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Vitamin D insufficiency is associated with challenge-proven food allergy in infants
Conclusions: These results provide the first direct evidence that vitamin D sufficiency may be an important protective factor for food allergy in the first year of life.
Source: Journal of Allergy and Clinical Immunology - March 1, 2013 Category: Allergy & Immunology Authors: Katrina J. Allen, Jennifer J. Koplin, Anne-Louise Ponsonby, Lyle C. Gurrin, Melissa Wake, Peter Vuillermin, Pamela Martin, Melanie Matheson, Adrian Lowe, Marnie Robinson, Dean Tey, Nicholas J. Osborne, Thanh Dang, Hern-Tze Tina Tan, Leone Thiele, Deborah Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research

Randomized controlled trial of ragweed allergy immunotherapy tablet efficacy and safety in North American adults.
CONCLUSION: In this trial, ragweed AIT was effective and well tolerated in ragweed-allergic North American adults. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00783198. PMID: 23706715 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 29, 2013 Category: Allergy & Immunology Authors: Nolte H, Hébert J, Berman G, Gawchik S, White M, Kaur A, Liu N, Lumry W, Maloney J Tags: Ann Allergy Asthma Immunol Source Type: research

The natural history of egg allergy in an observational cohort
Background: There are few studies on the natural history of egg allergy, and most are single-site and nonlongitudinal and have not identified early predictors of outcomes.Objective: We sought to describe the natural course of egg allergy and to identify early prognostic markers.Methods: Children age 3 to 15 months were enrolled in a multicenter observational study with either (1) a convincing history of an immediate allergic reaction to egg, milk, or both with a positive skin prick test (SPT) response to the trigger food and/or (2) moderate-to-severe atopic dermatitis and a positive SPT response to egg or milk. Children en...
Source: Journal of Allergy and Clinical Immunology - February 1, 2014 Category: Allergy & Immunology Authors: Scott H. Sicherer, Robert A. Wood, Brian P. Vickery, Stacie M. Jones, Andrew H. Liu, David M. Fleischer, Peter Dawson, Lloyd Mayer, A. Wesley Burks, Alexander Grishin, Donald Stablein, Hugh A. Sampson Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children
Conclusion: Higher maternal intake of peanut, milk, and wheat during early pregnancy was associated with reduced odds of mid-childhood allergy and asthma.
Source: Journal of Allergy and Clinical Immunology - February 11, 2014 Category: Allergy & Immunology Authors: Supinda Bunyavanich, Sheryl L. Rifas-Shiman, Thomas A. Platts-Mills, Lisa Workman, Joanne E. Sordillo, Carlos A. Camargo, Matthew W. Gillman, Diane R. Gold, Augusto A. Litonjua Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research

Skin testing only with penicillin G in children with a history of penicillin allergy.
CONCLUSION: Among children with a history of penicillin allergy, skin testing only with penicillin G followed by a 3-dose graded challenge to the incriminated penicillin is safe and yields a good NPV. This approach could be useful when PPL is unavailable. PMID: 24856884 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 22, 2014 Category: Allergy & Immunology Authors: Picard M, Paradis L, Bégin P, Paradis J, Des Roches A Tags: Ann Allergy Asthma Immunol Source Type: research

Correlation between skin-prick testing, individual specific IgE tests, and a multiallergen IgE assay for allergy detection in patients with chronic rhinitis.
CONCLUSION: This study shows good agreement and correlation between SPT with individual specific IgE test and multiple allergen simultaneous test on a majority of the tested allergens for patients with chronic rhinitis. Comparing the two in vitro tests, individual specific IgE test agrees with SPT better than multiple allergen simultaneous test. PMID: 25198024 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - September 1, 2014 Category: ENT & OMF Authors: Cho JH, Suh JD, Kim JK, Hong SC, Park IH, Lee HM Tags: Am J Rhinol Allergy Source Type: research

Clinical and Immunochemical Profiles of Food Challenge Proven or Anaphylactic Shrimp Allergy in the Tropical Singapore
ConclusionsThis study highlights the predominance of oral symptoms in shrimp allergy in tropical Asia and that a high provocation dose may be necessary to reveal shrimp allergy. Furthermore, specific IgE diagnostic tests and immunoblots were of limited use in this population.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 24, 2014 Category: Allergy & Immunology Authors: Meera Thalayasingam, Irvin Francis A. Gerez, Gaik Chin Yap, Genevieve V. Llanora, Irenaeus Paul Chia, Lynn Chua, Cheng Jin Alpha Omega Lee, Huy Duc Ta Le, Yew Kuang Cheng, Bernard Yu Hor Thong, Chwee Ying Tang, Hugo PS Van Bever, Lynette Pei‐Chi Shek, M Tags: Original Article‐Clinical Allergy Source Type: research

