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Cow's Milk Allergy in Children and Adults.
Authors: Fiocchi A, Dahdah L, Albarini M, Martelli A Abstract Cow's milk allergy is among the more frequent food allergies in infants and children. Because its suspicion stems from a plethora of symptoms, it is frequently reported. However, the development of a rigorous diagnostic pathway will reduce the diagnosed children to less than 50% of those reported. Cow's milk allergy is the only specific food allergy for which an EBM guideline exists. According to the guidelines (Diagnosis and Rationale for Action against Cow's Milk Allergy), a diagnostic process based on the pre-test probability of this condition is avai...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Food allergy in childhood (infancy to school age).
Authors: Bergmann MM, Eigenmann PA Abstract Food allergy is a potentially life-threatening condition affecting almost 10% of children, with an increasing incidence in the last few decades. It is defined as an immune reaction to food, and its pathogenesis may be IgE mediated, mixed IgE and non-IgE mediated, or non-IgE mediated. Potentially all foods can cause food allergy, but a minority of foods are responsible for the vast majority of reactions reported. A good clinical history is crucial for an accurate diagnosis. Allergy tests, including the skin prick test and measurement of specific IgE antibodies, are useful ...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Immunological Basis of Food Allergy (IgE-Mediated, Non-IgE-Mediated, and Tolerance).
Authors: Kim EH, Burks W Abstract Food allergy includes a number of diseases that present with adverse immunological reactions to foods and can be IgE-mediated, non-IgE-mediated, or a combination of both mechanisms. IgE-mediated food allergy involves immediate hypersensitivity through the action of mast cells, whereas non-IgE-mediated food allergy is most commonly cell-mediated. These food allergies are thought to occur as a result of a breakdown in oral tolerance and, more specifically, from an aberrant regulatory T-cell response. Ongoing studies of experimental treatments for food allergy strive to induce oral to...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs
Purpose of review: Unverified penicillin allergy is being increasingly recognized as a public health concern. The ideal protocol for verifying true clinically significant IgE-mediated penicillin allergy needs to use only commercially available materials, be well tolerated and easy to perform in both the inpatient and outpatient settings, and minimize false-positive determinations. This review concentrates on articles published in 2013 and 2014 that present new data relating to the diagnosis and management of penicillin allergy. Recent findings: Penicillin allergy can be safely evaluated at this time, in patients with an ap...
Source: Current Opinion in Allergy and Clinical Immunology - June 26, 2015 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Bernard Y.-H. Thong Source Type: research

Bovine Serum Albumin: a double allergy risk.
Authors: Voltolini S, Spigno F, Cioè A, Cagnati P, Bignardi D, Minale P Abstract We analyse two cases of Bovine Serum Albumin (BSA) allergy. The first regards a female laboratory technician with a history of bronchial asthma due to cat allergy, who developed an exacerbation of bronchial symptoms as a consequence of BSA powder inhalation at work. To date, sensitization to BSA as a cause of occupational asthma has rarely been reported in the scientific literature. The second case concerns a woman with a similar cat sensitivity, who presented an oral allergy syndrome-type clinical reaction, gastric pain and diarrhoea...
Source: European Annals of Allergy and Clinical Immunology - August 2, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

An overview of fruit allergy and the causative allergens.
Authors: Hassan AK, Venkatesh YP Abstract Plant allergens, being one of the most widespread allergenic substances, are hard to avoid. Hence, their identification and characterization are of prime importance for the diagnosis and treatment of food allergy. The reported allergies to fruits mainly evoke oral allergy syndrome caused by the presence of cross-reactive IgE to certain pollens and thus, allergy to fruits has also been linked to particular pollens. Many fruit allergies are being studied for their causative allergens, and are being characterized. Some tropical or exotic fruits are responsible for region-speci...
Source: European Annals of Allergy and Clinical Immunology - November 11, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy.
CONCLUSION: A high prevalence of A simplex sensitization in a large proportion of patients with mono-sensitization was found, confirming that eating habits influence sensitization to this nematode. Allergic symptoms from A simplex ingestion in raw or marinated fish were quite frequent, with symptoms ranging from oral allergy syndrome to anaphylaxis. Patients sensitized to A simplex were more prone to have allergic symptoms when they had co-sensitization to house dust mites or molds, suggesting possible cross-reactive but clinically relevant allergens between these allergenic sources. PMID: 26815707 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 28, 2016 Category: Allergy & Immunology Authors: Heffler E, Sberna ME, Sichili S, Intravaia R, Nicolosi G, Porto M, Liuzzo MT, Picardi G, Fichera S, Crimi N Tags: Ann Allergy Asthma Immunol Source Type: research

Association of food allergy and atopic dermatitis exacerbations.
CONCLUSION: Children with current AD are more frequently asymptomatically sensitized to the foods in question than those without AD. In addition, children suspected of food allergy should be considered for testing, regardless of the severity of their AD. Our results suggest that children with exacerbation of AD in the absence of other allergic symptoms are unlikely to be food allergic. PMID: 26947239 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 3, 2016 Category: Allergy & Immunology Authors: Roerdink EM, Flokstra-de Blok BM, Blok JL, Schuttelaar MA, Niggemann B, Werfel T, Van der Heide S, Kukler J, Kollen BJ, Dubois AE Tags: Ann Allergy Asthma Immunol Source Type: research

