linked to OAS. PMID: 29533053 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - March 15, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Systematic review of professional liability when prescribing beta-lactams for patients with a known penicillin allergy.
CONCLUSION: The cases with published legal outcomes found limited professional liability for clinicians who prescribed either cephalosporins or carbapenems to a patient with a known penicillin allergy. These results may decrease the litigation fears of providers and risk managers within healthcare systems. PMID: 29551402 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 15, 2018 Category: Allergy & Immunology Authors: Jeffres MN, Hall-Lipsy EA, King ST, Cleary JD Tags: Ann Allergy Asthma Immunol Source Type: research

Leaving the nest: improving food allergy management on college campuses.
CONCLUSION: The use of qualitative research methods, patient-centered design processes, and collaborations with diverse stakeholders-including pediatricians that care for adolescents-can provide a framework for designing coordinated systems and policies to provide comprehensive support to college students with food allergy. Next steps include rigorously testing implementation of the Spotlight intervention prototypes. PMID: 29679763 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - April 18, 2018 Category: Allergy & Immunology Authors: Dyer AA, O'Keefe A, Kanaley MK, Kao L, Gupta RS Tags: Ann Allergy Asthma Immunol Source Type: research

How to predict and improve prognosis of food allergy
Purpose of review The prevalence of food allergy is increasing. More children are being diagnosed with food allergies, and it is taking longer to outgrow them, among those who develop tolerance. The aim of this review is to draw the profile of the persistent food allergic, so that prevention strategies can be developed and active treatment set up. Recent findings Many determinants are involved in food allergy prognosis: ethnicity and sex, type of food, innate immune system, eliciting dose, sensitization status and other biomarkers determination, gut microbiome composition, and the presence of comorbidities. Once ident...
Source: Current Opinion in Allergy and Clinical Immunology - April 26, 2018 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Ocular allergy as a risk factor for dry eye in adults and children
Purpose of review To provide an overview of the pathogenic mechanisms underlying the correlation between ocular allergy and dry eye disease (DED), highlighting how the first condition may be a risk factor for the second one. Recent findings Recent advances in our comprehension of the pathogenesis of ocular allergy and DED allow identifying several pathways of interaction between these two conditions. A growing body of evidence supports the role of ocular allergy as a risk factor for DED. Ocular allergy, particularly the severe forms of keratoconjunctivitis, can impact on different key mechanisms of the DED vicious cyc...
Source: Current Opinion in Allergy and Clinical Immunology - August 31, 2018 Category: Allergy & Immunology Tags: EYE ALLERGY: Edited by Leonard Bielory and Abraham Solomon Source Type: research

The Basophil Activation Test reduces the need for a food challenge test in children suspected of IgE ‐mediated cow's milk allergy
Conclusions and Clinical RelevanceThe BAT seems reliable and cost ‐effective to diagnose patients with an IgE‐mediated cow's milk allergy. In IgE sensitized patients a BAT might replace a DBPCFC. For non‐IgE sensitized patients presenting with mild symptoms we propose to consider a (double‐blind) extended (time) challenge test at home.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - November 8, 2018 Category: Allergy & Immunology Authors: Janneke Ruinemans ‐Koerts, Yvonne Schmidt‐Hieltjes, A d Jansen, Huub F.J. Savelkoul, Annejet Plaisier, Petra van Setten Tags: Original Article ‐Clinical Allergy Source Type: research

Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine in p-phenylenediamine highly allergic volunteers using allergy alert test: the Italian experience.
Conclusions. Me-PPD may offer a safer alternative for PPD-allergic patients with an absent or reduced elicitation response in the allergy alert test simulating hair dye use conditions. Even patients with strong patch test reactions, with appropriate selection by allergy alert test and counselling, may be able to tolerate hair dyeing with Me-PPD containing products. PMID: 30702234 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - February 2, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Hyperresponsiveness to Boiled Egg Yolk in Early Life Leads to Prolonged Egg Allergy.
Authors: Horino S, Kitazawa H, Satou T, Miura K Abstract Hen's egg is the most common allergen in IgE-mediated food allergy among children in Japan. Although the majority of patients with egg allergy can eat heated egg yolk safely because of its low allergenicity, severely allergic patients show an immediate-type reaction to heated egg yolk. We hypothesized that patients with hyperresponsiveness to boiled egg yolk may have difficulty in acquiring tolerance to egg. The purpose of this study was to examine the prognosis of patients with hyperresponsiveness to boiled egg yolk. Data from 121 patients with egg allergy w...
Source: Allergy, Asthma and Immunology Research - March 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research