IgE, IgG4 and IgA specific for Bet v 1‐related food allergens do not predict oral allergy syndrome
ConclusionMeasurements of allergen‐specific immunoglobulins are not suitable for diagnosing Bet v 1‐mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac.This article is protected by copyright. All rights reserved.
Source: Allergy - October 19, 2014 Category: Allergy & Immunology Authors: Eva Elisabeth Guhsl, Gerlinde Hofstetter, Nina Lengger, Wolfgang Hemmer, Christof Ebner, Renate Fröschl, Merima Bublin, Christian Lupinek, Heimo Breiteneder, Christian Radauer Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Environmental pollution and allergy: historical aspects.
Authors: Behrendt H, Alessandrini F, Buters J, Krämer U, Koren H, Ring J Abstract It may be a coincidence, but it is a fact that the first clear characterization of hay fever began in England where modern industrialization started in Europe. Only at the end of the 20th century were associations of the increasing prevalence of allergy with outdoor air pollution discussed. The seminal study came from Japan from the group of T. Miyamoto linking the increase in Japanese cedar pollinosis to an increased prevalence of Diesel cars and probably exposure to Diesel exhaust in epidemiological, animal experimental and in vitr...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Neural and behavioral correlates of food allergy.
Authors: Costa-Pinto FA, Basso AS Abstract Food allergy accounts for a great number of reactions leading to diminished quality of life in western countries. There has been an abundance of reports of behavioral changes, as well as psychiatric conditions associated with food allergy over the past decades. Most of this field inspired little medical attention for its lack of a solid scientific ground. We review the literature on the association of food allergy and brain activity, leading to changes in emotion and behavior. Moreover, we describe an experimental paradigm employed to dissect the biological relevance of th...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients.
CONCLUSIONS: Der f 2 was the most frequently sensitized allergen among the HDM-sensitized respiratory and AD patients in Korea, and the combination of the group 1 and 2 major allergens increased the diagnostic sensitivity. Minor allergens did not significantly improve diagnostic sensitivity. However, further studies are needed to analyze the relationship between sensitization to other HDM allergens and the disease entity of the HDM allergy. PMID: 25749773 [PubMed - as supplied by publisher]
Source: Allergy, Asthma and Immunology Research - March 12, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Food for thought: progress in understanding the causes and mechanisms of food allergy
Purpose of review: The community burden of food allergy appears to be rising, yet the causes and mechanisms are not completely understood. The purpose of this review is to provide a snapshot of the state of play of IgE food allergies, with a focus on recent advances. Recent findings: There are still wide discrepancies regarding measures and definitions of food allergy. Even recent studies still rely on food sensitization, self-reporting, or parent-reporting rather than more robust measures. Population-based sampling strategies using objective measures are underway in some countries. Emerging data suggest substantial geogra...
Source: Current Opinion in Allergy and Clinical Immunology - April 29, 2015 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang Source Type: research

Food allergy: psychosocial impact and public policy implications.
Authors: Sharma HP, Herbert LJ Abstract Given its increasing prevalence and potential severity, food allergy not only negatively impacts the health and quality of life of affected individuals but also carries a significant economic burden. To address these problems, a community approach including efforts to increase awareness of food allergy among the general public and the implementation of appropriate public policies to keep affected individuals safe is required. This chapter reviews the general public's knowledge and perceptions of food allergy, the disease's psychosocial impact on affected individuals, and the ...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Fish and shellfish allergy.
Authors: Thalayasingam M, Lee BW Abstract Fish and shellfish consumption has increased worldwide, and there are increasing reports of adverse reactions to fish and shellfish, with an approximate prevalence of 0.5-5%. Fish allergy often develops early in life, whilst shellfish allergy tends to develop later, from adolescence onwards. Little is known about the natural history of these allergies, but both are thought to be persistent. The clinical manifestations of shellfish allergy, in particular, may vary from local to life-threatening 'anaphylactic' reactions within an individual and between individuals. Parvalbumi...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Hen's Egg Allergy.
Authors: Urisu A, Kondo Y, Tsuge I Abstract Egg allergy is one of the most frequent food allergies in infants and young children. The prevalence of egg allergy is estimated to be between 1.8 and 2% in children younger than 5 years of age. The reactions are mainly mediated by IgE and partially by non-IgE or are a mix of both types. Egg white contains more than 20 different proteins and glycoproteins. Ovomucoid (Gal d 1), ovalbumin (Gal d 2), conalbumin (ovotransferrin) (Gal d 3) and lysozyme (Gal d 4) have been identified as major allergens in hen's egg. Alpha-livetin (Gal d 5) is thought to be a main egg yolk aller...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research