Stinging insect identification: Are the allergy specialists any better than their patients?
CONCLUSION: Overall, allergists are more skilled at Hymenoptera identification. Most allergy specialists reported testing for all stinging insects when evaluating insect hypersensitivity, and skin testing was the preferred testing method in nearly 70% of allergists. These data support the practice parameter's recommendation to consider testing for all flying Hymenoptera insects during venom evaluation, which most of the participating allergists surveyed incorporate into their clinical practice. PMID: 26993171 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 16, 2016 Category: Allergy & Immunology Authors: Baker TW, Forester JP, Johnson ML, Sikora JM, Stolfi A, Stahl MC Tags: Ann Allergy Asthma Immunol Source Type: research

Climate Change and Air Pollution: Effects on Respiratory Allergy.
Authors: D'Amato G, Paw.ar R, Vitale C, Lanza M, Molino A, Stanziola A, Sanduzzi A, Vatrella A, D'Amato M Abstract A body of evidence suggests that major changes involving the atmosphere and the climate, including global warming induced by anthropogenic factors, have impact on the biosphere and human environment. Studies on the effects of climate change on respiratory allergy are still lacking and current knowledge is provided by epidemiological and experimental studies on the relationship between allergic respiratory diseases, asthma and environmental factors, such as meteorological variables, airborne allergens, ...
Source: Allergy, Asthma and Immunology Research - June 24, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Sensitization to Food Additives in Patients with Allergy: A Study Based on Skin Test and Open Oral Challenge.
Abstract There has been a great increase in the consumption of various food additives in recent years. The purpose of this study was to identify the incidence of sensitization to food additives by using skin prick test in patients with allergy and to determine the concordance rate between positive skin tests and oral challenge in hypersensitivity to additives. This cross-sectional study included 125 (female 71, male 54) patients aged 2-76 years with allergy and 100 healthy individuals. Skin tests were performed in both patient and control groups with 25 fresh food additives. Among patients with allergy, 22.4% show...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 31, 2016 Category: Allergy & Immunology Authors: Moghtaderi M, Hejrati Z, Dehghani Z, Dehghani F, Kolahi N Tags: Iran J Allergy Asthma Immunol Source Type: research

Effect of ivermectin on allergy-type manifestations in occult strongyloidiasis.
CONCLUSION: Serologic testing for strongyloides may be indicated for patients with allergy-type symptoms and a suggestive exposure history. Patients with strongyloidiasis and primarily cutaneous symptoms experienced significant symptomatic improvement after ivermectin therapy. PMID: 27566864 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - August 22, 2016 Category: Allergy & Immunology Authors: Rampur L, Jariwala SP, Hudes G, Rosenstreich DL, de Vos G Tags: Ann Allergy Asthma Immunol Source Type: research

Allergy to apple cultivars among patients with birch pollinosis and oral allergy syndrome.
CONCLUSION: We noted a substantial role for Bet v 1 sensitization in the allergic response based on evaluation of the allergenicity of 11 apple cultivars. The sIgE Bet v 1 and SPT results of patients with and without OAS allowed differentiation between low and high allergenic cultivars. PMID: 27593099 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Wagner A, Szwed A, Buczyłko K, Wagner W Tags: Ann Allergy Asthma Immunol Source Type: research

Influence of health literacy and trust in online information on food allergy quality of life and self-efficacy.
CONCLUSION: In this sample, health literacy and trust in online information sources were high, with high trust in online information sources negatively associated with QoL. Advocacy group membership had an independent negative association with QoL. PMID: 27613459 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Ditzler N, Greenhawt M Tags: Ann Allergy Asthma Immunol Source Type: research

Impact of IgE-mediated Food Allergy on Parental Quality of Life in Iranian Patients.
Abstract Food allergy is a common disorder especially in the first years of life. Strict avoidance of the responsible food is the most effective therapeutic measure so far. But this continuous vigilance could be stressful for the patient and family and decreases their quality of life (QOL). This survey was designed to evaluate the impact of IgE-mediated food allergy on parental QOL in Iranian patients and to develop a valid Persian version of "Food Allergy Quality Of Life- Parental Burden (FAQL-PB) questionnaire". 90 patients (28 females, 62 males) and their parents who were referred to the clinic of Allergy in Ch...
Source: Iranian Journal of Allergy, Asthma and Immunology - September 30, 2016 Category: Allergy & Immunology Authors: Fathi SM, Tavakol M, Rezaei N, Movahedi M, Aghamohammadi A, Shariat M, Sadeghi B, Behniafard N, Darabi B, Hajikhani A, Abdollahpour I, Gharagozlou M Tags: Iran J Allergy Asthma Immunol Source Type: research